DK115473B - Fremgangsmåde til fremstilling af 2,3,4,5-tetrahydro-1H-3-benzazepiner eller syreadditionssalte deraf. - Google Patents

Fremgangsmåde til fremstilling af 2,3,4,5-tetrahydro-1H-3-benzazepiner eller syreadditionssalte deraf.

Info

Publication number
DK115473B
DK115473B DK63068AA DK63068A DK115473B DK 115473 B DK115473 B DK 115473B DK 63068A A DK63068A A DK 63068AA DK 63068 A DK63068 A DK 63068A DK 115473 B DK115473 B DK 115473B
Authority
DK
Denmark
Prior art keywords
benzazepines
tetrahydro
preparation
acid addition
addition salts
Prior art date
Application number
DK63068AA
Other languages
Danish (da)
English (en)
Inventor
K Hoegerle
E Habicht
Original Assignee
Geigy Ag J R
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Geigy Ag J R filed Critical Geigy Ag J R
Publication of DK115473B publication Critical patent/DK115473B/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D203/00—Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D203/04—Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D203/06—Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D203/08—Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/16—Benzazepines; Hydrogenated benzazepines

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Drawers Of Furniture (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Plural Heterocyclic Compounds (AREA)
DK63068AA 1967-02-17 1968-02-16 Fremgangsmåde til fremstilling af 2,3,4,5-tetrahydro-1H-3-benzazepiner eller syreadditionssalte deraf. DK115473B (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH238667A CH481110A (de) 1967-02-17 1967-02-17 Verfahren zur Herstellung von 1,2,4,5-Tetrahydro-3-azepinen
CH1167167A CH488705A (de) 1967-02-17 1967-08-18 Verfahren zur Herstellung eines neuen Tetrahydroazepinderivates

Publications (1)

Publication Number Publication Date
DK115473B true DK115473B (da) 1969-10-13

Family

ID=25690322

Family Applications (1)

Application Number Title Priority Date Filing Date
DK63068AA DK115473B (da) 1967-02-17 1968-02-16 Fremgangsmåde til fremstilling af 2,3,4,5-tetrahydro-1H-3-benzazepiner eller syreadditionssalte deraf.

Country Status (13)

