DK106287A - GLYCERO-3 (2) -PHOSPHO-L-SERINE DERIVATIVES AND SALTS THEREOF, PROCEDURE FOR PREPARING SUCH COMPOUNDS, AND PHARMACEUTICAL PREPARATIONS CONTAINING THESE - Google Patents

GLYCERO-3 (2) -PHOSPHO-L-SERINE DERIVATIVES AND SALTS THEREOF, PROCEDURE FOR PREPARING SUCH COMPOUNDS, AND PHARMACEUTICAL PREPARATIONS CONTAINING THESE

Info

Publication number
DK106287A
DK106287A DK106287A DK106287A DK106287A DK 106287 A DK106287 A DK 106287A DK 106287 A DK106287 A DK 106287A DK 106287 A DK106287 A DK 106287A DK 106287 A DK106287 A DK 106287A
Authority
DK
Denmark
Prior art keywords
glycero
phospho
compounds
group
pharmaceutical preparations
Prior art date
Application number
DK106287A
Other languages
Danish (da)
Other versions
DK167978B1 (en
DK106287D0 (en
Inventor
Hans Brachwitz
Peter Langen
Christine Lehmann
Eckart Matthes
Juergen Schildt
Iduna Fichtner
Albin Hermetter
Friedrich Paltauf
Original Assignee
Chemie Linz Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DD27823185A external-priority patent/DD238979A1/en
Priority claimed from DD27823085A external-priority patent/DD238978A1/en
Priority claimed from DD27856085A external-priority patent/DD239208B1/en
Priority claimed from DD27856185A external-priority patent/DD239209A1/en
Priority claimed from DD27856285A external-priority patent/DD239405A1/en
Application filed by Chemie Linz Ag filed Critical Chemie Linz Ag
Publication of DK106287A publication Critical patent/DK106287A/en
Publication of DK106287D0 publication Critical patent/DK106287D0/en
Application granted granted Critical
Publication of DK167978B1 publication Critical patent/DK167978B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/08—Esters of oxyacids of phosphorus
    • C07F9/09—Esters of phosphoric acids
    • C07F9/10—Phosphatides, e.g. lecithin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)

Abstract

Previously unknown derivatives of glycero-3(2)-phospho-L- serin of the formula <IMAGE> in which A is optionally substituted C5-C30-alkoxy, optionally substituted C5-C30-alkenoxy, where a double bond in the alkenoxy group does not emanate from the oxygen-bonded C atom, halogen or a group of the formula -O-(CH2)n-CF3 (II) in which n is 0, 1, 2 or 3, and in which one of the groups B and C, which can be identical to the group A or different from it, has one of the meanings given for A or is hydrogen, while the other is a phosphatidyl-L-serine group of the formula <IMAGE> with the restriction that at least one of the groups A, B and C denote C5-C30-alkoxy or C5-C30-alkenoxy, are prepared by several different processes. The compounds (I) can be used as active constituents in pharmaceutical preparations which have a cytostatic effect.
DK106287A 1985-07-03 1987-03-02 GLYCERO-3 (2) -PHOSPHO-L-SERINE DERIVATIVES AND SALTS THEREOF, PROCEDURE FOR PREPARING SUCH COMPOUNDS AND PHARMACEUTICAL PREPARATIONS CONTAINING THESE DK167978B1 (en)

Applications Claiming Priority (12)

Application Number Priority Date Filing Date Title
DD27823185A DD238979A1 (en) 1985-07-03 1985-07-03 PROCESS FOR THE PREPARATION OF O-ALKYL GLYCEROPHOSPHOSERIN ANALOG
DD27823085A DD238978A1 (en) 1985-07-03 1985-07-03 PROCESS FOR THE PREPARATION OF 2-O-ALKYL-I-DES OXY-1 HALOGENGLYCERO-3-PHOSPHO-L-SERINES
DD27823085 1985-07-03
DD27823185 1985-07-03
DD27856185 1985-07-15
DD27856085A DD239208B1 (en) 1985-07-15 1985-07-15 PROCESS FOR THE PREPARATION OF 1-O-ALKYL-2-O-TRIFLUORALKYLGLYCEROPHOSPHO-L-SERINES
DD27856285 1985-07-15
DD27856185A DD239209A1 (en) 1985-07-15 1985-07-15 PROCESS FOR THE PREPARATION OF O-ALKYL SUBSTITUTED GLYCERO AND DESOXYGLYCEROPHOSPHO SERINES
DD27856285A DD239405A1 (en) 1985-07-15 1985-07-15 PROCESS FOR PREPARING TRIFLUORO ALKYL GLYCEROPHOSPHO-L-SERINES
DD27856085 1985-07-15
EP8600390 1986-07-02
PCT/EP1986/000390 WO1987000173A1 (en) 1985-07-03 1986-07-02 Derivatives of glycero-3(2)-phospho-l-serine and pharmaceutical preparations containing them

