DK1147200T3 - Campylobacterglycosyltransferaser til biosyntese af gangliosider og gangliosidmimetika - Google Patents

Campylobacterglycosyltransferaser til biosyntese af gangliosider og gangliosidmimetika

Info

Publication number
DK1147200T3
DK1147200T3 DK00901455T DK00901455T DK1147200T3 DK 1147200 T3 DK1147200 T3 DK 1147200T3 DK 00901455 T DK00901455 T DK 00901455T DK 00901455 T DK00901455 T DK 00901455T DK 1147200 T3 DK1147200 T3 DK 1147200T3
Authority
DK
Denmark
Prior art keywords
glycosyltransferases
gangliosides
biosynthesis
campylobacter
ganglioside
Prior art date
Application number
DK00901455T
Other languages
Danish (da)
English (en)
Inventor
Michel Gilbert
Warren W Wakarchuk
Original Assignee
Ca Nat Research Council
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ca Nat Research Council filed Critical Ca Nat Research Council
Application granted granted Critical
Publication of DK1147200T3 publication Critical patent/DK1147200T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/18—Preparation of compounds containing saccharide radicals produced by the action of a glycosyl transferase, e.g. alpha-, beta- or gamma-cyclodextrins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1025—Acyltransferases (2.3)
    • C12N9/1029—Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1048—Glycosyltransferases (2.4)
    • C12N9/1051—Hexosyltransferases (2.4.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1048—Glycosyltransferases (2.4)
    • C12N9/1081—Glycosyltransferases (2.4) transferring other glycosyl groups (2.4.99)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C12N9/1241—Nucleotidyltransferases (2.7.7)

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
DK00901455T 1999-02-01 2000-02-01 Campylobacterglycosyltransferaser til biosyntese af gangliosider og gangliosidmimetika DK1147200T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US11821399P 1999-02-01 1999-02-01
US09/495,406 US6503744B1 (en) 1999-02-01 2000-01-31 Campylobacter glycosyltransferases for biosynthesis of gangliosides and ganglioside mimics

Publications (1)

Publication Number Publication Date
DK1147200T3 true DK1147200T3 (da) 2006-10-09

Family

ID=26816090

Family Applications (1)

Application Number Title Priority Date Filing Date
DK00901455T DK1147200T3 (da) 1999-02-01 2000-02-01 Campylobacterglycosyltransferaser til biosyntese af gangliosider og gangliosidmimetika

Country Status (12)

Country Link
US (2) US6503744B1 (de)
EP (2) EP1652927B1 (de)
JP (3) JP4431283B2 (de)
AT (2) ATE329036T1 (de)
AU (2) AU772569B2 (de)
CA (1) CA2360205C (de)
DE (2) DE60038917D1 (de)
DK (1) DK1147200T3 (de)
ES (2) ES2308364T3 (de)
MX (1) MXPA01007853A (de)
PT (1) PT1147200E (de)
WO (1) WO2000046379A1 (de)

