DK1147200T3 - Campylobacterglycosyltransferaser til biosyntese af gangliosider og gangliosidmimetika - Google Patents
Campylobacterglycosyltransferaser til biosyntese af gangliosider og gangliosidmimetikaInfo
- Publication number
- DK1147200T3 DK1147200T3 DK00901455T DK00901455T DK1147200T3 DK 1147200 T3 DK1147200 T3 DK 1147200T3 DK 00901455 T DK00901455 T DK 00901455T DK 00901455 T DK00901455 T DK 00901455T DK 1147200 T3 DK1147200 T3 DK 1147200T3
- Authority
- DK
- Denmark
- Prior art keywords
- glycosyltransferases
- gangliosides
- biosynthesis
- campylobacter
- ganglioside
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/18—Preparation of compounds containing saccharide radicals produced by the action of a glycosyl transferase, e.g. alpha-, beta- or gamma-cyclodextrins
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/1025—Acyltransferases (2.3)
- C12N9/1029—Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/1048—Glycosyltransferases (2.4)
- C12N9/1051—Hexosyltransferases (2.4.1)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/1048—Glycosyltransferases (2.4)
- C12N9/1081—Glycosyltransferases (2.4) transferring other glycosyl groups (2.4.99)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
- C12N9/1241—Nucleotidyltransferases (2.7.7)
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Enzymes And Modification Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Saccharide Compounds (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US11821399P | 1999-02-01 | 1999-02-01 | |
US09/495,406 US6503744B1 (en) | 1999-02-01 | 2000-01-31 | Campylobacter glycosyltransferases for biosynthesis of gangliosides and ganglioside mimics |
Publications (1)
Publication Number | Publication Date |
---|---|
DK1147200T3 true DK1147200T3 (da) | 2006-10-09 |
Family
ID=26816090
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK00901455T DK1147200T3 (da) | 1999-02-01 | 2000-02-01 | Campylobacterglycosyltransferaser til biosyntese af gangliosider og gangliosidmimetika |
Country Status (12)
Country | Link |
---|---|
US (2) | US6503744B1 (da) |
EP (2) | EP1147200B1 (da) |
JP (3) | JP4431283B2 (da) |
AT (2) | ATE329036T1 (da) |
AU (2) | AU772569B2 (da) |
CA (1) | CA2360205C (da) |
DE (2) | DE60028541T2 (da) |
DK (1) | DK1147200T3 (da) |
ES (2) | ES2308364T3 (da) |
MX (1) | MXPA01007853A (da) |
PT (1) | PT1147200E (da) |
WO (1) | WO2000046379A1 (da) |
Families Citing this family (42)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6689604B1 (en) * | 1998-03-20 | 2004-02-10 | National Research Council Of Canada | Lipopolysaccharide α-2,3 sialyltransferase of Campylobacter jejuni and its uses |
US6503744B1 (en) | 1999-02-01 | 2003-01-07 | National Research Council Of Canada | Campylobacter glycosyltransferases for biosynthesis of gangliosides and ganglioside mimics |
US6699705B2 (en) * | 1999-02-01 | 2004-03-02 | National Research Council Of Canada | Campylobacter glycosyltransferases for biosynthesis of gangliosides and ganglioside mimics |
