DK113352B - Fremgangsmåde til fremstilling af et antibiotikum R-451 eller dets komponenter R-451A, R-451B, R-451C, R-451D og R-451E eller salte, ethere, N-acyl-derivater eller O-acyl-derivater af disse stoffer. - Google Patents

Fremgangsmåde til fremstilling af et antibiotikum R-451 eller dets komponenter R-451A, R-451B, R-451C, R-451D og R-451E eller salte, ethere, N-acyl-derivater eller O-acyl-derivater af disse stoffer.

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Publication number
DK113352B
DK113352B DK350064AA DK350064A DK113352B DK 113352 B DK113352 B DK 113352B DK 350064A A DK350064A A DK 350064AA DK 350064 A DK350064 A DK 350064A DK 113352 B DK113352 B DK 113352B
Authority
DK
Denmark
Prior art keywords
acyl derivatives
antibiotic
ethers
salts
substances
Prior art date
Application number
DK350064AA
Other languages
English (en)
Inventor
G Luedemann
M Weinstein
Original Assignee
Scherico Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Scherico Ltd filed Critical Scherico Ltd
Publication of DK113352B publication Critical patent/DK113352B/da

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    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20Bacteria; Culture media therefor
    • C12N1/205Bacterial isolates
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20Carbocyclic rings
    • C07H15/22Cyclohexane rings, substituted by nitrogen atoms
    • C07H15/222Cyclohexane rings substituted by at least two nitrogen atoms
    • C07H15/226Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings
    • C07H15/234Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings attached to non-adjacent ring carbon atoms of the cyclohexane rings, e.g. kanamycins, tobramycin, nebramycin, gentamicin A2
    • C07H15/236Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings attached to non-adjacent ring carbon atoms of the cyclohexane rings, e.g. kanamycins, tobramycin, nebramycin, gentamicin A2 a saccharide radical being substituted by an alkylamino radical in position 3 and by two substituents different from hydrogen in position 4, e.g. gentamicin complex, sisomicin, verdamycin
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P1/00Preparation of compounds or compositions, not provided for in groups C12P3/00 - C12P39/00, by using microorganisms or enzymes
    • C12P1/06Preparation of compounds or compositions, not provided for in groups C12P3/00 - C12P39/00, by using microorganisms or enzymes by using actinomycetales
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/18Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
    • C12P17/188Heterocyclic compound containing in the condensed system at least one hetero ring having nitrogen atoms and oxygen atoms as the only ring heteroatoms
    • C12P17/189Heterocyclic compound containing in the condensed system at least one hetero ring having nitrogen atoms and oxygen atoms as the only ring heteroatoms containing the rifamycin nucleus
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00Preparation of compounds containing saccharide radicals
    • C12P19/44Preparation of O-glycosides, e.g. glucosides
    • C12P19/46Preparation of O-glycosides, e.g. glucosides having an oxygen atom of the saccharide radical bound to a cyclohexyl radical, e.g. kasugamycin
    • C12P19/48Preparation of O-glycosides, e.g. glucosides having an oxygen atom of the saccharide radical bound to a cyclohexyl radical, e.g. kasugamycin the cyclohexyl radical being substituted by two or more nitrogen atoms, e.g. destomycin, neamin
    • C12P19/485Having two saccharide radicals bound through only oxygen to non-adjacent ring carbons of the cyclohexyl radical, e.g. gentamycin, kanamycin, sisomycin, verdamycin, mutamycin, tobramycin, nebramycin, antibiotics 66-40B, 66-40D, XK-62-2, 66-40, G-418, G-52
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12RINDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00Microorganisms ; Processes using microorganisms
    • C12R2001/01Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/29Micromonospora
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00Chemistry: molecular biology and microbiology
    • Y10S435/8215Microorganisms
    • Y10S435/822Microorganisms using bacteria or actinomycetales
    • Y10S435/863Mycobacterium

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Virology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Mycology (AREA)
  • Molecular Biology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Sheets, Magazines, And Separation Thereof (AREA)
DK350064AA 1962-04-02 1964-07-13 Fremgangsmåde til fremstilling af et antibiotikum R-451 eller dets komponenter R-451A, R-451B, R-451C, R-451D og R-451E eller salte, ethere, N-acyl-derivater eller O-acyl-derivater af disse stoffer. DK113352B (da)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US18448462A 1962-04-02 1962-04-02
US21115462A 1962-07-16 1962-07-16
US21180662A 1962-07-23 1962-07-23
US35416864A 1964-03-23 1964-03-23
US76250468A 1968-09-25 1968-09-25
US76912268A 1968-10-21 1968-10-21

Publications (1)

Publication Number Publication Date
DK113352B true DK113352B (da) 1969-03-17

Family

ID=27558749

Family Applications (3)

Application Number Title Priority Date Filing Date
DK350064AA DK113352B (da) 1962-04-02 1964-07-13 Fremgangsmåde til fremstilling af et antibiotikum R-451 eller dets komponenter R-451A, R-451B, R-451C, R-451D og R-451E eller salte, ethere, N-acyl-derivater eller O-acyl-derivater af disse stoffer.
DK350164AA DK114753B (da) 1962-04-02 1964-07-13 Fremgangsmåde til fremstilling af et antibiotikum SP-30 eller dets komponenter.
DK146065AA DK116862B (da) 1962-04-02 1965-03-22 Fremgangsmåde til fremstilling af et antibiotikum nr. 467.

