DK112686A - Fremgangsmaade og apparat til dyrkning af cellekulturer - Google Patents

Fremgangsmaade og apparat til dyrkning af cellekulturer Download PDF

Info

Publication number
DK112686A
DK112686A DK112686A DK112686A DK112686A DK 112686 A DK112686 A DK 112686A DK 112686 A DK112686 A DK 112686A DK 112686 A DK112686 A DK 112686A DK 112686 A DK112686 A DK 112686A
Authority
DK
Denmark
Prior art keywords
medium
cells
growth
cell
cell cultures
Prior art date
Application number
DK112686A
Other languages
English (en)
Other versions
DK112686D0 (da
Inventor
Philip C Famelletti
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of DK112686D0 publication Critical patent/DK112686D0/da
Publication of DK112686A publication Critical patent/DK112686A/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M23/00—Constructional details, e.g. recesses, hinges
    • C12M23/02—Form or structure of the vessel
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F33/00—Other mixers; Mixing plants; Combinations of mixers
    • B01F33/40—Mixers using gas or liquid agitation, e.g. with air supply tubes
    • B01F33/406—Mixers using gas or liquid agitation, e.g. with air supply tubes in receptacles with gas supply only at the bottom
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M29/00—Means for introduction, extraction or recirculation of materials, e.g. pumps
    • C12M29/06—Nozzles; Sprayers; Spargers; Diffusers
    • C12M29/08—Air lift
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/12—Means for regulation, monitoring, measurement or control, e.g. flow regulation of temperature
    • C12M41/18—Heat exchange systems, e.g. heat jackets or outer envelopes
    • C12M41/22—Heat exchange systems, e.g. heat jackets or outer envelopes in contact with the bioreactor walls

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • General Engineering & Computer Science (AREA)
  • Sustainable Development (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biomedical Technology (AREA)
  • Thermal Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Clinical Laboratory Science (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
DK112686A 1985-03-15 1986-03-11 Fremgangsmaade og apparat til dyrkning af cellekulturer DK112686A (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/711,932 US4649117A (en) 1985-03-15 1985-03-15 Air lift bioreactor

Publications (2)

Publication Number Publication Date
DK112686D0 DK112686D0 (da) 1986-03-11
DK112686A true DK112686A (da) 1986-09-16

Family

ID=24860098

Family Applications (1)

Application Number Title Priority Date Filing Date
DK112686A DK112686A (da) 1985-03-15 1986-03-11 Fremgangsmaade og apparat til dyrkning af cellekulturer

Country Status (7)

Country Link
US (1) US4649117A (da)
EP (1) EP0197299B1 (da)
JP (1) JPS61212283A (da)
AT (1) ATE38855T1 (da)
DE (1) DE3661273D1 (da)
DK (1) DK112686A (da)
NO (1) NO860991L (da)

