PT1114037E - Derivados de benzoxazina e de benzotiazina e sua utilizacao em medicamentos - Google Patents
Derivados de benzoxazina e de benzotiazina e sua utilizacao em medicamentosInfo
- Publication number
- PT1114037E PT1114037E PT99948841T PT99948841T PT1114037E PT 1114037 E PT1114037 E PT 1114037E PT 99948841 T PT99948841 T PT 99948841T PT 99948841 T PT99948841 T PT 99948841T PT 1114037 E PT1114037 E PT 1114037E
- Authority
- PT
- Portugal
- Prior art keywords
- benzotiazine
- benzoxazine
- medicines
- derivatives
- benzotiazine derivatives
- Prior art date
Links
- CMLFRMDBDNHMRA-UHFFFAOYSA-N 2h-1,2-benzoxazine Chemical compound C1=CC=C2C=CNOC2=C1 CMLFRMDBDNHMRA-UHFFFAOYSA-N 0.000 title 1
- 239000003814 drug Substances 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
- C07D265/34—1,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
- C07D265/34—1,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings
- C07D265/36—1,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings condensed with one six-membered ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D279/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
- C07D279/10—1,4-Thiazines; Hydrogenated 1,4-thiazines
- C07D279/14—1,4-Thiazines; Hydrogenated 1,4-thiazines condensed with carbocyclic rings or ring systems
- C07D279/16—1,4-Thiazines; Hydrogenated 1,4-thiazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Diabetes (AREA)
- Immunology (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Emergency Medicine (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Rheumatology (AREA)
- Endocrinology (AREA)
- Transplantation (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Cardiology (AREA)
- Psychology (AREA)
- Hospice & Palliative Care (AREA)
- Urology & Nephrology (AREA)
- Gastroenterology & Hepatology (AREA)
- Heart & Thoracic Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19844291A DE19844291A1 (de) | 1998-09-18 | 1998-09-18 | Benzoxazin- und Benzothiazin-Derivate und deren Verwendung in Arzneimitteln |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PT1114037E true PT1114037E (pt) | 2004-09-30 |
Family
ID=7882416
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT99948841T PT1114037E (pt) | 1998-09-18 | 1999-09-16 | Derivados de benzoxazina e de benzotiazina e sua utilizacao em medicamentos |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US6841550B1 (pt) |
| EP (1) | EP1114037B1 (pt) |
| JP (1) | JP2002526481A (pt) |
| KR (1) | KR20010075199A (pt) |
| CN (1) | CN1144794C (pt) |
| AR (1) | AR020474A1 (pt) |
| AT (1) | ATE266647T1 (pt) |
| AU (1) | AU751381B2 (pt) |
| BR (1) | BR9913856A (pt) |
| CA (1) | CA2341170A1 (pt) |
| CZ (1) | CZ2001988A3 (pt) |
| DE (2) | DE19844291A1 (pt) |
| DK (1) | DK1114037T3 (pt) |
| ES (1) | ES2221442T3 (pt) |
| HU (1) | HUP0103505A3 (pt) |
| NO (1) | NO20011339L (pt) |
| NZ (1) | NZ510562A (pt) |
| PE (1) | PE20001035A1 (pt) |
| PL (1) | PL346699A1 (pt) |
| PT (1) | PT1114037E (pt) |
| SK (1) | SK3712001A3 (pt) |
| WO (1) | WO2000017173A1 (pt) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE10020667A1 (de) * | 2000-04-19 | 2001-11-22 | Schering Ag | Neue Benzoxazin- und Benzothiazin-Derivate und deren Verwendung in Arzneimitteln |
| AU2001262200A1 (en) * | 2000-04-25 | 2001-11-07 | Schering Aktiengesellschaft | Benzoxazine derivatives and benzothiazine derivatives having nos-inhibitory and antioxidant properties |
| UA105182C2 (ru) | 2008-07-03 | 2014-04-25 | Ньюрексон, Інк. | Бензоксазины, бензотиазины и родственные соединения, которые имеют ингибирующую nos активность |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2509155A1 (de) * | 1975-03-03 | 1976-09-09 | Hoechst Ag | 1,4-benzoxazinderivate und verfahren zu ihrer herstellung |
| US4254121A (en) * | 1979-08-13 | 1981-03-03 | Ayerst, Mckenna & Harrison Inc. | 3-Oxo-5H-pyrimido[2,1-c][1,4 ]benzoxazines |
| US4254118A (en) * | 1979-08-13 | 1981-03-03 | Ayerst, Mckenna & Harrison Inc. | 1-Oxo-5H-pyrimido[2,1-c][1,4]benzthiazine-2-carboxylic acid esters |
| US4547499A (en) * | 1984-05-10 | 1985-10-15 | The Upjohn Company | 2,4-Dihydro-2(omega-aminoalkyl)-1H-[1,2,4]triazolo[3,4-c]benzoxazin-1-one anti-allergy drug compounds, compositions and use |
