ATE38855T1 - Verfahren und einrichtung zur zellenkultur. - Google Patents

Verfahren und einrichtung zur zellenkultur.

Info

Publication number
ATE38855T1
ATE38855T1 AT86102850T AT86102850T ATE38855T1 AT E38855 T1 ATE38855 T1 AT E38855T1 AT 86102850 T AT86102850 T AT 86102850T AT 86102850 T AT86102850 T AT 86102850T AT E38855 T1 ATE38855 T1 AT E38855T1
Authority
AT
Austria
Prior art keywords
medium
cells
growth
cell
cell culture
Prior art date
Application number
AT86102850T
Other languages
English (en)
Inventor
Philip C Familletti
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Application granted granted Critical
Publication of ATE38855T1 publication Critical patent/ATE38855T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M23/00—Constructional details, e.g. recesses, hinges
    • C12M23/02—Form or structure of the vessel
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F33/00—Other mixers; Mixing plants; Combinations of mixers
    • B01F33/40—Mixers using gas or liquid agitation, e.g. with air supply tubes
    • B01F33/406—Mixers using gas or liquid agitation, e.g. with air supply tubes in receptacles with gas supply only at the bottom
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M29/00—Means for introduction, extraction or recirculation of materials, e.g. pumps
    • C12M29/06—Nozzles; Sprayers; Spargers; Diffusers
    • C12M29/08—Air lift
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/12—Means for regulation, monitoring, measurement or control, e.g. flow regulation of temperature
    • C12M41/18—Heat exchange systems, e.g. heat jackets or outer envelopes
    • C12M41/22—Heat exchange systems, e.g. heat jackets or outer envelopes in contact with the bioreactor walls

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • General Engineering & Computer Science (AREA)
  • Sustainable Development (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biomedical Technology (AREA)
  • Thermal Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Clinical Laboratory Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
AT86102850T 1985-03-15 1986-03-05 Verfahren und einrichtung zur zellenkultur. ATE38855T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US06/711,932 US4649117A (en) 1985-03-15 1985-03-15 Air lift bioreactor
EP86102850A EP0197299B1 (de) 1985-03-15 1986-03-05 Verfahren und Einrichtung zur Zellenkultur

Publications (1)

Publication Number Publication Date
ATE38855T1 true ATE38855T1 (de) 1988-12-15

Family

ID=24860098

Family Applications (1)

Application Number Title Priority Date Filing Date
AT86102850T ATE38855T1 (de) 1985-03-15 1986-03-05 Verfahren und einrichtung zur zellenkultur.

Country Status (7)

Country Link
US (1) US4649117A (de)
EP (1) EP0197299B1 (de)
JP (1) JPS61212283A (de)
AT (1) ATE38855T1 (de)
DE (1) DE3661273D1 (de)
DK (1) DK112686A (de)
NO (1) NO860991L (de)

