DE60028541D1 - Campylobacter glycolsyltransferasen zur verwendung bei der biosynthese von gangliosiden und ganglioside imitatoren - Google Patents

Campylobacter glycolsyltransferasen zur verwendung bei der biosynthese von gangliosiden und ganglioside imitatoren

Info

Publication number
DE60028541D1
DE60028541D1 DE60028541T DE60028541T DE60028541D1 DE 60028541 D1 DE60028541 D1 DE 60028541D1 DE 60028541 T DE60028541 T DE 60028541T DE 60028541 T DE60028541 T DE 60028541T DE 60028541 D1 DE60028541 D1 DE 60028541D1
Authority
DE
Germany
Prior art keywords
glycosyltransferases
campylobacter
glycolsyl
imitators
gangliosides
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60028541T
Other languages
English (en)
Other versions
DE60028541T2 (de
Inventor
Michel Gilbert
W Wakarchuk
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
National Research Council of Canada
Original Assignee
National Research Council of Canada
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by National Research Council of Canada filed Critical National Research Council of Canada
Publication of DE60028541D1 publication Critical patent/DE60028541D1/de
Application granted granted Critical
Publication of DE60028541T2 publication Critical patent/DE60028541T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/18—Preparation of compounds containing saccharide radicals produced by the action of a glycosyl transferase, e.g. alpha-, beta- or gamma-cyclodextrins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1025—Acyltransferases (2.3)
    • C12N9/1029—Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1048—Glycosyltransferases (2.4)
    • C12N9/1051—Hexosyltransferases (2.4.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1048—Glycosyltransferases (2.4)
    • C12N9/1081—Glycosyltransferases (2.4) transferring other glycosyl groups (2.4.99)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C12N9/1241—Nucleotidyltransferases (2.7.7)

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
DE60028541T 1999-02-01 2000-02-01 Campylobacterglycosyltransferasen für die Biosynthese von Gangliosiden und Gangliosidmimetika Expired - Lifetime DE60028541T2 (de)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US11821399P 1999-02-01 1999-02-01
US118213P 1999-02-01
US09/495,406 US6503744B1 (en) 1999-02-01 2000-01-31 Campylobacter glycosyltransferases for biosynthesis of gangliosides and ganglioside mimics
US495406 2000-01-31
PCT/CA2000/000086 WO2000046379A1 (en) 1999-02-01 2000-02-01 Campylobacter glycosyltransferases for biosynthesis of gangliosides and ganglioside mimics

Publications (2)

Publication Number Publication Date
DE60028541D1 true DE60028541D1 (de) 2006-07-20
DE60028541T2 DE60028541T2 (de) 2007-06-06

Family

ID=26816090

Family Applications (2)

Application Number Title Priority Date Filing Date
DE60038917T Expired - Lifetime DE60038917D1 (de) 1999-02-01 2000-02-01 Campylobacter Glycolsyltransferasen zur Verwendung bei der Biosynthese von Gangliosiden und ganglioside Imitatoren
DE60028541T Expired - Lifetime DE60028541T2 (de) 1999-02-01 2000-02-01 Campylobacterglycosyltransferasen für die Biosynthese von Gangliosiden und Gangliosidmimetika

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DE60038917T Expired - Lifetime DE60038917D1 (de) 1999-02-01 2000-02-01 Campylobacter Glycolsyltransferasen zur Verwendung bei der Biosynthese von Gangliosiden und ganglioside Imitatoren

Country Status (12)

Country Link
US (2) US6503744B1 (de)
EP (2) EP1652927B1 (de)
JP (3) JP4431283B2 (de)
AT (2) ATE329036T1 (de)
AU (2) AU772569B2 (de)
CA (1) CA2360205C (de)
DE (2) DE60038917D1 (de)
DK (1) DK1147200T3 (de)
ES (2) ES2308364T3 (de)
MX (1) MXPA01007853A (de)
PT (1) PT1147200E (de)
WO (1) WO2000046379A1 (de)

