DK1048726T3 - Modificeret faktor VIII-cDNA - Google Patents
Modificeret faktor VIII-cDNAInfo
- Publication number
- DK1048726T3 DK1048726T3 DK00104677T DK00104677T DK1048726T3 DK 1048726 T3 DK1048726 T3 DK 1048726T3 DK 00104677 T DK00104677 T DK 00104677T DK 00104677 T DK00104677 T DK 00104677T DK 1048726 T3 DK1048726 T3 DK 1048726T3
- Authority
- DK
- Denmark
- Prior art keywords
- factor viii
- modified factor
- viii cdna
- blood coagulation
- expression
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/62—DNA sequences coding for fusion proteins
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6424—Serine endopeptidases (3.4.21)
- C12N9/644—Coagulation factor IXa (3.4.21.22)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/745—Blood coagulation or fibrinolysis factors
- C07K14/755—Factors VIII, e.g. factor VIII C (AHF), factor VIII Ag (VWF)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/67—General methods for enhancing the expression
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/21—Serine endopeptidases (3.4.21)
- C12Y304/21022—Coagulation factor IXa (3.4.21.22)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2800/00—Nucleic acids vectors
- C12N2800/10—Plasmid DNA
- C12N2800/108—Plasmid DNA episomal vectors
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/008—Vector systems having a special element relevant for transcription cell type or tissue specific enhancer/promoter combination
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/80—Vector systems having a special element relevant for transcription from vertebrates
- C12N2830/85—Vector systems having a special element relevant for transcription from vertebrates mammalian
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP99104050A EP1038959A1 (en) | 1999-03-17 | 1999-03-17 | Factor VIII without B-domain, comprising one or more insertions of a truncated intron I of factor IX |
EP99107397A EP1048736A1 (en) | 1999-04-27 | 1999-04-27 | DNA-construct for the tissue specific expression of a blood coagulation factor |
Publications (1)
Publication Number | Publication Date |
---|---|
DK1048726T3 true DK1048726T3 (da) | 2006-11-20 |
Family
ID=8237961
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK00104677T DK1048726T3 (da) | 1999-03-17 | 2000-03-03 | Modificeret faktor VIII-cDNA |
Country Status (11)
Country | Link |
---|---|
US (1) | US6884616B1 (da) |
EP (2) | EP1048736A1 (da) |
JP (1) | JP4373578B2 (da) |
KR (1) | KR100681719B1 (da) |
AT (1) | ATE339510T1 (da) |
AU (1) | AU779437B2 (da) |
CA (1) | CA2304376C (da) |
DE (1) | DE60030621T2 (da) |
DK (1) | DK1048726T3 (da) |
ES (1) | ES2270758T3 (da) |
PT (1) | PT1048726E (da) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ATE489105T1 (de) | 2004-03-19 | 2010-12-15 | Baxter Int | Faktor ixa zur behandlung von blutungsstörungen |
EP2205249B1 (en) | 2007-09-28 | 2018-11-07 | Intrexon Corporation | Therapeutic gene-switch constructs and bioreactors for the expression of biotherapeutic molecules, and uses thereof |
CN102112144A (zh) * | 2008-05-16 | 2011-06-29 | 拜耳医药保健有限公司 | 靶向性凝固因子及其使用方法 |
DK2912186T3 (da) * | 2012-10-24 | 2021-02-22 | Platelet Targeted Therapeutics Llc | Behandling rettet mod blodplader |
GB201420139D0 (en) | 2014-11-12 | 2014-12-24 | Ucl Business Plc | Factor IX gene therapy |
US10842885B2 (en) | 2018-08-20 | 2020-11-24 | Ucl Business Ltd | Factor IX encoding nucleotides |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2678282B1 (fr) * | 1991-06-28 | 1994-08-26 | Commissariat Energie Atomique | Sequences amplificateur et silenceur isolees du promoteur de la gpiib, et leurs applications. |
JPH08511423A (ja) * | 1993-06-10 | 1996-12-03 | ジェネティック セラピー,インコーポレイテッド | 血友病治療のためのアデノウイルスベクター |
US6066778A (en) * | 1996-11-06 | 2000-05-23 | The Regents Of The University Of Michigan | Transgenic mice expressing APC resistant factor V |
FR2763959A1 (fr) | 1997-06-02 | 1998-12-04 | Transgene Sa | Nouveaux vecteurs adenoviraux recombinants comprenant une sequence d'epissage |
-
1999
- 1999-04-27 EP EP99107397A patent/EP1048736A1/en not_active Withdrawn
-
2000
- 2000-03-03 DK DK00104677T patent/DK1048726T3/da active
- 2000-03-03 PT PT00104677T patent/PT1048726E/pt unknown
- 2000-04-08 ES ES00107616T patent/ES2270758T3/es not_active Expired - Lifetime
- 2000-04-08 EP EP00107616A patent/EP1048735B1/en not_active Expired - Lifetime
- 2000-04-08 AT AT00107616T patent/ATE339510T1/de active
- 2000-04-08 DE DE60030621T patent/DE60030621T2/de not_active Expired - Lifetime
- 2000-04-27 US US09/559,344 patent/US6884616B1/en not_active Expired - Fee Related
- 2000-04-28 JP JP2000129331A patent/JP4373578B2/ja not_active Expired - Fee Related
- 2000-04-28 AU AU30195/00A patent/AU779437B2/en not_active Ceased
- 2000-04-28 KR KR1020000022862A patent/KR100681719B1/ko not_active IP Right Cessation
- 2000-04-28 CA CA2304376A patent/CA2304376C/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
EP1048735A1 (en) | 2000-11-02 |
KR20010020795A (ko) | 2001-03-15 |
ES2270758T3 (es) | 2007-04-16 |
DE60030621T2 (de) | 2007-09-27 |
JP2000333687A (ja) | 2000-12-05 |
JP4373578B2 (ja) | 2009-11-25 |
AU779437B2 (en) | 2005-01-27 |
ATE339510T1 (de) | 2006-10-15 |
EP1048736A1 (en) | 2000-11-02 |
US6884616B1 (en) | 2005-04-26 |
CA2304376A1 (en) | 2000-10-29 |
CA2304376C (en) | 2010-06-01 |
PT1048726E (pt) | 2006-12-29 |
KR100681719B1 (ko) | 2007-02-15 |
EP1048735B1 (en) | 2006-09-13 |
DE60030621D1 (de) | 2006-10-26 |
AU3019500A (en) | 2000-11-02 |
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