DK156660C - METHOD OF ANALOGUE FOR THE PREPARATION OF IMIDAZOLYLTHIEN-2-YL OR IMIDAZOLYLALKYLTHIEN-2-YL-TETRAHYDRO PYRIDAZINES OR PHARMACEUTICAL ACCEPTABLE SALTS THEREOF - Google Patents

METHOD OF ANALOGUE FOR THE PREPARATION OF IMIDAZOLYLTHIEN-2-YL OR IMIDAZOLYLALKYLTHIEN-2-YL-TETRAHYDRO PYRIDAZINES OR PHARMACEUTICAL ACCEPTABLE SALTS THEREOF

Info

Publication number
DK156660C
DK156660C DK505983A DK505983A DK156660C DK 156660 C DK156660 C DK 156660C DK 505983 A DK505983 A DK 505983A DK 505983 A DK505983 A DK 505983A DK 156660 C DK156660 C DK 156660C
Authority
DK
Denmark
Prior art keywords
imidazolylthien
imidazolylalkylthien
analogue
preparation
acceptable salts
Prior art date
Application number
DK505983A
Other languages
Danish (da)
Other versions
DK505983D0 (en
DK505983A (en
DK156660B (en
Inventor
Gerd Hilboll
Gerrit Prop
Harald Borbe
Josef Peter Loehr
Elisabeth-Stephanie Doppelfeld
Original Assignee
Nattermann A & Cie
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nattermann A & Cie filed Critical Nattermann A & Cie
Publication of DK505983D0 publication Critical patent/DK505983D0/en
Publication of DK505983A publication Critical patent/DK505983A/en
Publication of DK156660B publication Critical patent/DK156660B/en
Application granted granted Critical
Publication of DK156660C publication Critical patent/DK156660C/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings

Abstract

The invention relates to new imidazolylalkylthienyltetrahydropyridazines of the general formula I <IMAGE> I their acid addition salts as well as processes for their use in the treatment of cardiovascular and/or thromboembolic illnesses in humans.
DK505983A 1982-11-06 1983-11-04 METHOD OF ANALOGUE FOR THE PREPARATION OF IMIDAZOLYLTHIEN-2-YL OR IMIDAZOLYLALKYLTHIEN-2-YL-TETRAHYDRO PYRIDAZINES OR PHARMACEUTICAL ACCEPTABLE SALTS THEREOF DK156660C (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19823241102 DE3241102A1 (en) 1982-11-06 1982-11-06 IMIDAZOLYLALKYLTHIENYL TETRAHYDROPYRIDAZINE AND METHOD FOR THE PRODUCTION THEREOF
DE3241102 1982-11-06

Publications (4)

Publication Number Publication Date
DK505983D0 DK505983D0 (en) 1983-11-04
DK505983A DK505983A (en) 1984-05-07
DK156660B DK156660B (en) 1989-09-18
DK156660C true DK156660C (en) 1990-03-05

Family

ID=6177509

Family Applications (1)

Application Number Title Priority Date Filing Date
DK505983A DK156660C (en) 1982-11-06 1983-11-04 METHOD OF ANALOGUE FOR THE PREPARATION OF IMIDAZOLYLTHIEN-2-YL OR IMIDAZOLYLALKYLTHIEN-2-YL-TETRAHYDRO PYRIDAZINES OR PHARMACEUTICAL ACCEPTABLE SALTS THEREOF

Country Status (11)

