DK108686A - Heterocycliske sulfider og deres anvendelse som immunmodulatorer - Google Patents

Heterocycliske sulfider og deres anvendelse som immunmodulatorer Download PDF

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Publication number
DK108686A
DK108686A DK108686A DK108686A DK108686A DK 108686 A DK108686 A DK 108686A DK 108686 A DK108686 A DK 108686A DK 108686 A DK108686 A DK 108686A DK 108686 A DK108686 A DK 108686A
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DK
Denmark
Prior art keywords
sulphids
heterocyclic
immune modulators
modulators
immune
Prior art date
Application number
DK108686A
Other languages
English (en)
Other versions
DK165110B (da
DK165110C (da
DK108686D0 (da
Inventor
Karl-Heinz Scheunemann
Walter Duerckheimer
Juergen Blumbach
Michael Limbert
Hans-Ulrich Schorlemmer
Gerhard Dickneite
Hans-Harald Sedlacek
Original Assignee
Hoechst Ag
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Filing date
Publication date
Application filed by Hoechst Ag filed Critical Hoechst Ag
Publication of DK108686D0 publication Critical patent/DK108686D0/da
Publication of DK108686A publication Critical patent/DK108686A/da
Publication of DK165110B publication Critical patent/DK165110B/da
Application granted granted Critical
Publication of DK165110C publication Critical patent/DK165110C/da

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/79—Acids; Esters
    • C07D213/80—Acids; Esters in position 3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D235/28—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C07D249/10—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D249/12—Oxygen or sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D253/00—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00
    • C07D253/02—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00 not condensed with other rings
    • C07D253/06—1,2,4-Triazines
    • C07D253/065—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members
    • C07D253/07—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members with hetero atoms, or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/36—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/38—Nitrogen atoms
    • C07D277/44—Acylated amino or imino radicals
    • C07D277/46—Acylated amino or imino radicals by carboxylic acids, or sulfur or nitrogen analogues thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
    • C07D277/62—Benzothiazoles
    • C07D277/68—Benzothiazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D277/70—Sulfur atoms
    • C07D277/74—Sulfur atoms substituted by carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
    • C07D285/01—Five-membered rings
    • C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
    • C07D285/04—Thiadiazoles; Hydrogenated thiadiazoles not condensed with other rings
    • C07D285/12—1,3,4-Thiadiazoles; Hydrogenated 1,3,4-thiadiazoles
    • C07D285/125—1,3,4-Thiadiazoles; Hydrogenated 1,3,4-thiadiazoles with oxygen, sulfur or nitrogen atoms, directly attached to ring carbon atoms, the nitrogen atoms not forming part of a nitro radical

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicinal Preparation (AREA)
DK108686A 1985-03-12 1986-03-10 Thiazolylsulfider, fremgangsmaade til deres fremstilling og pharmaceutisk praeparat indeholdende dem DK165110C (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE3508665 1985-03-12
DE19853508665 DE3508665A1 (de) 1985-03-12 1985-03-12 Heterocyclische sulfide und ihre anwendung als immunmodulatoren

Publications (4)

Publication Number Publication Date
DK108686D0 DK108686D0 (da) 1986-03-10
DK108686A true DK108686A (da) 1986-09-13
DK165110B DK165110B (da) 1992-10-12
DK165110C DK165110C (da) 1993-03-01

Family

ID=6264870

Family Applications (1)

Application Number Title Priority Date Filing Date
DK108686A DK165110C (da) 1985-03-12 1986-03-10 Thiazolylsulfider, fremgangsmaade til deres fremstilling og pharmaceutisk praeparat indeholdende dem

Country Status (21)

Country Link
US (1) US4762848A (da)
EP (1) EP0194572B1 (da)
JP (2) JPS61212590A (da)
KR (1) KR940002255B1 (da)
AR (1) AR247738A1 (da)
AT (1) ATE70973T1 (da)
AU (1) AU584993B2 (da)
CA (1) CA1268769A (da)
DE (2) DE3508665A1 (da)
DK (1) DK165110C (da)
ES (1) ES8801505A1 (da)
FI (1) FI87203C (da)
GR (1) GR860648B (da)
HU (1) HU199441B (da)
IE (1) IE58875B1 (da)
IL (1) IL78090A (da)
NO (1) NO167386C (da)
NZ (1) NZ215425A (da)
PH (1) PH24659A (da)
PT (1) PT82167B (da)
ZA (1) ZA861779B (da)

