DK1147103T3 - Phenanthridin-N-oxider med PDE-IV-inhiberende aktivitet - Google Patents
Phenanthridin-N-oxider med PDE-IV-inhiberende aktivitetInfo
- Publication number
- DK1147103T3 DK1147103T3 DK00901539T DK00901539T DK1147103T3 DK 1147103 T3 DK1147103 T3 DK 1147103T3 DK 00901539 T DK00901539 T DK 00901539T DK 00901539 T DK00901539 T DK 00901539T DK 1147103 T3 DK1147103 T3 DK 1147103T3
- Authority
- DK
- Denmark
- Prior art keywords
- oxides
- phenanthridine
- pde
- inhibitory activity
- compounds
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/04—Drugs for disorders of the respiratory system for throat disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP99100693 | 1999-01-15 | ||
PCT/EP2000/000192 WO2000042034A1 (en) | 1999-01-15 | 2000-01-13 | Phenanthridine-n-oxides with pde-iv inhibiting activity |
EP00901539A EP1147103B1 (en) | 1999-01-15 | 2000-01-13 | Phenantrhridine-n-oxides with pde-iv inhibiting activity |
Publications (1)
Publication Number | Publication Date |
---|---|
DK1147103T3 true DK1147103T3 (da) | 2005-08-29 |
Family
ID=8237350
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK00901539T DK1147103T3 (da) | 1999-01-15 | 2000-01-13 | Phenanthridin-N-oxider med PDE-IV-inhiberende aktivitet |
Country Status (12)
Country | Link |
---|---|
US (1) | US6534519B1 (pt) |
EP (1) | EP1147103B1 (pt) |
JP (1) | JP2003502278A (pt) |
AT (1) | ATE294793T1 (pt) |
AU (1) | AU2290000A (pt) |
CA (1) | CA2359449A1 (pt) |
DE (1) | DE60019894T2 (pt) |
DK (1) | DK1147103T3 (pt) |
ES (1) | ES2241571T3 (pt) |
PT (1) | PT1147103E (pt) |
SI (1) | SI1147103T1 (pt) |
WO (1) | WO2000042034A1 (pt) |
Families Citing this family (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
BR0007527B1 (pt) * | 1999-01-15 | 2011-12-27 | fenilfenantridinas com atividade inibitària de pde-iv, seu uso, bem como medicamento compreendendo as mesmas. | |
AU782908B2 (en) | 2000-01-11 | 2005-09-08 | Altana Pharma Ag | Phenanthridine-N-oxides |
SI1303506T1 (en) | 2000-07-14 | 2005-06-30 | Altana Pharma Ag | 6-heteroarylphenanthridines |
DE60310576T2 (de) * | 2002-08-29 | 2007-10-31 | Altana Pharma Ag | 2-hydroxy-6-phenylphenanthridine als pde-4-hemmer |
ATE353217T1 (de) | 2002-08-29 | 2007-02-15 | Altana Pharma Ag | 3-hydroxy-6-phenylphenanthridine als pde-4 inhibitoren |
EP1658271A1 (en) * | 2003-07-31 | 2006-05-24 | ALTANA Pharma AG | Novel 6-phenylphenanthridines |
EP1658270A1 (en) * | 2003-07-31 | 2006-05-24 | ALTANA Pharma AG | Novel 6-phenylphenantridines |
US20050187278A1 (en) * | 2003-08-28 | 2005-08-25 | Pharmacia Corporation | Treatment or prevention of vascular disorders with Cox-2 inhibitors in combination with cyclic AMP-specific phosphodiesterase inhibitors |
AU2004269923B2 (en) * | 2003-09-05 | 2010-05-13 | Takeda Gmbh | Use of PDE4 inhibitors for the treatment of diabetes mellitus |
CA2556086C (en) | 2004-02-18 | 2014-04-01 | Altana Pharma Ag | Novel guanidinyl-substituted hydroxy-6-phenylphenenthridines as effective phosphodiesterase (pde) 4 inhibitors |
EA017282B1 (ru) | 2004-03-03 | 2012-11-30 | Никомед Гмбх | Производное гидрокси-6-гетероарилфенантридина и его применение в качестве ингибитора pde4 |
AR049419A1 (es) * | 2004-03-03 | 2006-08-02 | Altana Pharma Ag | Hidroxi-6-fenilfenantridinas sustituidas con heterociclilo |
BRPI0508481A (pt) * | 2004-03-10 | 2007-07-31 | Altana Pharma Ag | hidróxi-6-fenilenantridinas amido-substituìdas e seu uso como inibidores de pde4 |
ES2337083T3 (es) | 2005-03-02 | 2010-04-20 | Nycomed Gmbh | (2r,4ar,10br)-6-(2,6-dimetoxipiridin-3-il)-9-exoti-8-metoxi-1,2,3,4,4a,10b-hexahidrofenantridin-2-ol, sal de hc1. |