Country Link
US (1) US4643998A (en)
EP (1) EP0112987B1 (en)
JP (1) JPS59108781A (en)
AT (1) ATE26274T1 (en)
DE (2) DE3241102A1 (en)
DK (1) DK156660C (en)
ES (1) ES8406472A1 (en)
GR (1) GR78945B (en)
IE (1) IE56127B1 (en)
PT (1) PT77616B (en)
ZA (1) ZA837976B (en)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3407509A1 (en) * 1984-03-01 1985-09-05 A. Nattermann & Cie GmbH, 5000 Köln NEW COMBINATION OF MEDICINAL PRODUCTS FOR TREATING HIGH BLOOD PRESSURE AND THROMBOEMBOLIC DISEASES
DE3606105A1 (en) * 1986-02-26 1987-08-27 Nattermann A & Cie METHOD FOR PRODUCING IMIDAZOLYL THIOPHENALDEHYDES
DE3626865A1 (en) * 1986-08-08 1988-02-11 Boehringer Mannheim Gmbh NEW PYRIDAZINONE DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF AND THEIR USE AS MEDICINAL PRODUCTS
US5958926A (en) * 1996-11-01 1999-09-28 Nitromed, Inc. Nitrosated and nitrosylated phosphodiesterase inhibitor compounds, compositions and their uses
US6518412B1 (en) 1997-09-29 2003-02-11 Jean-Louis Dasseux Gene therapy approaches to supply apolipoprotein A-I agonists and their use to treat dyslipidemic disorders
US6037323A (en) * 1997-09-29 2000-03-14 Jean-Louis Dasseux Apolipoprotein A-I agonists and their use to treat dyslipidemic disorders
US6046166A (en) * 1997-09-29 2000-04-04 Jean-Louis Dasseux Apolipoprotein A-I agonists and their use to treat dyslipidemic disorders
US6004925A (en) 1997-09-29 1999-12-21 J. L. Dasseux Apolipoprotein A-I agonists and their use to treat dyslipidemic disorders
US7217785B2 (en) * 2001-05-09 2007-05-15 The Regents Of The University Of California Cysteine-containing peptides having antioxidant properties
US7772188B2 (en) 2003-01-28 2010-08-10 Ironwood Pharmaceuticals, Inc. Methods and compositions for the treatment of gastrointestinal disorders
DE102004036075B3 (en) * 2004-07-24 2006-02-16 Bos Gmbh & Co. Kg Arrangement for side window blinds
NZ568694A (en) 2005-11-09 2011-09-30 Zalicus Inc Method, compositions, and kits for the treatment of medical conditions
US8969514B2 (en) 2007-06-04 2015-03-03 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
EA020466B1 (en) 2007-06-04 2014-11-28 Синерджи Фармасьютикалз Инк. Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
JP2011522828A (en) 2008-06-04 2011-08-04 シナジー ファーマシューティカルズ インコーポレイテッド Guanylate cyclase agonists useful for the treatment of gastrointestinal disorders, inflammation, cancer, and other disorders
CA2730603C (en) 2008-07-16 2019-09-24 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
US9616097B2 (en) 2010-09-15 2017-04-11 Synergy Pharmaceuticals, Inc. Formulations of guanylate cyclase C agonists and methods of use
CA2828346C (en) 2011-03-01 2021-01-26 Synergy Pharmaceuticals Inc. Process of preparing guanylate cyclase c agonists
WO2013097052A1 (en) 2011-12-30 2013-07-04 Abbott Laboratories Bromodomain inhibitors
US20150119399A1 (en) 2012-01-10 2015-04-30 President And Fellows Of Harvard College Beta-cell replication promoting compounds and methods of their use
AU2014218599C1 (en) 2013-02-25 2018-09-06 Bausch Health Ireland Limited Guanylate cyclase receptor agonists for use in colonic cleansing
JP2016514670A (en) 2013-03-15 2016-05-23 シナジー ファーマシューティカルズ インコーポレイテッド Guanylate cyclase receptor agonists in combination with other drugs
AU2014235215A1 (en) 2013-03-15 2015-10-01 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase and their uses
KR102272746B1 (en) 2013-06-05 2021-07-08 보슈 헬스 아일랜드 리미티드 Ultra-pure agonists of guanylate cyclase c, method of making and using same
MX2016001714A (en) 2013-08-09 2016-10-03 Ardelyx Inc Compounds and methods for inhibiting phosphate transport.
WO2016169514A1 (en) * 2015-04-24 2016-10-27 广东众生药业股份有限公司 Imidazole compound
EP3442972B1 (en) 2016-04-15 2020-03-04 AbbVie Inc. Bromodomain inhibitors
WO2018072702A1 (en) * 2016-10-20 2018-04-26 南京明德新药研发股份有限公司 Imidazole compound crystal form, salt type and preparation method therefor
JP2022533251A (en) 2019-05-21 2022-07-21 アルデリックス， インコーポレイテッド Combinations to lower serum phosphate in patients