Family Applications After (2)

Application Number Title Priority Date Filing Date
DK350164AA DK114753B (da) 1962-04-02 1964-07-13 Fremgangsmåde til fremstilling af et antibiotikum SP-30 eller dets komponenter.
DK146065AA DK116862B (da) 1962-04-02 1965-03-22 Fremgangsmåde til fremstilling af et antibiotikum nr. 467.

Country Status (15)

Country Link
US (2) US3499078A (da)
JP (2) JPS5130157B1 (da)
BE (1) BE661459A (da)
BR (1) BR6568037D0 (da)
CH (3) CH435561A (da)
DE (1) DE1271896B (da)
DK (3) DK113352B (da)
FI (3) FI43420B (da)
FR (2) FR1522202A (da)
GB (3) GB1021403A (da)
IL (1) IL22998A (da)
MY (1) MY7100131A (da)
NL (1) NL6503263A (da)
NO (1) NO120933B (da)
SE (1) SE322191B (da)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3915956A (en) * 1973-07-09 1975-10-28 Schering Corp Reduction products of everninomicins and methods for their manufacture
US4006225A (en) * 1973-10-31 1977-02-01 Schering Corporation Method of using reduction products of everninomicins as antibacterial agents and pharmaceutical compositions useful therefor
US3901973A (en) * 1973-11-05 1975-08-26 Schering Corp Antibiotic everninomicin 1
US3993748A (en) * 1975-01-20 1976-11-23 The Upjohn Company Antibiotic U-47,929 and its preparation
US3991183A (en) * 1975-05-01 1976-11-09 Pfizer Inc. Antibiotic produced by a species of micromonospora
JPS5371652U (da) * 1976-11-17 1978-06-15
JPS5492268U (da) * 1977-12-13 1979-06-29
JPS54138501A (en) * 1978-04-20 1979-10-27 Kyowa Hakko Kogyo Co Ltd Antibiotic dc-11 and preparation thereof
US4205068A (en) * 1978-05-18 1980-05-27 E. R. Squibb & Sons, Inc. β-Lactamase inhibitor EM4615
US4331659A (en) * 1980-09-10 1982-05-25 The Upjohn Company Antibiotic U-62,162 and process of making
US4692333A (en) * 1982-08-26 1987-09-08 Gruppo Lepetit S.P.A. Antimicrobial and antitumor antibiotic M 9026 and its pure individual factors 1, 2, and 3 and microbial process for production thereof
EP0277595B1 (de) * 1987-01-29 1992-06-17 Peter Schmidt Transportvorrichtung für Sportausrüstungen
CA2121345C (en) * 1991-10-16 1998-08-25 Mahesh Patel Lipophilic oligosaccharide antibiotic salt compositions
WO2001053533A2 (en) * 2000-01-21 2001-07-26 Kosan Biosciences, Inc. Method for cloning polyketide synthase genes
US7257562B2 (en) * 2000-10-13 2007-08-14 Thallion Pharmaceuticals Inc. High throughput method for discovery of gene clusters
JP5745045B2 (ja) 2010-06-30 2015-07-08 ケーエルエー−テンカー コーポレイション 入力媒体及び出力媒体の区画内に電子デバイスを配置する方法及び装置
US10696996B2 (en) 2015-12-09 2020-06-30 Vanderbilt Univeristy Biosynthesis of everninomicin analogs in Micromonospora carbonacea var aurantiaca

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1021401A (en) * 1961-11-14 1966-03-02 Scherico Ltd Novel antibiotics and processes for their manufacture

Also Published As

Publication number Publication date
GB1021403A (en) 1966-03-02
JPS5130158B1 (da) 1976-08-30
US3511909A (en) 1970-05-12
CH435561A (de) 1967-05-15
FR128F (da)
DE1271896B (de) 1968-07-04
IL22998A (en) 1969-01-29
DK114753B (da) 1969-08-04
JPS5130157B1 (da) 1976-08-30
SE322191B (da) 1970-04-06
FI43422B (da) 1970-12-31
FR1522202A (fr) 1968-04-26
NL6503263A (da) 1965-09-24
US3499078A (en) 1970-03-03
FI43420B (da) 1970-12-31
CH463020A (de) 1968-09-30
CH435560A (de) 1967-05-15
BE661459A (da) 1965-09-22
BR6568037D0 (pt) 1973-08-07
GB1021402A (en) 1966-03-02
DK116862B (da) 1970-02-23
MY7100131A (en) 1971-12-31
GB1083662A (en) 1967-09-20
NO120933B (da) 1970-12-28
FI43421B (da) 1970-12-31

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