DK1144620T3 - Magnetiske partikler til rensning af nucleinsyrer - Google Patents

Magnetiske partikler til rensning af nucleinsyrer

Info

Publication number
DK1144620T3
DK1144620T3 DK99959300T DK99959300T DK1144620T3 DK 1144620 T3 DK1144620 T3 DK 1144620T3 DK 99959300 T DK99959300 T DK 99959300T DK 99959300 T DK99959300 T DK 99959300T DK 1144620 T3 DK1144620 T3 DK 1144620T3
Authority
DK
Denmark
Prior art keywords
purification
nucleic acids
magnetic particles
particles
mum
Prior art date
Application number
DK99959300T
Other languages
Danish (da)
English (en)
Inventor
Herbert Harttig
Michael Riedling
Martin Mennig
Helmut Schmidt
Original Assignee
Roche Diagnostics Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE19855259A external-priority patent/DE19855259A1/de
Priority claimed from DE1998154973 external-priority patent/DE19854973B4/de
Application filed by Roche Diagnostics Gmbh filed Critical Roche Diagnostics Gmbh
Application granted granted Critical
Publication of DK1144620T3 publication Critical patent/DK1144620T3/da

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B03—SEPARATION OF SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS; MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C—MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C1/00—Magnetic separation
    • B03C1/005—Pretreatment specially adapted for magnetic separation
    • B03C1/01—Pretreatment specially adapted for magnetic separation by addition of magnetic adjuvants
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y25/00—Nanomagnetism, e.g. magnetoimpedance, anisotropic magnetoresistance, giant magnetoresistance or tunneling magnetoresistance
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1003—Extracting or separating nucleic acids from biological samples, e.g. pure separation or isolation methods; Conditions, buffers or apparatuses therefor
    • C12N15/1006—Extracting or separating nucleic acids from biological samples, e.g. pure separation or isolation methods; Conditions, buffers or apparatuses therefor by means of a solid support carrier, e.g. particles, polymers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1003—Extracting or separating nucleic acids from biological samples, e.g. pure separation or isolation methods; Conditions, buffers or apparatuses therefor
    • C12N15/1006—Extracting or separating nucleic acids from biological samples, e.g. pure separation or isolation methods; Conditions, buffers or apparatuses therefor by means of a solid support carrier, e.g. particles, polymers
    • C12N15/1013—Extracting or separating nucleic acids from biological samples, e.g. pure separation or isolation methods; Conditions, buffers or apparatuses therefor by means of a solid support carrier, e.g. particles, polymers by using magnetic beads
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6806—Preparing nucleic acids for analysis, e.g. for polymerase chain reaction [PCR] assay
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01F—MAGNETS; INDUCTANCES; TRANSFORMERS; SELECTION OF MATERIALS FOR THEIR MAGNETIC PROPERTIES
    • H01F1/00—Magnets or magnetic bodies characterised by the magnetic materials therefor; Selection of materials for their magnetic properties
    • H01F1/01—Magnets or magnetic bodies characterised by the magnetic materials therefor; Selection of materials for their magnetic properties of inorganic materials
    • H01F1/03—Magnets or magnetic bodies characterised by the magnetic materials therefor; Selection of materials for their magnetic properties of inorganic materials characterised by their coercivity
    • H01F1/032—Magnets or magnetic bodies characterised by the magnetic materials therefor; Selection of materials for their magnetic properties of inorganic materials characterised by their coercivity of hard-magnetic materials
    • H01F1/10—Magnets or magnetic bodies characterised by the magnetic materials therefor; Selection of materials for their magnetic properties of inorganic materials characterised by their coercivity of hard-magnetic materials non-metallic substances, e.g. ferrites, e.g. [(Ba,Sr)O(Fe2O3)6] ferrites with hexagonal structure
    • H01F1/11—Magnets or magnetic bodies characterised by the magnetic materials therefor; Selection of materials for their magnetic properties of inorganic materials characterised by their coercivity of hard-magnetic materials non-metallic substances, e.g. ferrites, e.g. [(Ba,Sr)O(Fe2O3)6] ferrites with hexagonal structure in the form of particles
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01F—MAGNETS; INDUCTANCES; TRANSFORMERS; SELECTION OF MATERIALS FOR THEIR MAGNETIC PROPERTIES
    • H01F1/00—Magnets or magnetic bodies characterised by the magnetic materials therefor; Selection of materials for their magnetic properties
    • H01F1/01—Magnets or magnetic bodies characterised by the magnetic materials therefor; Selection of materials for their magnetic properties of inorganic materials
    • H01F1/03—Magnets or magnetic bodies characterised by the magnetic materials therefor; Selection of materials for their magnetic properties of inorganic materials characterised by their coercivity
    • H01F1/032—Magnets or magnetic bodies characterised by the magnetic materials therefor; Selection of materials for their magnetic properties of inorganic materials characterised by their coercivity of hard-magnetic materials
    • H01F1/10—Magnets or magnetic bodies characterised by the magnetic materials therefor; Selection of materials for their magnetic properties of inorganic materials characterised by their coercivity of hard-magnetic materials non-metallic substances, e.g. ferrites, e.g. [(Ba,Sr)O(Fe2O3)6] ferrites with hexagonal structure
    • H01F1/11—Magnets or magnetic bodies characterised by the magnetic materials therefor; Selection of materials for their magnetic properties of inorganic materials characterised by their coercivity of hard-magnetic materials non-metallic substances, e.g. ferrites, e.g. [(Ba,Sr)O(Fe2O3)6] ferrites with hexagonal structure in the form of particles
    • H01F1/112—Magnets or magnetic bodies characterised by the magnetic materials therefor; Selection of materials for their magnetic properties of inorganic materials characterised by their coercivity of hard-magnetic materials non-metallic substances, e.g. ferrites, e.g. [(Ba,Sr)O(Fe2O3)6] ferrites with hexagonal structure in the form of particles with a skin
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
    • Y10T428/2989—Microcapsule with solid core [includes liposome]
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
    • Y10T428/2991—Coated
    • Y10T428/2993—Silicic or refractory material containing [e.g., tungsten oxide, glass, cement, etc.]
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
    • Y10T428/2991—Coated
    • Y10T428/2993—Silicic or refractory material containing [e.g., tungsten oxide, glass, cement, etc.]
    • Y10T428/2996—Glass particles or spheres

