DK0979819T3 - Fremgangsmåde til fremstilling af substituerede 3-hydroxypiperidiner - Google Patents
Fremgangsmåde til fremstilling af substituerede 3-hydroxypiperidinerInfo
- Publication number
- DK0979819T3 DK0979819T3 DK99115243T DK99115243T DK0979819T3 DK 0979819 T3 DK0979819 T3 DK 0979819T3 DK 99115243 T DK99115243 T DK 99115243T DK 99115243 T DK99115243 T DK 99115243T DK 0979819 T3 DK0979819 T3 DK 0979819T3
- Authority
- DK
- Denmark
- Prior art keywords
- aryl
- preparation
- cycloalkyl
- chem
- alkyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/89—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members with hetero atoms directly attached to the ring nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D211/70—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/40—Oxygen atoms
- C07D211/42—Oxygen atoms attached in position 3 or 5
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/40—Oxygen atoms
- C07D211/44—Oxygen atoms attached in position 4
- C07D211/52—Oxygen atoms attached in position 4 having an aryl radical as the second substituent in position 4
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP98114974 | 1998-08-10 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK0979819T3 true DK0979819T3 (da) | 2008-08-04 |
Family
ID=8232435
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK99115243T DK0979819T3 (da) | 1998-08-10 | 1999-08-02 | Fremgangsmåde til fremstilling af substituerede 3-hydroxypiperidiner |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US6274735B1 (da) |
| EP (1) | EP0979819B1 (da) |
| JP (1) | JP3366289B2 (da) |
| KR (1) | KR100371727B1 (da) |
| CN (1) | CN1161335C (da) |
| AT (1) | ATE393144T1 (da) |
| CA (1) | CA2279779C (da) |
| DE (1) | DE69938577T2 (da) |
| DK (1) | DK0979819T3 (da) |
| ES (1) | ES2306493T3 (da) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6268499B1 (en) | 1998-08-10 | 2001-07-31 | Hoffman-La Roche Inc. | Process and intermediates for preparation of substituted piperidine-epoxides |
| MXPA04004772A (es) | 2001-11-19 | 2005-06-06 | Elan Pharm Inc | Piperidinas y piperazinas 3,4-disustituidas, 3,5-disustituidas y 3,4,5-sustituidas. |
| JP2006516149A (ja) | 2002-12-18 | 2006-06-22 | エフ エム シー コーポレーション | Ｎ−（置換アリールメチル）−４−（二置換メチル）ピペリジン及びピリジン |
| US6916833B2 (en) * | 2003-03-13 | 2005-07-12 | Hoffmann-La Roche Inc. | Substituted piperidines |
| EP1968940B1 (en) * | 2005-12-30 | 2014-04-02 | Novartis AG | 3 , 5-substitued piperidine compounds as renin inhibitors |
| US7638541B2 (en) | 2006-12-28 | 2009-12-29 | Metabolex Inc. | 5-ethyl-2-{4-[4-(4-tetrazol-1-yl-phenoxymethyl)-thiazol-2-yl]-piperidin-1-yl}-pyrimidine |
| EA016446B1 (ru) | 2007-06-25 | 2012-05-30 | Новартис Аг | Производные n5-(2-этоксиэтил)-n3-(2-пиридинил)-3,5-пиперидиндикарбоксамида, предназначенные для применения в качестве ингибиторов ренина |
| US8183381B2 (en) | 2007-07-19 | 2012-05-22 | Metabolex Inc. | N-linked heterocyclic receptor agonists for the treatment of diabetes and metabolic disorders |
| MX2010010562A (es) * | 2008-03-31 | 2010-12-07 | Metabolex Inc | Compuestos de oximetilen-arilo y uso de los mismos. |
| EP2303859A4 (en) * | 2008-06-20 | 2012-08-22 | Metabolex Inc | ARYL GPR119 AGONISTS AND USES THEREOF |
| ES2497566T3 (es) * | 2009-10-01 | 2014-09-23 | Cymabay Therapeutics, Inc. | Sales de tetrazol-1-il-fenoximetil-tiazol-2-il-piperidinil-pirimidina sustituida |
| EP2585048B1 (en) | 2010-06-23 | 2018-04-11 | CymaBay Therapeutics, Inc. | Compositions of 5-ethyl-2-{4-[4-(4-tetrazol-1-yl-phenoxymethyl)-thiazol-2-yl]-piperidin-1-yl}-pyrimidine |
| KR20190035752A (ko) | 2016-08-03 | 2019-04-03 | 사이머베이 쎄라퓨틱스, 인코퍼레이티드 | 염증성 위장 질환 또는 위장 상태를 치료하기 위한 옥시메틸렌 아릴 화합물 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4132710A (en) * | 1976-12-20 | 1979-01-02 | Ayerst, Mckenna And Harrison, Ltd. | [2]Benzopyrano[3,4-c]pyridines and process therefor |
| KR100384979B1 (ko) | 1995-09-07 | 2003-10-17 | 에프. 호프만-라 로슈 아게 | 심부전증및신부전증치료용의신규한4-(옥시알콕시페닐)-3-옥시-피페리딘 |
-
1999
- 1999-07-01 US US09/345,917 patent/US6274735B1/en not_active Expired - Fee Related
- 1999-08-02 EP EP99115243A patent/EP0979819B1/en not_active Expired - Lifetime
- 1999-08-02 DE DE69938577T patent/DE69938577T2/de not_active Expired - Lifetime
- 1999-08-02 AT AT99115243T patent/ATE393144T1/de not_active IP Right Cessation
- 1999-08-02 DK DK99115243T patent/DK0979819T3/da active
- 1999-08-02 ES ES99115243T patent/ES2306493T3/es not_active Expired - Lifetime
- 1999-08-06 CA CA002279779A patent/CA2279779C/en not_active Expired - Fee Related
- 1999-08-09 CN CNB99117531XA patent/CN1161335C/zh not_active Expired - Fee Related
- 1999-08-09 JP JP22474499A patent/JP3366289B2/ja not_active Expired - Fee Related
- 1999-08-09 KR KR10-1999-0032561A patent/KR100371727B1/ko not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| ES2306493T3 (es) | 2008-11-01 |
| DE69938577D1 (de) | 2008-06-05 |
| US6274735B1 (en) | 2001-08-14 |
| KR100371727B1 (ko) | 2003-02-07 |
| ATE393144T1 (de) | 2008-05-15 |
| EP0979819B1 (en) | 2008-04-23 |
| KR20000017192A (ko) | 2000-03-25 |
| EP0979819A1 (en) | 2000-02-16 |
| DE69938577T2 (de) | 2009-06-04 |
| CA2279779C (en) | 2005-03-15 |
| JP2000063355A (ja) | 2000-02-29 |
| CN1161335C (zh) | 2004-08-11 |
| JP3366289B2 (ja) | 2003-01-14 |
| CA2279779A1 (en) | 2000-02-10 |
| CN1245800A (zh) | 2000-03-01 |
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