DK1131318T3 - Fremgangsmåde til fremstilling af 5-substituerede pyrazoler under anvendelse af dithietaner - Google Patents
Fremgangsmåde til fremstilling af 5-substituerede pyrazoler under anvendelse af dithietanerInfo
- Publication number
- DK1131318T3 DK1131318T3 DK99961578T DK99961578T DK1131318T3 DK 1131318 T3 DK1131318 T3 DK 1131318T3 DK 99961578 T DK99961578 T DK 99961578T DK 99961578 T DK99961578 T DK 99961578T DK 1131318 T3 DK1131318 T3 DK 1131318T3
- Authority
- DK
- Denmark
- Prior art keywords
- dithietanes
- preparation
- substituted pyrazoles
- substituted
- pyrazoles
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D231/18—One oxygen or sulfur atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D339/00—Heterocyclic compounds containing rings having two sulfur atoms as the only ring hetero atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Pyridine Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10917798P | 1998-11-20 | 1998-11-20 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK1131318T3 true DK1131318T3 (da) | 2004-06-01 |
Family
ID=22326224
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK99961578T DK1131318T3 (da) | 1998-11-20 | 1999-11-18 | Fremgangsmåde til fremstilling af 5-substituerede pyrazoler under anvendelse af dithietaner |
Country Status (14)
| Country | Link |
|---|---|
| US (6) | US6143892A (da) |
| EP (1) | EP1131318B1 (da) |
| JP (1) | JP2002530404A (da) |
| AT (1) | ATE262523T1 (da) |
| AU (1) | AU758811B2 (da) |
| CA (1) | CA2350081A1 (da) |
| DE (1) | DE69915862T2 (da) |
| DK (1) | DK1131318T3 (da) |
| ES (1) | ES2219092T3 (da) |
| IL (1) | IL142999A0 (da) |
| NZ (1) | NZ511594A (da) |
| PT (1) | PT1131318E (da) |
| WO (1) | WO2000031072A1 (da) |
| ZA (1) | ZA200103759B (da) |
Families Citing this family (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6979686B1 (en) | 2001-12-07 | 2005-12-27 | Pharmacia Corporation | Substituted pyrazoles as p38 kinase inhibitors |
| WO2000010563A1 (en) | 1998-08-20 | 2000-03-02 | Smithkline Beecham Corporation | Novel substituted triazole compounds |
| DE69915862T2 (de) * | 1998-11-20 | 2004-08-05 | G.D. Searle Llc | Verfahren zur herstellung 5-substituierter pyrazole unter verwendung von dithietane |
| US7122666B2 (en) | 1999-07-21 | 2006-10-17 | Sankyo Company, Limited | Heteroaryl-substituted pyrrole derivatives, their preparation and their therapeutic uses |
| US6759410B1 (en) * | 1999-11-23 | 2004-07-06 | Smithline Beecham Corporation | 3,4-dihydro-(1H)-quinazolin-2-ones and their use as CSBP/p38 kinase inhibitors |
| US7057049B2 (en) | 2001-09-25 | 2006-06-06 | Pharmacia Corporation | Process for making substituted pyrazoles |
| KR100697482B1 (ko) | 2001-09-25 | 2007-03-20 | 파마시아 코포레이션 | 치환된 피라졸의 제조 방법 |
| CA2476822A1 (en) * | 2002-02-19 | 2003-08-28 | Pharmacia Italia S.P.A. | Tricyclic pyrazole derivatives, process for their preparation and their use as antitumor agents |
| JP2005538958A (ja) * | 2002-06-05 | 2005-12-22 | ファルマシア・コーポレーション | ｐ３８キナーゼ阻害薬としてのピラゾール誘導体 |
| WO2004004725A2 (en) | 2002-07-09 | 2004-01-15 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Pharmaceutical compositions of anticholinergics and p38 kinase inhibitors in the treatment of respiratory diseases |
| TW200413351A (en) | 2002-08-21 | 2004-08-01 | Astrazeneca Ab | Chemical compounds |
| AU2003301226A1 (en) * | 2002-12-20 | 2004-07-22 | Pharmacia Corp | Acyclic pyrazole compounds for the inhibition of mitogen activated protein kinase-activated protein kinase-2 |
| US20060035893A1 (en) | 2004-08-07 | 2006-02-16 | Boehringer Ingelheim International Gmbh | Pharmaceutical compositions for treatment of respiratory and gastrointestinal disorders |
| PE20060777A1 (es) | 2004-12-24 | 2006-10-06 | Boehringer Ingelheim Int | Derivados de indolinona para el tratamiento o la prevencion de enfermedades fibroticas |
| WO2007021966A1 (en) * | 2005-08-12 | 2007-02-22 | Synta Pharmaceuticals Corp. | Pyrazole compounds that modulate hsp90 activity |
| EP1992344A1 (en) | 2007-05-18 | 2008-11-19 | Institut Curie | P38 alpha as a therapeutic target in pathologies linked to FGFR3 mutation |
| CA2687931C (en) * | 2007-05-31 | 2016-05-24 | Boehringer Ingelheim International Gmbh | Ccr2 receptor antagonists and uses thereof |
