DK1140150T3 - Fremgangsmåde til accelerering af hastigheden af mucociliær clearance under anvendelse af en serinproteaseinhibitor af Kunitz-type - Google Patents

Fremgangsmåde til accelerering af hastigheden af mucociliær clearance under anvendelse af en serinproteaseinhibitor af Kunitz-type

Info

Publication number
DK1140150T3
DK1140150T3 DK99963636T DK99963636T DK1140150T3 DK 1140150 T3 DK1140150 T3 DK 1140150T3 DK 99963636 T DK99963636 T DK 99963636T DK 99963636 T DK99963636 T DK 99963636T DK 1140150 T3 DK1140150 T3 DK 1140150T3
Authority
DK
Denmark
Prior art keywords
accelerating
rate
protease inhibitor
serine protease
mucociliary clearance
Prior art date
Application number
DK99963636T
Other languages
Danish (da)
English (en)
Inventor
Roderick Hall
Christopher T Poll
Benjamin B Newton
William J A Taylor
Original Assignee
Bayer Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Ag filed Critical Bayer Ag
Application granted granted Critical
Publication of DK1140150T3 publication Critical patent/DK1140150T3/da

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/55—Protease inhibitors
    • A61K38/57—Protease inhibitors from animals; from humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/10—Expectorants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/12—Mucolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/16—Otologicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Otolaryngology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
DK99963636T 1998-12-22 1999-12-22 Fremgangsmåde til accelerering af hastigheden af mucociliær clearance under anvendelse af en serinproteaseinhibitor af Kunitz-type DK1140150T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US21891398A 1998-12-22 1998-12-22
US44196699A 1999-11-17 1999-11-17
PCT/GB1999/004381 WO2000037099A2 (fr) 1998-12-22 1999-12-22 Technique permettant d'accelerer le debit de clairance mucociliaire en utilisant un inhibiteur de serine protease de type kunitz

Publications (1)

Publication Number Publication Date
DK1140150T3 true DK1140150T3 (da) 2004-03-22

Family

ID=26913378

Family Applications (2)

Application Number Title Priority Date Filing Date
DK03018789T DK1374891T3 (da) 1998-12-22 1999-12-22 Fremgangsmåde til fremskyndelse af hastigheden af mucociliær clearance
DK99963636T DK1140150T3 (da) 1998-12-22 1999-12-22 Fremgangsmåde til accelerering af hastigheden af mucociliær clearance under anvendelse af en serinproteaseinhibitor af Kunitz-type

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DK03018789T DK1374891T3 (da) 1998-12-22 1999-12-22 Fremgangsmåde til fremskyndelse af hastigheden af mucociliær clearance

Country Status (13)

Country Link
US (1) US20070086956A1 (fr)
EP (2) EP1374891B1 (fr)
JP (2) JP3819239B2 (fr)
CN (1) CN1229138C (fr)
AR (1) AR030257A1 (fr)
AT (2) ATE254473T1 (fr)
AU (1) AU758832B2 (fr)
CA (1) CA2356404C (fr)
DE (2) DE69939559D1 (fr)
DK (2) DK1374891T3 (fr)
ES (2) ES2318075T3 (fr)
TW (1) TWI249406B (fr)
WO (1) WO2000037099A2 (fr)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7244616B2 (en) 2003-06-27 2007-07-17 Bayer Pharmaceuticals Corporation Use of molecular chaperones for the enhanced production of secreted, recombinant proteins in mammalian cells
CN1332715C (zh) * 2003-09-09 2007-08-22 王继峰 蛋白酶抑制剂在制备预防和治疗肺部疾病的药物中的用途
EP1586587A1 (fr) * 2004-04-16 2005-10-19 Exonhit Therapeutics SA Préparations et méthodes pour détecter l'angiogenèse
GB0411145D0 (en) * 2004-05-19 2004-06-23 Imp College Innovations Ltd Protease inhibitors and their therapeutic applications
CN100408094C (zh) * 2005-08-29 2008-08-06 吉林圣元科技有限责任公司 蛋白酶抑制剂在保护肝细胞功能中的应用
CA2663795A1 (fr) * 2006-09-19 2008-03-27 Discovery Laboratories, Inc. Formulations de surfactant pulmonaire et procedes favorisant l'elimination du mucus
EP2854833A1 (fr) * 2012-05-25 2015-04-08 Inserm Agents pour le traitement de la mucoviscidose
JP2016204360A (ja) * 2015-02-25 2016-12-08 エー１エム ファーマ エービーＡ１Ｍ Ｐｈａｒｍａ ＡＢ 放射性核種療法における腎臓の保護に用いるためのアルファ−１−ミクログロブリン

