DK1005538T3 - Kaliumkanalproteiner til anvendelse i genterapi til afhjælpning af erektil dysfunktion - Google Patents

Kaliumkanalproteiner til anvendelse i genterapi til afhjælpning af erektil dysfunktion

Info

Publication number
DK1005538T3
DK1005538T3 DK98906170T DK98906170T DK1005538T3 DK 1005538 T3 DK1005538 T3 DK 1005538T3 DK 98906170 T DK98906170 T DK 98906170T DK 98906170 T DK98906170 T DK 98906170T DK 1005538 T3 DK1005538 T3 DK 1005538T3
Authority
DK
Denmark
Prior art keywords
smooth muscle
regulation
protein involved
present
dna
Prior art date
Application number
DK98906170T
Other languages
Danish (da)
English (en)
Inventor
Arnold Melman
George J Christ
Jan Geliebter
Jamil Rehman
Original Assignee
Einstein Coll Med
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Einstein Coll Med filed Critical Einstein Coll Med
Application granted granted Critical
Publication of DK1005538T3 publication Critical patent/DK1005538T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/45—Transferases (2)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y207/00—Transferases transferring phosphorus-containing groups (2.7)
    • C12Y207/11—Protein-serine/threonine kinases (2.7.11)
    • C12Y207/11013—Protein kinase C (2.7.11.13)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Epidemiology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Reproductive Health (AREA)
  • Endocrinology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Gynecology & Obstetrics (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
DK98906170T 1997-02-13 1998-02-05 Kaliumkanalproteiner til anvendelse i genterapi til afhjælpning af erektil dysfunktion DK1005538T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/799,144 US6150338A (en) 1997-02-13 1997-02-13 Gene therapy for alleviating erectile dysfunction

Publications (1)

Publication Number Publication Date
DK1005538T3 true DK1005538T3 (da) 2005-11-07

Family

ID=25175134

Family Applications (1)

Application Number Title Priority Date Filing Date
DK98906170T DK1005538T3 (da) 1997-02-13 1998-02-05 Kaliumkanalproteiner til anvendelse i genterapi til afhjælpning af erektil dysfunktion

Country Status (12)

Country Link
US (1) US6150338A (de)
EP (1) EP1005538B1 (de)
JP (1) JP4158163B2 (de)
KR (1) KR100535782B1 (de)
AT (1) ATE299931T1 (de)
AU (1) AU745637B2 (de)
CA (1) CA2280770C (de)
DE (1) DE69830910T2 (de)
DK (1) DK1005538T3 (de)
ES (1) ES2246066T3 (de)
PT (1) PT1005538E (de)
WO (1) WO1998036055A1 (de)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6271211B1 (en) 1997-02-13 2001-08-07 Albert Einstein College Of Medicine Of Yeshiva University Gene therapy for regulating penile smooth muscle tone
US7030096B1 (en) * 1997-02-13 2006-04-18 Albert Einstein College Of Medicine Of Yeshiva University Method of enhancing relaxation of penile smooth muscle by introduction of DNA encoding maxi-K potassium channel protein
CA2330660C (en) * 1998-05-01 2012-04-10 University Of Pittsburgh Muscle-derived cell mediated gene delivery for treating muscle-and bone-related injury or dysfunction
US7115417B1 (en) 1998-05-01 2006-10-03 Chancellor Michael B Soft tissue and bone augmentation and bulking utilizing muscle-derived progenito compositions, and treatments thereof
US6866842B1 (en) 1998-05-01 2005-03-15 University Of Pittsburgh Muscle-derived cells (MDCs) for treating muscle-or bone-related injury or dysfunction
KR20010076961A (ko) * 2000-01-29 2001-08-17 김제종 성기능장애 예방 및 치료용 약제
AU5159901A (en) 2000-04-14 2001-10-30 Univ Pittsburgh Soft tissue and bone augmentation and bulking utilizing muscle-derived progenitor cells, compositions and treatments thereof
WO2002067867A2 (en) 2001-02-23 2002-09-06 The University Of Pittsburgh Rapid preparation of stem cell matrices for use in tissue and organ treatment and repair
CN1812800B (zh) 2003-04-25 2013-01-16 匹兹堡大学 用于促进和增强神经修复和再生的肌肉来源的细胞(mdc)
CN1621094A (zh) * 2003-11-26 2005-06-01 犹太大学阿尔伯特爱因斯坦医学院 用于调节平滑肌张力的基因转移
CA2674795C (en) 2007-01-11 2016-08-23 University Of Pittsburgh Muscle derived cells for the treatment of urinary tract pathologies and methods of making and using the same
US20090042208A1 (en) * 2007-07-31 2009-02-12 Davies Kelvin P Assays for erectile and bladder dysfunction and vascular health
US9199003B2 (en) 2008-08-18 2015-12-01 University of Pittsburgh—of the Commonwealth System of Higher Education Bone augmentation utilizing muscle-derived progenitor compositions in biocompatible matrix, and treatments thereof
CN102242973B (zh) * 2010-05-11 2013-10-09 爱烙达股份有限公司 热水器的储水桶
WO2020100089A2 (en) 2018-11-14 2020-05-22 Urovant Sciences Gmbh Compositions and methods for the treatment of smooth muscle dysfunction

