DK1017713T3 - Cykliske antagonister af C5a-receptorer og G-protein-koblede receptorer - Google Patents
Cykliske antagonister af C5a-receptorer og G-protein-koblede receptorerInfo
- Publication number
- DK1017713T3 DK1017713T3 DK98930536T DK98930536T DK1017713T3 DK 1017713 T3 DK1017713 T3 DK 1017713T3 DK 98930536 T DK98930536 T DK 98930536T DK 98930536 T DK98930536 T DK 98930536T DK 1017713 T3 DK1017713 T3 DK 1017713T3
- Authority
- DK
- Denmark
- Prior art keywords
- receptors
- protein
- coupled receptors
- coupled
- cyclic antagonists
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/50—Cyclic peptides containing at least one abnormal peptide link
- C07K7/54—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring
- C07K7/56—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring the cyclisation not occurring through 2,4-diamino-butanoic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/472—Complement proteins, e.g. anaphylatoxin, C3a, C5a
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2299/00—Coordinates from 3D structures of peptides, e.g. proteins or enzymes
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Veterinary Medicine (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Immunology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Toxicology (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Rheumatology (AREA)
- Transplantation (AREA)
- Vascular Medicine (AREA)
- Physical Education & Sports Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Dermatology (AREA)
- Urology & Nephrology (AREA)
- Pulmonology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AUPO7550A AUPO755097A0 (en) | 1997-06-25 | 1997-06-25 | Receptor agonist and antagonist |
PCT/AU1998/000490 WO1999000406A1 (en) | 1997-06-25 | 1998-06-25 | CYCLIC AGONISTS AND ANTAGONISTS OF C5a RECEPTORS AND G PROTEIN-COUPLED RECEPTORS |
Publications (1)
Publication Number | Publication Date |
---|---|
DK1017713T3 true DK1017713T3 (da) | 2008-02-11 |
Family
ID=3801840
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK98930536T DK1017713T3 (da) | 1997-06-25 | 1998-06-25 | Cykliske antagonister af C5a-receptorer og G-protein-koblede receptorer |
Country Status (12)
Country | Link |
---|---|
US (5) | USRE41287E1 (pt) |
EP (1) | EP1017713B1 (pt) |
JP (1) | JP4686696B2 (pt) |
AT (1) | ATE377606T1 (pt) |
AU (2) | AUPO755097A0 (pt) |
CY (1) | CY1107133T1 (pt) |
DE (1) | DE69838678T2 (pt) |
DK (1) | DK1017713T3 (pt) |
ES (1) | ES2294816T3 (pt) |
HK (1) | HK1029595A1 (pt) |
PT (1) | PT1017713E (pt) |
WO (1) | WO1999000406A1 (pt) |
Families Citing this family (51)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AUPO755097A0 (en) | 1997-06-25 | 1997-07-17 | University Of Queensland, The | Receptor agonist and antagonist |
AUPQ339899A0 (en) | 1999-10-13 | 1999-11-04 | University Of Queensland, The | Novel molecules |
WO2002014265A1 (fr) | 2000-08-10 | 2002-02-21 | Mitsubishi Pharma Corporation | Nouveaux derives d'uree substitues en position 3, et leur utilisation en medecine |
