DK1147205T3 - Hej-effektive mammale genekspressionsvektorer, som indeholder eksogen promotor og hele den 5'-ikke-translaterede regions opstroms for startcodonet for inherent gen som transkriptionsregulatorisk sted - Google Patents

Hej-effektive mammale genekspressionsvektorer, som indeholder eksogen promotor og hele den 5'-ikke-translaterede regions opstroms for startcodonet for inherent gen som transkriptionsregulatorisk sted

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Publication number
DK1147205T3
DK1147205T3 DK99962556T DK99962556T DK1147205T3 DK 1147205 T3 DK1147205 T3 DK 1147205T3 DK 99962556 T DK99962556 T DK 99962556T DK 99962556 T DK99962556 T DK 99962556T DK 1147205 T3 DK1147205 T3 DK 1147205T3
Authority
DK
Denmark
Prior art keywords
expression vectors
entire
untranslated region
transcriptional regulatory
gene expression
Prior art date
Application number
DK99962556T
Other languages
English (en)
Inventor
Sunyoung Kim
Young Joo Lee
Seung Shin Yu
Duk-Kyung Kim
Original Assignee
Viromed Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Viromed Co Ltd filed Critical Viromed Co Ltd
Application granted granted Critical
Publication of DK1147205T3 publication Critical patent/DK1147205T3/da

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A61K38/1858—Platelet-derived growth factor [PDGF]
    • A61K38/1866—Vascular endothelial growth factor [VEGF]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2840/00—Vectors comprising a special translation-regulating system
    • C12N2840/20—Vectors comprising a special translation-regulating system translation of more than one cistron

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Organic Chemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Public Health (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Epidemiology (AREA)
  • Vascular Medicine (AREA)
  • Plant Pathology (AREA)
  • Biophysics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Immunology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Gastroenterology & Hepatology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Virology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
DK99962556T 1998-12-31 1999-12-31 Hej-effektive mammale genekspressionsvektorer, som indeholder eksogen promotor og hele den 5'-ikke-translaterede regions opstroms for startcodonet for inherent gen som transkriptionsregulatorisk sted DK1147205T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR1019980063711A KR20000046969A (ko) 1998-12-31 1998-12-31 이종 유전자 유래의 유전자 발현 조절요소를 포함하는 강력한전사 활성을 가진 진핵세포 발현벡더
PCT/KR1999/000855 WO2000040737A1 (en) 1998-12-31 1999-12-31 High efficiency mammalian gene expression vectors that contain exogenous promoter and entire 5' untranslated region in the upstream from start codon for inherent gene as transcription regulatory site

Publications (1)

Publication Number Publication Date
DK1147205T3 true DK1147205T3 (da) 2009-09-07

Family

ID=19570273

Family Applications (1)

Application Number Title Priority Date Filing Date
DK99962556T DK1147205T3 (da) 1998-12-31 1999-12-31 Hej-effektive mammale genekspressionsvektorer, som indeholder eksogen promotor og hele den 5'-ikke-translaterede regions opstroms for startcodonet for inherent gen som transkriptionsregulatorisk sted

Country Status (11)