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5324651A (en) * 1986-06-27 1994-06-28 Takeda Chemical Industries, Ltd. DNA encoding rat and human protein kinase C
JP2593476B2 (ja) * 1986-06-27 1997-03-26 武田薬品工業株式会社 Ｄｎａおよび形質転換体
DE3913954A1 (de) * 1989-04-27 1990-10-31 Stief Georg Arzneimittel zur behandlung erektiler dysfunktionen
US5594032A (en) * 1994-11-10 1997-01-14 Gonzalez-Cadavid; Nestor F. Amelioration of human erectile dysfunction by treatment with iNOS, inducers of iNOS or iNOS cDNA

Also Published As

Publication number Publication date
JP4158163B2 (ja) 2008-10-01
DE69830910T2 (de) 2006-04-20
KR20000071061A (ko) 2000-11-25
WO1998036055A1 (en) 1998-08-20
US6150338A (en) 2000-11-21
ES2246066T3 (es) 2006-02-01
JP2001517935A (ja) 2001-10-09
DE69830910D1 (de) 2005-08-25
AU6146898A (en) 1998-09-08
EP1005538B1 (de) 2005-07-20
CA2280770A1 (en) 1998-08-20
PT1005538E (pt) 2005-11-30
EP1005538A4 (de) 2002-12-04
EP1005538A1 (de) 2000-06-07
KR100535782B1 (ko) 2005-12-12
AU745637B2 (en) 2002-03-28
ATE299931T1 (de) 2005-08-15
CA2280770C (en) 2008-07-08

Similar Documents

Publication Publication Date Title
DK1005538T3 (da) Kaliumkanalproteiner til anvendelse i genterapi til afhjælpning af erektil dysfunktion
EE05138B1 (et) Rekombinantne MVA viirus ja selle kasutamine, isoleeritud eukarootne rakk, meetod rekombinantse HIV Nef-proteiini valmistamiseks ning vaktsiin
DE69840361D1 (de) Neue knochenmineralisierungsproteine, dna, vektoren, expressionssysteme
EP0414689A4 (en) Pox virus vectors
DK1200583T3 (da) Fremstilling af beta-foldeblad-proteiner med specifikke bindingsegenskaber
DE69434648D1 (de) Retroviraler vektor zum transfer und zur expression von therapeutischen genen in eukaryotezellen
EP1686181A3 (de) Verfahren zum verbesserten virusvermittelten DNA-Transfer unter Verwendung von Molekülen mit Virus- und Zell-bindenden Domänen
EP0169146A3 (de) Monoklonale Antikörper gegen den Rezeptor des menschlichen Rhinovirus
WO2003042362A3 (en) PGC-1β, A NOVEL PGC-1 HOMOLOGUE AND USES THEREFOR
DE69840333D1 (de) 2-m übergang des zellzyklus
ATE475713T1 (de) Trans-lentivirales vektor system
WO2000052164A3 (en) Potassium channel molecules and uses therefor
HUP9902585A2 (hu) Replikálódó molekulák in vivo előállítása
WO2001032872A3 (en) Twik potassium channel molecules and uses therefor
DE60124910D1 (de) Menschliche twik-8 moleküle und ihre verwendung
WO2002026983A3 (en) 56115, a novel human twik potassium channel and uses therefor
DE60234047D1 (de) 15603, ein mitglied der humanen ionenkanal-familie
Thiel et al. Intracellular cleavage of an SSV coded gag-related protein
MX9604240A (es) Transferencia mejorada de adn mediada por virus.