DK1028741T3 - Regulering af epitelvæv ved hjælp af hedgehog-lignende polypeptider og formuleringer og anvendelser, som er relateret hertil - Google Patents
Regulering af epitelvæv ved hjælp af hedgehog-lignende polypeptider og formuleringer og anvendelser, som er relateret hertilInfo
- Publication number
- DK1028741T3 DK1028741T3 DK98953814T DK98953814T DK1028741T3 DK 1028741 T3 DK1028741 T3 DK 1028741T3 DK 98953814 T DK98953814 T DK 98953814T DK 98953814 T DK98953814 T DK 98953814T DK 1028741 T3 DK1028741 T3 DK 1028741T3
- Authority
- DK
- Denmark
- Prior art keywords
- hedgehog
- polypeptides
- regulation
- applications
- epithelial tissue
- Prior art date
Links
- 210000000981 epithelium Anatomy 0.000 title abstract 2
- 229920001184 polypeptide Polymers 0.000 title abstract 2
- 102000004196 processed proteins & peptides Human genes 0.000 title abstract 2
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 2
- 238000009472 formulation Methods 0.000 title 1
- 239000000203 mixture Substances 0.000 title 1
- 241000289669 Erinaceus europaeus Species 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 238000012423 maintenance Methods 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0625—Epidermal cells, skin cells; Cells of the oral mucosa
- C12N5/0629—Keratinocytes; Whole skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
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- A—HUMAN NECESSITIES
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
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- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
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- A—HUMAN NECESSITIES
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- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
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- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/60—Sugars; Derivatives thereof
- A61K8/606—Nucleosides; Nucleotides; Nucleic acids
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- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
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- A—HUMAN NECESSITIES
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- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
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- A—HUMAN NECESSITIES
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- A61Q7/02—Preparations for inhibiting or slowing hair growth
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/43504—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates
- C07K14/43563—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from insects
- C07K14/43577—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from insects from flies
- C07K14/43581—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from insects from flies from Drosophila
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/461—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from fish
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/465—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from birds
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4702—Regulators; Modulating activity
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0625—Epidermal cells, skin cells; Cells of the oral mucosa
- C12N5/0627—Hair cells
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/40—Regulators of development
- C12N2501/41—Hedgehog proteins; Cyclopamine (inhibitor)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/70—Enzymes
