DK1114037T3 - Benzoxazin- og benzothiazin-derivater og deres anvendelse i lægemidler - Google Patents
Benzoxazin- og benzothiazin-derivater og deres anvendelse i lægemidlerInfo
- Publication number
- DK1114037T3 DK1114037T3 DK99948841T DK99948841T DK1114037T3 DK 1114037 T3 DK1114037 T3 DK 1114037T3 DK 99948841 T DK99948841 T DK 99948841T DK 99948841 T DK99948841 T DK 99948841T DK 1114037 T3 DK1114037 T3 DK 1114037T3
- Authority
- DK
- Denmark
- Prior art keywords
- benzoxazine
- pharmaceuticals
- benzothiazine derivatives
- benzothiazine
- derivatives
- Prior art date
Links
- UJVBZCCNLAAMOV-UHFFFAOYSA-N 2h-1,2-benzothiazine Chemical class C1=CC=C2C=CNSC2=C1 UJVBZCCNLAAMOV-UHFFFAOYSA-N 0.000 title 1
- CMLFRMDBDNHMRA-UHFFFAOYSA-N 2h-1,2-benzoxazine Chemical compound C1=CC=C2C=CNOC2=C1 CMLFRMDBDNHMRA-UHFFFAOYSA-N 0.000 title 1
- 239000003814 drug Substances 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
- C07D265/34—1,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
- C07D265/34—1,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings
- C07D265/36—1,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings condensed with one six-membered ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D279/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
- C07D279/10—1,4-Thiazines; Hydrogenated 1,4-thiazines
- C07D279/14—1,4-Thiazines; Hydrogenated 1,4-thiazines condensed with carbocyclic rings or ring systems
- C07D279/16—1,4-Thiazines; Hydrogenated 1,4-thiazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Diabetes (AREA)
- Pain & Pain Management (AREA)
- Immunology (AREA)
- Psychiatry (AREA)
- Hematology (AREA)
- Rheumatology (AREA)
- Obesity (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Psychology (AREA)
- Urology & Nephrology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Transplantation (AREA)
- Dermatology (AREA)
- Gastroenterology & Hepatology (AREA)
- Hospice & Palliative Care (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19844291A DE19844291A1 (de) | 1998-09-18 | 1998-09-18 | Benzoxazin- und Benzothiazin-Derivate und deren Verwendung in Arzneimitteln |
| PCT/EP1999/007089 WO2000017173A1 (fr) | 1998-09-18 | 1999-09-16 | Derives de benzoxazine et de benzothiazine et leur utilisation dans des produits pharmaceutiques |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK1114037T3 true DK1114037T3 (da) | 2004-08-16 |
Family
ID=7882416
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK99948841T DK1114037T3 (da) | 1998-09-18 | 1999-09-16 | Benzoxazin- og benzothiazin-derivater og deres anvendelse i lægemidler |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US6841550B1 (fr) |
| EP (1) | EP1114037B1 (fr) |
| JP (1) | JP2002526481A (fr) |
| KR (1) | KR20010075199A (fr) |
| CN (1) | CN1144794C (fr) |
| AR (1) | AR020474A1 (fr) |
| AT (1) | ATE266647T1 (fr) |
| AU (1) | AU751381B2 (fr) |
| BR (1) | BR9913856A (fr) |
| CA (1) | CA2341170A1 (fr) |
| CZ (1) | CZ2001988A3 (fr) |
| DE (2) | DE19844291A1 (fr) |
| DK (1) | DK1114037T3 (fr) |
| ES (1) | ES2221442T3 (fr) |
| HU (1) | HUP0103505A3 (fr) |
| NO (1) | NO20011339L (fr) |
| NZ (1) | NZ510562A (fr) |
| PE (1) | PE20001035A1 (fr) |
| PL (1) | PL346699A1 (fr) |
| PT (1) | PT1114037E (fr) |
| SK (1) | SK3712001A3 (fr) |
| WO (1) | WO2000017173A1 (fr) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE10020667A1 (de) * | 2000-04-19 | 2001-11-22 | Schering Ag | Neue Benzoxazin- und Benzothiazin-Derivate und deren Verwendung in Arzneimitteln |
| AU2001262200A1 (en) * | 2000-04-25 | 2001-11-07 | Schering Aktiengesellschaft | Benzoxazine derivatives and benzothiazine derivatives having nos-inhibitory and antioxidant properties |
| UA105182C2 (ru) * | 2008-07-03 | 2014-04-25 | Ньюрексон, Інк. | Бензоксазины, бензотиазины и родственные соединения, которые имеют ингибирующую nos активность |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2509155A1 (de) * | 1975-03-03 | 1976-09-09 | Hoechst Ag | 1,4-benzoxazinderivate und verfahren zu ihrer herstellung |
| US4254121A (en) * | 1979-08-13 | 1981-03-03 | Ayerst, Mckenna & Harrison Inc. | 3-Oxo-5H-pyrimido[2,1-c][1,4 ]benzoxazines |
| US4254118A (en) * | 1979-08-13 | 1981-03-03 | Ayerst, Mckenna & Harrison Inc. | 1-Oxo-5H-pyrimido[2,1-c][1,4]benzthiazine-2-carboxylic acid esters |