| CN1077886C (zh) * | 1993-10-21 | 2002-01-16 | G·D·瑟尔公司 | 用作一氧化一氮合酶抑制剂的脒基衍生物 |
| US5629322A (en) * | 1994-11-15 | 1997-05-13 | Merck & Co., Inc. | Cyclic amidine analogs as inhibitors of nitric oxide synthase |
| DE4442116A1 (de) * | 1994-11-25 | 1996-05-30 | Cassella Ag | 2-Amino-1,3-thiazine als Hemmstoffe der Stickstoffmonoxid-Synthase |
| IT1277486B1 (it) * | 1994-12-14 | 1997-11-10 | Japan Tobacco Inc | Derivati di tiazina o di tiazepina |
| TW397812B (en) * | 1995-02-11 | 2000-07-11 | Astra Ab | Bicyclic isothiourea derivatives useful in therapy |
| BR9509297A (pt) * | 1995-08-10 | 1998-07-07 | Astra Ab | Composto composição farmacêutica utilização de um composto e processos de tratamento ou prolifaxia de uma doença ou condição na qual a síntese ou suprasintese da sintetase de óxido nitrico forma uma parte contribuinte e desordens neurodegenerativas ou de enxaqueca ou de prevenção e reversão da tolerância a opiatos e diazepinas ou de tratamento do vicio em tóxicos e de preparação de um composto |
| TW440563B (en) * | 1996-05-23 | 2001-06-16 | Hoffmann La Roche | Aryl pyrimidine derivatives and a pharmaceutical composition thereof |
| ES2191180T3 (es) * | 1996-05-29 | 2003-09-01 | Warner Lambert Co | Antagonistas de los receptores de la dopamina benzoxazinona d4. |
| ATE336485T1 (de) * | 1997-05-02 | 2006-09-15 | Schering Ag | Substituierte heterocyclen und deren verwendung in arzneimitteln |
| ATE255567T1 (de) | 1997-09-08 | 2003-12-15 | Schering Ag | Benzoxazin- und benzothiazin-derivate und deren verwendung in arzneimitteln |
-
1998
- 1998-09-18 DE DE19844291A patent/DE19844291A1/de not_active Withdrawn
-
1999
- 1999-09-15 PE PE1999000934A patent/PE20001035A1/es not_active Application Discontinuation
- 1999-09-16 HU HU0103505A patent/HUP0103505A3/hu unknown
- 1999-09-16 JP JP2000574083A patent/JP2002526481A/ja active Pending
- 1999-09-16 DK DK99948841T patent/DK1114037T3/da active
- 1999-09-16 PL PL99346699A patent/PL346699A1/xx not_active Application Discontinuation
- 1999-09-16 SK SK371-2001A patent/SK3712001A3/sk unknown
- 1999-09-16 AU AU61954/99A patent/AU751381B2/en not_active Ceased
- 1999-09-16 DE DE59909486T patent/DE59909486D1/de not_active Expired - Fee Related
- 1999-09-16 CA CA002341170A patent/CA2341170A1/en not_active Abandoned
- 1999-09-16 WO PCT/EP1999/007089 patent/WO2000017173A1/de not_active Application Discontinuation
- 1999-09-16 ES ES99948841T patent/ES2221442T3/es not_active Expired - Lifetime
- 1999-09-16 US US09/787,396 patent/US6841550B1/en not_active Expired - Fee Related
- 1999-09-16 EP EP99948841A patent/EP1114037B1/de not_active Expired - Lifetime
- 1999-09-16 NZ NZ510562A patent/NZ510562A/en unknown
- 1999-09-16 CN CNB998111244A patent/CN1144794C/zh not_active Expired - Fee Related
- 1999-09-16 KR KR1020017003496A patent/KR20010075199A/ko not_active Application Discontinuation
- 1999-09-16 AT AT99948841T patent/ATE266647T1/de not_active IP Right Cessation
- 1999-09-16 CZ CZ2001988A patent/CZ2001988A3/cs unknown
- 1999-09-16 BR BR9913856-5A patent/BR9913856A/pt not_active IP Right Cessation
- 1999-09-16 PT PT99948841T patent/PT1114037E/pt unknown
- 1999-09-17 AR ARP990104683A patent/AR020474A1/es unknown
-
2001
- 2001-03-16 NO NO20011339A patent/NO20011339L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| CN1319097A (zh) | 2001-10-24 |
| HUP0103505A3 (en) | 2003-05-28 |
| DK1114037T3 (da) | 2004-08-16 |
| CZ2001988A3 (cs) | 2001-08-15 |
| ES2221442T3 (es) | 2004-12-16 |
| NZ510562A (en) | 2003-08-29 |
| AR020474A1 (es) | 2002-05-15 |
| NO20011339L (no) | 2001-05-09 |
| ATE266647T1 (de) | 2004-05-15 |
| JP2002526481A (ja) | 2002-08-20 |
| PL346699A1 (en) | 2002-02-25 |
| HUP0103505A2 (hu) | 2002-02-28 |
| AU751381B2 (en) | 2002-08-15 |
| CA2341170A1 (en) | 2000-03-30 |
| CN1144794C (zh) | 2004-04-07 |
| BR9913856A (pt) | 2001-06-12 |
| SK3712001A3 (en) | 2001-09-11 |
| DE19844291A1 (de) | 2000-03-23 |
| US6841550B1 (en) | 2005-01-11 |
| AU6195499A (en) | 2000-04-10 |
| WO2000017173A1 (de) | 2000-03-30 |
| DE59909486D1 (de) | 2004-06-17 |
| EP1114037A1 (de) | 2001-07-11 |
| PE20001035A1 (es) | 2000-10-18 |
| KR20010075199A (ko) | 2001-08-09 |
| EP1114037B1 (de) | 2004-05-12 |
| NO20011339D0 (no) | 2001-03-16 |
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