DK114978B - Fremgangsmåde til fremstilling af (3-amino-pyrazinoyl)-guanidin-forbindelser eller salte heraf. - Google Patents
Fremgangsmåde til fremstilling af (3-amino-pyrazinoyl)-guanidin-forbindelser eller salte heraf.Info
- Publication number
- DK114978B DK114978B DK512263AA DK512263A DK114978B DK 114978 B DK114978 B DK 114978B DK 512263A A DK512263A A DK 512263AA DK 512263 A DK512263 A DK 512263A DK 114978 B DK114978 B DK 114978B
- Authority
- DK
- Denmark
- Prior art keywords
- pyrazinoyl
- salts
- amino
- preparation
- guanidine compounds
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/36—Radicals substituted by singly-bound nitrogen atoms
- C07D213/40—Acylated substituent nitrogen atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D241/24—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D241/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with nitrogen atoms directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D475/00—Heterocyclic compounds containing pteridine ring systems
- C07D475/02—Heterocyclic compounds containing pteridine ring systems with an oxygen atom directly attached in position 4
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US23423062A | 1962-10-30 | 1962-10-30 | |
| US313315A US3313813A (en) | 1962-10-30 | 1963-10-07 | (3-amino-5, 6-disubstituted-pyrazinoyl) guanidines |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK114978B true DK114978B (da) | 1969-08-25 |
Family
ID=26927694
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK512263AA DK114978B (da) | 1962-10-30 | 1963-10-30 | Fremgangsmåde til fremstilling af (3-amino-pyrazinoyl)-guanidin-forbindelser eller salte heraf. |
| DK453364AA DK116943B (da) | 1962-10-30 | 1964-09-14 | Fremgangsmåde til fremstilling af (3-amino-5,6-disubstituerede-pyrazinoyl)-guanidinforbindelser eller syreadditionssalte deraf. |
| DK619865AA DK114557B (da) | 1962-10-30 | 1965-12-02 | Fremgangsmåde til fremstilling af pteridin-forbindelser. |
| DK619765AA DK115403B (da) | 1962-10-30 | 1965-12-02 | Fremgangsmåde til fremstilling af (3-amino-pyrazinoyl)-guanidiner. |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK453364AA DK116943B (da) | 1962-10-30 | 1964-09-14 | Fremgangsmåde til fremstilling af (3-amino-5,6-disubstituerede-pyrazinoyl)-guanidinforbindelser eller syreadditionssalte deraf. |
| DK619865AA DK114557B (da) | 1962-10-30 | 1965-12-02 | Fremgangsmåde til fremstilling af pteridin-forbindelser. |
| DK619765AA DK115403B (da) | 1962-10-30 | 1965-12-02 | Fremgangsmåde til fremstilling af (3-amino-pyrazinoyl)-guanidiner. |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US3313813A (xx) |
| BE (1) | BE639386A (xx) |
| BR (1) | BR6354164D0 (xx) |
| CH (1) | CH465617A (xx) |
| CY (1) | CY440A (xx) |
| DE (2) | DE1795438C2 (xx) |
| DK (4) | DK114978B (xx) |
| FI (1) | FI47102C (xx) |
| FR (1) | FR1563612A (xx) |
| GB (1) | GB1066855A (xx) |
| MY (1) | MY6900026A (xx) |
| NL (2) | NL142413B (xx) |
| SE (1) | SE321230B (xx) |
Families Citing this family (73)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL6409714A (xx) * | 1962-10-30 | 1965-10-01 | ||