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3130252A1 (en) * 1981-07-31 1983-02-17 A. Nattermann & Cie GmbH, 5000 Köln 6- (5 - ((OMEGA) - (1-IMIDAZOLYL) ALKYL) -THIEN-2-YL) -3-OXO-2,3,4,5-TETRAHYDRO-PYRIDAZINE AND THEIR ACID ADDITION SALTS, METHOD FOR THE PRODUCTION THEREOF AND THESE PHARMACEUTICAL PREPARATIONS
HU190412B (en) * 1981-09-17 1986-09-29 Warner-Lambert Co,Us Process for producing substituted 4,5-dihiydro-6-bracket-substituted-bracket closed-phenyl-3-bracket-2h-bracket closed-pyridazinones and 6-bracket-substituted-bracket closed-phenyl-3-bracket-2h-bracket closed-pyridazinones
US4353905A (en) * 1981-09-17 1982-10-12 Warner-Lambert Company Substituted 4,5-dihydro-6-[4-(1H-imidazol-1-yl)phenyl]-3(2H)-pyridazinones and 6-[4-(1H-imidazol-1-yl)phenyl]-3(2H)-pyridazinones

Also Published As

Publication number Publication date
PT77616B (en) 1986-03-19
JPH054391B2 (en) 1993-01-19
ES527027A0 (en) 1984-07-01
IE832484L (en) 1984-05-06
ZA837976B (en) 1984-06-27
EP0112987B1 (en) 1987-04-01
DK505983D0 (en) 1983-11-04
DK505983A (en) 1984-05-07
IE56127B1 (en) 1991-04-24
JPS59108781A (en) 1984-06-23
DK156660B (en) 1989-09-18
DE3370626D1 (en) 1987-05-07
ES8406472A1 (en) 1984-07-01
GR78945B (en) 1984-10-02
EP0112987A1 (en) 1984-07-11
DE3241102A1 (en) 1984-05-10
ATE26274T1 (en) 1987-04-15
US4643998A (en) 1987-02-17
PT77616A (en) 1983-12-01

