DK1097171T3 - Fremgangsmåde til oprensning af hæmoglobin - Google Patents
Fremgangsmåde til oprensning af hæmoglobinInfo
- Publication number
- DK1097171T3 DK1097171T3 DK99930467T DK99930467T DK1097171T3 DK 1097171 T3 DK1097171 T3 DK 1097171T3 DK 99930467 T DK99930467 T DK 99930467T DK 99930467 T DK99930467 T DK 99930467T DK 1097171 T3 DK1097171 T3 DK 1097171T3
- Authority
- DK
- Denmark
- Prior art keywords
- column
- hemoglobin
- buffer solution
- solution
- hydroxymethyl
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N1/00—Preservation of bodies of humans or animals, or parts thereof
- A01N1/02—Preservation of living parts
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N1/00—Preservation of bodies of humans or animals, or parts thereof
- A01N1/02—Preservation of living parts
- A01N1/0205—Chemical aspects
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N1/00—Preservation of bodies of humans or animals, or parts thereof
- A01N1/02—Preservation of living parts
- A01N1/0205—Chemical aspects
- A01N1/021—Preservation or perfusion media, liquids, solids or gases used in the preservation of cells, tissue, organs or bodily fluids
- A01N1/0221—Freeze-process protecting agents, i.e. substances protecting cells from effects of the physical process, e.g. cryoprotectants, osmolarity regulators like oncotic agents
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B32—LAYERED PRODUCTS
- B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
- B32B15/00—Layered products comprising a layer of metal
- B32B15/04—Layered products comprising a layer of metal comprising metal as the main or only constituent of a layer, which is next to another layer of the same or of a different material
- B32B15/08—Layered products comprising a layer of metal comprising metal as the main or only constituent of a layer, which is next to another layer of the same or of a different material of synthetic resin
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B32—LAYERED PRODUCTS
- B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
- B32B27/00—Layered products comprising a layer of synthetic resin
- B32B27/06—Layered products comprising a layer of synthetic resin as the main or only constituent of a layer, which is next to another layer of the same or of a different material
- B32B27/08—Layered products comprising a layer of synthetic resin as the main or only constituent of a layer, which is next to another layer of the same or of a different material of synthetic resin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/795—Porphyrin- or corrin-ring-containing peptides
- C07K14/805—Haemoglobins; Myoglobins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
- A61J1/05—Containers specially adapted for medical or pharmaceutical purposes for collecting, storing or administering blood, plasma or medical fluids ; Infusion or perfusion containers
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Dentistry (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Environmental Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US09/113,953 US6150507A (en) | 1995-03-23 | 1998-07-10 | Method for producing a purified hemoglobin product |
PCT/US1999/013922 WO2000002921A1 (en) | 1998-07-10 | 1999-06-21 | Method for purifying hemoglobin |
Publications (1)
Publication Number | Publication Date |
---|---|
DK1097171T3 true DK1097171T3 (da) | 2007-04-10 |
Family
ID=22352497
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK99930467T DK1097171T3 (da) | 1998-07-10 | 1999-06-21 | Fremgangsmåde til oprensning af hæmoglobin |
Country Status (13)
Country | Link |
---|---|
US (1) | US6150507A (ja) |
EP (1) | EP1097171B1 (ja) |
JP (1) | JP4581110B2 (ja) |
CN (1) | CN1166689C (ja) |
AT (1) | ATE347564T1 (ja) |