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5223482A (en) * 1986-11-17 1993-06-29 Scios Nova Inc. Recombinant Alzheimer's protease inhibitory amyloid protein and method of use
US5106833A (en) * 1987-07-23 1992-04-21 Washington University Coagulation inhibitors
US5663143A (en) * 1988-09-02 1997-09-02 Dyax Corp. Engineered human-derived kunitz domains that inhibit human neutrophil elastase
US5223409A (en) * 1988-09-02 1993-06-29 Protein Engineering Corp. Directed evolution of novel binding proteins
ES2066033T3 (es) * 1989-05-13 1995-03-01 Bayer Ag Inhibidores de las proteinasas, procedimiento para su preparacion y composiciones farmaceuticas que los contienen.
DK408089D0 (da) * 1989-08-18 1989-08-18 Novo Nordisk As Proteiner
DK0573603T3 (da) * 1991-03-01 2003-10-20 Dyax Corp Inhibitorer af human neutrofil elastase og human cathepsin G
RU2054180C1 (ru) * 1991-08-21 1996-02-10 Жирнов Олег Петрович (н/п) Способ лечения вирусных респираторных инфекций
IL104325A (en) * 1992-01-07 2000-10-31 Novo Nordisk As Variants of human kunitz-type protease inhibitor domain II of tissue factor pathway inhibitor (TFPI) pharmaceutical compositions containing them a DNA construct encoding them their expression vectors a cell containing said DNA constructs and methods for the production of all the above
JPH07509229A (ja) * 1992-07-13 1995-10-12 コルバス・インターナショナル、インコーポレイテッド ウシ膵トリプシン阻害因子から誘導される因子Ｘａの阻害因子
AU5684594A (en) * 1992-12-02 1994-06-22 Novo Nordisk A/S Novel human amyloid protein precursor homologue and kunitz-type inhibitors
US5436153A (en) * 1992-12-02 1995-07-25 Sprecher; Cindy A. Human amyloid protein precursor homolog and Kunitz-type inhibitor
JP2769083B2 (ja) * 1993-02-22 1998-06-25 日清食品株式会社 エラスターゼ阻害活性を有する新規ペプチドおよびその製造方法
US5455338A (en) * 1993-11-05 1995-10-03 Zymogenetics, Inc. DNA encoding novel human kunitz-type inhibitors and methods relating thereto
JP3805785B2 (ja) * 1994-01-11 2006-08-09 ダイアックス コープ． カリクレイン阻害クニッツドメイン蛋白質およびその相同体
US5795954A (en) * 1994-03-04 1998-08-18 Genentech, Inc. Factor VIIa inhibitors from Kunitz domain proteins
US5786328A (en) * 1995-06-05 1998-07-28 Genentech, Inc. Use of kunitz type plasma kallikrein inhibitors
EP0758682B1 (fr) * 1995-07-24 2004-05-12 Mitsubishi Chemical Corporation Inhibiteur d'activateur du facteur de croissance d'hépatocyte
US5736364A (en) * 1995-12-04 1998-04-07 Genentech, Inc. Factor viia inhibitors
CA2247888A1 (fr) * 1996-03-11 1997-09-18 Bayer Corporation Bikunine humaine
US20070140979A1 (en) * 1998-12-22 2007-06-21 Bayer Aktiengesellschaft Method for accelerating the rate of mucociliary clearance

Also Published As

Publication number Publication date
WO2000037099A2 (fr) 2000-06-29
EP1374891B1 (fr) 2008-09-10
WO2000037099A3 (fr) 2000-10-26
CN1334743A (zh) 2002-02-06
CA2356404A1 (fr) 2000-06-29
CA2356404C (fr) 2010-03-30
ES2318075T3 (es) 2009-05-01
JP2002532558A (ja) 2002-10-02
TWI249406B (en) 2006-02-21
EP1140150A2 (fr) 2001-10-10
AR030257A1 (es) 2003-08-20
AU1987800A (en) 2000-07-12
ES2209542T3 (es) 2004-06-16
JP2006232810A (ja) 2006-09-07
US20070086956A1 (en) 2007-04-19
JP3819239B2 (ja) 2006-09-06
DK1374891T3 (da) 2009-01-26
EP1374891A1 (fr) 2004-01-02
CN1229138C (zh) 2005-11-30
AU758832B2 (en) 2003-04-03
ATE254473T1 (de) 2003-12-15
DE69939559D1 (de) 2008-10-23
DE69912988D1 (de) 2003-12-24
DE69912988T2 (de) 2004-11-11
ATE407694T1 (de) 2008-09-15
EP1140150B1 (fr) 2003-11-19

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