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- Dermatology (AREA)
- Biochemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Toxicology (AREA)
- Wood Science & Technology (AREA)
- Biophysics (AREA)
- Biotechnology (AREA)
- Insects & Arthropods (AREA)
- Immunology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Marine Sciences & Fisheries (AREA)
- Cell Biology (AREA)
- Birds (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Gerontology & Geriatric Medicine (AREA)
- Tropical Medicine & Parasitology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US95555297A | 1997-10-20 | 1997-10-20 | |
US09/151,999 US6639051B2 (en) | 1997-10-20 | 1998-09-11 | Regulation of epithelial tissue by hedgehog-like polypeptides, and formulations and uses related thereto |
PCT/US1998/022227 WO1999020298A1 (en) | 1997-10-20 | 1998-10-20 | Regulation of epithelial tissue by hedgehog-like polypeptides, and formulations and uses related thereto |
Publications (1)
Publication Number | Publication Date |
---|---|
DK1028741T3 true DK1028741T3 (da) | 2004-05-17 |
Family
ID=26849158
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK98953814T DK1028741T3 (da) | 1997-10-20 | 1998-10-20 | Regulering af epitelvæv ved hjælp af hedgehog-lignende polypeptider og formuleringer og anvendelser, som er relateret hertil |
Country Status (16)
Country | Link |
---|---|
US (5) | US6639051B2 (da) |
EP (1) | EP1028741B1 (da) |
JP (1) | JP2001520202A (da) |
KR (1) | KR20010031266A (da) |
CN (1) | CN1306436A (da) |
AT (1) | ATE257391T1 (da) |
AU (1) | AU760939B2 (da) |
CA (1) | CA2307322C (da) |
CY (1) | CY2016003I1 (da) |
DE (1) | DE69821021T2 (da) |
DK (1) | DK1028741T3 (da) |
ES (1) | ES2214744T3 (da) |
HK (1) | HK1030365A1 (da) |
LU (1) | LU92977I2 (da) |
PT (1) | PT1028741E (da) |
WO (1) | WO1999020298A1 (da) |
Families Citing this family (60)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6639051B2 (en) * | 1997-10-20 | 2003-10-28 | Curis, Inc. | Regulation of epithelial tissue by hedgehog-like polypeptides, and formulations and uses related thereto |
TW570805B (en) | 1998-09-01 | 2004-01-11 | Hoffmann La Roche | Water-soluble pharmaceutical composition in an ionic complex |
ATE458497T1 (de) * | 1998-09-11 | 2010-03-15 | Curis Inc | Antagonisten von 'hedgehog' und 'patched' zur inhibierung des wachstums und der differenzierung von zellen und geweben, als auch deren verwendungen |
AU761298C (en) | 1998-09-11 | 2005-04-21 | President And Fellows Of Harvard College | Regulation of lung tissue by hedgehog-like polypeptides, and formulations and uses related thereto |
US6159950A (en) * | 1998-10-16 | 2000-12-12 | Cornell Research Foundation, Inc. | Method of modulating hair growth |
CA2348773C (en) * | 1998-11-02 | 2010-04-13 | Biogen, Inc. | Functional antagonists of hedgehog activity |
US6884427B1 (en) * | 1999-02-08 | 2005-04-26 | Aderans Research Institute, Inc. | Filamentary means for introducing agents into tissue of a living host |
EP1183271A1 (en) * | 1999-06-01 | 2002-03-06 | Biogen, Inc. | Polymer conjugates of hedgehog proteins and uses |
JP2003501395A (ja) * | 1999-06-08 | 2003-01-14 | ローランティス・リミテッド | 治療的使用 |
US20070021493A1 (en) | 1999-09-16 | 2007-01-25 | Curis, Inc. | Mediators of hedgehog signaling pathways, compositions and uses related thereto |
CA2385736C (en) * | 1999-09-16 | 2011-11-15 | Curis, Inc. | Mediators of hedgehog signaling pathways, compositions and uses related thereto |