| US3472848A (en) * | 1966-11-17 | 1969-10-14 | Merck & Co Inc | 3-hydroxy and 3-mercapto-pyrazinoyl-guanidines,corresponding ethers and thioethers and processes for their preparation |
| US3948895A (en) * | 1971-09-28 | 1976-04-06 | E. I. Du Pont De Nemours And Company | Synthesis of 3,5-diaminopyrazinoic acid from 3,5-diamino-2,6-dicyanopyrazine and intermediates |
| US4085211A (en) * | 1975-12-15 | 1978-04-18 | Merck & Co., Inc. | Pyrazinecarboxamides and processes for preparing same |
| US4087526A (en) * | 1976-07-23 | 1978-05-02 | Merck & Co., Inc. | (3-Amino-5-substituted-6-fluoropyrazinoyl or pyrazamido)-guanidines and their derivatives bearing substituents on the guanidino nitrogens |
| US4208413A (en) * | 1977-03-04 | 1980-06-17 | Merck & Co., Inc. | N-Pyrazinecarbonyl-N'-alkoxycarbonyl and N',N"-bis(alkoxycarbonyl)guanidines and processes for preparing same |
| US4108859A (en) * | 1977-06-06 | 1978-08-22 | The Dow Chemical Company | Microbicidal (pyridinylamino) alkyl guanidines |
| US4140776A (en) * | 1977-09-16 | 1979-02-20 | Merck & Co., Inc. | N-pyrazinecarbonyl-N'-acylguanidines |
| US4190655A (en) * | 1978-08-28 | 1980-02-26 | Merck & Co., Inc. | Amiloride citrate |
| EP0009054A1 (en) * | 1978-09-19 | 1980-04-02 | Merck & Co. Inc. | N-Pyrazinecarbonyl-N'-substituted-sulfamoyl-guanidine and processes for preparing same |
| US4246406A (en) * | 1979-03-27 | 1981-01-20 | Merck & Co., Inc. | Heterocyclic substituted pyrazinoylguanidines |
| US4224447A (en) * | 1979-03-27 | 1980-09-23 | Merck & Co., Inc. | Novel pyrazinecarboxamides and processes for preparing same |
| US4309540A (en) * | 1980-05-19 | 1982-01-05 | Merck & Co., Inc. | Substituted pyrazinyl-1,2,4-oxadiazoles |
| US4362724A (en) * | 1980-05-19 | 1982-12-07 | Merck & Co., Inc. | Method of treating edema and hypertension and pharmaceutical composition therefor in which the active ingredient comprises a novel substituted pyrazinyl-1,2,4-oxadiazole and a kaliuretic diuretic |
| US4454132A (en) * | 1981-03-16 | 1984-06-12 | Merck & Co., Inc. | Pharmaceutical compositions of novel substituted pyrazinyl-1,2,4-oxadiazoles useful in the treatment of edema and hypertension |
| US4510322A (en) * | 1981-07-13 | 1985-04-09 | Merck & Co., Inc. | Indacrinone having enhanced uricosuric |
| US4663322A (en) * | 1982-01-04 | 1987-05-05 | Beyer Jr Karl H | Antihypertensive hyperuretic and saluretic agent combinations |
| US4952582A (en) * | 1982-01-04 | 1990-08-28 | Beyer Jr Karl H | Pyrazinoylguanidine and derivatives thereof having few polar substituents and being useful as hyperuretic agents |
| DE3312516A1 (de) * | 1983-04-07 | 1984-10-11 | Brigitte Dr. 7400 Tübingen Pfeiffer | Kernsubstituierte phenylalkylenguanidinderivate, verfahren zu ihrer herstellung und sie enthaltende arzneimittel |
| US4604394A (en) * | 1984-10-01 | 1986-08-05 | Merck & Co., Inc. | Antiarrhythmic compositions and method |
| DE3925847A1 (de) * | 1989-08-04 | 1991-02-07 | Huels Chemische Werke Ag | Verfahren zur herstellung von 3-aminopyrazin-2-carbonsaeuremethylester |