JPWO2002088364A1 (ja) * | 2001-04-23 | 2004-08-19 | 協和醗酵工業株式会社 | β1,3−ガラクトース転移酵素および該酵素をコードするDNA |
AU2002330968B2 (en) * | 2001-08-17 | 2007-03-22 | Neose Technologies, Inc. | Chemo-enzymatic synthesis of sialylated oligosaccharides |
AU2002344055A1 (en) * | 2001-09-26 | 2003-04-07 | Kyowa Hakko Kogyo Co., Ltd. | Process for producing alpha2,3/alpha2,8-sialyltransferase and sialic acid-containing complex sugar |
US7214660B2 (en) | 2001-10-10 | 2007-05-08 | Neose Technologies, Inc. | Erythropoietin: remodeling and glycoconjugation of erythropoietin |
US7173003B2 (en) | 2001-10-10 | 2007-02-06 | Neose Technologies, Inc. | Granulocyte colony stimulating factor: remodeling and glycoconjugation of G-CSF |
DE10204000A1 (de) * | 2002-02-01 | 2003-08-14 | Nutricia Nv | Sialysierte Kohlenhydrate |
ES2258214T3 (es) | 2002-03-07 | 2006-08-16 | Eidgenossische Technische Hochschule Zurich | Sistema y procedimiento para la produccion de proteinas glucosiladas recombinantes en un huesped procariotico. |
JP4727927B2 (ja) * | 2002-03-07 | 2011-07-20 | アイトゲネシシェ・テッヒニシェ・ホーホシューレ・チューリッヒ | 原核宿主における組換えグリコシル化タンパク質産生のためのシステムおよび方法 |
JP2006519878A (ja) | 2003-03-06 | 2006-08-31 | ネオーズ テクノロジーズ, インコーポレイテッド | ガングリオシドの酵素合成のための方法および化合物 |
US20070026485A1 (en) | 2003-04-09 | 2007-02-01 | Neose Technologies, Inc. | Glycopegylation methods and proteins/peptides produced by the methods |
WO2005012484A2 (en) | 2003-07-25 | 2005-02-10 | Neose Technologies, Inc. | Antibody-toxin conjugates |
US20080305992A1 (en) | 2003-11-24 | 2008-12-11 | Neose Technologies, Inc. | Glycopegylated erythropoietin |
US20090215115A1 (en) * | 2004-09-17 | 2009-08-27 | National Research Council Of Canada | Sialyltransferases comprising conserved sequence motifs |
ES2572779T3 (es) | 2004-10-29 | 2016-06-02 | Ratiopharm Gmbh | Remodelación y glucopegilación del Factor de Crecimiento de Fibroblastos (FGF) |
WO2006052841A2 (en) | 2004-11-09 | 2006-05-18 | Neose Technologies, Inc. | Glycolipids |
ES2449195T3 (es) | 2005-01-10 | 2014-03-18 | Ratiopharm Gmbh | Factor estimulante de colonias de granulocitos glicopegilado |
EP2386571B1 (en) | 2005-04-08 | 2016-06-01 | ratiopharm GmbH | Compositions and methods for the preparation of protease resistant human growth hormone glycosylation mutants |
US8278069B2 (en) | 2005-04-11 | 2012-10-02 | National Research Council Of Canada | Identification of a β-1,3-N-acetylgalactosaminyltransferase (CGTE) from Campylobacter jejuni LIO87 |
KR101524636B1 (ko) | 2005-05-11 | 2015-06-03 | 에테하 취리히 | 원핵 세포로부터의 재조합 n-글리코실화 단백질 |
US7820422B2 (en) | 2005-06-16 | 2010-10-26 | Centre National De La Recherche Scientifique (Cnrs) | Efficient production of oligosaccharides using metabolically engineered microorganisms |
CA2618769C (en) | 2005-08-11 | 2014-03-04 | National Research Council Of Canada | Orf11 from campylobacter jejuni is a sialate-o-acetyltransferase |
US20070105755A1 (en) | 2005-10-26 | 2007-05-10 | Neose Technologies, Inc. | One pot desialylation and glycopegylation of therapeutic peptides |