Families Citing this family (46)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8515636D0 (en) * 1985-06-20 1985-07-24 Celltech Ltd Fermenter
US5185255A (en) * 1986-05-09 1993-02-09 Rikagaku Kenkyusho Cell culture method
JPS63133978A (ja) * 1986-11-26 1988-06-06 Rikagaku Kenkyusho 細胞培養装置
EP0276154A3 (en) * 1987-01-23 1988-12-28 Bellco Glass, Inc. Method and apparatus for cell culture
US5081036A (en) * 1987-01-23 1992-01-14 Hoffmann-La Roche Inc. Method and apparatus for cell culture
US4904600A (en) * 1987-02-05 1990-02-27 Floyd Ramp Bioreactor for continuous processing of a reactant fluid
US5028541A (en) * 1987-06-01 1991-07-02 The United States Of America As Represented By The Secretary Of The Air Force Flow-through cell cultivation system
US5089385A (en) * 1987-06-01 1992-02-18 The United States Of America As Represented By The Secretary Of The Air Force Method of culturing cells in a flow-through cell cultivation system
US5372943A (en) * 1987-07-24 1994-12-13 Cetus Corporation Lipid microemulsions for culture media
US4847203A (en) * 1987-08-31 1989-07-11 Allelix, Inc. Fermentation vessels
US5605835A (en) * 1988-05-23 1997-02-25 Regents Of The University Of Minnesota Bioreactor device with application as a bioartificial liver
US4988623A (en) * 1988-06-30 1991-01-29 The United States Of America As Represented By The Administrator Of The National Aeronautics And Space Administration Rotating bio-reactor cell culture apparatus
US5153131A (en) * 1990-12-11 1992-10-06 The United States Of America As Represented By The Administrator Of The National Aeronautics And Space Administration High aspect reactor vessel and method of use
US5026650A (en) * 1988-06-30 1991-06-25 The United States Of Amercia As Represented By The Administrator Of The National Aeronautics And Space Administration Horizontally rotated cell culture system with a coaxial tubular oxygenator
US5002890A (en) * 1988-11-29 1991-03-26 The United States Of America As Represented By The Administrator Of The National Aeronautics And Space Administration Spiral vane bioreactor
US5073491A (en) * 1988-12-23 1991-12-17 Hoffman-La Roche Inc. Immobilization of cells in alginate beads containing cavities for growth of cells in airlift bioreactors
US4960706A (en) * 1989-03-27 1990-10-02 Baxter International, Inc. Static oxygenator for suspension culture of animal cells
US5260211A (en) * 1989-12-07 1993-11-09 Snow Brand Milk Products Co., Ltd. Process for cultivating adhesive cells in a packed bed of solid cell matrix
US5232596A (en) * 1991-10-07 1993-08-03 Radian Corporation Bio-slurry reaction system and process for hazardous waste treatment
US5443985A (en) * 1993-07-22 1995-08-22 Alberta Research Council Cell culture bioreactor
NZ272544A (en) * 1994-08-24 1996-03-26 Mitsubishi Heavy Ind Ltd Removal of sulphur from hydrogen sulphide-containing gas at geothermal power plants using a cell breeding culture tank independent of the biochemical treatment tank
US6146891A (en) * 1997-01-31 2000-11-14 Schering Corporation Methods for cultivating cells and propagating viruses
GB2342054A (en) * 1998-10-01 2000-04-05 Roy Mason Mixing apparatus comprising two chambers with bubble lift and siphon return flow therebetween
EP1087010B1 (de) * 1999-09-08 2011-11-09 Levitronix LLC Bioreaktor mit Einmalpumpe
US20020117445A1 (en) * 1999-12-16 2002-08-29 Whiteman G. Robert Fermentation systems, methods, and apparatus
US9969633B2 (en) * 1999-12-16 2018-05-15 Robert Whiteman Systems and methods for treating oil, fat and grease in collection systems
US7879593B2 (en) * 1999-12-16 2011-02-01 Whiteman G Robert Fermentation systems, methods and apparatus
US7198940B2 (en) 2000-10-25 2007-04-03 Shot Hardware Optimization Technology, Inc. Bioreactor apparatus and cell culturing system
KR100698549B1 (ko) * 2001-06-04 2007-03-21 에스케이케미칼주식회사 오·폐수처리용 미생물 배양기
US6938810B2 (en) 2003-04-15 2005-09-06 Illinois Tool Works Inc. Fuel cell adapter system for combustion tools
JP4845737B2 (ja) * 2003-11-18 2011-12-28 ネステク ソシエテ アノニム 細胞培養システム
GB2433266A (en) 2005-12-16 2007-06-20 Kevin Andrew Auton Cell culture vessel
US9057044B2 (en) 2006-08-30 2015-06-16 Meir Israelowitz Laminar flow reactor
WO2008101127A2 (en) * 2007-02-15 2008-08-21 Broadley-James Corporation Bioreactor jacket
GB2450337B (en) * 2007-06-19 2009-06-17 Cellexus Biosystems Plc Cell culture and mixing vessel
WO2009151514A1 (en) 2008-06-11 2009-12-17 Millipore Corporation Stirred tank bioreactor
PT104278B (pt) 2008-12-04 2019-03-20 A4Tec Association For The Advancement Of Tissue Engineering And Cell Based Tech & Therapies Bioreator de fluxo contínuo bi-direcional, para cultura, em suporte tridimensional, de substitutos de tecidos de mamíferos
US8569050B1 (en) 2009-05-04 2013-10-29 John D. Ericsson Enclosed bioreactor system and methods associated therewith
WO2013030340A1 (de) 2011-09-01 2013-03-07 Gicon Grossmann Ingenieur Consult Gmbh Verfahren und vorrichtung zur gezielten einspeisung von gasen oder gasgemischen in eine flüssigkeit, suspension oder emulsion in einem reaktor
EP3231859A1 (de) * 2016-04-11 2017-10-18 MIAL GmbH Für die kultivierung photosynthetisch aktiver zellen geeignetes reaktionssystem und dessen verwendung
DE102016119391B3 (de) 2016-10-12 2018-01-18 Yoen Ok Roth Mikrobioreaktor-Modul
RU203688U1 (ru) * 2019-07-16 2021-04-15 Мария Алексеевна Затолокина Портативная камера для культивирования животных клеток, на примере GCT - cells
US11254477B2 (en) * 2019-10-16 2022-02-22 Morgan Specialty Services, Inc. Extraction pressure vessel, method of manufacture, method of use
CN112877210B (zh) * 2021-02-25 2022-07-26 上海揽微赛尔生物科技有限公司 一种pH值可控的干细胞培养灌流装置
EP4253515A1 (en) * 2022-04-01 2023-10-04 Samabriva Optimized hairy roots bioreactor
CN116120100A (zh) * 2023-03-30 2023-05-16 广西大学 病死畜禽无害化加工肥料的工方法及其装置