AU (1) | AU755280B2 (ja) |
CA (1) | CA2336808C (ja) |
DE (1) | DE69934312T2 (ja) |
DK (1) | DK1097171T3 (ja) |
ES (1) | ES2278450T3 (ja) |
HK (1) | HK1037643A1 (ja) |
NZ (1) | NZ509257A (ja) |
WO (1) | WO2000002921A1 (ja) |
Families Citing this family (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2001076507A2 (en) | 2000-04-11 | 2001-10-18 | The University Of Miami | Use of oxygen carriers to improve grafted cell survival in neural transplantation |
FR2824568B1 (fr) * | 2001-05-11 | 2004-04-09 | Lab Francais Du Fractionnement | Procede de preparation de concentres d'immunoglobulines humaines a usage therapeutique |
US7038016B2 (en) | 2001-08-21 | 2006-05-02 | Apex Bioscience, Inc. | Methods for purification of an activated PEG solution and for the synthesis of a modified hemoglobin solution |
AU2003265994B2 (en) | 2002-09-11 | 2010-04-01 | Genentech, Inc. | Protein purification |
JP2006502231A (ja) * | 2002-10-03 | 2006-01-19 | ノースフィールド ラボラトリーズ、インコーポレイテッド | 大量失血を被っている患者の処置方法 |
MXPA05007885A (es) * | 2003-01-29 | 2005-09-21 | Northfield Lab | Soluciones de hemoglobina polimerizada que tienen cantidad reducida de tetramero y metodo para prepararlas. |
EP1712562A4 (en) * | 2003-12-26 | 2007-02-07 | Oxygenix Co Ltd | PROCESS FOR PURIFYING THE HEMOGLOBIN |
US20090117207A1 (en) * | 2005-11-29 | 2009-05-07 | Zoltani Csaba K | Methods and compositions for treatment of poison-caused pathology |
US20090004159A1 (en) * | 2006-01-24 | 2009-01-01 | The Board Of Trustees Of The University Of Illinoi | Polymerized Hemoglobin Media and Its Use in Isolation and Transplantation of Islet Cells |
US20070196810A1 (en) * | 2006-01-24 | 2007-08-23 | Northfield Laboratories Inc. | Polymerized Hemoglobin Media and its Use in Isolation and Transplantation of Islet Cells |
CN101522884B (zh) * | 2006-08-15 | 2013-08-21 | 巴斯夫欧洲公司 | 从生产细胞中分离蛋白质的方法 |
JP2011207853A (ja) * | 2010-03-30 | 2011-10-20 | Terumo Corp | 人工酸素運搬体製造に用いるヘモグロビン原料中間生成物 |
JP6786917B2 (ja) * | 2016-07-08 | 2020-11-18 | 東ソー株式会社 | ヘモグロビン調製液及びヘモグロビン類測定液体クロマトグラフィー法 |
US20200393472A1 (en) * | 2018-04-18 | 2020-12-17 | Sekisui Medical Co., Ltd. | Haemoglobin analysis method |
CN110128531B (zh) * | 2019-05-17 | 2022-03-08 | 润方(北京)生物医药研究院有限公司 | 一种无碳酸酐酶血红蛋白的制备方法 |
CN110563836A (zh) * | 2019-09-09 | 2019-12-13 | 润方(北京)生物医药研究院有限公司 | 交联血红蛋白的制备方法及包含该血红蛋白的器官灌注液 |
Family Cites Families (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2449885C3 (de) * | 1974-10-21 | 1980-04-30 | Biotest-Serum-Institut Gmbh, 6000 Frankfurt | Verfahren zur Herstellung von chemisch modifizierten haltbaren Hämoglobinpräparaten sowie das nach diesem Verfahren hergestellte modifizierte Hämoglobinpräparat |
US4059512A (en) * | 1974-12-27 | 1977-11-22 | Preventive Systems, Inc. | Process for removing endotoxin from biological fluids |
US3959128A (en) * | 1974-12-27 | 1976-05-25 | Preventive Systems, Inc | Process for removing endotoxin from biological fluids |
DK144800C (da) * | 1980-04-21 | 1982-10-25 | Forenede Bryggerier As | Fremgangsmaade til udvinding af enzymer,fortrinsvis cu,zn-superoxid-dismutase (sod),catalase og carbonsyreanhydrase,fra blod |
US4381239A (en) * | 1981-02-10 | 1983-04-26 | Tanabe Seiyaku Co., Ltd. | Method for reducing the pyrogen content of or removing pyrogens from substances contaminated therewith |
US4473647A (en) * | 1981-02-27 | 1984-09-25 | Amf Inc. | Tissue culture medium |
US4468330A (en) * | 1981-04-27 | 1984-08-28 | Sekisui Kagaku Kogyo Kabushiki Kaisha | Filler for liquid chromatography useful for separating a hemoglobin variant in blood |
US4584130A (en) * | 1985-03-29 | 1986-04-22 | University Of Maryland | Intramolecularly cross-linked hemoglobin and method of preparation |
