DK1012244T3 - Rhabdovira med genteknologisk manipulerede kapper - Google Patents
Rhabdovira med genteknologisk manipulerede kapperInfo
- Publication number
- DK1012244T3 DK1012244T3 DK98933339T DK98933339T DK1012244T3 DK 1012244 T3 DK1012244 T3 DK 1012244T3 DK 98933339 T DK98933339 T DK 98933339T DK 98933339 T DK98933339 T DK 98933339T DK 1012244 T3 DK1012244 T3 DK 1012244T3
- Authority
- DK
- Denmark
- Prior art keywords
- hiv
- recombinant
- virus
- receptor
- gene
- Prior art date
Links
- 241000700605 Viruses Species 0.000 abstract 3
- 108090000288 Glycoproteins Proteins 0.000 abstract 2
- 241000711975 Vesicular stomatitis virus Species 0.000 abstract 2
- 210000004027 cell Anatomy 0.000 abstract 2
- 102000003886 Glycoproteins Human genes 0.000 abstract 1
- 208000031886 HIV Infections Diseases 0.000 abstract 1
- 102000006481 HIV Receptors Human genes 0.000 abstract 1
- 108010083930 HIV Receptors Proteins 0.000 abstract 1
- 208000037357 HIV infectious disease Diseases 0.000 abstract 1
- 210000001744 T-lymphocyte Anatomy 0.000 abstract 1
- 230000002950 deficient Effects 0.000 abstract 1
- 208000033519 human immunodeficiency virus infectious disease Diseases 0.000 abstract 1
- 210000004779 membrane envelope Anatomy 0.000 abstract 1
- 230000001717 pathogenic effect Effects 0.000 abstract 1
- 229920001184 polypeptide Polymers 0.000 abstract 1
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 1
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 108020003175 receptors Proteins 0.000 abstract 1
- 102000005962 receptors Human genes 0.000 abstract 1
- 230000003362 replicative effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/16011—Human Immunodeficiency Virus, HIV
- C12N2740/16111—Human Immunodeficiency Virus, HIV concerning HIV env
- C12N2740/16122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/20011—Rhabdoviridae
- C12N2760/20041—Use of virus, viral particle or viral elements as a vector
- C12N2760/20043—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2810/00—Vectors comprising a targeting moiety
- C12N2810/50—Vectors comprising as targeting moiety peptide derived from defined protein
- C12N2810/60—Vectors comprising as targeting moiety peptide derived from defined protein from viruses
- C12N2810/6045—RNA rev transcr viruses
- C12N2810/6054—Retroviridae
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Virology (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- General Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Biophysics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Plant Pathology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Physics & Mathematics (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Oncology (AREA)
- Gastroenterology & Hepatology (AREA)
- Communicable Diseases (AREA)
- Microbiology (AREA)
- Tropical Medicine & Parasitology (AREA)
- AIDS & HIV (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Confectionery (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US5236697P | 1997-07-11 | 1997-07-11 | |
| PCT/US1998/014527 WO1999002657A1 (en) | 1997-07-11 | 1998-07-10 | Rhabdoviruses with reengineered coats |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK1012244T3 true DK1012244T3 (da) | 2007-09-10 |