Families Citing this family (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6689604B1 (en) * 1998-03-20 2004-02-10 National Research Council Of Canada Lipopolysaccharide α-2,3 sialyltransferase of Campylobacter jejuni and its uses
US6699705B2 (en) 1999-02-01 2004-03-02 National Research Council Of Canada Campylobacter glycosyltransferases for biosynthesis of gangliosides and ganglioside mimics
US6503744B1 (en) 1999-02-01 2003-01-07 National Research Council Of Canada Campylobacter glycosyltransferases for biosynthesis of gangliosides and ganglioside mimics
US6974687B2 (en) * 2001-04-23 2005-12-13 Kyowa Hakko Kyogo Co., Ltd. β1,3-galactosyltransferase and DNA encoding the enzyme
AU2002330968B2 (en) * 2001-08-17 2007-03-22 Neose Technologies, Inc. Chemo-enzymatic synthesis of sialylated oligosaccharides
AU2002344055A1 (en) * 2001-09-26 2003-04-07 Kyowa Hakko Kogyo Co., Ltd. Process for producing alpha2,3/alpha2,8-sialyltransferase and sialic acid-containing complex sugar
AU2004236174B2 (en) 2001-10-10 2011-06-02 Novo Nordisk A/S Glycopegylation methods and proteins/peptides produced by the methods
US7214660B2 (en) 2001-10-10 2007-05-08 Neose Technologies, Inc. Erythropoietin: remodeling and glycoconjugation of erythropoietin
US7173003B2 (en) 2001-10-10 2007-02-06 Neose Technologies, Inc. Granulocyte colony stimulating factor: remodeling and glycoconjugation of G-CSF
DE10204000A1 (de) * 2002-02-01 2003-08-14 Nutricia Nv Sialysierte Kohlenhydrate
DK1481057T3 (da) 2002-03-07 2006-05-15 Eidgenoess Tech Hochschule System og fremgangsmåde til fremstilling af rekombinante glycosylerede proteiner i en prokaryot vært
CA2818688A1 (en) * 2002-03-07 2003-09-12 Eidgenossische Technische Hochschule Zurich System and method for the production of recombinant glycosylated proteins in a prokaryotic host
NZ542148A (en) 2003-03-06 2008-05-30 Neose Technologies Inc Methods and compositions for the enzymatic synthesis of gangliosides
US9005625B2 (en) 2003-07-25 2015-04-14 Novo Nordisk A/S Antibody toxin conjugates
US20080305992A1 (en) 2003-11-24 2008-12-11 Neose Technologies, Inc. Glycopegylated erythropoietin
US20090215115A1 (en) * 2004-09-17 2009-08-27 National Research Council Of Canada Sialyltransferases comprising conserved sequence motifs
DK2586456T3 (en) 2004-10-29 2016-03-21 Ratiopharm Gmbh Conversion and glycopegylation of fibroblast growth factor (FGF)
WO2006052841A2 (en) 2004-11-09 2006-05-18 Neose Technologies, Inc. Glycolipids
EP1858543B1 (de) 2005-01-10 2013-11-27 BioGeneriX AG Glycopegylierten Granulocyten-Kolonie-stimulierender Faktor
EP2386571B1 (de) 2005-04-08 2016-06-01 ratiopharm GmbH Zusammensetzungen und Verfahren zur Herstellung von Glycosylierungsmutanten eines Proteaseresistenten menschlichen Wachstumshormons