| BRPI0923051B1 (pt) | 2008-12-19 | 2022-07-19 | Centrexion Therapeutics Corporation | Pirimidin-4-carboxamidas cíclicas como antagonistas do receptor de ccr2 para o tratamento de inflamação, asma e copd, seu uso, formulação e combinação farmacêutica que os compreende |
| EP2308866A1 (de) | 2009-10-09 | 2011-04-13 | Bayer CropScience AG | Phenylpyri(mi)dinylpyrazole und ihre Verwendung als Fungizide |
| KR101530234B1 (ko) | 2009-12-17 | 2015-06-19 | 베링거 인겔하임 인터내셔날 게엠베하 | 신규한 ｃｃｒ２ 수용체 길항제 및 이의 용도 |
| EP2569298B1 (en) | 2010-05-12 | 2015-11-25 | Boehringer Ingelheim International GmbH | Novel ccr2 receptor antagonists, method for producing the same, and use thereof as medicaments |
| JP5646736B2 (ja) | 2010-05-12 | 2014-12-24 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 新規ｃｃｒ２受容体アンタゴニスト、これらの製造方法、及び薬物としてのこれらの使用 |
| WO2011144501A1 (en) | 2010-05-17 | 2011-11-24 | Boehringer Ingelheim International Gmbh | Ccr2 antagonists and uses thereof |
| JP5636094B2 (ja) | 2010-05-25 | 2014-12-03 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | Ｃｃｒ２受容体アンタゴニスト |
| JP5721242B2 (ja) | 2010-06-01 | 2015-05-20 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 新規ｃｃｒ２アンタゴニスト |
| EP2731941B1 (en) | 2011-07-15 | 2019-05-08 | Boehringer Ingelheim International GmbH | Novel and selective ccr2 antagonists |
| BR112014008223A2 (pt) | 2011-10-06 | 2017-04-25 | Bayer Ip Gmbh | heterociclilpiri (mi) dinilpirazol |
| WO2016184378A1 (zh) | 2015-05-18 | 2016-11-24 | 沈阳中化农药化工研发有限公司 | 含嘧啶的取代吡唑类化合物及其制备方法和用途 |
| CN108026087B (zh) | 2015-07-02 | 2021-06-04 | 中枢疗法公司 | 氨基嘧啶甲酮衍生物的柠檬酸盐 |
| WO2017151409A1 (en) | 2016-02-29 | 2017-09-08 | University Of Florida Research Foundation, Incorporated | Chemotherapeutic methods |
| CN111004180A (zh) * | 2019-09-11 | 2020-04-14 | 浙江埃森化学有限公司 | 一种制备氟虫腈的方法 |
| CN115124471B (zh) * | 2021-03-24 | 2024-02-13 | 中国工程物理研究院化工材料研究所 | 一类具有高能和低熔点特性的吡唑环类炸药及其合成方法 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS63119468A (ja) * | 1986-11-05 | 1988-05-24 | Takeda Chem Ind Ltd | ピラゾ−ル誘導体の製造法 |
| DE69915862T2 (de) | 1998-11-20 | 2004-08-05 | G.D. Searle Llc | Verfahren zur herstellung 5-substituierter pyrazole unter verwendung von dithietane |
-
1999
- 1999-11-18 DE DE69915862T patent/DE69915862T2/de not_active Expired - Fee Related
- 1999-11-18 AT AT99961578T patent/ATE262523T1/de not_active IP Right Cessation
- 1999-11-18 EP EP19990961578 patent/EP1131318B1/en not_active Expired - Lifetime
- 1999-11-18 AU AU18126/00A patent/AU758811B2/en not_active Ceased
- 1999-11-18 DK DK99961578T patent/DK1131318T3/da active
- 1999-11-18 PT PT99961578T patent/PT1131318E/pt unknown
- 1999-11-18 IL IL14299999A patent/IL142999A0/xx unknown
- 1999-11-18 ES ES99961578T patent/ES2219092T3/es not_active Expired - Lifetime
- 1999-11-18 CA CA002350081A patent/CA2350081A1/en not_active Abandoned
- 1999-11-18 JP JP2000583900A patent/JP2002530404A/ja active Pending
- 1999-11-18 WO PCT/US1999/026011 patent/WO2000031072A1/en active IP Right Grant
- 1999-11-18 NZ NZ511594A patent/NZ511594A/xx unknown
- 1999-11-18 US US09/442,971 patent/US6143892A/en not_active Expired - Fee Related
-
2000
- 2000-08-07 US US09/633,726 patent/US6242612B1/en not_active Expired - Fee Related
-
2001
- 2001-01-30 US US09/772,743 patent/US6342608B1/en not_active Expired - Fee Related
- 2001-05-09 ZA ZA200103759A patent/ZA200103759B/xx unknown
- 2001-08-06 US US09/922,819 patent/US6482955B2/en not_active Expired - Fee Related
-
2002
- 2002-10-10 US US10/268,818 patent/US6750338B2/en not_active Expired - Fee Related
-
2004
- 2004-02-14 US US10/778,432 patent/US20040220232A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| AU758811B2 (en) | 2003-04-03 |
| DE69915862T2 (de) | 2004-08-05 |
| EP1131318A1 (en) | 2001-09-12 |
| US6482955B2 (en) | 2002-11-19 |
| US6143892A (en) | 2000-11-07 |
| US6242612B1 (en) | 2001-06-05 |
| CA2350081A1 (en) | 2000-06-02 |
| ATE262523T1 (de) | 2004-04-15 |
| US20030135057A1 (en) | 2003-07-17 |
| NZ511594A (en) | 2003-01-31 |
| ZA200103759B (en) | 2002-11-27 |
| US6750338B2 (en) | 2004-06-15 |
| US6342608B1 (en) | 2002-01-29 |
| WO2000031072A1 (en) | 2000-06-02 |
| EP1131318B1 (en) | 2004-03-24 |
| ES2219092T3 (es) | 2004-11-16 |
| US20040220232A1 (en) | 2004-11-04 |
| IL142999A0 (en) | 2002-04-21 |
| DE69915862D1 (de) | 2004-04-29 |
| PT1131318E (pt) | 2004-07-30 |
| AU1812600A (en) | 2000-06-13 |
| US20020115868A1 (en) | 2002-08-22 |
| JP2002530404A (ja) | 2002-09-17 |
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