Family
ID=21977148
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK98933339T DK1012244T3 (da) | 1997-07-11 | 1998-07-10 | Rhabdovira med genteknologisk manipulerede kapper |
Country Status (10)
| Country | Link |
|---|---|
| EP (1) | EP1012244B1 (da) |
| JP (1) | JP4434478B2 (da) |
| AT (1) | ATE361973T1 (da) |
| AU (1) | AU731663B2 (da) |
| CA (1) | CA2295858C (da) |
| DE (1) | DE69837764T2 (da) |
| DK (1) | DK1012244T3 (da) |
| ES (1) | ES2287977T3 (da) |
| PT (1) | PT1012244E (da) |
| WO (1) | WO1999002657A1 (da) |
Families Citing this family (66)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7485440B2 (en) | 1995-09-27 | 2009-02-03 | The United States Of America As Represented By The Department Of Health And Human Services | Production of attenuated respiratory syncytial virus vaccines involving modification of M2 ORF2 |
| US6699476B1 (en) | 1996-07-15 | 2004-03-02 | Peter L. Collins | Production of recombinant respiratory syncytial viruses expressing immune modulatory molecules |
| ATE451451T1 (de) | 1996-07-15 | 2009-12-15 | Us Gov Health & Human Serv | Herstellung von attenuierten respiratorischen syncytialvirus-impfstoffen aus klonierten nukleotidsequenzen |
| US20030082209A1 (en) | 2000-07-05 | 2003-05-01 | Skiadopoulos Mario H. | Attenuated human-bovine chimeric parainfluenza virus (PIV) vaccines |
| US7250171B1 (en) | 1997-05-23 | 2007-07-31 | United States Of America As Represented By The Dept. Of Health & Human Services | Construction and use of recombinant parainfluenza viruses expressing a chimeric glycoprotein |
| US7314631B1 (en) | 1997-05-23 | 2008-01-01 | The United States Of America As Represented By The Department Of Health And Human Services | Use of recombinant live-attenuated parainfluenza virus (PIV) as a vector to protect against disease caused by PIV and respiratory syncytial virus (RSV) |
| US7208161B1 (en) | 1997-05-23 | 2007-04-24 | The United States Of America, Represented By The Secretary, Department Of Health And Human Services | Production of attenuated parainfluenza virus vaccines from cloned nucleotide sequences |
| US7201907B1 (en) | 1997-05-23 | 2007-04-10 | The United States Of America, Represented By The Secretary, Department Of Health And Human Services | Attenuated human-bovine chimeric parainfluenza virus(PIV) vaccines |
| US7951383B2 (en) | 1997-05-23 | 2011-05-31 | The United States Of America As Represented By The Department Of Health And Human Services | Attenuated parainfluenza virus (PIV) vaccines |
| US7632508B2 (en) | 1997-05-23 | 2009-12-15 | The United States Of America | Attenuated human-bovine chimeric parainfluenza virus (PIV) vaccines |
| EP1085904B1 (en) | 1998-06-12 | 2012-11-28 | Mount Sinai School of Medicine | Attenuated negative strand viruses with altered interferon antagonist activity for use as vaccines and pharmaceuticals |
| DE69937999T2 (de) | 1998-06-12 | 2009-01-29 | Avir Green Hills Biotechnology Research Development Trade Ag | Interferon induzierende genetisch veränderte attenuierte viren |
| US6146642A (en) | 1998-09-14 | 2000-11-14 | Mount Sinai School Of Medicine, Of The City University Of New York | Recombinant new castle disease virus RNA expression systems and vaccines |
