DK115403B - Fremgangsmåde til fremstilling af (3-amino-pyrazinoyl)-guanidiner. - Google Patents
Fremgangsmåde til fremstilling af (3-amino-pyrazinoyl)-guanidiner.Info
- Publication number
- DK115403B DK115403B DK619765AA DK619765A DK115403B DK 115403 B DK115403 B DK 115403B DK 619765A A DK619765A A DK 619765AA DK 619765 A DK619765 A DK 619765A DK 115403 B DK115403 B DK 115403B
- Authority
- DK
- Denmark
- Prior art keywords
- pyrazinoyl
- guanidines
- amino
- preparation
- Prior art date
Links
- GTOFYYPYNNNMLP-UHFFFAOYSA-N 3-amino-n-(diaminomethylidene)pyrazine-2-carboxamide Chemical class NC(N)=NC(=O)C1=NC=CN=C1N GTOFYYPYNNNMLP-UHFFFAOYSA-N 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/36—Radicals substituted by singly-bound nitrogen atoms
- C07D213/40—Acylated substituent nitrogen atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D241/24—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D241/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with nitrogen atoms directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D475/00—Heterocyclic compounds containing pteridine ring systems
- C07D475/02—Heterocyclic compounds containing pteridine ring systems with an oxygen atom directly attached in position 4
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US23423062A | 1962-10-30 | 1962-10-30 | |
| US313315A US3313813A (en) | 1962-10-30 | 1963-10-07 | (3-amino-5, 6-disubstituted-pyrazinoyl) guanidines |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK115403B true DK115403B (da) | 1969-10-06 |
Family
ID=26927694
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK512263AA DK114978B (da) | 1962-10-30 | 1963-10-30 | Fremgangsmåde til fremstilling af (3-amino-pyrazinoyl)-guanidin-forbindelser eller salte heraf. |
| DK453364AA DK116943B (da) | 1962-10-30 | 1964-09-14 | Fremgangsmåde til fremstilling af (3-amino-5,6-disubstituerede-pyrazinoyl)-guanidinforbindelser eller syreadditionssalte deraf. |
| DK619765AA DK115403B (da) | 1962-10-30 | 1965-12-02 | Fremgangsmåde til fremstilling af (3-amino-pyrazinoyl)-guanidiner. |
| DK619865AA DK114557B (da) | 1962-10-30 | 1965-12-02 | Fremgangsmåde til fremstilling af pteridin-forbindelser. |
Family Applications Before (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK512263AA DK114978B (da) | 1962-10-30 | 1963-10-30 | Fremgangsmåde til fremstilling af (3-amino-pyrazinoyl)-guanidin-forbindelser eller salte heraf. |
| DK453364AA DK116943B (da) | 1962-10-30 | 1964-09-14 | Fremgangsmåde til fremstilling af (3-amino-5,6-disubstituerede-pyrazinoyl)-guanidinforbindelser eller syreadditionssalte deraf. |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK619865AA DK114557B (da) | 1962-10-30 | 1965-12-02 | Fremgangsmåde til fremstilling af pteridin-forbindelser. |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US3313813A (da) |
| BE (1) | BE639386A (da) |
| BR (1) | BR6354164D0 (da) |
| CH (1) | CH465617A (da) |
| CY (1) | CY440A (da) |
| DE (2) | DE1470053A1 (da) |
| DK (4) | DK114978B (da) |
| FI (1) | FI47102C (da) |
| FR (1) | FR1563612A (da) |