WO2001041786A1 (en) * | 1999-12-10 | 2001-06-14 | The General Hospital Corporation | METHODS TO STIMULATE INSULIN PRODUCTION BY PANCREATIC β-CELLS |
DE60143192D1 (de) * | 2000-02-08 | 2010-11-18 | Sangamo Biosciences Inc | Zellen zur entdeckung von medikamenten |
US7115653B2 (en) | 2000-03-30 | 2006-10-03 | Curis, Inc. | Small organic molecule regulators of cell proliferation |
US8852937B2 (en) | 2000-03-30 | 2014-10-07 | Curis, Inc. | Small organic molecule regulators of cell proliferation |
ES2338097T3 (es) * | 2000-04-14 | 2010-05-04 | Genencor International, Inc. | Procedimiento de identificacion selectiva. |
WO2001098344A2 (en) * | 2000-06-16 | 2001-12-27 | Curis, Inc. | Angiogenesis-modulating compositions and uses |
BR0113107A (pt) * | 2000-08-08 | 2004-01-06 | Bioamide Inc | Armações para cabelo com manipulação tecidual |
AU9684401A (en) | 2000-10-13 | 2002-04-22 | Curis Inc | Hedgehog antagonists, methods and uses related thereto |
US7708998B2 (en) | 2000-10-13 | 2010-05-04 | Curis, Inc. | Methods of inhibiting unwanted cell proliferation using hedgehog antagonists |
US20040068284A1 (en) * | 2002-01-29 | 2004-04-08 | Barrows Thomas H. | Method for stimulating hair growth and kit for carrying out said method |
EP2213292B2 (en) * | 2002-02-01 | 2016-06-22 | Life Technologies Corporation | Double-stranded oligonucleotides |
US20060009409A1 (en) | 2002-02-01 | 2006-01-12 | Woolf Tod M | Double-stranded oligonucleotides |
WO2003070265A2 (en) * | 2002-02-20 | 2003-08-28 | Academisch Ziekenhuis Bij De Universiteit Van Amsterdam | Hedgehog-related prophylaxis, therapy and diagnosis of gi tract carcinogenesis |
JP2003267966A (ja) * | 2002-03-13 | 2003-09-25 | Pola Chem Ind Inc | フラバン誘導体、皮膚線維芽細胞増殖抑制剤および皮膚外用剤 |
WO2005042740A1 (ja) * | 2003-10-31 | 2005-05-12 | Renomedix Institute Inc. | インディアン ヘッジホッグ遺伝子導入によるヒト不死化骨髄ストローマ細胞の造血支持能の増強方法 |
DK1730280T3 (da) * | 2004-03-26 | 2019-02-04 | Curis Inc | RNA-interferensmodulatorer for hedgehog-signalering og anvendelser deraf |
US7597885B2 (en) | 2004-03-26 | 2009-10-06 | Aderans Research Institute, Inc. | Tissue engineered biomimetic hair follicle graft |
DE102004025881A1 (de) * | 2004-05-19 | 2006-01-05 | Beiersdorf Ag | Oligoribonukleotide zur Beeinflussung des Haarwachstums |
AR050212A1 (es) * | 2004-08-13 | 2006-10-04 | Aderans Res Inst Inc | Organogenesis a partir de celulas disociadas |
WO2006039569A1 (en) * | 2004-09-30 | 2006-04-13 | The University Of Chicago | Combination therapy of hedgehog inhibitors, radiation and chemotherapeutic agents |
US20060105950A1 (en) * | 2004-10-25 | 2006-05-18 | Caritas St. Elizabeth's Medical Center Of Boston, Inc. | Morphogen compositions and use thereof to treat wounds |
US20060293228A1 (en) * | 2005-06-24 | 2006-12-28 | Bhatnagar Rajendra S | Therapeutic compositions and methods using transforming growth factor-beta mimics |
US20060293227A1 (en) * | 2005-06-24 | 2006-12-28 | Bhatnagar Rajendra S | Cosmetic compositions and methods using transforming growth factor-beta mimics |
TW200731982A (en) * | 2005-10-17 | 2007-09-01 | Aderans Res Inst Inc | Method of delivering cells to the skin |
US20070148138A1 (en) | 2005-11-22 | 2007-06-28 | Aderans Research Institute, Inc. | Hair follicle graft from tissue engineered skin |
EP3000480A1 (en) | 2005-12-01 | 2016-03-30 | ProNAi Therapeutics, Inc. | Cancer therapies and pharmaceutical compositions used therein |