PT1318140E (pt) | 2000-09-14 | 2011-05-26 | Mitsubishi Tanabe Pharma Corp | Novos derivados de amida e sua utiliza??o medicinal |
AUPR833401A0 (en) * | 2001-10-17 | 2001-11-08 | University Of Queensland, The | G protein-coupled receptor antagonists |
EP1492811B1 (en) | 2002-03-19 | 2011-09-21 | Cincinnati Childrens's Hospital Medical Center | Muteins of the c5a anaphylatoxin, nucleic acid molecules encoding such muteins, and pharmaceutical uses of muteins of the c5a anaphylatoxin |
JP2005530719A (ja) * | 2002-03-29 | 2005-10-13 | ニューロジェン コーポレーション | 病原性炎症要素を有する状態の治療のための組み合わせ療法 |
AUPS160602A0 (en) | 2002-04-08 | 2002-05-16 | University Of Queensland, The | Therapeutic method |
AU2002950657A0 (en) | 2002-08-08 | 2002-09-12 | Alchemia Limited | Derivatives of monosaccharides for drug discovery |
AU2003266858B2 (en) * | 2002-10-11 | 2006-09-14 | Vast Bioscience Pty Limited | Classes of compounds that interact with GPCRs |
AU2002951995A0 (en) * | 2002-10-11 | 2002-10-31 | Alchemia Limited | Classes of compounds that interact with gpcrs |
AU2002952086A0 (en) * | 2002-10-16 | 2002-11-07 | The University Of Queensland | Treatment of osteoarthritis |
US7410945B2 (en) * | 2002-10-16 | 2008-08-12 | The University Of Queensland | Treatment of inflammatory bowel disease |
AU2002952129A0 (en) * | 2002-10-17 | 2002-10-31 | The University Of Queensland | Treatment of hypersensitivity conditions |
AU2003902354A0 (en) * | 2003-05-15 | 2003-05-29 | Harkin, Denis W. | Treatment of haemorrhagic shock |
AU2003902586A0 (en) * | 2003-05-26 | 2003-06-12 | The University Of Queensland | Treatment of burns |
WO2005014849A2 (en) * | 2003-07-03 | 2005-02-17 | Euro-Celtique, S.A. | Genes associated with responses to neuropathic pain |
EP1498422A1 (de) * | 2003-07-17 | 2005-01-19 | Jerini AG | C5a-Rezeptor-Antagonisten |
JP2008516194A (ja) * | 2004-10-04 | 2008-05-15 | アルケミア リミティッド | 選択的阻害剤 |
WO2006074964A1 (en) * | 2005-01-17 | 2006-07-20 | Jerini Ag | C5a receptor antagonists |
AU2006223108A1 (en) * | 2005-03-11 | 2006-09-21 | Potentia Pharmaceuticals, Inc. | Compositions comprising modulators of G-protein-coupled receptor for treatment of macular degeneration |
EP1739078A1 (de) | 2005-05-30 | 2007-01-03 | Jerini AG | C5a-Rezeptor-Antagonisten |
US20070292421A1 (en) * | 2005-07-28 | 2007-12-20 | Feinberg Bruce B | Method for treating preeclampsia |
US8168584B2 (en) | 2005-10-08 | 2012-05-01 | Potentia Pharmaceuticals, Inc. | Methods of treating age-related macular degeneration by compstatin and analogs thereof |
ES2545775T3 (es) | 2007-02-05 | 2015-09-15 | Apellis Pharmaceuticals, Inc. | Análogos de compstatina para uso en el tratamiento de afecciones inflamatorias del sistema respiratorio |
US20110092446A1 (en) * | 2007-07-20 | 2011-04-21 | Cedric Francois | Compositions and methods for treatment of trauma |
EP2278987A4 (en) * | 2008-03-28 | 2012-08-22 | Apellis Ag | MODULATION AND REPLY / IMPROVEMENT OF THE COMPLEMENTARY SYSTEM IN THE TREATMENT OF TRAUMATISM |
US20100000604A1 (en) * | 2008-07-02 | 2010-01-07 | Saint-Gobain Performance Plastics Chaineux | Framed device, seal, and method for manufacturing same |