CA2604621C (en) 2005-04-11 2014-01-21 National Research Council Of Canada Identification of a beta-1,3-n-acetylgalactosaminyltransferase (cgte) from campylobacter jejuni lio87
ES2353814T3 (es) 2005-05-11 2011-03-07 Eth Zuerich Proteinas n-glicosiladas recombinantes de celulas procariotas.
US7820422B2 (en) * 2005-06-16 2010-10-26 Centre National De La Recherche Scientifique (Cnrs) Efficient production of oligosaccharides using metabolically engineered microorganisms
CA2618769C (en) * 2005-08-11 2014-03-04 National Research Council Of Canada Orf11 from campylobacter jejuni is a sialate-o-acetyltransferase
US20070105755A1 (en) 2005-10-26 2007-05-10 Neose Technologies, Inc. One pot desialylation and glycopegylation of therapeutic peptides
US20090048440A1 (en) 2005-11-03 2009-02-19 Neose Technologies, Inc. Nucleotide Sugar Purification Using Membranes
CA2638779C (en) * 2006-01-31 2017-01-03 National Research Council Of Canada Production of polysialic acid containing glyconjugates using a self-priming polysialyltransferase
EP1984013B1 (de) * 2006-02-01 2012-01-25 BioGeneriX AG Cst-ii-modifzierungen für erhöhte proteinexpression
EP2049144B8 (de) 2006-07-21 2015-02-18 ratiopharm GmbH Glycosylierung von peptiden über o-verbundene glycosylierungssequenzen
US20100075375A1 (en) 2006-10-03 2010-03-25 Novo Nordisk A/S Methods for the purification of polypeptide conjugates
CN101796063B (zh) 2007-04-03 2017-03-22 拉蒂奥法姆有限责任公司 使用糖聚乙二醇化g‑csf的治疗方法
EP2137305B1 (de) * 2007-04-20 2014-11-05 National Research Council Of Canada Manipulierte versionen von cgtb (beta-1,3- galactosyltransferase)-enzymen mit verstärkten enzymatischen eigenschaften
ES2551123T3 (es) 2007-06-12 2015-11-16 Ratiopharm Gmbh Proceso mejorado para la producción de azúcares de nucleótido
WO2008151448A1 (en) 2007-06-15 2008-12-18 National Research Council Of Canada Engineered versions of polysialyltransferases with enhanced enzymatic properties
CN101983070B (zh) 2008-02-20 2016-03-30 格林考瓦因有限公司 由来源于原核细胞的重组n-糖基化蛋白制备生物共轭物
MX2010009154A (es) 2008-02-27 2010-09-09 Novo Nordisk As Moleculas conjugadas del factor viii.
US20120035120A1 (en) 2009-03-25 2012-02-09 Seneb Biosciences, Inc. Glycolipids as treatment for disease
DK2501406T3 (en) 2009-11-19 2018-02-26 Glaxosmithkline Biologicals Sa BIOSYNTHESE SYSTEM PRODUCING IMMUNOGENIC POLYSACCHARIDES IN PROCARYOTIC CELLS
KR20130063510A (ko) 2010-05-06 2013-06-14 글리코박신 아게 캡슐형 그람-양성 세균 생체접합체 백신
US9616114B1 (en) 2014-09-18 2017-04-11 David Gordon Bermudes Modified bacteria having improved pharmacokinetics and tumor colonization enhancing antitumor activity
US11180535B1 (en) 2016-12-07 2021-11-23 David Gordon Bermudes Saccharide binding, tumor penetration, and cytotoxic antitumor chimeric peptides from therapeutic bacteria
US11129906B1 (en) 2016-12-07 2021-09-28 David Gordon Bermudes Chimeric protein toxins for expression by therapeutic bacteria