| US4547499A (en) * | 1984-05-10 | 1985-10-15 | The Upjohn Company | 2,4-Dihydro-2(omega-aminoalkyl)-1H-[1,2,4]triazolo[3,4-c]benzoxazin-1-one anti-allergy drug compounds, compositions and use |
| RU2136661C1 (ru) * | 1993-10-21 | 1999-09-10 | Джи Ди Сирл энд Ко. | Амидинопроизводные, их применение и фармацевтическая композиция |
| US5629322A (en) * | 1994-11-15 | 1997-05-13 | Merck & Co., Inc. | Cyclic amidine analogs as inhibitors of nitric oxide synthase |
| DE4442116A1 (de) * | 1994-11-25 | 1996-05-30 | Cassella Ag | 2-Amino-1,3-thiazine als Hemmstoffe der Stickstoffmonoxid-Synthase |
| DE19530870A1 (de) * | 1994-12-14 | 1996-06-20 | Japan Tobacco Inc | Thiazin- oder Thiazepinderivate |
| TW397812B (en) * | 1995-02-11 | 2000-07-11 | Astra Ab | Bicyclic isothiourea derivatives useful in therapy |
| CZ287969B6 (cs) * | 1995-08-10 | 2001-03-14 | Astra Pharmaceuticals Limited | Amidinový derivát, způsob jeho přípravy, farmaceutický prostředek s jeho obsahem a použití |
| TW440563B (en) * | 1996-05-23 | 2001-06-16 | Hoffmann La Roche | Aryl pyrimidine derivatives and a pharmaceutical composition thereof |
| EP0906294B1 (fr) * | 1996-05-29 | 2003-01-29 | Warner-Lambert Company | Antagonistes des recepteurs de la dopamine d4, a groupe benzoxazinone |
| ATE336485T1 (de) * | 1997-05-02 | 2006-09-15 | Schering Ag | Substituierte heterocyclen und deren verwendung in arzneimitteln |
| DE59810359D1 (de) | 1997-09-08 | 2004-01-15 | Schering Ag | Benzoxazin- und benzothiazin-derivate und deren verwendung in arzneimitteln |
-
1998
- 1998-09-18 DE DE19844291A patent/DE19844291A1/de not_active Withdrawn
-
1999
- 1999-09-15 PE PE1999000934A patent/PE20001035A1/es not_active Application Discontinuation
- 1999-09-16 PT PT99948841T patent/PT1114037E/pt unknown
- 1999-09-16 AT AT99948841T patent/ATE266647T1/de not_active IP Right Cessation
- 1999-09-16 US US09/787,396 patent/US6841550B1/en not_active Expired - Fee Related
- 1999-09-16 JP JP2000574083A patent/JP2002526481A/ja active Pending
- 1999-09-16 PL PL99346699A patent/PL346699A1/xx not_active Application Discontinuation
- 1999-09-16 ES ES99948841T patent/ES2221442T3/es not_active Expired - Lifetime
- 1999-09-16 KR KR1020017003496A patent/KR20010075199A/ko not_active Application Discontinuation
- 1999-09-16 DE DE59909486T patent/DE59909486D1/de not_active Expired - Fee Related
- 1999-09-16 BR BR9913856-5A patent/BR9913856A/pt not_active IP Right Cessation
- 1999-09-16 NZ NZ510562A patent/NZ510562A/en unknown
- 1999-09-16 AU AU61954/99A patent/AU751381B2/en not_active Ceased
- 1999-09-16 WO PCT/EP1999/007089 patent/WO2000017173A1/fr not_active Application Discontinuation
- 1999-09-16 EP EP99948841A patent/EP1114037B1/fr not_active Expired - Lifetime
- 1999-09-16 DK DK99948841T patent/DK1114037T3/da active
- 1999-09-16 CN CNB998111244A patent/CN1144794C/zh not_active Expired - Fee Related
- 1999-09-16 CZ CZ2001988A patent/CZ2001988A3/cs unknown
- 1999-09-16 HU HU0103505A patent/HUP0103505A3/hu unknown
- 1999-09-16 CA CA002341170A patent/CA2341170A1/fr not_active Abandoned
- 1999-09-16 SK SK371-2001A patent/SK3712001A3/sk unknown
- 1999-09-17 AR ARP990104683A patent/AR020474A1/es unknown
-
2001
- 2001-03-16 NO NO20011339A patent/NO20011339L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| PT1114037E (pt) | 2004-09-30 |
| WO2000017173A1 (fr) | 2000-03-30 |
| CN1319097A (zh) | 2001-10-24 |
| ES2221442T3 (es) | 2004-12-16 |
| AU6195499A (en) | 2000-04-10 |
| DE19844291A1 (de) | 2000-03-23 |
| HUP0103505A3 (en) | 2003-05-28 |
| CN1144794C (zh) | 2004-04-07 |
| SK3712001A3 (en) | 2001-09-11 |
| JP2002526481A (ja) | 2002-08-20 |
| AR020474A1 (es) | 2002-05-15 |
| NO20011339D0 (no) | 2001-03-16 |
| ATE266647T1 (de) | 2004-05-15 |
| NO20011339L (no) | 2001-05-09 |
| CZ2001988A3 (cs) | 2001-08-15 |
| PE20001035A1 (es) | 2000-10-18 |
| NZ510562A (en) | 2003-08-29 |
| HUP0103505A2 (hu) | 2002-02-28 |
| DE59909486D1 (de) | 2004-06-17 |
| BR9913856A (pt) | 2001-06-12 |
| EP1114037B1 (fr) | 2004-05-12 |
| US6841550B1 (en) | 2005-01-11 |
| EP1114037A1 (fr) | 2001-07-11 |
| CA2341170A1 (fr) | 2000-03-30 |
| AU751381B2 (en) | 2002-08-15 |
| KR20010075199A (ko) | 2001-08-09 |
| PL346699A1 (en) | 2002-02-25 |
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