| JP3481236B2 (ja) * | 1990-10-05 | 2003-12-22 | ザ ユニバーシティ オブ ノース カロライナ アット チャペル ヒル | 固体粒状薬剤及び固体粒状薬剤エーロゾル投薬装置 |
| US5304125A (en) * | 1990-10-05 | 1994-04-19 | The University Of North Carolina | Apparatus for administering solid particulate aerosols to the lungs |
| TW213903B (xx) * | 1991-08-16 | 1993-10-01 | Boehringer Ingelheim Kg | |
| US6169107B1 (en) | 1993-04-28 | 2001-01-02 | Sumitomo Pharmaceutical Co., Ltd. | Indoloylguanidine derivatives |
| DE4337609A1 (de) * | 1993-11-04 | 1995-05-11 | Boehringer Ingelheim Kg | Neue Pyrazincarboxamidderivate, ihre Herstellung und ihre Verwendung in Arzneimitteln |
| US5656256A (en) * | 1994-12-14 | 1997-08-12 | The University Of North Carolina At Chapel Hill | Methods of treating lung disease by an aerosol containing benzamil or phenamil |
| TW372967B (en) * | 1994-12-27 | 1999-11-01 | Kanebo Ltd | 1,4 benzoxazine derivative, pharmaceutical composition containing the same and use thereof |
| US5635160A (en) * | 1995-06-07 | 1997-06-03 | The University Of North Carolina At Chapel Hill | Dinucleotides useful for the treatment of cystic fibrosis and for hydrating mucus secretions |
| US5628984A (en) * | 1995-07-31 | 1997-05-13 | University Of North Carolina At Chapel Hill | Method of detecting lung disease |
| US5801177A (en) * | 1995-12-14 | 1998-09-01 | Beyer, Jr.; Karl H. | Method for controlling and/or lowering serum glucose and fatty acid concentrations and hypertensive blood pressure in non-insulin-dependent diabetic patients |
| US5877217A (en) * | 1995-12-26 | 1999-03-02 | Alteon Inc. | N-acylaminoalkyl-hydrazinecarboximidamides |
| EP1011688B1 (en) * | 1997-08-29 | 2005-02-02 | The University of North Carolina at Chapel Hill | Use of uridine 5'-diphosphate and analogs thereof for the treatment of lung diseases |
| WO2000023023A1 (en) * | 1998-10-20 | 2000-04-27 | The University Of North Carolina At Chapel Hill | Methods of hydrating mucosal surfaces |
| AU2740500A (en) * | 1999-01-29 | 2000-08-18 | Beyer, Camille F. | Composition and method for treating diabetes |
| EP1196396B1 (en) | 1999-07-19 | 2008-03-26 | University Of North Carolina At Chapel Hill | Pharmacologically active compounds with two covalently linked active principles (sodium channnel blocker/p2y2 receptor agonist) for the treatment of mucosal surfaces |
| EP1336407B1 (en) | 2000-11-21 | 2006-05-03 | Sankyo Company, Limited | Composition containing an angiotensin ii receptor antagonist and a diuretic and its use for the treatment of hypertension |
| US6858615B2 (en) * | 2002-02-19 | 2005-02-22 | Parion Sciences, Inc. | Phenyl guanidine sodium channel blockers |
| US6858614B2 (en) * | 2002-02-19 | 2005-02-22 | Parion Sciences, Inc. | Phenolic guanidine sodium channel blockers |
| AU2003234464B2 (en) * | 2002-05-03 | 2009-06-04 | Exelixis, Inc. | Protein kinase modulators and methods of use |
| US7704995B2 (en) * | 2002-05-03 | 2010-04-27 | Exelixis, Inc. | Protein kinase modulators and methods of use |