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GB8515636D0 (en) * 1985-06-20 1985-07-24 Celltech Ltd Fermenter
US5185255A (en) * 1986-05-09 1993-02-09 Rikagaku Kenkyusho Cell culture method
JPS63133978A (ja) * 1986-11-26 1988-06-06 Rikagaku Kenkyusho 細胞培養装置
US5081036A (en) * 1987-01-23 1992-01-14 Hoffmann-La Roche Inc. Method and apparatus for cell culture
EP0276154A3 (de) * 1987-01-23 1988-12-28 Bellco Glass, Inc. Methode und Apparat zur Züchtung von Zellen
US4904600A (en) * 1987-02-05 1990-02-27 Floyd Ramp Bioreactor for continuous processing of a reactant fluid
US5089385A (en) * 1987-06-01 1992-02-18 The United States Of America As Represented By The Secretary Of The Air Force Method of culturing cells in a flow-through cell cultivation system
US5028541A (en) * 1987-06-01 1991-07-02 The United States Of America As Represented By The Secretary Of The Air Force Flow-through cell cultivation system
US5372943A (en) * 1987-07-24 1994-12-13 Cetus Corporation Lipid microemulsions for culture media
US4847203A (en) * 1987-08-31 1989-07-11 Allelix, Inc. Fermentation vessels
US5605835A (en) * 1988-05-23 1997-02-25 Regents Of The University Of Minnesota Bioreactor device with application as a bioartificial liver
US4988623A (en) * 1988-06-30 1991-01-29 The United States Of America As Represented By The Administrator Of The National Aeronautics And Space Administration Rotating bio-reactor cell culture apparatus
US5026650A (en) * 1988-06-30 1991-06-25 The United States Of Amercia As Represented By The Administrator Of The National Aeronautics And Space Administration Horizontally rotated cell culture system with a coaxial tubular oxygenator
US5153131A (en) * 1990-12-11 1992-10-06 The United States Of America As Represented By The Administrator Of The National Aeronautics And Space Administration High aspect reactor vessel and method of use
US5002890A (en) * 1988-11-29 1991-03-26 The United States Of America As Represented By The Administrator Of The National Aeronautics And Space Administration Spiral vane bioreactor
US5073491A (en) * 1988-12-23 1991-12-17 Hoffman-La Roche Inc. Immobilization of cells in alginate beads containing cavities for growth of cells in airlift bioreactors
US4960706A (en) * 1989-03-27 1990-10-02 Baxter International, Inc. Static oxygenator for suspension culture of animal cells
US5260211A (en) * 1989-12-07 1993-11-09 Snow Brand Milk Products Co., Ltd. Process for cultivating adhesive cells in a packed bed of solid cell matrix
US5232596A (en) * 1991-10-07 1993-08-03 Radian Corporation Bio-slurry reaction system and process for hazardous waste treatment
US5443985A (en) * 1993-07-22 1995-08-22 Alberta Research Council Cell culture bioreactor
NZ272544A (en) * 1994-08-24 1996-03-26 Mitsubishi Heavy Ind Ltd Removal of sulphur from hydrogen sulphide-containing gas at geothermal power plants using a cell breeding culture tank independent of the biochemical treatment tank
US6146891A (en) * 1997-01-31 2000-11-14 Schering Corporation Methods for cultivating cells and propagating viruses
GB2342054A (en) * 1998-10-01 2000-04-05 Roy Mason Mixing apparatus comprising two chambers with bubble lift and siphon return flow therebetween
EP2290049B1 (de) * 1999-09-08 2012-08-15 Levitronix Technologies, LLC Bioreaktor
US7879593B2 (en) * 1999-12-16 2011-02-01 Whiteman G Robert Fermentation systems, methods and apparatus
US9969633B2 (en) * 1999-12-16 2018-05-15 Robert Whiteman Systems and methods for treating oil, fat and grease in collection systems
US20020117445A1 (en) * 1999-12-16 2002-08-29 Whiteman G. Robert Fermentation systems, methods, and apparatus
US7198940B2 (en) 2000-10-25 2007-04-03 Shot Hardware Optimization Technology, Inc. Bioreactor apparatus and cell culturing system
KR100698549B1 (ko) * 2001-06-04 2007-03-21 에스케이케미칼주식회사 오·폐수처리용 미생물 배양기
US6938810B2 (en) 2003-04-15 2005-09-06 Illinois Tool Works Inc. Fuel cell adapter system for combustion tools
CN100523167C (zh) * 2003-11-18 2009-08-05 雀巢技术公司 细胞培养系统
GB2433266A (en) * 2005-12-16 2007-06-20 Kevin Andrew Auton Cell culture vessel
US9057044B2 (en) 2006-08-30 2015-06-16 Meir Israelowitz Laminar flow reactor
US20100075405A1 (en) * 2007-02-15 2010-03-25 Broadley-James Corporation Bioreactor jacket
GB2450337B (en) * 2007-06-19 2009-06-17 Cellexus Biosystems Plc Cell culture and mixing vessel
WO2009151514A1 (en) 2008-06-11 2009-12-17 Millipore Corporation Stirred tank bioreactor
PT104278B (pt) 2008-12-04 2019-03-20 A4Tec Association For The Advancement Of Tissue Engineering And Cell Based Tech & Therapies Bioreator de fluxo contínuo bi-direcional, para cultura, em suporte tridimensional, de substitutos de tecidos de mamíferos
US8569050B1 (en) 2009-05-04 2013-10-29 John D. Ericsson Enclosed bioreactor system and methods associated therewith
EP2751255B1 (de) * 2011-09-01 2020-10-21 GICON Grossmann Ingenieur Consult GmbH Verfahren und vorrichtung zur gezielten einspeisung von gasen oder gasgemischen in eine flüssigkeit, suspension oder emulsion in einem photobioreaktor
EP3231859A1 (de) * 2016-04-11 2017-10-18 MIAL GmbH Für die kultivierung photosynthetisch aktiver zellen geeignetes reaktionssystem und dessen verwendung
DE102016119391B3 (de) 2016-10-12 2018-01-18 Yoen Ok Roth Mikrobioreaktor-Modul
RU203688U1 (ru) * 2019-07-16 2021-04-15 Мария Алексеевна Затолокина Портативная камера для культивирования животных клеток, на примере GCT - cells
US11254477B2 (en) * 2019-10-16 2022-02-22 Morgan Specialty Services, Inc. Extraction pressure vessel, method of manufacture, method of use
EP4256025A4 (de) 2020-12-04 2025-09-03 Sciperio Inc Kontinuierlich expandierender volumenbioreaktor
CN112877210B (zh) * 2021-02-25 2022-07-26 上海揽微赛尔生物科技有限公司 一种pH值可控的干细胞培养灌流装置
EP4253515A1 (de) * 2022-04-01 2023-10-04 Samabriva Optimierter haarwurzel-bioreaktor
CN120712135A (zh) * 2023-03-13 2025-09-26 宏布雷彻康系统工程公司 用于提供混合物的混合装置和方法
CN116120100A (zh) * 2023-03-30 2023-05-16 广西大学 病死畜禽无害化加工肥料的工方法及其装置