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US6689604B1 (en) * 1998-03-20 2004-02-10 National Research Council Of Canada Lipopolysaccharide α-2,3 sialyltransferase of Campylobacter jejuni and its uses
US6699705B2 (en) 1999-02-01 2004-03-02 National Research Council Of Canada Campylobacter glycosyltransferases for biosynthesis of gangliosides and ganglioside mimics
US6503744B1 (en) 1999-02-01 2003-01-07 National Research Council Of Canada Campylobacter glycosyltransferases for biosynthesis of gangliosides and ganglioside mimics
US6974687B2 (en) * 2001-04-23 2005-12-13 Kyowa Hakko Kyogo Co., Ltd. β1,3-galactosyltransferase and DNA encoding the enzyme
AU2002330968B2 (en) * 2001-08-17 2007-03-22 Neose Technologies, Inc. Chemo-enzymatic synthesis of sialylated oligosaccharides
AU2002344055A1 (en) * 2001-09-26 2003-04-07 Kyowa Hakko Kogyo Co., Ltd. Process for producing alpha2,3/alpha2,8-sialyltransferase and sialic acid-containing complex sugar
AU2004236174B2 (en) 2001-10-10 2011-06-02 Novo Nordisk A/S Glycopegylation methods and proteins/peptides produced by the methods
US7214660B2 (en) 2001-10-10 2007-05-08 Neose Technologies, Inc. Erythropoietin: remodeling and glycoconjugation of erythropoietin
US7173003B2 (en) 2001-10-10 2007-02-06 Neose Technologies, Inc. Granulocyte colony stimulating factor: remodeling and glycoconjugation of G-CSF
DE10204000A1 (de) * 2002-02-01 2003-08-14 Nutricia Nv Sialysierte Kohlenhydrate
DK1481057T3 (da) 2002-03-07 2006-05-15 Eidgenoess Tech Hochschule System og fremgangsmåde til fremstilling af rekombinante glycosylerede proteiner i en prokaryot vært
CA2818688A1 (en) * 2002-03-07 2003-09-12 Eidgenossische Technische Hochschule Zurich System and method for the production of recombinant glycosylated proteins in a prokaryotic host
NZ542148A (en) 2003-03-06 2008-05-30 Neose Technologies Inc Methods and compositions for the enzymatic synthesis of gangliosides
US9005625B2 (en) 2003-07-25 2015-04-14 Novo Nordisk A/S Antibody toxin conjugates
US20080305992A1 (en) 2003-11-24 2008-12-11 Neose Technologies, Inc. Glycopegylated erythropoietin
US20090215115A1 (en) * 2004-09-17 2009-08-27 National Research Council Of Canada Sialyltransferases comprising conserved sequence motifs
DK2586456T3 (en) 2004-10-29 2016-03-21 Ratiopharm Gmbh Conversion and glycopegylation of fibroblast growth factor (FGF)
WO2006052841A2 (en) 2004-11-09 2006-05-18 Neose Technologies, Inc. Glycolipids
EP1858543B1 (de) 2005-01-10 2013-11-27 BioGeneriX AG Glycopegylierten Granulocyten-Kolonie-stimulierender Faktor
EP2386571B1 (de) 2005-04-08 2016-06-01 ratiopharm GmbH Zusammensetzungen und Verfahren zur Herstellung von Glycosylierungsmutanten eines Proteaseresistenten menschlichen Wachstumshormons
CA2604621C (en) 2005-04-11 2014-01-21 National Research Council Of Canada Identification of a beta-1,3-n-acetylgalactosaminyltransferase (cgte) from campylobacter jejuni lio87
ES2353814T3 (es) 2005-05-11 2011-03-07 Eth Zuerich Proteinas n-glicosiladas recombinantes de celulas procariotas.
US7820422B2 (en) * 2005-06-16 2010-10-26 Centre National De La Recherche Scientifique (Cnrs) Efficient production of oligosaccharides using metabolically engineered microorganisms
CA2618769C (en) * 2005-08-11 2014-03-04 National Research Council Of Canada Orf11 from campylobacter jejuni is a sialate-o-acetyltransferase
US20070105755A1 (en) 2005-10-26 2007-05-10 Neose Technologies, Inc. One pot desialylation and glycopegylation of therapeutic peptides
US20090048440A1 (en) 2005-11-03 2009-02-19 Neose Technologies, Inc. Nucleotide Sugar Purification Using Membranes
CA2638779C (en) * 2006-01-31 2017-01-03 National Research Council Of Canada Production of polysialic acid containing glyconjugates using a self-priming polysialyltransferase
EP1984013B1 (de) * 2006-02-01 2012-01-25 BioGeneriX AG Cst-ii-modifzierungen für erhöhte proteinexpression
EP2049144B8 (de) 2006-07-21 2015-02-18 ratiopharm GmbH Glycosylierung von peptiden über o-verbundene glycosylierungssequenzen
US20100075375A1 (en) 2006-10-03 2010-03-25 Novo Nordisk A/S Methods for the purification of polypeptide conjugates
CN101796063B (zh) 2007-04-03 2017-03-22 拉蒂奥法姆有限责任公司 使用糖聚乙二醇化g‑csf的治疗方法
EP2137305B1 (de) * 2007-04-20 2014-11-05 National Research Council Of Canada Manipulierte versionen von cgtb (beta-1,3- galactosyltransferase)-enzymen mit verstärkten enzymatischen eigenschaften
ES2551123T3 (es) 2007-06-12 2015-11-16 Ratiopharm Gmbh Proceso mejorado para la producción de azúcares de nucleótido
WO2008151448A1 (en) 2007-06-15 2008-12-18 National Research Council Of Canada Engineered versions of polysialyltransferases with enhanced enzymatic properties
CN101983070B (zh) 2008-02-20 2016-03-30 格林考瓦因有限公司 由来源于原核细胞的重组n-糖基化蛋白制备生物共轭物
MX2010009154A (es) 2008-02-27 2010-09-09 Novo Nordisk As Moleculas conjugadas del factor viii.
US20120035120A1 (en) 2009-03-25 2012-02-09 Seneb Biosciences, Inc. Glycolipids as treatment for disease
DK2501406T3 (en) 2009-11-19 2018-02-26 Glaxosmithkline Biologicals Sa BIOSYNTHESE SYSTEM PRODUCING IMMUNOGENIC POLYSACCHARIDES IN PROCARYOTIC CELLS
KR20130063510A (ko) 2010-05-06 2013-06-14 글리코박신 아게 캡슐형 그람-양성 세균 생체접합체 백신
US9616114B1 (en) 2014-09-18 2017-04-11 David Gordon Bermudes Modified bacteria having improved pharmacokinetics and tumor colonization enhancing antitumor activity
US11180535B1 (en) 2016-12-07 2021-11-23 David Gordon Bermudes Saccharide binding, tumor penetration, and cytotoxic antitumor chimeric peptides from therapeutic bacteria
US11129906B1 (en) 2016-12-07 2021-09-28 David Gordon Bermudes Chimeric protein toxins for expression by therapeutic bacteria

