DK1040097T3 - Stoffer, som åbner kaliumkanaler - Google Patents

Stoffer, som åbner kaliumkanaler

Info

Publication number
DK1040097T3
DK1040097T3 DK98963249T DK98963249T DK1040097T3 DK 1040097 T3 DK1040097 T3 DK 1040097T3 DK 98963249 T DK98963249 T DK 98963249T DK 98963249 T DK98963249 T DK 98963249T DK 1040097 T3 DK1040097 T3 DK 1040097T3
Authority
DK
Denmark
Prior art keywords
substances
potassium channels
open potassium
opening
potassium channel
Prior art date
Application number
DK98963249T
Other languages
Danish (da)
English (en)
Inventor
William A Carroll
James P Sullivan
Irene Drizin
Henry Q Zhang
Mark W Holladay
Original Assignee
Abbott Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US09/206,055 external-priority patent/US6265417B1/en
Application filed by Abbott Lab filed Critical Abbott Lab
Application granted granted Critical
Publication of DK1040097T3 publication Critical patent/DK1040097T3/da

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D221/00Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/04Ortho- or peri-condensed ring systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/06Antiasthmatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/02Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/04Centrally acting analgesics, e.g. opioids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/06Antimigraine agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/08Antiepileptics; Anticonvulsants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/08Vasodilators for multiple indications
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/12Antihypertensives
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/27Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation
    • C07C45/29Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation of hydroxy groups
    • C07C45/298Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation of hydroxy groups with manganese derivatives
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D215/00Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/36Sulfur atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D495/00Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D495/00Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/12Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D495/14Ortho-condensed systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Pain & Pain Management (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Pulmonology (AREA)
  • Urology & Nephrology (AREA)
  • Nutrition Science (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Glass Compositions (AREA)
  • Iron Core Of Rotating Electric Machines (AREA)
  • Crystals, And After-Treatments Of Crystals (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pyridine Compounds (AREA)
  • Ladders (AREA)
  • Weting (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Gyroscopes (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Polyesters Or Polycarbonates (AREA)
  • Feeding And Controlling Fuel (AREA)
DK98963249T 1997-12-18 1998-12-16 Stoffer, som åbner kaliumkanaler DK1040097T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US99339297A 1997-12-18 1997-12-18
US09/206,055 US6265417B1 (en) 1997-12-18 1998-12-04 Potassium channel openers
PCT/US1998/026780 WO1999031059A1 (en) 1997-12-18 1998-12-16 Potassium channel openers

Publications (1)

Publication Number Publication Date
DK1040097T3 true DK1040097T3 (da) 2004-08-02

Family

ID=26901004

Family Applications (1)

Application Number Title Priority Date Filing Date
DK98963249T DK1040097T3 (da) 1997-12-18 1998-12-16 Stoffer, som åbner kaliumkanaler

Country Status (22)

Country Link
US (1) US20010036950A1 (xx)
EP (1) EP1040097B1 (xx)
JP (1) JP2002508354A (xx)
CN (1) CN1158259C (xx)
AT (1) ATE264303T1 (xx)
AU (1) AU756505B2 (xx)
BG (1) BG64309B1 (xx)
BR (1) BR9813634A (xx)
CA (1) CA2314948A1 (xx)
DE (1) DE69823227T2 (xx)
DK (1) DK1040097T3 (xx)
ES (1) ES2222000T3 (xx)
HK (1) HK1032583A1 (xx)
HU (1) HUP0100112A3 (xx)
IL (1) IL135985A0 (xx)
NO (1) NO317099B1 (xx)
NZ (1) NZ504371A (xx)
PL (1) PL341298A1 (xx)
PT (1) PT1040097E (xx)
SK (1) SK8732000A3 (xx)
TR (1) TR200001715T2 (xx)
WO (1) WO1999031059A1 (xx)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6265417B1 (en) 1997-12-18 2001-07-24 Abbott Laboratories Potassium channel openers
US6593335B1 (en) 1997-12-18 2003-07-15 Abbott Laboratories Potassium channel openers
US6642222B2 (en) * 1998-10-28 2003-11-04 Abbott Laboratories Pyrano, piperidino, and thiopyrano compounds and methods of use
US6191140B1 (en) * 1998-10-28 2001-02-20 Abbott Laboratories Pyrano, piperidino, and thiopyrano compounds and methods of use
EP1131322A2 (en) * 1998-10-28 2001-09-12 Abbott Laboratories Dihydropyridine compounds and methods of use
US6518279B2 (en) 1999-03-04 2003-02-11 Abbott Laboratories Cyclopentanone dihydropyridine compounds useful as potassium channel openers
WO2002006237A1 (fr) * 2000-07-18 2002-01-24 Yamanouchi Pharmaceutical Co., Ltd. Medicament comprenant un derive de dicyanopyridine
EP1476415A1 (en) * 2002-02-19 2004-11-17 Abbott Laboratories Iodination of 4-fluoro-benzaldehyde

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2658804A1 (de) * 1976-12-24 1978-07-06 Bayer Ag Kreislaufbeeinflussende mittel
DE2747513A1 (de) * 1977-10-22 1979-05-03 Bayer Ag Dihydropyridine mit schwefelhaltigen estergruppierungen
US4777167A (en) * 1986-04-09 1988-10-11 Ortho Pharmaceutical Corporation Pharmaceutically useful substituted thiacycloalkeno [3,2-b]pyridines, compositions and method of use
US4879384A (en) * 1988-06-15 1989-11-07 Ortho Pharmaceutical Corporation Preparation of thiocycloalkno [3,2-b] pyridines
US5075440A (en) * 1990-05-03 1991-12-24 Ortho Pharmaceutical Corporation Novel pyrido[2,3-f](1,4)thiazepines and pyrido[3,2-b](1,5)benzothiazepines
ATE161531T1 (de) * 1991-10-21 1998-01-15 Zeneca Ltd Acridine-1,8-dionderivate als therapeutisches mittel
GB9318935D0 (en) * 1992-10-20 1993-10-27 Zeneca Ltd Heterocyclic derivatives
DE4424678A1 (de) * 1994-07-13 1996-01-18 Bayer Ag Dioxo-thiopyrano-pyridin-carbonsäure-derivate

Also Published As

Publication number Publication date
ES2222000T3 (es) 2005-01-16
JP2002508354A (ja) 2002-03-19
AU1830799A (en) 1999-07-05
DE69823227D1 (de) 2004-05-19
CN1282321A (zh) 2001-01-31
IL135985A0 (en) 2001-05-20
PT1040097E (pt) 2004-08-31
CN1158259C (zh) 2004-07-21
PL341298A1 (en) 2001-04-09
HUP0100112A3 (en) 2004-05-28
EP1040097A1 (en) 2000-10-04
BG64309B1 (bg) 2004-09-30
ATE264303T1 (de) 2004-04-15
TR200001715T2 (tr) 2000-12-21
US20010036950A1 (en) 2001-11-01
HK1032583A1 (en) 2001-07-27
CA2314948A1 (en) 1999-06-24
EP1040097B1 (en) 2004-04-14
DE69823227T2 (de) 2005-03-10
NO20003104L (no) 2000-08-17
AU756505B2 (en) 2003-01-16
SK8732000A3 (en) 2000-11-07
NO20003104D0 (no) 2000-06-16
NO317099B1 (no) 2004-08-09
NZ504371A (en) 2002-02-01
WO1999031059A1 (en) 1999-06-24
BR9813634A (pt) 2000-10-17
BG104594A (en) 2001-03-30
HUP0100112A2 (hu) 2001-08-28

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