| US6544785B1 (en) | 1998-09-14 | 2003-04-08 | Mount Sinai School Of Medicine Of New York University | Helper-free rescue of recombinant negative strand RNA viruses |
| BR0013195A (pt) | 1999-07-09 | 2002-07-23 | Government Of The Us Dept Of H | Produção de vacinas de virus sincicial respiratório quimérico humano-bovino, atenuado |
| US8147822B1 (en) | 1999-09-17 | 2012-04-03 | Wellstat Biologics Corporation | Oncolytic virus |
| CA2386920C (en) * | 1999-09-17 | 2012-01-24 | Pro-Virus, Inc. | Oncolytic virus |
| EP1130089A1 (en) * | 2000-02-17 | 2001-09-05 | Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts | Composition comprising membrane virus subviral target and fusion particles and vaccine comprising said composition |
| US6764685B1 (en) | 2000-03-21 | 2004-07-20 | Medimmune Vaccines, Inc. | Recombinant parainfluenza virus expression systems and vaccines |
| AU2001257001A1 (en) | 2000-04-10 | 2001-10-23 | Mount Sinai School Of Medicine Of New York University | Screening methods for identifying viral proteins with interferon antagonizing functions and potential antiviral agents |
| CN101921732A (zh) | 2001-01-19 | 2010-12-22 | 维洛诺瓦蒂夫公司 | 在易感哺乳动物中引起呼吸道疾病的病毒 |
| US8715922B2 (en) | 2001-01-19 | 2014-05-06 | ViroNovative | Virus causing respiratory tract illness in susceptible mammals |
| JP4553589B2 (ja) | 2002-02-21 | 2010-09-29 | メディミューン，エルエルシー | 組換えパラインフルエンザウイルス発現系とメタニューモウイルスから得られる異種抗原を含むワクチン |
| AU2003231083A1 (en) | 2002-04-26 | 2003-11-10 | Medimmune, Llc | Multi plasmid system for the production of influenza virus |
| US7465456B2 (en) | 2002-04-26 | 2008-12-16 | Medimmune, Llc | Multi plasmid system for the production of influenza virus |
| CN101410519B (zh) | 2003-04-25 | 2013-04-24 | 免疫医疗有限责任公司 | 间质肺病毒株及其在疫苗制剂中以及用作抗原性序列表达载体的用途和繁殖病毒的方法 |
| EP1633312A4 (en) | 2003-06-16 | 2012-09-26 | Medimmune Llc | INFLUENZA HEMAGGLUTININE AND NEURAMINIDASE VARIANTS |
| ES2345492T3 (es) | 2003-12-23 | 2010-09-24 | Medimmune, Llc | Sistema multiplasmido para la produccion del virus de la gripe. |
| EP2465927B1 (en) | 2004-05-25 | 2014-12-24 | MedImmune, LLC | Influenza hemagglutinin and neuraminidase variants |
| EP1773384B1 (en) | 2004-06-01 | 2015-08-12 | Icahn School of Medicine at Mount Sinai | Genetically engineered swine influenza virus and uses thereof |
| US8137676B2 (en) | 2005-02-15 | 2012-03-20 | Mount Sinai School Of Medicine | Genetically engineered equine influenza virus and uses thereof |
| WO2006098901A2 (en) | 2005-03-08 | 2006-09-21 | Medimmune Vaccines, Inc. | Influenza hemagglutinin and neuraminidase variants |
| US7790434B2 (en) | 2005-06-21 | 2010-09-07 | Medimmune, Llc | Methods and compositions for expressing negative-sense viral RNA in canine cells |
| KR20080025171A (ko) | 2005-06-21 | 2008-03-19 | 메드이뮨 백신즈 인코포레이티드 | 이종성 프로테아제를 발현시키기 위한 방법 및 조성물 |
| KR101492643B1 (ko) | 2005-12-02 | 2015-02-12 | 이칸 스쿨 오브 메디슨 엣 마운트 시나이 | 비-천연 표면 단백질을 제시하는 키메라 바이러스 및 그의용도 |
| EP2016194B1 (en) | 2006-04-19 | 2015-04-08 | MedImmune, LLC | Methods and compositions for expressing negative-sense viral rna in canine cells |
| US7601356B2 (en) | 2006-07-21 | 2009-10-13 | Medimmune, Llc | Methods and compositions for increasing replication capacity of an influenza virus |