NZ560269A (en) | 2005-03-08 | 2010-12-24 | Nycomed Gmbh | Roflumilast for the treatment of diabetes mellitus |
WO2009043784A1 (en) | 2007-10-04 | 2009-04-09 | F. Hoffmann-La Roche Ag | Cyclopropyl aryl amide derivatives and uses thereof |
US20150119399A1 (en) | 2012-01-10 | 2015-04-30 | President And Fellows Of Harvard College | Beta-cell replication promoting compounds and methods of their use |
Family Cites Families (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5455252A (en) * | 1993-03-31 | 1995-10-03 | Syntex (U.S.A.) Inc. | Optionally substituted 6,8-quinolines |
US5475003A (en) * | 1994-03-03 | 1995-12-12 | Syntex (U.S.A.) Inc. | 8-phenylcyclopentenoquinoline and 8-phenylcyclohexenoquinoline derivatives |
CA2143143A1 (en) * | 1994-03-08 | 1995-09-09 | Toshihiko Tanaka | 3-phenylpyrrolidine derivatives |
US5466697A (en) * | 1994-07-13 | 1995-11-14 | Syntex (U.S.A.) Inc. | 8-phenyl-1,6-naphthyridin-5-ones |
EE03523B1 (et) | 1996-01-31 | 2001-10-15 | Byk Gulden Lomberg Chemische Fabrik Gmbh | Fenantridiinid, neid sisaldavad ravimid ja nende kasutamine |
US6127378A (en) | 1996-03-26 | 2000-10-03 | Byk Gulden Lomberg Chemische Fabrik Gmbh | Phenanthridines substituted in the 6 position |
JP4141501B2 (ja) * | 1996-03-26 | 2008-08-27 | ニコメッド ゲゼルシャフト ミット ベシュレンクテル ハフツング | 新規の6位置換フェナントリジン |
GB9622386D0 (en) * | 1996-10-28 | 1997-01-08 | Sandoz Ltd | Organic compounds |
GEP20012390B (en) | 1996-11-11 | 2001-03-25 | Byk Gulden Lomberg Chem Fab | Benzonaphthyridines as Bronchial Therapeutics |
GB9626643D0 (en) | 1996-12-21 | 1997-02-12 | Astra Pharma Prod | Compounds |
PT968211E (pt) | 1997-03-07 | 2004-01-30 | Altana Pharma Ag | Derivados de tetrazoles |
JP2002502403A (ja) | 1997-06-03 | 2002-01-22 | ビイク グルデン ロンベルク ヒエーミツシエ フアブリーク ゲゼルシヤフト ミツト ベシユレンクテル ハフツング | ベンゾナフチリジン |
CZ293725B6 (cs) * | 1997-07-25 | 2004-07-14 | Altana Pharma Ag | Tetrazolové deriváty |
SI1109810T1 (en) | 1998-08-31 | 2004-12-31 | Altana Pharma Ag | Benzonaphthyridine-n-oxides comprising a pde3 and pde4 inhibiting activity |
-
2000
- 2000-01-13 JP JP2000593602A patent/JP2003502278A/ja not_active Withdrawn
- 2000-01-13 ES ES00901539T patent/ES2241571T3/es not_active Expired - Lifetime
- 2000-01-13 CA CA002359449A patent/CA2359449A1/en not_active Abandoned
- 2000-01-13 SI SI200030713T patent/SI1147103T1/xx unknown
- 2000-01-13 US US09/889,146 patent/US6534519B1/en not_active Expired - Fee Related
- 2000-01-13 AU AU22900/00A patent/AU2290000A/en not_active Abandoned
- 2000-01-13 WO PCT/EP2000/000192 patent/WO2000042034A1/en active IP Right Grant
- 2000-01-13 DE DE60019894T patent/DE60019894T2/de not_active Expired - Fee Related
- 2000-01-13 PT PT00901539T patent/PT1147103E/pt unknown
- 2000-01-13 AT AT00901539T patent/ATE294793T1/de not_active IP Right Cessation
- 2000-01-13 EP EP00901539A patent/EP1147103B1/en not_active Expired - Lifetime
- 2000-01-13 DK DK00901539T patent/DK1147103T3/da active
Also Published As
Publication number | Publication date |
---|---|
EP1147103A1 (en) | 2001-10-24 |
AU2290000A (en) | 2000-08-01 |
PT1147103E (pt) | 2005-08-31 |
SI1147103T1 (en) | 2005-10-31 |
JP2003502278A (ja) | 2003-01-21 |
US6534519B1 (en) | 2003-03-18 |
DE60019894D1 (de) | 2005-06-09 |
ATE294793T1 (de) | 2005-05-15 |
DE60019894T2 (de) | 2006-01-12 |
EP1147103B1 (en) | 2005-05-04 |
CA2359449A1 (en) | 2000-07-20 |
ES2241571T3 (es) | 2005-11-01 |
WO2000042034A1 (en) | 2000-07-20 |
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