GB2439377A (en) * | 2006-06-09 | 2007-12-27 | Pasteur Institut Korea | Methods of identifying modulators of and modulating GPCR cellular distribution and medical uses thereof |
WO2008005910A2 (en) | 2006-07-06 | 2008-01-10 | Bristol-Myers Squibb Company | Pyridone/hydroxypyridine 11-beta hydroxysteroid dehydrogenase type i inhibitors |
US8273747B2 (en) | 2006-11-02 | 2012-09-25 | Curis, Inc. | Small organic molecule regulators of cell proliferation |
US7922688B2 (en) | 2007-01-08 | 2011-04-12 | Restoration Robotics, Inc. | Automated delivery of a therapeutic or cosmetic substance to cutaneous, subcutaneous and intramuscular tissue regions |
US7985537B2 (en) | 2007-06-12 | 2011-07-26 | Aderans Research Institute, Inc. | Methods for determining the hair follicle inductive properties of a composition |
US9068166B2 (en) * | 2010-09-16 | 2015-06-30 | Industry-Academic Cooperation Foundation Yonsei University | Use of compounds for inducing differentiation of mesenchymal stem cells to chondrocytes |
CA2890725A1 (en) | 2012-11-05 | 2014-05-08 | Pronai Therapeutics, Inc. | Methods of using biomarkers for the treatment of cancer by modulation of bcl2|expression |
WO2015073691A1 (en) | 2013-11-14 | 2015-05-21 | The Board Of Trustees Of The Leland Stanford Junior University | Methods for treating cancer by activation of bmp signaling |
WO2015075166A1 (en) | 2013-11-22 | 2015-05-28 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and pharmaceutical compositions for treatment of a bacterial infection |
WO2015118407A2 (en) | 2014-01-29 | 2015-08-13 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Oligonucleotides and methods for inhibiting or reducing bacterial biofilms |
CA3043886A1 (en) * | 2016-11-16 | 2018-05-24 | Aivita Biomedical, Inc. | Use of cell membrane-bound signaling factors |
WO2018125746A1 (en) | 2016-12-30 | 2018-07-05 | Frequency Therapeutics, Inc. | 1h-pyrrole-2,5-dione compounds and methods of using them to induce self-renewal of stem/progenitor supporting cells |
WO2019048898A1 (en) | 2017-09-05 | 2019-03-14 | INSERM (Institut National de la Santé et de la Recherche Médicale) | PHARMACEUTICAL COMPOSITIONS FOR THE TREATMENT OF ENDOTHELIAL DYSFUNCTION |
US11261445B2 (en) | 2017-10-17 | 2022-03-01 | Inserm (Institut National De La Sante Et De La Recherche Medicale) | Combination treatment for cystic fibrosis |
NZ764440A (en) * | 2017-11-16 | 2024-03-22 | Aivita Biomedical Inc | Use of cell membrane-bound signaling factors |
KR102176832B1 (ko) * | 2017-11-29 | 2020-11-10 | 주식회사 파이안바이오테크놀로지 | 헤지호그 단백질 및 생체 적합성 물질을 포함하는 미세 입자 및 이를 포함하는 탈모 예방 또는 치료용 조성물 |
US20220251567A1 (en) | 2019-07-10 | 2022-08-11 | Inserm (Institut National De La Santè Et De La Recherche Médicale) | Methods for the treatment of epilepsy |
WO2021074657A1 (en) | 2019-10-17 | 2021-04-22 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Combination treatment for cystic fibrosis |
WO2021099394A1 (en) | 2019-11-19 | 2021-05-27 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Antisense oligonucleotides and their use for the treatment of cancer |
EP4179091A1 (en) | 2020-07-10 | 2023-05-17 | Institut National De La Sante Et De La Recherche Medicale - Inserm | Methods and compositions for treating epilepsy |
JPWO2022244502A1 (da) * | 2021-05-21 | 2022-11-24 | ||
WO2023152369A1 (en) | 2022-02-14 | 2023-08-17 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Nucleic acid mir-9 inhibitor for the treatment of cystic fibrosis |