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1090758A (en) * 1963-10-30 1967-11-15 Wellcome Found Improvements in or relating to animal cell cultures
US3649465A (en) * 1969-06-24 1972-03-14 Virtis Co Inc Spinner flask
FR2133355A5 (da) * 1971-04-09 1972-11-24 Progil
US3985622A (en) * 1975-01-30 1976-10-12 Phillips Petroleum Company Method and apparatus for conducting fermentation
US4036693A (en) * 1976-02-02 1977-07-19 Massachusetts Institute Of Technology Treatment of cell culture microcarries
US4173516A (en) * 1976-07-15 1979-11-06 Chemap Ag Device for cultivating cells of animal and human tissues
AT345224B (de) * 1976-07-15 1978-09-11 Chemap Ag Verfahren und vorrichtung zum kultivieren von tierischen und humanen gewebezellen
FR2381824A1 (fr) * 1977-02-23 1978-09-22 Setric Procede et dispositif de fermentation
US4208483A (en) * 1978-09-21 1980-06-17 The University Of Toledo Tissue culture system
GB2073243B (en) * 1980-03-04 1984-12-05 Tokyo Rikakikai Kk Continuous fermentor or reactor
DE3047101A1 (de) * 1980-12-13 1982-07-22 Hoechst Ag, 6000 Frankfurt Verfahren zum verbessern der gasverteilung in mammut-schlaufenreaktoren
JPS58179495A (ja) * 1982-04-12 1983-10-20 Ajinomoto Co Inc ヒトリンホカインの製造法

Also Published As

Publication number Publication date
JPS61212283A (ja) 1986-09-20
DK112686D0 (da) 1986-03-11
DE3661273D1 (en) 1988-12-29
NO860991L (no) 1986-09-16
EP0197299A1 (en) 1986-10-15
EP0197299B1 (en) 1988-11-23
US4649117A (en) 1987-03-10
ATE38855T1 (de) 1988-12-15

Similar Documents

Publication Publication Date Title
DK112686D0 (da) Fremgangsmaade og apparat til dyrkning af cellekulturer
IL87196A (en) Serum free medium for the growthof insect cells and expressionof products thereby
CA2107036A1 (en) Cell Culture Insert
WO1997012960A3 (en) Solid support for use in cell cultivation, especially for the cultivation of liver cells, biological reactor containing said solid support and the use thereof in a bio-artificial liver system
MX9303274A (es) Proceso para produccion de vacuna de virus varicela zoster atenuado.
SE8306190D0 (sv) A process and a device for improved oxygenation of biological cultures
THIELE et al. A new method for axenic mass cultivation of Paramecium tetraurelia
ES2038965T3 (es) Procedimiento y dispositivo para el cultivo de celulas.
EP0121981A1 (en) Immobilized cell composite and process using said composite
Yasuhara et al. Production of neutral protease from Aspergillus oryzae by a novel cultivation method on a microporous membrane
DK679087D0 (da) Fremgangsmaade til fremstilling af l-sorbose og apparat til dyrkning af mikroorganismer
Ikemoto et al. Continuous hydrogen photoproduction from sulfide by an immobilized marine photosynthetic bacterium, Chromatium sp. Miami PBS 1071
EP0256512A3 (en) Immortalization by dna transfer
JPH0787955A (ja) 光合成によるｃｏ２固定化方法およびその装置
EP0276154A3 (en) Method and apparatus for cell culture
ATE115183T1 (de) Zellzüchtungsverfahren.
DK0497330T3 (da) Fremgangsmåde og apparat til overfladedyrkning af cellekerneholdige celler og cellekulturafhængige stoffer
CN117286026A (zh) 肌肉组织干细胞培养生化反应装置设计
Familletti Air lift bioreactor.
WO2002064811A3 (fr) Procede pour produire des proteines recombinantes, marquees par au moins un isotope
Clasesson et al. Algal Assay Procedure with One or Five Species. Minitest
Barker et al. Cell culture insert
KR890006809A (ko) 전세포 효소를 성장과 동시에 고정화하는 방법
Morrison Technology Inc.
JPS6192563A (ja) 微生物培養方法

Legal Events

Date Code Title Description
AHB Application shelved due to non-payment