| GB (1) | GB1066855A (da) |
| MY (1) | MY6900026A (da) |
| NL (2) | NL142413B (da) |
| SE (1) | SE321230B (da) |
Families Citing this family (73)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL6409714A (da) * | 1962-10-30 | 1965-10-01 | ||
| US3472848A (en) * | 1966-11-17 | 1969-10-14 | Merck & Co Inc | 3-hydroxy and 3-mercapto-pyrazinoyl-guanidines,corresponding ethers and thioethers and processes for their preparation |
| US3948895A (en) * | 1971-09-28 | 1976-04-06 | E. I. Du Pont De Nemours And Company | Synthesis of 3,5-diaminopyrazinoic acid from 3,5-diamino-2,6-dicyanopyrazine and intermediates |
| US4085211A (en) * | 1975-12-15 | 1978-04-18 | Merck & Co., Inc. | Pyrazinecarboxamides and processes for preparing same |
| US4087526A (en) * | 1976-07-23 | 1978-05-02 | Merck & Co., Inc. | (3-Amino-5-substituted-6-fluoropyrazinoyl or pyrazamido)-guanidines and their derivatives bearing substituents on the guanidino nitrogens |
| US4208413A (en) * | 1977-03-04 | 1980-06-17 | Merck & Co., Inc. | N-Pyrazinecarbonyl-N'-alkoxycarbonyl and N',N"-bis(alkoxycarbonyl)guanidines and processes for preparing same |
| US4108859A (en) * | 1977-06-06 | 1978-08-22 | The Dow Chemical Company | Microbicidal (pyridinylamino) alkyl guanidines |
| US4140776A (en) * | 1977-09-16 | 1979-02-20 | Merck & Co., Inc. | N-pyrazinecarbonyl-N'-acylguanidines |
| US4190655A (en) * | 1978-08-28 | 1980-02-26 | Merck & Co., Inc. | Amiloride citrate |
| EP0009054A1 (en) * | 1978-09-19 | 1980-04-02 | Merck & Co. Inc. | N-Pyrazinecarbonyl-N'-substituted-sulfamoyl-guanidine and processes for preparing same |
| US4246406A (en) * | 1979-03-27 | 1981-01-20 | Merck & Co., Inc. | Heterocyclic substituted pyrazinoylguanidines |
| US4224447A (en) * | 1979-03-27 | 1980-09-23 | Merck & Co., Inc. | Novel pyrazinecarboxamides and processes for preparing same |
| US4309540A (en) * | 1980-05-19 | 1982-01-05 | Merck & Co., Inc. | Substituted pyrazinyl-1,2,4-oxadiazoles |
| US4362724A (en) * | 1980-05-19 | 1982-12-07 | Merck & Co., Inc. | Method of treating edema and hypertension and pharmaceutical composition therefor in which the active ingredient comprises a novel substituted pyrazinyl-1,2,4-oxadiazole and a kaliuretic diuretic |
| US4454132A (en) * | 1981-03-16 | 1984-06-12 | Merck & Co., Inc. | Pharmaceutical compositions of novel substituted pyrazinyl-1,2,4-oxadiazoles useful in the treatment of edema and hypertension |
| US4510322A (en) * | 1981-07-13 | 1985-04-09 | Merck & Co., Inc. | Indacrinone having enhanced uricosuric |
| US4952582A (en) * | 1982-01-04 | 1990-08-28 | Beyer Jr Karl H | Pyrazinoylguanidine and derivatives thereof having few polar substituents and being useful as hyperuretic agents |
| US4663322A (en) * | 1982-01-04 | 1987-05-05 | Beyer Jr Karl H | Antihypertensive hyperuretic and saluretic agent combinations |
| DE3312516A1 (de) * | 1983-04-07 | 1984-10-11 | Brigitte Dr. 7400 Tübingen Pfeiffer | Kernsubstituierte phenylalkylenguanidinderivate, verfahren zu ihrer herstellung und sie enthaltende arzneimittel |
