PT1028741E - Regulacao de tecido epitelial por polipeptideos do tipo hedgehog e formulacoes e utilizacoes relacionadas com os mesmos - Google Patents
Regulacao de tecido epitelial por polipeptideos do tipo hedgehog e formulacoes e utilizacoes relacionadas com os mesmosInfo
- Publication number
- PT1028741E PT1028741E PT98953814T PT98953814T PT1028741E PT 1028741 E PT1028741 E PT 1028741E PT 98953814 T PT98953814 T PT 98953814T PT 98953814 T PT98953814 T PT 98953814T PT 1028741 E PT1028741 E PT 1028741E
- Authority
- PT
- Portugal
- Prior art keywords
- hedgehog
- polypeptidees
- utilizations
- formulations
- regulation
- Prior art date
Links
- 210000000981 epithelium Anatomy 0.000 title abstract 2
- 239000000203 mixture Substances 0.000 title 1
- 241000289669 Erinaceus europaeus Species 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 238000012423 maintenance Methods 0.000 abstract 1
- 229920001184 polypeptide Polymers 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 1
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0625—Epidermal cells, skin cells; Cells of the oral mucosa
- C12N5/0629—Keratinocytes; Whole skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/60—Sugars; Derivatives thereof
- A61K8/606—Nucleosides; Nucleotides; Nucleic acids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/14—Drugs for dermatological disorders for baldness or alopecia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q7/00—Preparations for affecting hair growth
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q7/00—Preparations for affecting hair growth
- A61Q7/02—Preparations for inhibiting or slowing hair growth
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/43504—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates
- C07K14/43563—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from insects
- C07K14/43577—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from insects from flies
- C07K14/43581—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from insects from flies from Drosophila
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/461—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from fish
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/465—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from birds
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4702—Regulators; Modulating activity
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0625—Epidermal cells, skin cells; Cells of the oral mucosa
- C12N5/0627—Hair cells
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/40—Regulators of development
- C12N2501/41—Hedgehog proteins; Cyclopamine (inhibitor)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/70—Enzymes
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- Dermatology (AREA)
- Pharmacology & Pharmacy (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Epidemiology (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Wood Science & Technology (AREA)
- Toxicology (AREA)
- Biotechnology (AREA)
- Biophysics (AREA)
- Insects & Arthropods (AREA)
- General Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Marine Sciences & Fisheries (AREA)
- Cell Biology (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Birds (AREA)
- Tropical Medicine & Parasitology (AREA)
- Gerontology & Geriatric Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US95555297A | 1997-10-20 | 1997-10-20 | |
US09/151,999 US6639051B2 (en) | 1997-10-20 | 1998-09-11 | Regulation of epithelial tissue by hedgehog-like polypeptides, and formulations and uses related thereto |
Publications (1)
Publication Number | Publication Date |
---|---|
PT1028741E true PT1028741E (pt) | 2004-05-31 |
Family
ID=26849158
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PT98953814T PT1028741E (pt) | 1997-10-20 | 1998-10-20 | Regulacao de tecido epitelial por polipeptideos do tipo hedgehog e formulacoes e utilizacoes relacionadas com os mesmos |
Country Status (16)
Country | Link |
---|---|
US (5) | US6639051B2 (pt) |
EP (1) | EP1028741B1 (pt) |
JP (1) | JP2001520202A (pt) |
KR (1) | KR20010031266A (pt) |
CN (1) | CN1306436A (pt) |
AT (1) | ATE257391T1 (pt) |