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2106301C (en) 1991-03-18 1999-04-06 Chi-Huey Wong Oligosaccharide enzyme substrates and inhibitors: method and compositions
US5352670A (en) 1991-06-10 1994-10-04 Alberta Research Council Methods for the enzymatic synthesis of alpha-sialylated oligosaccharide glycosides
US5374541A (en) 1993-05-04 1994-12-20 The Scripps Research Institute Combined use of β-galactosidase and sialyltransferase coupled with in situ regeneration of CMP-sialic acid for one pot synthesis of oligosaccharides
US5545553A (en) 1994-09-26 1996-08-13 The Rockefeller University Glycosyltransferases for biosynthesis of oligosaccharides, and genes encoding them
US5728554A (en) 1995-04-11 1998-03-17 Cytel Corporation Enzymatic synthesis of glycosidic linkages
US6689604B1 (en) * 1998-03-20 2004-02-10 National Research Council Of Canada Lipopolysaccharide α-2,3 sialyltransferase of Campylobacter jejuni and its uses
US6503744B1 (en) 1999-02-01 2003-01-07 National Research Council Of Canada Campylobacter glycosyltransferases for biosynthesis of gangliosides and ganglioside mimics

Also Published As

Publication number Publication date
EP1652927A3 (de) 2006-07-19
US20050064550A1 (en) 2005-03-24
PT1147200E (pt) 2006-10-31
ATE395415T1 (de) 2008-05-15
DE60038917D1 (de) 2008-06-26
US7371838B2 (en) 2008-05-13
JP2002535992A (ja) 2002-10-29
AU2274300A (en) 2000-08-25
JP4397955B2 (ja) 2010-01-13
EP1147200B1 (de) 2006-06-07
US6503744B1 (en) 2003-01-07
EP1652927B1 (de) 2008-05-14
WO2000046379A1 (en) 2000-08-10
EP1147200A1 (de) 2001-10-24
JP4398502B2 (ja) 2010-01-13
JP2008259515A (ja) 2008-10-30
WO2000046379A8 (en) 2000-11-02
ATE329036T1 (de) 2006-06-15
MXPA01007853A (es) 2003-09-25
AU2004203474B2 (en) 2007-09-20
JP2008259516A (ja) 2008-10-30
CA2360205A1 (en) 2000-08-10
EP1652927A2 (de) 2006-05-03
DK1147200T3 (da) 2006-10-09
AU2004203474A1 (en) 2004-08-26
AU2004203474B9 (en) 2008-03-20
CA2360205C (en) 2012-03-27
AU772569B2 (en) 2004-04-29
JP4431283B2 (ja) 2010-03-10
ES2269098T3 (es) 2007-04-01
ES2308364T3 (es) 2008-12-01
DE60028541T2 (de) 2007-06-06

Similar Documents

Publication Publication Date Title
DE60028541D1 (de) Campylobacter glycolsyltransferasen zur verwendung bei der biosynthese von gangliosiden und ganglioside imitatoren
MXPA03008565A (es) Glicosiltransferasas de campylobacter para la biosintesis de gangliosidos y mimeticos de gangliocido.
MXPA01004982A (es) Manufactura de bajo costo de oligosacaridos.
DE69535975D1 (de) Glycosyltransferasen für die biosynthese von oligosacchariden und dafür kodierende gene
DE60336826D1 (de) Synthese von oligosacchariden, glykolipiden und glykoproteinen unter verwendung bakterieller glykosyltransferasen
EP1151085B8 (de) Alternansucrase-kodierende nukleinsäure moleküle
GEP20032871B (en) Regulation of Quinolate Phosphoribosyl Transferase Expression
WO1999054459A8 (en) Nucleic acid molecules with novel chemical compositions capable of modulating gene expression
NZ337701A (en) Process for processing sucrose into glucose and fructose
AU5445396A (en) Improved enzymatic synthesis of oligosaccharides
DE69231127D1 (de) Oligosaccharide als enzymsubstrate und -inhibitoren: verfahren und zusammensetzungen
WO1999031224A3 (en) Fusion proteins for use in enzymatic synthesis of oligosaccharides
DE69920247D1 (de) Veränderung der dns methyltransferase durch kombinationstherapie
WO2001040491A3 (en) Udp-glucose:aglycon-glucosyltransferase
Messer et al. Biosynthesis of marsupial milk oligosaccharides: characterization and developmental changes of two galactosyltransferases in lactating mammary glands of the tammar wallaby Macropus eugenii
ATE371041T1 (de) Kontrolle der immunantworten durch regulierung der aktivität von glykosyltransferasen
WO2006029538A8 (en) Sialyltransferases comprising conserved sequence motifs
ATE408697T1 (de) Enzymatische umwandlung von gdp-mannose in gdp- fucose
ATE397667T1 (de) Fruktosyltransferase (inulosucrase und levansucrase) von lactobacillus reuteri
IL94053A0 (en) Methods and nucleic acid sequences for the expression of the cellulose synthase operon
Öhrlein et al. Transferase-catalyzed synthesis of non-natural oligosaccharide-libraries (SLea-and SLex-analogues)
EP0904101A4 (de) Für die gdp-fucose-pyrophosphorylase kodierende nukleinsäure
WO2001000796A3 (en) Glycosyltransferases of helicobacter pylori
ATE378421T1 (de) Glycosyltransferase inhibitoren
ATE477334T1 (de) Verfahren zur herstellung von multifunktionellen lysyl hydroxylasen mit glycosyltransferaseaktivität

Legal Events

Date Code Title Description
8364 No opposition during term of opposition