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US5047540A (en) * 1987-12-17 1991-09-10 Shionogi & Co., Ltd. Lipid derivatives
DE3816603A1 (de) * 1988-05-16 1989-11-30 Behringwerke Ag Verwendung des thiazol-derivates tiprotimod zur herstellung eines mittels zur therapie von virusinfektionen
DE3915094A1 (de) 1989-05-09 1991-01-10 Hoechst Ag Verfahren zur herstellung von 2-mercapto-4-methyl-1,3-thiazol-5-yl-essigsaeure und deren ester
TW252112B (da) * 1993-08-19 1995-07-21 Pfizer
WO1999015524A1 (en) * 1997-09-23 1999-04-01 Fujisawa Pharmaceutical Co., Ltd. Thiazole derivatives
WO2002090314A1 (en) * 2001-05-03 2002-11-14 Galileo Laboratories, Inc. Pyruvate derivatives
TWI359810B (en) * 2004-11-04 2012-03-11 Mitsubishi Tanabe Pharma Corp Carboxylic acid derivative containing thiazole rin
MX2011004505A (es) 2008-10-29 2011-05-31 Merck Sharp & Dohme Derivados novedosos de bencimidazol ciclico, utiles como agentes antidiabeticos.
CN102271509A (zh) 2008-10-31 2011-12-07 默沙东公司 用于抗糖尿病药的新型环苯并咪唑衍生物
EP4205203A1 (en) * 2020-08-26 2023-07-05 The Lubrizol Corporation 2,5-dimercapto-1,3,4-thiadiazole ("dmtd") metal salt derivatives

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US2776976A (en) * 1952-10-21 1957-01-08 Monsanto Chemicals Halogen substituted unsaturated thiazolylthioethers
US2886487A (en) * 1955-08-22 1959-05-12 Ortho Pharma Corp Quaternary ammonium salt and n-thiotrichloromethyl hydantoin vaginal composition
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DE1695093A1 (de) * 1965-10-21 1970-12-10 Geigy Ag J R Neue Imidazolderivate
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DE2359922A1 (de) * 1973-12-01 1975-06-05 Hoechst Ag (1-alkyl-5-nitro-imidazolyl-2-alkyl)- heteroaryl-verbindungen und verfahren zu ihrer herstellung
GB1462521A (en) * 1974-02-11 1977-01-26 Wyeth John & Brother Ltd Triazole derivatives
US4107438A (en) * 1974-09-30 1978-08-15 Victor Lafon Cyclic phenylsulphinyl-amidine derivatives
FR2285859A1 (fr) * 1974-09-30 1976-04-23 Lafon Labor Phenylsulfinyl-amidines et derives
US4022607A (en) * 1975-06-09 1977-05-10 Sandoz, Inc. Substituted oxazoles and thiazoles as herbicides
DE2533604A1 (de) * 1975-07-26 1977-02-10 Bayer Ag 2-substituierte 5-trifluormethyl1,3,4-thiadiazole, verfahren zu ihrer herstellung sowie ihre verwendung als fungizide und insektizide
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US4002624A (en) * 1976-01-26 1977-01-11 The Dow Chemical Company Substituted-3-thio-1,2,4-triazines
US4202901A (en) * 1976-03-04 1980-05-13 Ciba-Geigy Corporation 2-Pyridinecarbonitrile compounds
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US4451471A (en) * 1981-03-18 1984-05-29 Ciba-Geigy Corporation Certain 2,4,5-tri-substituted thiazoles, pharmaceutical compositions containing same and methods of using same
DE3118126A1 (de) * 1981-05-07 1982-12-02 Bayer Ag, 5090 Leverkusen Sulfenamide zur verwendung in arzneimitteln
DE3216416A1 (de) * 1982-05-03 1983-11-03 Bayer Ag, 5090 Leverkusen Heteroarylthiovinyl-verbindungen, ein verfahren zu ihrer herstellung und ihre verwendung als schaedlingsbekaempfungsmittel
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ZA854550B (en) * 1984-06-18 1986-04-30 Smithkline Beckman Corp Leukotriene antagonists

Also Published As

Publication number Publication date
JPS6452719A (en) 1989-02-28
HU199441B (en) 1990-02-28
NO167386B (no) 1991-07-22
EP0194572A1 (de) 1986-09-17
IE58875B1 (en) 1993-12-01
HUT44524A (en) 1988-03-28
NO167386C (no) 1991-10-30
NZ215425A (en) 1990-01-29
DK165110B (da) 1992-10-12
PT82167A (de) 1986-04-01
ZA861779B (en) 1986-10-29
ES8801505A1 (es) 1988-01-16
EP0194572B1 (de) 1992-01-02
ES552841A0 (es) 1988-01-16
JPS61212590A (ja) 1986-09-20
DK165110C (da) 1993-03-01
US4762848A (en) 1988-08-09
NO860907L (no) 1986-09-15
IE860631L (en) 1986-09-12
AU584993B2 (en) 1989-06-08
DE3683172D1 (de) 1992-02-13
CA1268769A (en) 1990-05-08
FI87203C (fi) 1992-12-10
AU5460686A (en) 1986-10-16
DK108686D0 (da) 1986-03-10
GR860648B (en) 1986-07-11
PH24659A (en) 1990-09-07
PT82167B (pt) 1988-07-29
FI860981A0 (fi) 1986-03-10
DE3508665A1 (de) 1986-09-18
ATE70973T1 (de) 1992-01-15
KR940002255B1 (ko) 1994-03-19
FI860981A (fi) 1986-09-13
FI87203B (fi) 1992-08-31
JPH0380792B2 (da) 1991-12-26
KR860007235A (ko) 1986-10-10
AR247738A1 (es) 1995-03-31
IL78090A (en) 1991-08-16
IL78090A0 (en) 1986-07-31

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