AU (1) | AU760939B2 (pt) |
CA (1) | CA2307322C (pt) |
CY (1) | CY2016003I1 (pt) |
DE (1) | DE69821021T2 (pt) |
DK (1) | DK1028741T3 (pt) |
ES (1) | ES2214744T3 (pt) |
HK (1) | HK1030365A1 (pt) |
LU (1) | LU92977I2 (pt) |
PT (1) | PT1028741E (pt) |
WO (1) | WO1999020298A1 (pt) |
Families Citing this family (61)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6639051B2 (en) * | 1997-10-20 | 2003-10-28 | Curis, Inc. | Regulation of epithelial tissue by hedgehog-like polypeptides, and formulations and uses related thereto |
TW570805B (en) | 1998-09-01 | 2004-01-11 | Hoffmann La Roche | Water-soluble pharmaceutical composition in an ionic complex |
CA2341683C (en) | 1998-09-11 | 2015-07-21 | President And Fellows Of Harvard College | Regulation of lung tissue by hedgehog-like polypeptides, and formulations and uses related thereto |
WO2000018428A2 (en) * | 1998-09-11 | 2000-04-06 | Biogen, Inc. | Hedgehog and patched antagonists for inhibiting cell and tissue growth and differentiation and uses therefor |
US6159950A (en) * | 1998-10-16 | 2000-12-12 | Cornell Research Foundation, Inc. | Method of modulating hair growth |
JP4574012B2 (ja) * | 1998-11-02 | 2010-11-04 | キュリス,インコーポレイテッド | ヘッジホッグ活性の機能的アンタゴニスト |
US6884427B1 (en) * | 1999-02-08 | 2005-04-26 | Aderans Research Institute, Inc. | Filamentary means for introducing agents into tissue of a living host |
AU782493B2 (en) * | 1999-06-01 | 2005-08-04 | Curis, Inc. | Polymer conjugates of hedgehog proteins and uses |
DE60016402T2 (de) * | 1999-06-08 | 2005-10-27 | Lorantis Ltd. | Therapeutische verwendung eines inhibitors des hedgehog signalübertragungsweges |
EP1216234B1 (en) * | 1999-09-16 | 2004-12-29 | Curis, Inc. | Mediators of hedgehog signaling pathways, compositions and uses related thereto |
US20070021493A1 (en) | 1999-09-16 | 2007-01-25 | Curis, Inc. | Mediators of hedgehog signaling pathways, compositions and uses related thereto |
AU2429201A (en) * | 1999-12-10 | 2001-06-18 | General Hospital Corporation, The | Methods to stimulate insulin production by pancreatic beta-cells |
JP5047437B2 (ja) * | 2000-02-08 | 2012-10-10 | サンガモ バイオサイエンシーズ, インコーポレイテッド | 薬物の発見のための細胞 |
US8852937B2 (en) | 2000-03-30 | 2014-10-07 | Curis, Inc. | Small organic molecule regulators of cell proliferation |
US7115653B2 (en) | 2000-03-30 | 2006-10-03 | Curis, Inc. | Small organic molecule regulators of cell proliferation |
WO2001079479A2 (en) * | 2000-04-14 | 2001-10-25 | Genencor International, Inc. | Methods for selective targeting |
CA2412215A1 (en) * | 2000-06-16 | 2001-12-27 | Curis, Inc. | Angiogenesis-modulating compositions and uses |
JP4017977B2 (ja) * | 2000-08-08 | 2007-12-05 | アデランス リサーチ インスティテュート インコーポレイテッド | 組織工学で処置した毛髪用の台 |
JP5196700B2 (ja) | 2000-10-13 | 2013-05-15 | キュリス,インコーポレイテッド | ヘッジホッグアンタゴニスト、それらに関する方法及び利用 |
US7708998B2 (en) | 2000-10-13 | 2010-05-04 | Curis, Inc. | Methods of inhibiting unwanted cell proliferation using hedgehog antagonists |
US20040068284A1 (en) * | 2002-01-29 | 2004-04-08 | Barrows Thomas H. | Method for stimulating hair growth and kit for carrying out said method |
US20060009409A1 (en) | 2002-02-01 | 2006-01-12 | Woolf Tod M | Double-stranded oligonucleotides |
EP2221377B2 (en) * | 2002-02-01 | 2017-05-17 | Life Technologies Corporation | Oligonucleotide compositions with enhanced efficiency |
AU2003206443A1 (en) * | 2002-02-20 | 2003-09-09 | Academisch Ziekenhuis Bij De Universiteit Van Amsterdam | Hedgehog-related prophylaxis, therapy and diagnosis of gi tract carcinogenesis |
JP2003267966A (ja) * | 2002-03-13 | 2003-09-25 | Pola Chem Ind Inc | フラバン誘導体、皮膚線維芽細胞増殖抑制剤および皮膚外用剤 |
EP1690936A1 (en) * | 2003-10-31 | 2006-08-16 | Renomedix Institute Inc. | Method of enhancing hematopoiesis-supporting ability of immortalized human bone marrow stroma cell by transferring indian hedgehog gene |
DK1730280T3 (en) * | 2004-03-26 | 2019-02-04 | Curis Inc | RNA interference modulators for hedgehog signaling and applications thereof |
US7597885B2 (en) | 2004-03-26 | 2009-10-06 | Aderans Research Institute, Inc. | Tissue engineered biomimetic hair follicle graft |
DE102004025881A1 (de) * | 2004-05-19 | 2006-01-05 | Beiersdorf Ag | Oligoribonukleotide zur Beeinflussung des Haarwachstums |