Landscapes

  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Power Engineering (AREA)
  • Nanotechnology (AREA)
  • Plant Pathology (AREA)
  • Immunology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Dermatology (AREA)
  • Glass Compositions (AREA)
  • Glanulating (AREA)
  • Soft Magnetic Materials (AREA)
  • Treatment Of Liquids With Adsorbents In General (AREA)
  • Glass Melting And Manufacturing (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
  • Saccharide Compounds (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Powder Metallurgy (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Cleaning And De-Greasing Of Metallic Materials By Chemical Methods (AREA)
  • Cleaning Or Drying Semiconductors (AREA)
DK99959300T 1998-11-30 1999-11-23 Magnetiske partikler til rensning af nucleinsyrer DK1144620T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE19855259A DE19855259A1 (de) 1998-11-30 1998-11-30 Magnetische Partikel zur Reinigung von Nukleinsäuren
DE1998154973 DE19854973B4 (de) 1998-11-30 1998-11-30 Verfahren zur Reinigung von Nukleinsäuren
PCT/EP1999/008996 WO2000032762A1 (fr) 1998-11-30 1999-11-23 Particules magnetiques pour purifier des acides nucleiques

Publications (1)

Publication Number Publication Date
DK1144620T3 true DK1144620T3 (da) 2004-01-05

Family

ID=26050440

Family Applications (1)

Application Number Title Priority Date Filing Date
DK99959300T DK1144620T3 (da) 1998-11-30 1999-11-23 Magnetiske partikler til rensning af nucleinsyrer

Country Status (12)