Country Link
US (1) US3652543A (Direct)
AT (1) AT275533B (Direct)
BE (1) BE710872A (Direct)
CH (2) CH481110A (Direct)
DE (2) DE1695124A1 (Direct)
DK (1) DK115473B (Direct)
ES (1) ES350574A1 (Direct)
FR (2) FR1560654A (Direct)
GB (2) GB1222397A (Direct)
IL (1) IL29485A (Direct)
NL (1) NL6802257A (Direct)
NO (1) NO124369B (Direct)
SE (1) SE342043B (Direct)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT289812B (de) * 1968-08-09 1971-05-10 Geigy Ag J R Verfahren zur Herstellung des neuen 2-Methyl-7-chlor-2,3,4,5-tetrahydro-1H-3-benzazepins sowie seiner Säureadditionssalze
DE2016136A1 (de) * 1970-04-04 1971-10-14 C H Boehnnger Sohn, 6507 Ingel heim Neue 7 Acyl 1,2,4,5 tetrahydro (3H) 3 benzazepine
DE2143204C3 (de) * 1971-08-28 1979-09-27 Deutsche Gold- Und Silber-Scheideanstalt Vormals Roessler, 6000 Frankfurt N-Fluoralkyl-phenylisopropylamin-Derivate und deren Salze, Verfahren zu deren Herstellung und Arzneimittel auf deren Basis
FR2171879A1 (en) * 1972-02-14 1973-09-28 Pennwalt Corp 1,2,4,5-tetrahydro-3h-3-benzazepines - analgesics narcotic antagonists, antihistamines etc
EP0161350A1 (en) * 1981-11-27 1985-11-21 Smithkline Beckman Corporation Process for preparing benzazepines
US4541954A (en) * 1984-09-05 1985-09-17 Smithkline Beckman Corporation Method for preparing 6-chloro-N-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine
HU199805B (en) * 1986-01-16 1990-03-28 Schering Corp Process for producing condensed benzazepine derivatives and pharmaceutical compositions comprising such compounds
US5302716A (en) * 1986-01-16 1994-04-12 Schering Corporation Fused benzazepines
US4973586A (en) * 1986-01-16 1990-11-27 Schering Corporation Fused benzazepines, compositions of, and medical use thereof
US5015639A (en) * 1987-03-27 1991-05-14 Schering Corporation Substituted benzazepines, their preparation and pharmaceutical compositions containing them
EP0363353B1 (en) * 1987-07-15 1992-07-22 Schering Corporation Fused benzazepines
ATE126511T1 (de) * 1990-02-02 1995-09-15 Schering Corp 4,5-cycloalkano-3-benzazepin-7-ol-derivate und ihre verwendung.
US6953787B2 (en) 2002-04-12 2005-10-11 Arena Pharmaceuticals, Inc. 5HT2C receptor modulators
US20030220661A1 (en) * 2002-05-21 2003-11-27 Heartstent Corporation Transmyocardial implant delivery system
EP2332920A3 (en) * 2003-06-17 2011-12-21 Arena Pharmaceuticals, Inc. Processes for preparing 3-benzazepines
BRPI0411613B8 (pt) 2003-06-17 2021-05-25 Arena Pharm Inc sal de 3-benzazepinas
US20070275949A1 (en) * 2003-10-22 2007-11-29 Arena Pharmaceuticals, Inc. Benzazepine Derivatives and Methods of Prophylaxis or Treatment of 5Ht2C Receptor Associated Diseases
US20080009478A1 (en) * 2003-10-22 2008-01-10 Arena Pharmaceuticals, Inc. Benzazepine Derivatives and Methods of Prophylaxis or Treatment of 5Ht2c Receptor Associated Diseases
US8168624B2 (en) 2004-12-21 2012-05-01 Arena Pharmaceuticals, Inc. Crystalline forms of (R)-8-chloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine hydrochloride
NZ555482A (en) 2004-12-23 2011-01-28 Arena Pharm Inc Compositions comprising a 5HT2C receptor modulator and 2-methylamphetamine and methods of use
EP2001852A2 (en) * 2006-04-03 2008-12-17 Arena Pharmaceuticals, Inc. Processes for the preparation of 8-chloro-1-methyl-2,3,4,5-tetrahydro-1h-3-benzazepine and intermediates related thereto
ES2522587T3 (es) * 2006-12-05 2014-11-17 Arena Pharmaceuticals, Inc. Procesos para preparar (R)-8-cloro-1-metil-2,3,4,5-tetrahidro-1H-3-benzacepina e intermedios de la misma
WO2009111004A1 (en) * 2008-03-04 2009-09-11 Arena Pharmaceuticals, Inc. Processes for the preparation of intermediates related to the 5-ht2c agonist (r)-8-chloro-1-methyl-2,3,4,5-tetrahydro-1h-3-benzazepine
CN102648170A (zh) 2009-06-18 2012-08-22 艾尼纳制药公司 制备5-ht2c受体激动剂的方法
US20120253036A1 (en) 2009-12-11 2012-10-04 Yukinori Nagakura Agent for treating fibromyalgia
WO2011153206A1 (en) 2010-06-02 2011-12-08 Arena Pharmaceuticals, Inc. Processes for the preparation of 5-ht2c receptor agonists
CA2808890A1 (en) 2010-09-01 2012-03-08 Arena Pharmaceuticals, Inc. Administration of lorcaserin to individuals with renal impairment
JP2013539470A (ja) 2010-09-01 2013-10-24 アリーナ ファーマシューティカルズ， インコーポレイテッド ロルカセリンと光学活性な酸との塩
MX2013002421A (es) 2010-09-01 2013-05-17 Arena Pharm Inc Sales no hidroscopicas de agonistas de 5-ht2c.
KR101913442B1 (ko) 2010-09-01 2018-10-30 에자이 알앤드디 매니지먼트 가부시키가이샤 체중 관리에 유용한 5-ｈｔ2ｃ 작동제의 변형-방출 투여 형태
RU2674670C1 (ru) 2012-10-09 2018-12-12 Арена Фармасьютикалз, Инк. Способ коррекции массы тела

Also Published As

Publication number Publication date
DE1668915A1 (de) 1972-03-09
ES350574A1 (es) 1969-11-16
BE710872A (Direct) 1968-08-16
AT275533B (de) 1969-10-27
CH488705A (de) 1970-04-15
GB1222397A (en) 1971-02-10
GB1221324A (en) 1971-02-03
DE1695124A1 (de) 1970-08-20
US3652543A (en) 1972-03-28
NO124369B (Direct) 1972-04-10
SE342043B (Direct) 1972-01-24
IL29485A (en) 1971-07-28
NL6802257A (Direct) 1968-08-19
FR1561479A (Direct) 1969-03-28
CH481110A (de) 1969-11-15
FR1560654A (Direct) 1969-03-21

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