AR050212A1 (es) * | 2004-08-13 | 2006-10-04 | Aderans Res Inst Inc | Organogenesis a partir de celulas disociadas |
WO2006039569A1 (en) * | 2004-09-30 | 2006-04-13 | The University Of Chicago | Combination therapy of hedgehog inhibitors, radiation and chemotherapeutic agents |
US20060105950A1 (en) * | 2004-10-25 | 2006-05-18 | Caritas St. Elizabeth's Medical Center Of Boston, Inc. | Morphogen compositions and use thereof to treat wounds |
US20060293228A1 (en) * | 2005-06-24 | 2006-12-28 | Bhatnagar Rajendra S | Therapeutic compositions and methods using transforming growth factor-beta mimics |
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US20070148138A1 (en) | 2005-11-22 | 2007-06-28 | Aderans Research Institute, Inc. | Hair follicle graft from tissue engineered skin |
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WO2012036512A2 (ko) * | 2010-09-16 | 2012-03-22 | 연세대학교 산학협력단 | 중간엽 줄기세포의 연골 세포로의 분화 유도를 위한 화합물의 용도 |
JP2016509572A (ja) | 2012-11-05 | 2016-03-31 | プロナイ セラピューティクス インコーポレイテッド | Bcl2発現の調節による癌の処置のためにバイオマーカーを使用する方法 |
WO2015073691A1 (en) | 2013-11-14 | 2015-05-21 | The Board Of Trustees Of The Leland Stanford Junior University | Methods for treating cancer by activation of bmp signaling |
WO2015075166A1 (en) | 2013-11-22 | 2015-05-28 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and pharmaceutical compositions for treatment of a bacterial infection |
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-
1998
- 1998-09-11 US US09/151,999 patent/US6639051B2/en not_active Expired - Lifetime
- 1998-10-20 CN CN98812216A patent/CN1306436A/zh active Pending
- 1998-10-20 ES ES98953814T patent/ES2214744T3/es not_active Expired - Lifetime
- 1998-10-20 DE DE69821021T patent/DE69821021T2/de not_active Expired - Lifetime
- 1998-10-20 WO PCT/US1998/022227 patent/WO1999020298A1/en active IP Right Grant
- 1998-10-20 EP EP98953814A patent/EP1028741B1/en not_active Expired - Lifetime
- 1998-10-20 CA CA2307322A patent/CA2307322C/en not_active Expired - Lifetime
- 1998-10-20 DK DK98953814T patent/DK1028741T3/da active
- 1998-10-20 AT AT98953814T patent/ATE257391T1/de active
- 1998-10-20 PT PT98953814T patent/PT1028741E/pt unknown
- 1998-10-20 JP JP2000516694A patent/JP2001520202A/ja active Pending
- 1998-10-20 KR KR1020007004253A patent/KR20010031266A/ko not_active Application Discontinuation
- 1998-10-20 AU AU11089/99A patent/AU760939B2/en not_active Expired
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2001
- 2001-02-19 HK HK01101169A patent/HK1030365A1/xx not_active IP Right Cessation
- 2001-04-05 US US09/827,110 patent/US20030104970A1/en not_active Abandoned
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2005
- 2005-07-15 US US11/182,691 patent/US20070110698A1/en not_active Abandoned
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2008
- 2008-07-03 US US12/217,329 patent/US20090118187A1/en not_active Abandoned
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2011
- 2011-12-19 US US13/330,631 patent/US20120238500A1/en not_active Abandoned
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2016
- 2016-02-09 CY CY2016003C patent/CY2016003I1/el unknown
- 2016-02-09 LU LU92977C patent/LU92977I2/xx unknown
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US20120238500A1 (en) | 2012-09-20 |
DK1028741T3 (da) | 2004-05-17 |
US20070110698A1 (en) | 2007-05-17 |
US6639051B2 (en) | 2003-10-28 |
ATE257391T1 (de) | 2004-01-15 |
CY2016003I2 (el) | 2019-07-10 |
ES2214744T3 (es) | 2004-09-16 |
US20020151460A1 (en) | 2002-10-17 |
DE69821021D1 (de) | 2004-02-12 |
AU760939B2 (en) | 2003-05-22 |
LU92977I2 (fr) | 2016-04-11 |
EP1028741A1 (en) | 2000-08-23 |
JP2001520202A (ja) | 2001-10-30 |
CN1306436A (zh) | 2001-08-01 |
US20090118187A1 (en) | 2009-05-07 |
CA2307322C (en) | 2017-02-28 |
DE69821021T2 (de) | 2004-10-21 |
AU1108999A (en) | 1999-05-10 |
CA2307322A1 (en) | 1999-04-29 |
KR20010031266A (ko) | 2001-04-16 |
CY2016003I1 (el) | 2019-07-10 |
WO1999020298A1 (en) | 1999-04-29 |
EP1028741B1 (en) | 2004-01-07 |
HK1030365A1 (en) | 2001-05-04 |
US20030104970A1 (en) | 2003-06-05 |
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