WO2024017990A1 (en) | 2022-07-21 | 2024-01-25 | Institut National de la Santé et de la Recherche Médicale | Methods and compositions for treating chronic pain disorders |
Family Cites Families (57)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US456687A (en) * | 1891-07-28 | William bader | ||
US4456687A (en) | 1978-11-16 | 1984-06-26 | President And Fellows Of Harvard College | Agents for promoting growth of epithelial cells |
US4816567A (en) * | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
EP0249873B1 (en) | 1986-06-16 | 1993-07-28 | Daiichi Pharmaceutical Co., Ltd. | Therapeutic agent for skin ulcers |
JPH0745383B2 (ja) | 1986-09-30 | 1995-05-17 | 第一製薬株式会社 | 環状アデノシン誘導体含有毛髪用剤 |
AU1362488A (en) * | 1987-01-28 | 1988-08-24 | Peter H. Proctor | Topical composition and method for stimulating hair growth with stable free radicals |
DE68927933T2 (de) | 1988-09-02 | 1997-08-14 | Dyax Corp | Herstellung und auswahl von rekombinantproteinen mit verschiedenen bindestellen |
DE3942114C2 (de) | 1988-12-26 | 1997-09-04 | Hiroyoshi Hidaka | Verbindungen mit einer Wirkung für eine gleichmäßige Gefäßmuskelentspannung und pharmazeutische Zusammensetzung, die diese enthält |
JPH02273610A (ja) * | 1989-04-17 | 1990-11-08 | Chugai Pharmaceut Co Ltd | 発毛促進剤 |
US5789650A (en) * | 1990-08-29 | 1998-08-04 | Genpharm International, Inc. | Transgenic non-human animals for producing heterologous antibodies |
JPH04305528A (ja) * | 1991-02-22 | 1992-10-28 | Dai Ichi Seiyaku Co Ltd | ケラチノサイト及び皮膚線維芽細胞の増殖刺激剤 |
EP0575485A1 (en) | 1991-03-01 | 1993-12-29 | Dyax Corp. | Process for the development of binding mini-proteins |
US5223408A (en) | 1991-07-11 | 1993-06-29 | Genentech, Inc. | Method for making variant secreted proteins with altered properties |
WO1993019177A1 (en) * | 1992-03-18 | 1993-09-30 | The General Hospital Corporation | FOUR NOVEL RECEPTORS OF THE TGF-β RECEPTOR FAMILY |
JP2893029B2 (ja) | 1992-08-10 | 1999-05-17 | 旭化成工業株式会社 | 心臓保護剤 |
US6333168B1 (en) | 1993-05-20 | 2001-12-25 | The Trustees Of Columbia University In The City Of New York | Cloning, expression and uses of dorsalin-1 |
US5519035A (en) | 1993-07-02 | 1996-05-21 | Cornell Research Foundation, Inc. | Treatment of stroke or in anticipation of the occurrence of brain ischemia |
US6610656B1 (en) * | 1993-12-30 | 2003-08-26 | President And Fellows Of Harvard College | Method of promoting chondrocyte differentiation with hedgehog related polypeptides |
US5789543A (en) | 1993-12-30 | 1998-08-04 | President And Fellows Of Harvard College | Vertebrate embryonic pattern-inducing proteins and uses related thereto |
NZ278765A (en) | 1993-12-30 | 1998-05-27 | Harvard College | Vertebrate proteins involved in spatial arrangements of differentiated tissues called hedgehog proteins, their production and use |
US20030186357A1 (en) * | 1993-12-30 | 2003-10-02 | Philip W. Ingham | Vertebrate embryonic pattern-inducing proteins, and uses related thereto |
US6384192B1 (en) * | 1993-12-30 | 2002-05-07 | President & Fellows Of Harvard College | Vertebrate embryonic pattern-inducing proteins |
US6884775B1 (en) * | 1993-12-30 | 2005-04-26 | President And Fellows Of Harvard College | Methods and compositions for regulating skeletogenic formation |
US6165747A (en) * | 1993-12-30 | 2000-12-26 | President & Fellows Of Harvard College | Nucleic acids encoding hedgehog proteins |
US6261786B1 (en) * | 1993-12-30 | 2001-07-17 | Imperial Cancer Res. Technology | Screening assays for hedgehog agonists and antagonists |