CA1244349A (en) * | 1985-06-26 | 1988-11-08 | Jen-Chang Hsia | Purification of hemoglobin and modified hemoglobin by affinity chromatography |
GB8600582D0 (en) * | 1986-01-10 | 1986-02-19 | Ca Minister Nat Defence | Purifying biological materials |
US5084558A (en) * | 1987-10-13 | 1992-01-28 | Biopure Corporation | Extra pure semi-synthetic blood substitute |
AU622610B2 (en) * | 1986-11-10 | 1992-04-16 | Biopure Corporation | Extra pure semi-synthetic blood substitute |
CA1312009C (en) * | 1986-11-10 | 1992-12-29 | Carl W. Rausch | Extra pure semi-synthetic blood substitute |
EP0379534A4 (en) * | 1988-06-15 | 1991-03-13 | Baxter International Inc. | Method of purifying cross-linked hemoglobin |
CA1338244C (en) * | 1988-08-17 | 1996-04-09 | Xiang-Fu Wu | Purification of hemoglobin and methemoglobin by bioselective elution |
US5128452A (en) * | 1989-04-19 | 1992-07-07 | Baxter International Inc. | Process for the production of crosslinked hemoglobin in the presence of sodium tripolyphosphate |
US5234903A (en) * | 1989-11-22 | 1993-08-10 | Enzon, Inc. | Chemically modified hemoglobin as an effective, stable non-immunogenic red blood cell substitute |
HUT64571A (en) * | 1990-11-29 | 1994-01-28 | Upjohn Co | A method for producing hemoglobin preparatives containing imido ester cross bind |
US5250665A (en) * | 1991-05-31 | 1993-10-05 | The University Of Toronto Innovations Foundation | Specifically β-β cross-linked hemoglobins and method of preparation |
US5264555A (en) * | 1992-07-14 | 1993-11-23 | Enzon, Inc. | Process for hemoglobin extraction and purification |
US5578564A (en) * | 1993-07-23 | 1996-11-26 | Somatogen, Inc. | Nickel-free hemoglobin and methods for producing such hemoglobin |
US5840851A (en) * | 1993-07-23 | 1998-11-24 | Plomer; J. Jeffrey | Purification of hemoglobin |
US5665869A (en) * | 1993-11-15 | 1997-09-09 | Somatogen, Inc. | Method for the rapid removal of protoporphyrin from protoporphyrin IX-containing solutions of hemoglobin |
EP1094079A3 (en) * | 1995-03-23 | 2001-05-02 | Biopure Corporation | Stable polymerized hemoglobin blood-substitute |
-
1998
- 1998-07-10 US US09/113,953 patent/US6150507A/en not_active Expired - Lifetime
-
1999
- 1999-06-21 DK DK99930467T patent/DK1097171T3/da active
- 1999-06-21 AU AU47003/99A patent/AU755280B2/en not_active Ceased
- 1999-06-21 EP EP99930467A patent/EP1097171B1/en not_active Expired - Lifetime
- 1999-06-21 WO PCT/US1999/013922 patent/WO2000002921A1/en active IP Right Grant
- 1999-06-21 AT AT99930467T patent/ATE347564T1/de not_active IP Right Cessation
- 1999-06-21 JP JP2000559150A patent/JP4581110B2/ja not_active Expired - Fee Related
- 1999-06-21 NZ NZ509257A patent/NZ509257A/xx not_active IP Right Cessation
- 1999-06-21 CN CNB998082864A patent/CN1166689C/zh not_active Expired - Fee Related
- 1999-06-21 CA CA002336808A patent/CA2336808C/en not_active Expired - Fee Related
- 1999-06-21 DE DE69934312T patent/DE69934312T2/de not_active Expired - Lifetime
- 1999-06-21 ES ES99930467T patent/ES2278450T3/es not_active Expired - Lifetime
-
2001
- 2001-12-12 HK HK01108725A patent/HK1037643A1/xx not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
JP2002520338A (ja) | 2002-07-09 |
JP4581110B2 (ja) | 2010-11-17 |
ATE347564T1 (de) | 2006-12-15 |
EP1097171A1 (en) | 2001-05-09 |
US6150507A (en) | 2000-11-21 |
NZ509257A (en) | 2003-03-28 |
HK1037643A1 (en) | 2002-02-15 |
CN1166689C (zh) | 2004-09-15 |
CA2336808A1 (en) | 2000-01-20 |
EP1097171B1 (en) | 2006-12-06 |
ES2278450T3 (es) | 2007-08-01 |
CA2336808C (en) | 2008-08-19 |
CN1308636A (zh) | 2001-08-15 |
DE69934312T2 (de) | 2007-07-12 |
AU4700399A (en) | 2000-02-01 |
AU755280B2 (en) | 2002-12-05 |
DE69934312D1 (de) | 2007-01-18 |
WO2000002921A1 (en) | 2000-01-20 |
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