Similar Documents

Publication Publication Date Title
DK156660C (en) METHOD OF ANALOGUE FOR THE PREPARATION OF IMIDAZOLYLTHIEN-2-YL OR IMIDAZOLYLALKYLTHIEN-2-YL-TETRAHYDRO PYRIDAZINES OR PHARMACEUTICAL ACCEPTABLE SALTS THEREOF
DK153399C (en) METHOD OF ANALOGUE FOR THE PREPARATION OF 2,4-DIAMINOQUINAZOLINE COMPOUNDS OR PHARMACEUTICAL ACCEPTABLE ACID ADDITION SALTS AND 4-AMINOQUINAZOLINE COMPOUNDS FOR USE AS THE EXAMPLE
DK145339C (en) METHOD OF ANALOGUE FOR THE PREPARATION OF 4-AMINO-5-HEXENIC ACID OR PHARMACEUTICAL ACCEPTABLE SALTS THEREOF
DK151010C (en) METHOD OF ANALOGUE FOR THE PREPARATION OF N- (SUBSTITUTED AMINOAL COOL) -2-OXO-1-PYRROLIDINACETAMIDES OR PHARMACEUTICAL ACCEPTABLE ACID ADDITION SALTS.
DE3369508D1 (en) Triphenylimidazolyloxyalcanoic acids and their derivatives, process for their preparation and pharmaceutical compositions containing them
DK151884C (en) METHOD OF ANALOGUE FOR THE PREPARATION OF 3- (1-IMIDAZOLYLALKYL) INCIDENTAL OR PHARMACEUTICAL ACCEPTABLE ACID ADDITION SALTS THEREOF
NO820686L (en) PROCEDURE FOR THE PREPARATION OF NEW AROYLIMIDAZOLONS
DK422583A (en) METHOD FOR PREPARING DIAZOBICYCLO (3,3,1) NONANES
DK148183D0 (en) METHOD FOR PREPARING IMIDAZOLYLPHENYL-TETRAHYDROPYRIDAZINES
DK161968C (en) METHOD OF ANALOGUE FOR THE PREPARATION OF IMIDAZO-PYRAZOLO-PYRIMIDINES OR PHARMACEUTICAL ACCEPTABLE SALTS
DK151017C (en) METHOD OF ANALOGUE FOR THE PREPARATION OF SUBSTITUTED N- (4-INDOLYL-PIPERIDINO-ALKYL) -BENZIMIDAZOLONES OR PHYSIOLOGICALLY ACCEPTABLE ACID ADDITION SALTS THEREOF
DK163181C (en) METHOD OF ANALOGUE FOR THE PREPARATION OF N, N&#39;-DI (ARYLALKYLENE) ALKYLENDIAMIN OR PHARMACEUTICAL ACCEPTABLE SALTS THEREOF
DK160942C (en) PROCEDURE FOR THE PREPARATION OF 7- (SUBSTITUTED SUBSTITUTED AMINO) -3- (SUBSTITUTED) THIOMETHYL-DELTA3-CEPHEM-4-CARBOXYLIC ACID COMPOUNDS OR DERIVATIVES IN THE CARBOXYL GROUP OR THEREOF
DK154950C (en) METHOD OF ANALOGUE FOR THE PREPARATION OF 1- (BENZAZOLYLALKYL) -PIPERIDE INGREDIENTS OR THE PHARMACEUTICAL ACCEPTABLE ACID ADDITION SALTS
DK158658C (en) METHOD OF ANALOGUE FOR THE PREPARATION OF 9-AMINOAL COOLFluorens OR PHARMACEUTICAL ACCEPTABLE SALTS THEREOF
DE3371515D1 (en) Cycloalkyl derivatives of benzisoselenazolones, process for their preparation and pharmaceutical compositions containing them
DK149590C (en) METHOD OF ANALOGUE FOR THE PREPARATION OF 2-ARYL-3,4-DIAZA-BICYCLO (4,1,0) HEPTEN- (2) -ON- (5) COMPOUNDS
DK152427C (en) METHOD OF ANALOGUE FOR THE PREPARATION OF 4-THIOMETHYLPYRIDINE COMPOUNDS OR PHARMACEUTICAL ACCEPTABLE ACID ADDITION SALTS THEREOF
DK150481C (en) METHOD OF ANALOGUE FOR THE PREPARATION OF 3 &#39;, 4&#39;-DIHYDRO-SPIRO- (IMIDAZOLIDIN-4,1&#39; - (2&#39;H) -NAPHTHALEN) -5-ON OR PHARMACEUTICAL ACCEPTABLE ACID ADDITION SALTS THEREOF
DK229090A (en) INTERMEDIATES FOR USE IN THE PREPARATION OF 2 (2-AMINO-THIAZOL-4-YL) GLYOXYLIC ACID DERIVATIVES OR SALTS THEREOF AND PROCEDURES FOR THE PRODUCTION OF THE INTERMEDIATES
DK160874C (en) METHOD OF ANALOGUE FOR THE PREPARATION OF ERGOL-8-ONE OR ERGOLIN COMPOUNDS OR PHARMACEUTICAL ACCEPTABLE ACID ADDITION SALTS THEREOF
DK157686C (en) METHOD OF ANALOGUE FOR THE PREPARATION OF 7-BETA SUBSTITUTED IMIDAZOLIDINYL-3-CHLOR-3-CEPHEM-4-CARBOXYLIC ACID OR PHARMACEUTICAL ACCEPTABLE SALTS THEREOF
DK154217C (en) METHOD OF ANALOGUE FOR THE PREPARATION OF 3-AZETIDINYLA ETHYL-1-PHENYL-2-IMIDAZOLIDINE UNDERIVATIVES OR PHARMACEUTICAL ACCEPTABLE ACID ADDITION SALTS.
DK156393C (en) METHOD OF ANALOGUE FOR THE PREPARATION OF 2-ISOPROPYLAMINO-PYRIMIDINE-N-OXIDE OR THERAPEUTIC ACCEPTABLE SALTS THEREOF
DK163432C (en) METHOD OF ANALOGUE FOR THE PREPARATION OF OE1,2,4AATRIAZOLO-OE4,3-AAAQUINOXALIN-4-AMINE DERIVATIVES OR PHARMACEUTICAL ACCEPTABLE ACID ADDITION SALTS THEREOF

Legal Events

Date Code Title Description
PBP Patent lapsed