| CN104278014A (zh) | 2006-08-09 | 2015-01-14 | 米迪缪尼有限公司 | 流感血凝素和神经氨酸酶变体 |
| JP5666905B2 (ja) | 2007-06-18 | 2015-02-12 | メディミューン，エルエルシー | ヘマグルチニンポリペプチド中に変化を有するインフルエンザｂウイルス |
| EP2574344A1 (en) | 2008-07-11 | 2013-04-03 | MedImmune, LLC | Influenza hemagglutinin and neuraminidase variants |
| ES2550179T3 (es) | 2009-02-05 | 2015-11-05 | Icahn School Of Medicine At Mount Sinai | Virus quiméricos de la enfermedad de Newcastle y usos de los mismos |
| US8613935B2 (en) | 2009-02-12 | 2013-12-24 | Medimmune, Llc | Influenza hemagglutinin and neuraminidase variants |
| EP3009145A1 (en) | 2009-03-30 | 2016-04-20 | Mount Sinai School of Medicine of New York University | Influenza virus vaccines and uses thereof |
| DE102009024721A1 (de) | 2009-06-12 | 2010-12-16 | Erwin Bienek | Dezentrale Ladestation für batteriebetriebene Elektromobile |
| US9217157B2 (en) | 2009-07-27 | 2015-12-22 | Icahn School Of Medicine At Mount Sinai | Recombinant influenza viruses and uses thereof |
| WO2011014645A1 (en) | 2009-07-30 | 2011-02-03 | Mount Sinai School Of Medicine Of New York University | Influenza viruses and uses thereof |
| AU2011235220B2 (en) | 2010-03-30 | 2016-03-10 | Mount Sinai School Of Medicine | Influenza virus vaccines and uses thereof |
| KR20140068205A (ko) | 2011-09-20 | 2014-06-05 | 마운트 시나이 스쿨 오브 메디슨 | 인플루엔자 바이러스 백신 및 이의 용도 |
| NZ627796A (en) | 2012-12-18 | 2017-07-28 | Icahn School Med Mount Sinai | Influenza virus vaccines and uses thereof |
| JP6596411B2 (ja) | 2013-03-14 | 2019-10-23 | アイカーン スクール オブ メディシン アット マウント サイナイ | ニューカッスル病ウイルス及びその使用 |
| WO2014159960A1 (en) | 2013-03-14 | 2014-10-02 | Icahn School Of Medicine At Mount Sinai | Antibodies against influenza virus hemagglutinin and uses thereof |
| AU2015222685A1 (en) | 2014-02-27 | 2016-09-08 | Viralytics Limited | Combination method for treatment of cancer |
| AU2016209032A1 (en) | 2015-01-23 | 2017-08-10 | Icahn School Of Medicine At Mount Sinai | Influenza virus vaccination regimens |
| MX2017010908A (es) | 2015-02-26 | 2017-12-07 | Boehringer Ingelheim Vetmedica Gmbh | Vacuna bivalente contra el virus de gripe porcina. |
| EP3337504A1 (en) | 2015-08-20 | 2018-06-27 | University of Rochester | Live-attenuated vaccine having mutations in viral polymerase for the treatment and prevention of canine influenza virus |
| WO2017031408A1 (en) | 2015-08-20 | 2017-02-23 | University Of Rochester | Single-cycle virus for the development of canine influenza vaccines |
| WO2017031401A2 (en) | 2015-08-20 | 2017-02-23 | University Of Rochester | Ns1 truncated virus for the development of canine influenza vaccines |
| BR112018074910A2 (pt) | 2016-06-03 | 2019-03-12 | University Of Rochester | composição imunológica, e, método de indução de uma resposta imunológica contra o vírus da influenza equina em um sujeito |
| BR112018075032A2 (pt) | 2016-06-15 | 2019-03-26 | Icahn School Of Medicine At Mount Sinai | proteínas de hemaglutinina do vírus influenza e seus uso |
| CA3058652A1 (en) | 2017-04-07 | 2018-10-11 | Icahn School Of Medicine At Mount Sinai | Anti-influenza b virus neuraminidase antibodies and uses thereof |
| JOP20190256A1 (ar) | 2017-05-12 | 2019-10-28 | Icahn School Med Mount Sinai | فيروسات داء نيوكاسل واستخداماتها |