Publications (3)

Publication Number Publication Date
DK106287A true DK106287A (en) 1987-03-02
DK106287D0 DK106287D0 (en) 1987-03-02
DK167978B1 DK167978B1 (en) 1994-01-10

Family

ID=27509737

Family Applications (1)

Application Number Title Priority Date Filing Date
DK106287A DK167978B1 (en) 1985-07-03 1987-03-02 GLYCERO-3 (2) -PHOSPHO-L-SERINE DERIVATIVES AND SALTS THEREOF, PROCEDURE FOR PREPARING SUCH COMPOUNDS AND PHARMACEUTICAL PREPARATIONS CONTAINING THESE

Country Status (8)

Country Link
EP (1) EP0229128B1 (en)
JP (1) JPH0751588B2 (en)
DE (1) DE3671630D1 (en)
DK (1) DK167978B1 (en)
FI (1) FI82473C (en)
HU (1) HU198076B (en)
NO (1) NO169171C (en)
WO (1) WO1987000173A1 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1249063B (en) * 1991-05-28 1995-02-11 Fidia Spa USE OF PHOSPHOLIPIDIC DERIVATIVES FOR THE PREPARATION OF PHARMACEUTICAL COMPOSITIONS HAVING IMMUNOSOPPRESSIVE ACTIVITY
ES2034885B1 (en) * 1991-07-10 1994-03-01 Menarini Lab PROCEDURE FOR THE PREPARATION OF CETOALQUILGLICEROFOSFOLIPIDOS.
DE4229877C2 (en) * 1992-09-04 1994-09-15 Max Delbrueck Centrum Phospho- or phosphono- (N-acyl) -serines and their preparation
IT1311929B1 (en) * 1999-04-28 2002-03-20 Chemi Spa PROCEDURE FOR THE PREPARATION OF PHOSPHATIDYLSERINS.
WO2005077963A1 (en) * 2004-01-16 2005-08-25 Institut Superieur Agricole De Beauvais Saccharide and itol derivatives having an o-alkyl group or an o-alkyl group and an o-n butanyl group, uses as medicines in tumoral or benign proliferative pathologies

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1123142B (en) * 1979-09-14 1986-04-30 Lpb Ist Farm USE OF GLYCERYLPHOSPHORIL DERIVATIVES IN THE THERAPY OF DYSLIPEMIA AND HEPATITIS, AND RELATED PHARMACEUTICAL COMPOSITIONS
DD222595A1 (en) * 1984-01-24 1985-05-22 Zi F Molekularbiologie PROCESS FOR PREPARING 1-0-ALKYL-2-0- (2,2,2-TRIFLUORETHYL) GLYCERO-3-PHOSPHOCHOLINES

Also Published As

Publication number Publication date
HUT43861A (en) 1987-12-28
EP0229128B1 (en) 1990-05-30
WO1987000173A1 (en) 1987-01-15
NO870834L (en) 1987-02-27
NO169171C (en) 1992-05-20
DK167978B1 (en) 1994-01-10
JPH0751588B2 (en) 1995-06-05
FI82473B (en) 1990-11-30
FI82473C (en) 1991-03-11
DE3671630D1 (en) 1990-07-05
NO870834D0 (en) 1987-02-27
NO169171B (en) 1992-02-10
DK106287D0 (en) 1987-03-02
HU198076B (en) 1989-07-28
FI870732A (en) 1987-02-20
FI870732A0 (en) 1987-02-20
JPS63500658A (en) 1988-03-10
EP0229128A1 (en) 1987-07-22

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