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1090758A (en) * 1963-10-30 1967-11-15 Wellcome Found Improvements in or relating to animal cell cultures
US3649465A (en) * 1969-06-24 1972-03-14 Virtis Co Inc Spinner flask
FR2133355A5 (de) * 1971-04-09 1972-11-24 Progil
US3985622A (en) * 1975-01-30 1976-10-12 Phillips Petroleum Company Method and apparatus for conducting fermentation
US4036693A (en) * 1976-02-02 1977-07-19 Massachusetts Institute Of Technology Treatment of cell culture microcarries
AT345224B (de) * 1976-07-15 1978-09-11 Chemap Ag Verfahren und vorrichtung zum kultivieren von tierischen und humanen gewebezellen
US4173516A (en) * 1976-07-15 1979-11-06 Chemap Ag Device for cultivating cells of animal and human tissues
FR2381824A1 (fr) * 1977-02-23 1978-09-22 Setric Procede et dispositif de fermentation
US4208483A (en) * 1978-09-21 1980-06-17 The University Of Toledo Tissue culture system
GB2073243B (en) * 1980-03-04 1984-12-05 Tokyo Rikakikai Kk Continuous fermentor or reactor
DE3047101A1 (de) * 1980-12-13 1982-07-22 Hoechst Ag, 6000 Frankfurt Verfahren zum verbessern der gasverteilung in mammut-schlaufenreaktoren
JPS58179495A (ja) * 1982-04-12 1983-10-20 Ajinomoto Co Inc ヒトリンホカインの製造法

Also Published As

Publication number Publication date
NO860991L (no) 1986-09-16
EP0197299A1 (de) 1986-10-15
DK112686D0 (da) 1986-03-11
EP0197299B1 (de) 1988-11-23
DE3661273D1 (en) 1988-12-29
DK112686A (da) 1986-09-16
JPS61212283A (ja) 1986-09-20
US4649117A (en) 1987-03-10

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Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
EEIH Change in the person of patent owner
REN Ceased due to non-payment of the annual fee