NZ614351A (en) | 2008-11-10 | 2015-05-29 | Alexion Pharma Inc | Methods and compositions for treating complement-associated disorders |
CA2825137A1 (en) * | 2010-01-22 | 2011-07-28 | University Of Louisville Research Foundation, Inc | Methods of treating or preventing periodontitis and diseases associated with periodontitis |
SG185383A1 (en) | 2010-04-30 | 2012-12-28 | Alexion Pharma Inc | Anti-c5a antibodies and methods for using the antibodies |
EP2588121A4 (en) | 2010-06-29 | 2013-12-04 | Univ Nebraska | C5A ANALOGUES AND METHODS OF USE THEREOF |
EP2468295A1 (en) | 2010-12-21 | 2012-06-27 | Affiris AG | Vaccines based on peptides of the complement protein C5a |
AU2012272706B2 (en) | 2011-06-22 | 2017-07-06 | Apellis Pharmaceuticals, Inc. | Methods of treating chronic disorders with complement inhibitors |
US9289467B2 (en) | 2011-08-10 | 2016-03-22 | Case Western Reserve University | Compositions and methods for treating bone conditions |
WO2014043223A1 (en) * | 2012-09-11 | 2014-03-20 | Hospital For Special Surgery | Irhom2 inhibition for the treatment of complement mediated disorders |
DK2920201T3 (da) | 2012-11-15 | 2020-04-14 | Apellis Pharmaceuticals Inc | Langtidsvirkende compstatin-analoger og relaterede sammensætninger og fremgangsmåder |
WO2014152391A1 (en) | 2013-03-15 | 2014-09-25 | Apellis Pharmaceuticals, Inc. | Cell-penetrating compstatin analogs and uses thereof |
AU2014248252A1 (en) * | 2013-04-02 | 2015-10-29 | M. Reza Ghadiri | Uses of cyclic peptides for treating and preventing atherosclerosis |
AU2014306002B2 (en) | 2013-08-07 | 2017-05-25 | Alexion Pharmaceuticals, Inc. | Atypical hemolytic uremic syndrome (aHUS) biomarker proteins |
WO2017062879A2 (en) | 2015-10-07 | 2017-04-13 | Apellis Pharmaceuticals, Inc. | Dosing regimens |
SG11201811412XA (en) | 2016-07-29 | 2019-02-27 | Pfizer | Cyclic peptides as c5 a receptor antagonists |
US20200057046A1 (en) | 2016-10-27 | 2020-02-20 | Alexion Pharmaceuticals, Inc. | Assay for c5b-9 deposition in complement-associated disorders |
TW202348249A (zh) | 2017-04-03 | 2023-12-16 | 德商因夫萊亞斯有限公司 | 使用c5a活性抑制劑於發炎性疾病之治療 |
US10376595B2 (en) | 2017-04-03 | 2019-08-13 | Inflarx Gmbh | Treatment of inflammatory diseases with inhibitors of C5a activity |
CN116059313A (zh) | 2017-04-07 | 2023-05-05 | 阿佩利斯制药有限公司 | 给药方案以及相关组合物和方法 |
KR20200020727A (ko) | 2017-06-23 | 2020-02-26 | 인플라알엑스 게엠베하 | C5a 활성의 억제제를 사용한 염증 질병의 치료 |
US20220356234A1 (en) | 2019-10-02 | 2022-11-10 | Alexion Pharmaceuticals, Inc. | Complement inhibitors for treating drug-induced complement-mediated response |
CA3172421A1 (en) | 2020-03-27 | 2021-09-30 | Niels C. Riedemann | Inhibitors of c5a for the treatment of corona virus infection |
CN115667925A (zh) | 2020-05-15 | 2023-01-31 | 阿雷克森制药公司 | 使用细胞外囊泡来检测补体激活的方法以及其用于评估和/或监测补体介导的疾病的治疗的用途 |
WO2023186054A1 (zh) * | 2022-04-02 | 2023-10-05 | 舒泰神(北京)生物制药股份有限公司 | 特异性识别c5a的抗体及其应用 |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5386011A (en) * | 1990-12-27 | 1995-01-31 | Abbott Laboratories | Hexapeptide anaphylatoxin-receptor ligands |