Family Cites Families (7)

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Publication number Priority date Publication date Assignee Title
CA2106301C (en) 1991-03-18 1999-04-06 Chi-Huey Wong Oligosaccharide enzyme substrates and inhibitors: method and compositions
US5352670A (en) 1991-06-10 1994-10-04 Alberta Research Council Methods for the enzymatic synthesis of alpha-sialylated oligosaccharide glycosides
US5374541A (en) 1993-05-04 1994-12-20 The Scripps Research Institute Combined use of β-galactosidase and sialyltransferase coupled with in situ regeneration of CMP-sialic acid for one pot synthesis of oligosaccharides
US5545553A (en) 1994-09-26 1996-08-13 The Rockefeller University Glycosyltransferases for biosynthesis of oligosaccharides, and genes encoding them
US5728554A (en) 1995-04-11 1998-03-17 Cytel Corporation Enzymatic synthesis of glycosidic linkages
US6689604B1 (en) * 1998-03-20 2004-02-10 National Research Council Of Canada Lipopolysaccharide α-2,3 sialyltransferase of Campylobacter jejuni and its uses
US6503744B1 (en) 1999-02-01 2003-01-07 National Research Council Of Canada Campylobacter glycosyltransferases for biosynthesis of gangliosides and ganglioside mimics

Also Published As

Publication number Publication date
EP1652927A3 (de) 2006-07-19
US20050064550A1 (en) 2005-03-24
PT1147200E (pt) 2006-10-31
ATE395415T1 (de) 2008-05-15
DE60038917D1 (de) 2008-06-26
US7371838B2 (en) 2008-05-13
JP2002535992A (ja) 2002-10-29
AU2274300A (en) 2000-08-25
JP4397955B2 (ja) 2010-01-13
EP1147200B1 (de) 2006-06-07
US6503744B1 (en) 2003-01-07
EP1652927B1 (de) 2008-05-14
WO2000046379A1 (en) 2000-08-10
EP1147200A1 (de) 2001-10-24
JP4398502B2 (ja) 2010-01-13
JP2008259515A (ja) 2008-10-30
WO2000046379A8 (en) 2000-11-02
ATE329036T1 (de) 2006-06-15
MXPA01007853A (es) 2003-09-25
AU2004203474B2 (en) 2007-09-20
JP2008259516A (ja) 2008-10-30
CA2360205A1 (en) 2000-08-10
EP1652927A2 (de) 2006-05-03
AU2004203474A1 (en) 2004-08-26
AU2004203474B9 (en) 2008-03-20
CA2360205C (en) 2012-03-27
AU772569B2 (en) 2004-04-29
JP4431283B2 (ja) 2010-03-10
DE60028541D1 (de) 2006-07-20
ES2269098T3 (es) 2007-04-01
ES2308364T3 (es) 2008-12-01
DE60028541T2 (de) 2007-06-06

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