US7060450B1 (en) * | 1993-12-30 | 2006-06-13 | President And Fellows Of Harvard College | Screening assays for agonists and antagonists of the hedgehog signaling pathway |
JPH09509574A (ja) | 1994-02-25 | 1997-09-30 | ザ・トラスティーズ・オブ・コランビア・ユニバーシティー・イン・ザ・シティー・オブ・ニューヨーク | 脊索によって発現されるヘッジホッグ、Vhh−1、の脊椎動物相同体をコードするDNA、及びこれらの使用 |
US5585087A (en) | 1994-06-08 | 1996-12-17 | President And Fellows Of Harvard College | Assay for identifying extracellular signaling proteins |
US5554608A (en) | 1994-09-28 | 1996-09-10 | Ahluwalia; Gurpreet S. | Inhibition of hair growth |
US6429354B1 (en) * | 1994-10-07 | 2002-08-06 | The Board Of Trustees Of The Leland Stanford Junior University | Patched genes and uses related thereto |
US6027882A (en) | 1994-10-07 | 2000-02-22 | The Regents Of The University Of California | Patched genes and their use for diagnostics |
US6946257B1 (en) * | 1994-10-07 | 2005-09-20 | Regents Of The University Of California | Patched genes and uses related thereto |
DE69534310T2 (de) * | 1994-10-07 | 2006-04-27 | The Board Of Trustees Of The Leland Stanford Junior University, Palo Alto | Ptc gene und ihre verwendung |
US6281332B1 (en) | 1994-12-02 | 2001-08-28 | The Johns Hopkins University School Of Medicine | Hedgehog-derived polypeptides |
US5643915A (en) | 1995-06-06 | 1997-07-01 | Andrulis Pharmaceuticals Corp. | Treatment of ischemia/reperfusion injury with thalidomide alone or in combination with other therapies |
CA2232299A1 (en) | 1995-09-21 | 1997-03-27 | The Trustees Of Columbia University In The City Of New York | Uses of bone morphogenetic proteins |
DK0935656T3 (da) | 1996-09-20 | 2006-12-11 | Harvard College | Hedgehog interagerende proteiner og anvendelser relateret dertil |
US5990281A (en) | 1996-09-30 | 1999-11-23 | Genentech, Inc. | Vertebrate smoothened proteins |
JP2002503088A (ja) | 1996-10-07 | 2002-01-29 | ザ ジョーンズ ホプキンス ユニバーシティー スクール オブ メディシン | 新規ヘッジホッグ由来ポリペプチド |
US5759811A (en) | 1996-11-13 | 1998-06-02 | The Regents Of The University Of California | Mutant human hedgehog gene |
JPH10194987A (ja) | 1997-01-14 | 1998-07-28 | Youtai Iwamoto | 骨・軟骨形成用組成物 |
DE69841320D1 (de) * | 1997-02-10 | 2010-01-07 | Harvard College | Verfahren zur modulation von hämatopoese und vaskulärem wachstum |
JPH114695A (ja) | 1997-04-25 | 1999-01-12 | Hayashibara Biochem Lab Inc | ヘッジホッグ蛋白質 |
EP0879888A3 (en) | 1997-05-23 | 1999-07-14 | Smithkline Beecham Plc | Patched-2 polypeptides and polynucleotides and methods for their production |
WO1999000117A2 (en) | 1997-06-27 | 1999-01-07 | Ontogeny, Inc. | Neuroprotective methods and reagents |
US6218144B1 (en) | 1997-06-30 | 2001-04-17 | The Board Of Trustees Of The Leland Stanford Junior University | Costal2 genes and their uses |
AU8380898A (en) | 1997-07-01 | 1999-01-25 | Ingham, Philip W | Vertebrate smoothened gene, gene products, and uses related thereto |
US7144997B2 (en) | 1997-07-24 | 2006-12-05 | Curis, Inc. | Vertebrate embryonic patterning-inducing proteins, compositions and uses related therto |
EP1009424A2 (en) | 1997-08-29 | 2000-06-21 | Ontogeny, Inc. | Regulation of muscle tissues by hedgehog-like polypeptides, and formulations and uses related thereto |
US6639051B2 (en) * | 1997-10-20 | 2003-10-28 | Curis, Inc. | Regulation of epithelial tissue by hedgehog-like polypeptides, and formulations and uses related thereto |
AU761298C (en) * | 1998-09-11 | 2005-04-21 | President And Fellows Of Harvard College | Regulation of lung tissue by hedgehog-like polypeptides, and formulations and uses related thereto |