| US4604394A (en) * | 1984-10-01 | 1986-08-05 | Merck & Co., Inc. | Antiarrhythmic compositions and method |
| DE3925847A1 (de) * | 1989-08-04 | 1991-02-07 | Huels Chemische Werke Ag | Verfahren zur herstellung von 3-aminopyrazin-2-carbonsaeuremethylester |
| US5304125A (en) * | 1990-10-05 | 1994-04-19 | The University Of North Carolina | Apparatus for administering solid particulate aerosols to the lungs |
| KR930701992A (ko) * | 1990-10-05 | 1993-09-08 | 웨인 알.조운즈 | 환자의 폐에 잔존하는 점액 분비물의 제거 방법 |
| TW213903B (da) * | 1991-08-16 | 1993-10-01 | Boehringer Ingelheim Kg | |
| US6169107B1 (en) | 1993-04-28 | 2001-01-02 | Sumitomo Pharmaceutical Co., Ltd. | Indoloylguanidine derivatives |
| DE4337609A1 (de) * | 1993-11-04 | 1995-05-11 | Boehringer Ingelheim Kg | Neue Pyrazincarboxamidderivate, ihre Herstellung und ihre Verwendung in Arzneimitteln |
| US5656256A (en) * | 1994-12-14 | 1997-08-12 | The University Of North Carolina At Chapel Hill | Methods of treating lung disease by an aerosol containing benzamil or phenamil |
| TW372967B (en) * | 1994-12-27 | 1999-11-01 | Kanebo Ltd | 1,4 benzoxazine derivative, pharmaceutical composition containing the same and use thereof |
| US5635160A (en) * | 1995-06-07 | 1997-06-03 | The University Of North Carolina At Chapel Hill | Dinucleotides useful for the treatment of cystic fibrosis and for hydrating mucus secretions |
| US5628984A (en) * | 1995-07-31 | 1997-05-13 | University Of North Carolina At Chapel Hill | Method of detecting lung disease |
| US5801177A (en) * | 1995-12-14 | 1998-09-01 | Beyer, Jr.; Karl H. | Method for controlling and/or lowering serum glucose and fatty acid concentrations and hypertensive blood pressure in non-insulin-dependent diabetic patients |
| US5877217A (en) * | 1995-12-26 | 1999-03-02 | Alteon Inc. | N-acylaminoalkyl-hydrazinecarboximidamides |
| CA2300146A1 (en) * | 1997-08-29 | 1999-03-04 | Richard C. Boucher, Jr. | Use of uridine 5'-diphosphate and analogs thereof for the treatment of lung diseases |
| WO2000023023A1 (en) | 1998-10-20 | 2000-04-27 | The University Of North Carolina At Chapel Hill | Methods of hydrating mucosal surfaces |
| CA2360687A1 (en) * | 1999-01-29 | 2000-08-03 | Karl H. Beyer, Jr. (Deceased) | Composition and method for treating diabetes |
| CA2378181A1 (en) | 1999-07-19 | 2001-01-25 | Richard C. Boucher, Jr. | Conjugates of sodium channel blockers and methods of using the same |
| PT1336407E (pt) | 2000-11-21 | 2006-07-31 | Sankyo Co | Composicao contendo um antagonista do receptor de angiotensina e um diuretico e sua utilizacao para o tratamento da hipertensao |
| US6858614B2 (en) * | 2002-02-19 | 2005-02-22 | Parion Sciences, Inc. | Phenolic guanidine sodium channel blockers |
| US6858615B2 (en) * | 2002-02-19 | 2005-02-22 | Parion Sciences, Inc. | Phenyl guanidine sodium channel blockers |
| US7704995B2 (en) * | 2002-05-03 | 2010-04-27 | Exelixis, Inc. | Protein kinase modulators and methods of use |
| CA2484209C (en) * | 2002-05-03 | 2013-06-11 | Exelixis, Inc. | Protein kinase modulators and methods of use |