| CN1681495B (zh) | 2002-08-19 | 2010-05-12 | 辉瑞产品公司 | 用于治疗过度增生性疾病的组合物 |
| US6903105B2 (en) * | 2003-02-19 | 2005-06-07 | Parion Sciences, Inc. | Sodium channel blockers |
| AU2004248859C1 (en) * | 2003-06-26 | 2011-11-24 | Biotron Limited | Antiviral acylguanidine compounds and methods |
| NZ544671A (en) * | 2003-06-26 | 2009-02-28 | Biotron Ltd | Antiviral compounds and methods |
| US7326706B2 (en) * | 2003-08-15 | 2008-02-05 | Bristol-Myers Squibb Company | Pyrazine modulators of cannabinoid receptors |
| EP1663235B1 (en) * | 2003-08-18 | 2013-07-24 | Parion Sciences, Inc. | Capped pyrazinoylguanidine sodium channel blockers |
| US20050090505A1 (en) * | 2003-08-18 | 2005-04-28 | Johnson Michael R. | Methods of reducing risk of infection from pathogens |
| US7375107B2 (en) * | 2003-08-18 | 2008-05-20 | Parion Sciences, Inc. | Alaphatic pyrazinoylguanidine sodium channel blockers |
| US7745442B2 (en) | 2003-08-20 | 2010-06-29 | Parion Sciences, Inc. | Methods of reducing risk of infection from pathogens |
| US20090253714A1 (en) * | 2003-08-20 | 2009-10-08 | Johnson Michael R | Methods of reducing risk of infection from pathogens |
| US20070099968A1 (en) * | 2004-06-26 | 2007-05-03 | Biotron Limited | Antiviral compounds and methods |
| US20070021439A1 (en) * | 2005-07-25 | 2007-01-25 | Parion Sciences, Inc. | Methods of reducing risk of infection from pathogens with soluble amide and ester pyrazinoylguanidine sodium channel blockers |
| US7741317B2 (en) | 2005-10-21 | 2010-06-22 | Bristol-Myers Squibb Company | LXR modulators |
| US8642278B2 (en) * | 2005-11-22 | 2014-02-04 | University Of South Florida | Inhibition of cell proliferation |
| US7888376B2 (en) | 2005-11-23 | 2011-02-15 | Bristol-Myers Squibb Company | Heterocyclic CETP inhibitors |
| JP5498168B2 (ja) | 2006-12-01 | 2014-05-21 | ブリストル−マイヤーズ スクイブ カンパニー | アテローム性動脈硬化および循環器疾患の治療のためのｃｅｔｐ阻害剤としてのｎ−（（３−ベンジル）−２，２−（ビス−フェニル）−プロパン−１−アミン誘導体 |
| US8551534B2 (en) * | 2007-10-10 | 2013-10-08 | Parion Sciences, Inc. | Inhaled hypertonic saline delivered by a heated nasal cannula |
| CN101951913A (zh) * | 2008-02-26 | 2011-01-19 | 帕里昂科学公司 | 聚芳族钠通道阻断剂 |
| DE102008053024B4 (de) | 2008-10-24 | 2015-04-30 | RUHR-UNIVERSITäT BOCHUM | Verwendung von Amilorid-Derivaten zur Bekämpfung von Insekten und Milben |
| US8247436B2 (en) | 2010-03-19 | 2012-08-21 | Novartis Ag | Pyridine and pyrazine derivative for the treatment of CF |
| US8945605B2 (en) | 2011-06-07 | 2015-02-03 | Parion Sciences, Inc. | Aerosol delivery systems, compositions and methods |
| SI2723176T1 (sl) | 2011-06-27 | 2017-09-29 | Parion Sciences, Inc. | Kemijsko in metabolno stabilni dipeptid, ki ima močno aktivnost blokiranja natrijevega kanala |
| AR086745A1 (es) | 2011-06-27 | 2014-01-22 | Parion Sciences Inc | 3,5-diamino-6-cloro-n-(n-(4-(4-(2-(hexil(2,3,4,5,6-pentahidroxihexil)amino)etoxi)fenil)butil)carbamimidoil)pirazina-2-carboxamida |
| AU2013267504B2 (en) | 2012-05-29 | 2017-11-02 | Parion Sciences, Inc. | Dendrimer like amino amides possessing sodium channel blocker activity for the treatment of dry eye and other mucosal diseases |