Country Link
US (2) US6545143B1 (fr)
EP (1) EP1144620B1 (fr)
JP (2) JP3561235B2 (fr)
AT (1) ATE248911T1 (fr)
AU (1) AU762188B2 (fr)
CA (1) CA2352490C (fr)
DE (1) DE59906909D1 (fr)
DK (1) DK1144620T3 (fr)
ES (1) ES2205914T3 (fr)
NO (1) NO329549B1 (fr)
PT (1) PT1144620E (fr)
WO (1) WO2000032762A1 (fr)

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KR100463475B1 (ko) * 1995-06-08 2005-06-22 로셰 디아그노스틱스 게엠베하 자기성피그먼트
DE19743518A1 (de) * 1997-10-01 1999-04-15 Roche Diagnostics Gmbh Automatisierbare universell anwendbare Probenvorbereitungsmethode
DK1144620T3 (da) 1998-11-30 2004-01-05 Roche Diagnostics Gmbh Magnetiske partikler til rensning af nucleinsyrer
HUP0203386A3 (en) * 1999-11-17 2010-01-28 Roche Diagnostics Gmbh Magnetic glass particles, method for their preparation and uses thereof
DE10035953A1 (de) * 2000-07-21 2002-01-31 Fraunhofer Ges Forschung Sphärische, magnetische Silica-Partikel mit einstellbarer Teilchen- und Porengröße sowie einstellbarem Magnetgehalt für die Aufreinigung von Nukleinsäuren und anderen Biomolekülen
AU2003235767A1 (en) 2002-01-08 2003-07-24 Roche Diagnostics Gmbh Use of silica material in an amplification reaction
ATE375512T1 (de) * 2002-06-27 2007-10-15 Toyo Boseki Magnetischer träger für biologische substanzen, verfahren zur seiner produktion und seiner verwendung zur isolierung dieser biologischen substanzen
US9394332B2 (en) 2002-08-29 2016-07-19 Epigenomics Ag Method for bisulfite treatment
ES2294462T5 (es) 2003-01-29 2015-05-06 Epigenomics Ag Método mejorado para el tratamiento de bisulfito
CA2524130A1 (fr) * 2003-05-14 2004-12-02 Exelixis, Inc. Ranbp2 constituant un modificateur de la voie pten/igf et methodes d'utilisation
DE10355409A1 (de) * 2003-11-25 2005-06-30 Magnamedics Gmbh Sphärische, magnetische Silicagel-Träger mit vergrößerter Oberfläche für die Aufreinigung von Nukleinsäuren
EP1692315A1 (fr) 2003-12-02 2006-08-23 Roche Diagnostics GmbH Procede ameliore de traitement au bisulfite
EP1642648A1 (fr) 2004-09-30 2006-04-05 Roche Diagnostics GmbH Dispositif et proeédé pour regler la temperature d'un liquide
JP4674794B2 (ja) * 2004-12-15 2011-04-20 日産自動車株式会社 クリヤー塗料組成物及びクリヤー塗膜
WO2007148734A1 (fr) 2006-06-20 2007-12-27 Hitachi Metals, Ltd. Particule métallique, perle métallique pour l'extraction de substances biologiques et leurs procédés de fabricaton
WO2008035681A1 (fr) 2006-09-20 2008-03-27 Hitachi Metals, Ltd. Fines particules métalliques enrobées et procédé de production
KR100850430B1 (ko) 2006-12-11 2008-08-05 (주)바이오니아 입자상 물질을 사용하는 핵산 분리 방법 및 핵산 분리용조성물
EP2108699B1 (fr) 2008-04-08 2014-06-25 F.Hoffmann-La Roche Ag Dispositif de traitement et de détection analytique
BRPI0911715A2 (pt) 2008-07-31 2019-09-24 Alma Mater Studiorum - Universita' Di Bologna partículas ativas para aplicações bio-analíticas e métodos para sua preparação.
KR101503104B1 (ko) * 2011-08-01 2015-03-16 삼성전기주식회사 금속 자성 분말, 상기 금속 자성 분말을 포함하는 자성층 재료, 및 자성층 재료를 이용한 자성층을 포함하는 적층형 칩 부품
US20140322706A1 (en) 2012-10-24 2014-10-30 Jon Faiz Kayyem Integrated multipelx target analysis