US20090048440A1 (en) | 2005-11-03 | 2009-02-19 | Neose Technologies, Inc. | Nucleotide Sugar Purification Using Membranes |
CA2638779C (en) * | 2006-01-31 | 2017-01-03 | National Research Council Of Canada | Production of polysialic acid containing glyconjugates using a self-priming polysialyltransferase |
US7968310B2 (en) * | 2006-02-01 | 2011-06-28 | Biogenerix Ag | Tagged sialyltransferase proteins |
US9187532B2 (en) | 2006-07-21 | 2015-11-17 | Novo Nordisk A/S | Glycosylation of peptides via O-linked glycosylation sequences |
EP2054521A4 (en) | 2006-10-03 | 2012-12-19 | Novo Nordisk As | METHODS OF PURIFYING CONJUGATES OF POLYPEPTIDES |
CA2682897C (en) | 2007-04-03 | 2016-11-22 | Biogenerix Ag | Methods of treatment using glycopegylated g-csf |
JP5921065B2 (ja) * | 2007-04-20 | 2016-05-24 | ナショナル リサーチ カウンシル オブ カナダ | 増強された酵素的特性をもつCgtB(β−1,3−ガラクトシルトランスフェラーゼ)酵素の操作された型 |
CN101778859B (zh) | 2007-06-12 | 2014-03-26 | 诺和诺德公司 | 改良的用于生产核苷酸糖的方法 |
CN101730739B (zh) | 2007-06-15 | 2013-07-31 | 加拿大国家研究院 | 经工程改造的酶活性改善的聚唾液酸转移酶及其用途 |
SI2257307T1 (sl) | 2008-02-20 | 2018-09-28 | Glaxosmithkline Biologicals S.A. | Biokonjugati, izdelani iz rekombinantnih N-glikoziliranih proteinov iz prokariontskih celic |
US20130189239A1 (en) | 2008-02-27 | 2013-07-25 | Novo Nordisk A/S | Conjugated Factor VIII Molecules |
EP2410846B1 (en) | 2009-03-25 | 2016-09-07 | Seneb Biosciences, Inc. | Glycolipids as treatment for disease |
PT2501406T (pt) | 2009-11-19 | 2018-02-21 | Glaxosmithkline Biologicals Sa | Sistema de biossíntese que produz polissacáridos imunogénicos em células procariotas |
ES2844596T3 (es) | 2010-05-06 | 2021-07-22 | Glaxosmithkline Biologicals Sa | Vacunas de bioconjugados de bacterias grampositivas capsulares |
US9616114B1 (en) | 2014-09-18 | 2017-04-11 | David Gordon Bermudes | Modified bacteria having improved pharmacokinetics and tumor colonization enhancing antitumor activity |
US11129906B1 (en) | 2016-12-07 | 2021-09-28 | David Gordon Bermudes | Chimeric protein toxins for expression by therapeutic bacteria |
US11180535B1 (en) | 2016-12-07 | 2021-11-23 | David Gordon Bermudes | Saccharide binding, tumor penetration, and cytotoxic antitumor chimeric peptides from therapeutic bacteria |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ATE193551T1 (de) | 1991-03-18 | 2000-06-15 | Scripps Research Inst | Oligosaccharide als enzymsubstrate und - inhibitoren: verfahren und zusammensetzungen |
US5352670A (en) | 1991-06-10 | 1994-10-04 | Alberta Research Council | Methods for the enzymatic synthesis of alpha-sialylated oligosaccharide glycosides |
US5374541A (en) | 1993-05-04 | 1994-12-20 | The Scripps Research Institute | Combined use of β-galactosidase and sialyltransferase coupled with in situ regeneration of CMP-sialic acid for one pot synthesis of oligosaccharides |
US5545553A (en) | 1994-09-26 | 1996-08-13 | The Rockefeller University | Glycosyltransferases for biosynthesis of oligosaccharides, and genes encoding them |
US5728554A (en) | 1995-04-11 | 1998-03-17 | Cytel Corporation | Enzymatic synthesis of glycosidic linkages |