EP0733107A1 (en) * | 1993-12-06 | 1996-09-25 | Novartis AG | C5a RECEPTOR ANTAGONISTS HAVING SUBSTANTIALLY NO AGONIST ACTIVITY |
US5807824A (en) | 1993-12-06 | 1998-09-15 | Ciba-Geigy Corporation | C5A receptor antagonists having substantially no agonist activity |
US5614370A (en) * | 1994-03-18 | 1997-03-25 | Merck & Co., Inc. | Assay to identify human C5a antagonists and agonists |
US5696230A (en) | 1994-08-31 | 1997-12-09 | The Board Of Regents Of The University Of Nebraska | High-affinity response-selective C-terminal analogs of C5a anaphylatoxin |
AUPO755097A0 (en) | 1997-06-25 | 1997-07-17 | University Of Queensland, The | Receptor agonist and antagonist |
AUPR833401A0 (en) | 2001-10-17 | 2001-11-08 | University Of Queensland, The | G protein-coupled receptor antagonists |
AUPS160602A0 (en) * | 2002-04-08 | 2002-05-16 | University Of Queensland, The | Therapeutic method |
AU2002952086A0 (en) * | 2002-10-16 | 2002-11-07 | The University Of Queensland | Treatment of osteoarthritis |
-
1997
- 1997-06-25 AU AUPO7550A patent/AUPO755097A0/en not_active Abandoned
-
1998
- 1998-06-25 US US12/045,088 patent/USRE41287E1/en not_active Expired - Fee Related
- 1998-06-25 AT AT98930536T patent/ATE377606T1/de active
- 1998-06-25 PT PT98930536T patent/PT1017713E/pt unknown
- 1998-06-25 EP EP98930536A patent/EP1017713B1/en not_active Expired - Lifetime
- 1998-06-25 DK DK98930536T patent/DK1017713T3/da active
- 1998-06-25 AU AU80926/98A patent/AU744991B2/en not_active Ceased
- 1998-06-25 DE DE69838678T patent/DE69838678T2/de not_active Expired - Lifetime
- 1998-06-25 US US09/446,109 patent/US6821950B1/en not_active Expired - Lifetime
- 1998-06-25 WO PCT/AU1998/000490 patent/WO1999000406A1/en active IP Right Grant
- 1998-06-25 ES ES98930536T patent/ES2294816T3/es not_active Expired - Lifetime
- 1998-06-25 JP JP50515499A patent/JP4686696B2/ja not_active Expired - Fee Related
-
2001
- 2001-01-12 HK HK01100346A patent/HK1029595A1/xx unknown
-
2004
- 2004-09-10 US US10/937,852 patent/US20060160726A1/en not_active Abandoned
-
2008
- 2008-01-10 CY CY20081100033T patent/CY1107133T1/el unknown
- 2008-08-19 US US12/193,943 patent/US20090203760A1/en not_active Abandoned
-
2012
- 2012-01-12 US US13/348,869 patent/US20130005644A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
US20090203760A1 (en) | 2009-08-13 |
US20060160726A1 (en) | 2006-07-20 |
WO1999000406A1 (en) | 1999-01-07 |
HK1029595A1 (en) | 2001-04-06 |
DE69838678D1 (de) | 2007-12-20 |
USRE41287E1 (en) | 2010-04-27 |
EP1017713A4 (en) | 2002-07-24 |
CY1107133T1 (el) | 2012-10-24 |
US6821950B1 (en) | 2004-11-23 |
AUPO755097A0 (en) | 1997-07-17 |
DE69838678T2 (de) | 2008-10-30 |
PT1017713E (pt) | 2007-12-18 |
AU8092698A (en) | 1999-01-19 |
EP1017713B1 (en) | 2007-11-07 |
ATE377606T1 (de) | 2007-11-15 |
US20130005644A1 (en) | 2013-01-03 |
EP1017713A1 (en) | 2000-07-12 |
AU744991B2 (en) | 2002-03-07 |
JP4686696B2 (ja) | 2011-05-25 |
JP2002508767A (ja) | 2002-03-19 |
ES2294816T3 (es) | 2008-04-01 |
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