| EP3758748A1 (en) | 2018-02-27 | 2021-01-06 | University of Rochester | Multivalent live-attenuated influenza vaccine for prevention and control of equine influenza virus (eiv) in horses |
| US11166996B2 (en) | 2018-12-12 | 2021-11-09 | Flagship Pioneering Innovations V, Inc. | Anellovirus compositions and methods of use |
| MX2021010343A (es) | 2019-02-27 | 2022-01-18 | Univ Rochester | Vacuna para la influenza multivalente con virus vivo atenuado para la prevencion y el control del virus de la influenza equina (eiv) en caballos. |
| RU2769125C1 (ru) * | 2021-09-02 | 2022-03-28 | Федеральное бюджетное учреждение науки "Государственный научный центр вирусологии и биотехнологии "Вектор" Федеральной службы по надзору в сфере защиты прав потребителей и благополучия человека (ФБУН ГНЦ ВБ "Вектор" Роспотребнадзора) | Генетическая конструкция для экспрессии генов mNG_CD4-CCR5, рекомбинантная плазмида rVSV_mNG_CD4-CCR5 и рекомбинантный штамм вируса везикулярного стоматита rVSV_mNG_CD4-CCR5, обеспечивающий таргетный виролизис клеток, экспонирующих на своей поверхности белки gp120/gp41 ВИЧ-1 тропности R5 |
| RU2768032C1 (ru) * | 2021-09-02 | 2022-03-23 | Федеральное бюджетное учреждение науки "Государственный научный центр вирусологии и биотехнологии "Вектор" Федеральной службы по надзору в сфере защиты прав потребителей и благополучия человека (ФБУН ГНЦ ВБ "Вектор" Роспотребнадзора) | Генетическая конструкция для экспрессии генов mNG_CD4-CXCR4, рекомбинантная плазмида rVSV_mNG_CD4-CXCR4 и рекомбинантный штамм вируса везикулярного стоматита rVSV_mNG_CD4-CXCR4, обеспечивающий таргетный виролизис клеток, экспонирующих на своей поверхности белки gp120/gp 41 ВИЧ-1 тропности X4 |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0702085B2 (en) * | 1994-07-18 | 2010-01-13 | Conzelmann, Karl-Klaus, Prof. Dr. | Recombinant infectious non-segmented negative strand RNA virus |
-
1998
- 1998-07-10 AU AU83002/98A patent/AU731663B2/en not_active Expired
- 1998-07-10 ES ES98933339T patent/ES2287977T3/es not_active Expired - Lifetime
- 1998-07-10 DE DE69837764T patent/DE69837764T2/de not_active Expired - Lifetime
- 1998-07-10 JP JP2000502155A patent/JP4434478B2/ja not_active Expired - Lifetime
- 1998-07-10 AT AT98933339T patent/ATE361973T1/de active
- 1998-07-10 PT PT98933339T patent/PT1012244E/pt unknown
- 1998-07-10 CA CA2295858A patent/CA2295858C/en not_active Expired - Lifetime
- 1998-07-10 WO PCT/US1998/014527 patent/WO1999002657A1/en active IP Right Grant
- 1998-07-10 EP EP98933339A patent/EP1012244B1/en not_active Expired - Lifetime
- 1998-07-10 DK DK98933339T patent/DK1012244T3/da active
Also Published As
| Publication number | Publication date |
|---|---|
| EP1012244A1 (en) | 2000-06-28 |
| ES2287977T3 (es) | 2007-12-16 |
| EP1012244A4 (en) | 2004-09-15 |
| CA2295858A1 (en) | 1999-01-21 |
| AU731663B2 (en) | 2001-04-05 |
| DE69837764T2 (de) | 2008-01-31 |
| AU8300298A (en) | 1999-02-08 |
| EP1012244B1 (en) | 2007-05-09 |
| JP2003527064A (ja) | 2003-09-16 |
| JP4434478B2 (ja) | 2010-03-17 |
| PT1012244E (pt) | 2007-08-21 |
| WO1999002657A1 (en) | 1999-01-21 |
| DE69837764D1 (de) | 2007-06-21 |
| CA2295858C (en) | 2011-05-10 |
| ATE361973T1 (de) | 2007-06-15 |
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