ATE458497T1 (de) * | 1998-09-11 | 2010-03-15 | Curis Inc | Antagonisten von 'hedgehog' und 'patched' zur inhibierung des wachstums und der differenzierung von zellen und geweben, als auch deren verwendungen |
US6159950A (en) * | 1998-10-16 | 2000-12-12 | Cornell Research Foundation, Inc. | Method of modulating hair growth |
WO2001098344A2 (en) * | 2000-06-16 | 2001-12-27 | Curis, Inc. | Angiogenesis-modulating compositions and uses |
US7498304B2 (en) * | 2000-06-16 | 2009-03-03 | Curis, Inc. | Angiogenesis-modulating compositions and uses |
US7708998B2 (en) * | 2000-10-13 | 2010-05-04 | Curis, Inc. | Methods of inhibiting unwanted cell proliferation using hedgehog antagonists |
AU9684401A (en) * | 2000-10-13 | 2002-04-22 | Curis Inc | Hedgehog antagonists, methods and uses related thereto |
-
1998
- 1998-09-11 US US09/151,999 patent/US6639051B2/en not_active Expired - Lifetime
- 1998-10-20 KR KR1020007004253A patent/KR20010031266A/ko not_active Application Discontinuation
- 1998-10-20 CA CA2307322A patent/CA2307322C/en not_active Expired - Lifetime
- 1998-10-20 WO PCT/US1998/022227 patent/WO1999020298A1/en active IP Right Grant
- 1998-10-20 DK DK98953814T patent/DK1028741T3/da active
- 1998-10-20 EP EP98953814A patent/EP1028741B1/en not_active Expired - Lifetime
- 1998-10-20 AU AU11089/99A patent/AU760939B2/en not_active Expired
- 1998-10-20 AT AT98953814T patent/ATE257391T1/de active
- 1998-10-20 CN CN98812216A patent/CN1306436A/zh active Pending
- 1998-10-20 DE DE69821021T patent/DE69821021T2/de not_active Expired - Lifetime
- 1998-10-20 PT PT98953814T patent/PT1028741E/pt unknown
- 1998-10-20 JP JP2000516694A patent/JP2001520202A/ja active Pending
- 1998-10-20 ES ES98953814T patent/ES2214744T3/es not_active Expired - Lifetime
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2001
- 2001-02-19 HK HK01101169A patent/HK1030365A1/xx not_active IP Right Cessation
- 2001-04-05 US US09/827,110 patent/US20030104970A1/en not_active Abandoned
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2005
- 2005-07-15 US US11/182,691 patent/US20070110698A1/en not_active Abandoned
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2008
- 2008-07-03 US US12/217,329 patent/US20090118187A1/en not_active Abandoned
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2011
- 2011-12-19 US US13/330,631 patent/US20120238500A1/en not_active Abandoned
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2016
- 2016-02-09 CY CY2016003C patent/CY2016003I1/el unknown
- 2016-02-09 LU LU92977C patent/LU92977I2/xx unknown
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US20070110698A1 (en) | 2007-05-17 |
CA2307322C (en) | 2017-02-28 |
AU760939B2 (en) | 2003-05-22 |
KR20010031266A (ko) | 2001-04-16 |
US20030104970A1 (en) | 2003-06-05 |
US6639051B2 (en) | 2003-10-28 |
PT1028741E (pt) | 2004-05-31 |
EP1028741B1 (en) | 2004-01-07 |
ES2214744T3 (es) | 2004-09-16 |
LU92977I2 (fr) | 2016-04-11 |
CN1306436A (zh) | 2001-08-01 |
US20120238500A1 (en) | 2012-09-20 |
JP2001520202A (ja) | 2001-10-30 |
CY2016003I2 (el) | 2019-07-10 |
DE69821021T2 (de) | 2004-10-21 |
EP1028741A1 (en) | 2000-08-23 |
US20090118187A1 (en) | 2009-05-07 |
US20020151460A1 (en) | 2002-10-17 |
CA2307322A1 (en) | 1999-04-29 |
WO1999020298A1 (en) | 1999-04-29 |
DE69821021D1 (de) | 2004-02-12 |
HK1030365A1 (en) | 2001-05-04 |
AU1108999A (en) | 1999-05-10 |
ATE257391T1 (de) | 2004-01-15 |
CY2016003I1 (el) | 2019-07-10 |
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