| PT2931713T (pt) | 2012-12-17 | 2017-02-22 | Parion Sciences Inc | Derivados de cloro-pirazina carboxamida úteis para o tratamento de doenças favorecidas por insuficiente hidratação das mucosas |
| BR112015014178A2 (pt) | 2012-12-17 | 2017-07-11 | Parion Sciences Inc | compostos de 3,5-diamino-6-cloro-n-(n-(4-fenilbutil)carbamimidoil) pirazina-2- carboxamida |
| EP2986599A1 (en) | 2013-04-17 | 2016-02-24 | Pfizer Inc. | N-piperidin-3-ylbenzamide derivatives for treating cardiovascular diseases |
| JP6449870B2 (ja) * | 2013-07-08 | 2019-01-09 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 肺および気道の疾患を処置するための上皮性ナトリウムチャネルの阻害剤としてのアミロライド型化合物 |
| US9102633B2 (en) | 2013-12-13 | 2015-08-11 | Parion Sciences, Inc. | Arylalkyl- and aryloxyalkyl-substituted epithelial sodium channel blocking compounds |
| WO2016055901A1 (en) | 2014-10-08 | 2016-04-14 | Pfizer Inc. | Substituted amide compounds |
| EP3495348A4 (en) | 2016-07-29 | 2020-01-22 | Toray Industries, Inc. | GUANIDINE DERIVATIVE AND USE THEREOF FOR MEDICAL PURPOSES |
| BR112021013807A2 (pt) | 2019-01-18 | 2021-11-30 | Astrazeneca Ab | Inibidores de pcsk9 e seus métodos de uso |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL299929A (xx) * | 1962-10-30 |
-
0
- BE BE639386D patent/BE639386A/xx unknown
- NL NL299931D patent/NL299931A/xx unknown
-
1963
- 1963-10-07 US US313315A patent/US3313813A/en not_active Expired - Lifetime
- 1963-10-24 GB GB42062/63A patent/GB1066855A/en not_active Expired
- 1963-10-28 DE DE1795438A patent/DE1795438C2/de not_active Expired
- 1963-10-28 DE DE19631470053 patent/DE1470053A1/de active Pending
- 1963-10-29 SE SE11899/63A patent/SE321230B/xx unknown
- 1963-10-29 FR FR952219A patent/FR1563612A/fr not_active Expired
- 1963-10-29 CH CH1329763A patent/CH465617A/de unknown
- 1963-10-30 BR BR154164/63A patent/BR6354164D0/pt unknown
- 1963-10-30 DK DK512263AA patent/DK114978B/da unknown
- 1963-10-30 NL NL63299931A patent/NL142413B/xx not_active IP Right Cessation
-
1964
- 1964-04-27 FI FI640911A patent/FI47102C/fi active
- 1964-09-14 DK DK453364AA patent/DK116943B/da unknown
-
1965
- 1965-12-02 DK DK619865AA patent/DK114557B/da unknown
- 1965-12-02 DK DK619765AA patent/DK115403B/da unknown
-
1968
- 1968-05-18 CY CY44068A patent/CY440A/xx unknown
-
1969
- 1969-12-31 MY MY196926A patent/MY6900026A/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| DE1795438B1 (de) | 1973-09-06 |
| NL142413B (nl) | 1974-06-17 |
| DK116943B (da) | 1970-03-02 |
| DE1795438C2 (de) | 1974-04-11 |
| US3313813A (en) | 1967-04-11 |
| CH465617A (de) | 1968-11-30 |
| CY440A (en) | 1968-05-18 |
| BE639386A (xx) | |
| MY6900026A (en) | 1969-12-31 |
| SE321230B (xx) | 1970-03-02 |
| DK114557B (da) | 1969-07-14 |
| DE1470053A1 (de) | 1969-06-26 |
| DK115403B (da) | 1969-10-06 |
| FI47102C (fi) | 1973-09-10 |
| FR1563612A (xx) | 1969-04-18 |
| BR6354164D0 (pt) | 1973-09-18 |
| GB1066855A (en) | 1967-04-26 |
| FI47102B (xx) | 1973-05-31 |
| NL299931A (xx) |
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