| EP1545519B1 (en) | 2002-08-19 | 2011-03-23 | Pfizer Inc. | Combination therapy for hyperproliferative diseases |
| US6903105B2 (en) * | 2003-02-19 | 2005-06-07 | Parion Sciences, Inc. | Sodium channel blockers |
| AU2004248859C1 (en) * | 2003-06-26 | 2011-11-24 | Biotron Limited | Antiviral acylguanidine compounds and methods |
| BRPI0411900B8 (pt) | 2003-06-26 | 2021-05-25 | Biotron Ltd | compostos e composições farmacêuticas compreendendo os mesmos |
| US7326706B2 (en) * | 2003-08-15 | 2008-02-05 | Bristol-Myers Squibb Company | Pyrazine modulators of cannabinoid receptors |
| US20050090505A1 (en) * | 2003-08-18 | 2005-04-28 | Johnson Michael R. | Methods of reducing risk of infection from pathogens |
| SI1663235T1 (sl) * | 2003-08-18 | 2013-12-31 | Parion Sciences, Inc. | Zaščiteni pirazinoilgvanidinski blokatorji natrijevega kanala |
| KR20060115348A (ko) * | 2003-08-18 | 2006-11-08 | 패리온 사이언스 인코퍼레이티드 | 지방족 피라지노일구아니딘 나트륨 채널 차단제 |
| US7745442B2 (en) | 2003-08-20 | 2010-06-29 | Parion Sciences, Inc. | Methods of reducing risk of infection from pathogens |
| US20090253714A1 (en) * | 2003-08-20 | 2009-10-08 | Johnson Michael R | Methods of reducing risk of infection from pathogens |
| US20070099968A1 (en) * | 2004-06-26 | 2007-05-03 | Biotron Limited | Antiviral compounds and methods |
| US20070021439A1 (en) * | 2005-07-25 | 2007-01-25 | Parion Sciences, Inc. | Methods of reducing risk of infection from pathogens with soluble amide and ester pyrazinoylguanidine sodium channel blockers |
| US7741317B2 (en) | 2005-10-21 | 2010-06-22 | Bristol-Myers Squibb Company | LXR modulators |
| WO2007062222A2 (en) | 2005-11-22 | 2007-05-31 | University Of South Florida | Inhibition of cell proliferation |
| US7888376B2 (en) | 2005-11-23 | 2011-02-15 | Bristol-Myers Squibb Company | Heterocyclic CETP inhibitors |
| JP5498168B2 (ja) | 2006-12-01 | 2014-05-21 | ブリストル−マイヤーズ スクイブ カンパニー | アテローム性動脈硬化および循環器疾患の治療のためのｃｅｔｐ阻害剤としてのｎ−（（３−ベンジル）−２，２−（ビス−フェニル）−プロパン−１−アミン誘導体 |
| EP2211956A4 (en) | 2007-10-10 | 2014-07-09 | Parion Sciences Inc | DISPOSAL OF OSMOLYTES WITH A NOSE CANNULA |
| AU2009246799B2 (en) * | 2008-02-26 | 2014-02-27 | Parion Sciences, Inc. | Poly aromatic pyrazinoylguanidine sodium channel blockers |
| DE102008053024B4 (de) | 2008-10-24 | 2015-04-30 | RUHR-UNIVERSITäT BOCHUM | Verwendung von Amilorid-Derivaten zur Bekämpfung von Insekten und Milben |
| US8247436B2 (en) | 2010-03-19 | 2012-08-21 | Novartis Ag | Pyridine and pyrazine derivative for the treatment of CF |
| US8945605B2 (en) | 2011-06-07 | 2015-02-03 | Parion Sciences, Inc. | Aerosol delivery systems, compositions and methods |
| PL2723176T3 (pl) | 2011-06-27 | 2018-01-31 | Parion Sciences Inc | Chemicznie i metabolicznie stabilny dipeptyd o silnej aktywności blokera kanału sodowego |
| AR086745A1 (es) | 2011-06-27 | 2014-01-22 | Parion Sciences Inc | 3,5-diamino-6-cloro-n-(n-(4-(4-(2-(hexil(2,3,4,5,6-pentahidroxihexil)amino)etoxi)fenil)butil)carbamimidoil)pirazina-2-carboxamida |
| CA2872029A1 (en) | 2012-05-29 | 2013-12-05 | Parion Sciences, Inc. | Dendrimer like amino amides possessing sodium channel blocker activity for the treatment of dry eye and other mucosal diseases |