JP6466336B2 (ja) 2012-10-24 2019-02-06 ジェンマーク ダイアグノスティクス， インコーポレイテッド 一体型多重標的分析
US9410663B2 (en) 2013-03-15 2016-08-09 Genmark Diagnostics, Inc. Apparatus and methods for manipulating deformable fluid vessels
US9409148B2 (en) 2013-08-08 2016-08-09 Uchicago Argonne, Llc Compositions and methods for direct capture of organic materials from process streams
USD881409S1 (en) 2013-10-24 2020-04-14 Genmark Diagnostics, Inc. Biochip cartridge
US9498778B2 (en) 2014-11-11 2016-11-22 Genmark Diagnostics, Inc. Instrument for processing cartridge for performing assays in a closed sample preparation and reaction system
US9598722B2 (en) 2014-11-11 2017-03-21 Genmark Diagnostics, Inc. Cartridge for performing assays in a closed sample preparation and reaction system
US10005080B2 (en) 2014-11-11 2018-06-26 Genmark Diagnostics, Inc. Instrument and cartridge for performing assays in a closed sample preparation and reaction system employing electrowetting fluid manipulation
JP2016102038A (ja) * 2014-11-28 2016-06-02 新技術創造研究所株式会社 金属酸化物ガラス膜の製造方法
JP7036722B2 (ja) * 2016-01-05 2022-03-15 エフ．ホフマン－ラ ロシュ アーゲー 磁性ガラス粒子による核酸の連続的な補足
JP7083756B2 (ja) 2016-05-13 2022-06-13 エフ．ホフマン－ラ ロシュ アーゲー タンパク質系試料回収マトリックス及び装置
ES2951666T3 (es) 2016-09-12 2023-10-24 Hoffmann La Roche Procedimientos y composiciones para purificar ácidos nucleicos bicatenarios
WO2021185682A1 (fr) 2020-03-17 2021-09-23 F. Hoffmann-La Roche Ag Procédé d'amélioration de la récupération de cellules dans une analyse monocellulaire
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DE19520398B4 (de) * 1995-06-08 2009-04-16 Roche Diagnostics Gmbh Magnetisches Pigment
DE19520964A1 (de) 1995-06-08 1996-12-12 Inst Neue Mat Gemein Gmbh Beschichtete anorganische Pigmente, Verfahren zu deren Herstellung und deren Verwendung
DE19622885A1 (de) 1996-06-07 1997-12-11 Boehringer Mannheim Gmbh Reagenzzubereitung enthaltend magnetische Partikel in Form einer Tablette
US6027945A (en) * 1997-01-21 2000-02-22 Promega Corporation Methods of isolating biological target materials using silica magnetic particles
US5990479A (en) * 1997-11-25 1999-11-23 Regents Of The University Of California Organo Luminescent semiconductor nanocrystal probes for biological applications and process for making and using such probes
DK1144620T3 (da) * 1998-11-30 2004-01-05 Roche Diagnostics Gmbh Magnetiske partikler til rensning af nucleinsyrer

Also Published As

Publication number Publication date
NO20012620L (no) 2001-07-27
CA2352490A1 (fr) 2000-06-08
ES2205914T3 (es) 2004-05-01
US6919444B2 (en) 2005-07-19
JP3561235B2 (ja) 2004-09-02
NO329549B1 (no) 2010-11-08
CA2352490C (fr) 2006-07-11
JP3561270B2 (ja) 2004-09-02
PT1144620E (pt) 2004-01-30
US6545143B1 (en) 2003-04-08
JP2004135678A (ja) 2004-05-13
AU1652800A (en) 2000-06-19
DE59906909D1 (de) 2003-10-09
ATE248911T1 (de) 2003-09-15
AU762188B2 (en) 2003-06-19
WO2000032762A1 (fr) 2000-06-08
EP1144620A1 (fr) 2001-10-17
EP1144620B1 (fr) 2003-09-03
US20030125542A1 (en) 2003-07-03
JP2002531084A (ja) 2002-09-24
NO20012620D0 (no) 2001-05-29

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