Country Link
EP (1) EP1147205B1 (da)
JP (2) JP3924125B2 (da)
KR (2) KR20000046969A (da)
CN (1) CN100368550C (da)
AT (1) ATE434047T1 (da)
AU (1) AU1896500A (da)
DE (1) DE69941013D1 (da)
DK (1) DK1147205T3 (da)
ES (1) ES2328096T3 (da)
HK (1) HK1043812B (da)
WO (1) WO2000040737A1 (da)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7279568B2 (en) 1998-12-31 2007-10-09 Viromed Limited Highly efficient eukaryotic expression vector comprising an exogenous transcription regulatory element
WO2001051626A2 (en) * 2000-01-10 2001-07-19 Elim Biopharmaceuticals, Inc. Novel plasmid expression vectors
US7175840B2 (en) 2001-01-05 2007-02-13 Viromed Co., Ltd. Compositions for gene therapy of rheumatoid arthritis including a gene encoding an anti-angiogenic protein or parts thereof
US7429480B2 (en) 2005-01-10 2008-09-30 National Taiwan University Promoter sequences from WSSV immediate early genes and their uses in recombinant DNA techniques
WO2008044869A1 (en) 2006-10-10 2008-04-17 Viromed Co., Ltd. Expression vectors with improved safety
US20090202606A1 (en) 2008-01-25 2009-08-13 Viromed Co., Ltd. Treatment and Prevention of Cardiac Conditions Using Two or More Isoforms of Hepatocyte Growth Factor
FR2981946B1 (fr) * 2011-10-28 2015-02-20 Lfb Biotechnologies Unites de transcription et leur utilisation dans des vecteurs d'expression (yb2/0)
JP2015502165A (ja) * 2011-12-22 2015-01-22 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ 発現ベクター構成、新規の産生細胞生成法、およびポリペプチドの組換え産生のためのそれらの使用
US10278373B2 (en) * 2013-10-18 2019-05-07 Taiho Pharmaceutical Co., Ltd. HLA class I-expressing non-human animal
WO2015060650A2 (ko) 2013-10-22 2015-04-30 주식회사 바이로메드 간세포 성장인자의 둘 이상의 이형체를 이용한 근위축성 측삭 경화증 예방 또는 치료용 조성물
MX2016005006A (es) 2013-10-22 2016-07-14 Viromed Co Ltd Composicion para prevenir a tratar la esclerosis lateral amiotrofica usando dos o mas isoformas del factor de crecimiento de hepatocito.
ES2822924T3 (es) 2014-09-26 2021-05-05 Helixmith Co Ltd Composición para prevenir o tratar una enfermedad arterial periférica utilizando el factor de crecimiento de hepatocitos y el factor 1a derivado de células del estroma
CN106754921A (zh) * 2016-12-12 2017-05-31 孙浩 哺乳动物细胞表达启动子及其制造和使用方法
WO2019245066A1 (ko) * 2018-06-19 2019-12-26 서울대학교산학협력단 박테리아에서의 고품질 재조합 단백질 생산을 위해 전사 완료 후 번역이 개시되는 유전자 발현 카세트
KR20210052443A (ko) * 2018-07-17 2021-05-10 뉴로마이언 주식회사 Igf-1 이형체를 발현하는 dna 컨스트럭트를 이용한 신경병증의 치료

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0255320A3 (en) * 1986-07-28 1989-09-06 Genzyme Corporation Production of proteins in myeloma cells
GB8717430D0 (en) * 1987-07-23 1987-08-26 Celltech Ltd Recombinant dna product
JPH07313187A (ja) * 1994-05-24 1995-12-05 Sagami Chem Res Center 抗体作製法
KR200144488Y1 (ko) * 1997-04-15 1999-06-15 정대인 낚시용리일의 역회전 방지장치
US5888809A (en) * 1997-05-01 1999-03-30 Icos Corporation Hamster EF-1α transcriptional regulatory DNA
KR100432151B1 (ko) * 2001-03-26 2004-05-17 한국생명공학연구원 포유동물용 발현벡터, 이 발현벡터로 형질전환된 세포 및 이 세포를 이용한 이종단백질의 생산방법

Also Published As

Publication number Publication date
WO2000040737A9 (en) 2003-06-12
DE69941013D1 (de) 2009-07-30
EP1147205B1 (en) 2009-06-17
JP4354971B2 (ja) 2009-10-28
EP1147205A1 (en) 2001-10-24
EP1147205A4 (en) 2003-01-08
ATE434047T1 (de) 2009-07-15
HK1043812B (zh) 2008-07-18
KR20000046969A (ko) 2000-07-25
CN100368550C (zh) 2008-02-13
AU1896500A (en) 2000-07-24
ES2328096T3 (es) 2009-11-06
JP2006271394A (ja) 2006-10-12
WO2000040737A1 (en) 2000-07-13
CN1335890A (zh) 2002-02-13
HK1043812A1 (en) 2002-09-27
KR20020013486A (ko) 2002-02-20
JP2002534092A (ja) 2002-10-15
KR100454533B1 (ko) 2004-11-05
JP3924125B2 (ja) 2007-06-06

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