| PE20151054A1 (es) | 2012-12-17 | 2015-08-07 | Parion Sciences Inc | Derivados de cloro-pirazin carboxamida con actividad bloqueadora sobre los canales de sodio epiteliales |
| MX2015007797A (es) | 2012-12-17 | 2015-10-05 | Parion Sciences Inc | Compuestos de 3,5-diamino-6-cloro-n-(n-(4-fenilbutil) carbamimidoil) pirazin-2-carboxamida. |
| SG11201507496UA (en) | 2013-04-17 | 2015-11-27 | Pfizer | N-piperidin-3-ylbenzamide derivatives for treating cardiovascular diseases |
| EP3019492B1 (en) * | 2013-07-08 | 2017-09-06 | Boehringer Ingelheim International GmbH | Amiloride-type compounds as inhibitors in epithelial sodium channels for the treatment of diseases of the lungs and airways |
| US9102633B2 (en) | 2013-12-13 | 2015-08-11 | Parion Sciences, Inc. | Arylalkyl- and aryloxyalkyl-substituted epithelial sodium channel blocking compounds |
| WO2016055901A1 (en) | 2014-10-08 | 2016-04-14 | Pfizer Inc. | Substituted amide compounds |
| CN109476599A (zh) * | 2016-07-29 | 2019-03-15 | 东丽株式会社 | 胍衍生物和其医药用途 |
| US11248001B2 (en) | 2019-01-18 | 2022-02-15 | Astrazeneca Ab | PCSK9 inhibitors and methods of use thereof |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE639393A (da) * | 1962-10-30 |
-
0
- BE BE639386D patent/BE639386A/xx unknown
- NL NL299931D patent/NL299931A/xx unknown
-
1963
- 1963-10-07 US US313315A patent/US3313813A/en not_active Expired - Lifetime
- 1963-10-24 GB GB42062/63A patent/GB1066855A/en not_active Expired
- 1963-10-28 DE DE19631470053 patent/DE1470053A1/de active Pending
- 1963-10-28 DE DE1795438A patent/DE1795438C2/de not_active Expired
- 1963-10-29 SE SE11899/63A patent/SE321230B/xx unknown
- 1963-10-29 FR FR952219A patent/FR1563612A/fr not_active Expired
- 1963-10-29 CH CH1329763A patent/CH465617A/de unknown
- 1963-10-30 NL NL63299931A patent/NL142413B/xx not_active IP Right Cessation
- 1963-10-30 BR BR154164/63A patent/BR6354164D0/pt unknown
- 1963-10-30 DK DK512263AA patent/DK114978B/da unknown
-
1964
- 1964-04-27 FI FI640911A patent/FI47102C/fi active
- 1964-09-14 DK DK453364AA patent/DK116943B/da unknown
-
1965
- 1965-12-02 DK DK619765AA patent/DK115403B/da unknown
- 1965-12-02 DK DK619865AA patent/DK114557B/da unknown
-
1968
- 1968-05-18 CY CY44068A patent/CY440A/xx unknown
-
1969
- 1969-12-31 MY MY196926A patent/MY6900026A/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CY440A (en) | 1968-05-18 |
| DE1470053A1 (de) | 1969-06-26 |
| DK116943B (da) | 1970-03-02 |
| DK114557B (da) | 1969-07-14 |
| FR1563612A (da) | 1969-04-18 |
| GB1066855A (en) | 1967-04-26 |
| NL142413B (nl) | 1974-06-17 |
| DE1795438C2 (de) | 1974-04-11 |
| CH465617A (de) | 1968-11-30 |
| SE321230B (da) | 1970-03-02 |
| BR6354164D0 (pt) | 1973-09-18 |
| DK114978B (da) | 1969-08-25 |
| MY6900026A (en) | 1969-12-31 |
| NL299931A (da) | |
| DE1795438B1 (de) | 1973-09-06 |
| FI47102C (fi) | 1973-09-10 |
| BE639386A (da) | |
| FI47102B (da) | 1973-05-31 |
| US3313813A (en) | 1967-04-11 |
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