US6689604B1 (en) * | 1998-03-20 | 2004-02-10 | National Research Council Of Canada | Lipopolysaccharide α-2,3 sialyltransferase of Campylobacter jejuni and its uses |
US6503744B1 (en) | 1999-02-01 | 2003-01-07 | National Research Council Of Canada | Campylobacter glycosyltransferases for biosynthesis of gangliosides and ganglioside mimics |
-
2000
- 2000-01-31 US US09/495,406 patent/US6503744B1/en not_active Expired - Lifetime
- 2000-02-01 EP EP00901455A patent/EP1147200B1/en not_active Expired - Lifetime
- 2000-02-01 ES ES05025316T patent/ES2308364T3/es not_active Expired - Lifetime
- 2000-02-01 DE DE60028541T patent/DE60028541T2/de not_active Expired - Lifetime
- 2000-02-01 WO PCT/CA2000/000086 patent/WO2000046379A1/en active IP Right Grant
- 2000-02-01 ES ES00901455T patent/ES2269098T3/es not_active Expired - Lifetime
- 2000-02-01 AT AT00901455T patent/ATE329036T1/de active
- 2000-02-01 AU AU22743/00A patent/AU772569B2/en not_active Expired
- 2000-02-01 DE DE60038917T patent/DE60038917D1/de not_active Expired - Lifetime
- 2000-02-01 MX MXPA01007853A patent/MXPA01007853A/es active IP Right Grant
- 2000-02-01 EP EP05025316A patent/EP1652927B1/en not_active Expired - Lifetime
- 2000-02-01 JP JP2000597438A patent/JP4431283B2/ja not_active Expired - Lifetime
- 2000-02-01 AT AT05025316T patent/ATE395415T1/de not_active IP Right Cessation
- 2000-02-01 PT PT00901455T patent/PT1147200E/pt unknown
- 2000-02-01 DK DK00901455T patent/DK1147200T3/da active
- 2000-02-01 CA CA2360205A patent/CA2360205C/en not_active Expired - Lifetime
-
2004
- 2004-04-22 US US10/830,997 patent/US7371838B2/en not_active Expired - Lifetime
- 2004-07-29 AU AU2004203474A patent/AU2004203474B9/en not_active Expired
-
2008
- 2008-06-23 JP JP2008163888A patent/JP4398502B2/ja not_active Expired - Lifetime
- 2008-06-23 JP JP2008163889A patent/JP4397955B2/ja not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
EP1147200B1 (en) | 2006-06-07 |
DE60038917D1 (de) | 2008-06-26 |
ATE395415T1 (de) | 2008-05-15 |
EP1652927A3 (en) | 2006-07-19 |
US20050064550A1 (en) | 2005-03-24 |
ES2308364T3 (es) | 2008-12-01 |
WO2000046379A8 (en) | 2000-11-02 |
JP2008259515A (ja) | 2008-10-30 |
DE60028541D1 (de) | 2006-07-20 |
AU2004203474B9 (en) | 2008-03-20 |
JP4398502B2 (ja) | 2010-01-13 |
US6503744B1 (en) | 2003-01-07 |
EP1652927A2 (en) | 2006-05-03 |
ES2269098T3 (es) | 2007-04-01 |
JP2008259516A (ja) | 2008-10-30 |
PT1147200E (pt) | 2006-10-31 |
AU2004203474B2 (en) | 2007-09-20 |
AU2274300A (en) | 2000-08-25 |
CA2360205A1 (en) | 2000-08-10 |
ATE329036T1 (de) | 2006-06-15 |
WO2000046379A1 (en) | 2000-08-10 |
JP2002535992A (ja) | 2002-10-29 |
JP4397955B2 (ja) | 2010-01-13 |
JP4431283B2 (ja) | 2010-03-10 |
CA2360205C (en) | 2012-03-27 |
EP1147200A1 (en) | 2001-10-24 |
AU772569B2 (en) | 2004-04-29 |
DE60028541T2 (de) | 2007-06-06 |
AU2004203474A1 (en) | 2004-08-26 |
MXPA01007853A (es) | 2003-09-25 |
US7371838B2 (en) | 2008-05-13 |
EP1652927B1 (en) | 2008-05-14 |
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