DK0975638T3 - Sidekædemodificerede epothiloner - Google Patents

Sidekædemodificerede epothiloner

Info

Publication number
DK0975638T3
DK0975638T3 DK98912388T DK98912388T DK0975638T3 DK 0975638 T3 DK0975638 T3 DK 0975638T3 DK 98912388 T DK98912388 T DK 98912388T DK 98912388 T DK98912388 T DK 98912388T DK 0975638 T3 DK0975638 T3 DK 0975638T3
Authority
DK
Denmark
Prior art keywords
chain modified
modified epothilones
epothilones
chain
modified
Prior art date
Application number
DK98912388T
Other languages
Danish (da)
English (en)
Inventor
Gerhard Hoefle
Michael Sefkow
Original Assignee
Biotechnolog Forschung Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biotechnolog Forschung Gmbh filed Critical Biotechnolog Forschung Gmbh
Application granted granted Critical
Publication of DK0975638T3 publication Critical patent/DK0975638T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Epoxy Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Silicon Polymers (AREA)
  • Polyesters Or Polycarbonates (AREA)
  • Other Resins Obtained By Reactions Not Involving Carbon-To-Carbon Unsaturated Bonds (AREA)
DK98912388T 1997-02-25 1998-02-25 Sidekædemodificerede epothiloner DK0975638T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19707505 1997-02-25
PCT/EP1998/001060 WO1998038192A1 (de) 1997-02-25 1998-02-25 Seitenkettenmodifizierte epothilone

Publications (1)

Publication Number Publication Date
DK0975638T3 true DK0975638T3 (da) 2002-11-18

Family

ID=7821415

Family Applications (1)

Application Number Title Priority Date Filing Date
DK98912388T DK0975638T3 (da) 1997-02-25 1998-02-25 Sidekædemodificerede epothiloner

Country Status (24)

Country Link
US (1) US6359140B1 (cs)
EP (2) EP0975638B1 (cs)
JP (1) JP2001513098A (cs)
KR (1) KR100494179B1 (cs)
CN (2) CN1544436A (cs)
AR (1) AR011878A1 (cs)
AT (1) ATE221888T1 (cs)
AU (1) AU736062B2 (cs)
BR (1) BR9807742B1 (cs)
CA (1) CA2281105A1 (cs)
CZ (1) CZ298027B6 (cs)
DE (2) DE59805110D1 (cs)
DK (1) DK0975638T3 (cs)
ES (1) ES2183338T3 (cs)
HU (1) HU228851B1 (cs)
IL (1) IL131343A (cs)
NO (1) NO327211B1 (cs)
NZ (1) NZ337195A (cs)
PL (1) PL190422B1 (cs)
PT (1) PT975638E (cs)
RU (1) RU2201932C2 (cs)
TW (1) TW480263B (cs)
WO (1) WO1998038192A1 (cs)
ZA (1) ZA981575B (cs)

Families Citing this family (98)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE59609305D1 (de) 1995-11-17 2002-07-11 Biotechnolog Forschung Gmbh Epothilon-Derivate und deren Herstellung
NZ335383A (en) 1996-11-18 2000-10-27 Biotechnolog Forschung Gmbh Epothilone C,D,E and F for plant protection and cytostatic effects shown in kidney cells
US6867305B2 (en) 1996-12-03 2005-03-15 Sloan-Kettering Institute For Cancer Research Synthesis of epothilones, intermediates thereto and analogues thereof
US20050043376A1 (en) * 1996-12-03 2005-02-24 Danishefsky Samuel J. Synthesis of epothilones, intermediates thereto, analogues and uses thereof
CA2273083C (en) * 1996-12-03 2012-09-18 Sloan-Kettering Institute For Cancer Research Synthesis of epothilones, intermediates thereto, analogues and uses thereof
US6204388B1 (en) 1996-12-03 2001-03-20 Sloan-Kettering Institute For Cancer Research Synthesis of epothilones, intermediates thereto and analogues thereof
US6380394B1 (en) 1996-12-13 2002-04-30 The Scripps Research Institute Epothilone analogs
US6441186B1 (en) * 1996-12-13 2002-08-27 The Scripps Research Institute Epothilone analogs
US6660758B1 (en) 1996-12-13 2003-12-09 The Scripps Research Institute Epothilone analogs
KR100494179B1 (ko) * 1997-02-25 2005-06-10 게젤샤프트 퓌어 비오테크놀로기쉐 포르슝 엠베하(게베에프) 변환된 측쇄를 가진 에포틸론
US6605599B1 (en) 1997-07-08 2003-08-12 Bristol-Myers Squibb Company Epothilone derivatives
US6320045B1 (en) 1997-12-04 2001-11-20 Bristol-Myers Squibb Company Process for the reduction of oxiranyl epothilones to olefinic epothilones
US6365749B1 (en) 1997-12-04 2002-04-02 Bristol-Myers Squibb Company Process for the preparation of ring-opened epothilone intermediates which are useful for the preparation of epothilone analogs
US6683100B2 (en) 1999-01-19 2004-01-27 Novartis Ag Organic compounds
US6498257B1 (en) 1998-04-21 2002-12-24 Bristol-Myers Squibb Company 2,3-olefinic epothilone derivatives
US6399638B1 (en) 1998-04-21 2002-06-04 Bristol-Myers Squibb Company 12,13-modified epothilone derivatives
DE19826988A1 (de) * 1998-06-18 1999-12-23 Biotechnolog Forschung Gmbh Epothilon-Nebenkomponenten
ES2175575T3 (es) * 1998-08-05 2002-11-16 Biotechnolog Forschung Gmbh Agentes farmaceuticos que contienen n-oxido de epotilona a y/o n-oxidode epotilona b.
US6780620B1 (en) 1998-12-23 2004-08-24 Bristol-Myers Squibb Company Microbial transformation method for the preparation of an epothilone
US6596875B2 (en) 2000-02-07 2003-07-22 James David White Method for synthesizing epothilones and epothilone analogs
DE19907588A1 (de) * 1999-02-22 2000-08-24 Biotechnolog Forschung Gmbh C-21 Modifizierte Epothilone
TWI270546B (en) 1999-02-22 2007-01-11 Bristol Myers Squibb Co C-21 modified epothilones
US20020058286A1 (en) * 1999-02-24 2002-05-16 Danishefsky Samuel J. Synthesis of epothilones, intermediates thereto and analogues thereof
US6291684B1 (en) 1999-03-29 2001-09-18 Bristol-Myers Squibb Company Process for the preparation of aziridinyl epothilones from oxiranyl epothilones
US7125875B2 (en) 1999-04-15 2006-10-24 Bristol-Myers Squibb Company Cyclic protein tyrosine kinase inhibitors
IL144910A0 (en) 1999-04-15 2002-06-30 Bristol Myers Squibb Co Cyclic compounds and pharmaceutical compositions containing the same
PE20010116A1 (es) * 1999-04-30 2001-02-15 Schering Ag Derivados de 6-alquenil-, 6-alquinil- y 6-epoxi-epotilona, procedimientos para su preparacion
AU772750C (en) * 1999-04-30 2005-02-24 Schering Aktiengesellschaft 6-alkenyl-, 6-alkinyl- and 6-epoxy-epothilone derivatives, process for their production, and their use in pharmaceutical preparations
WO2001024763A2 (en) 1999-10-01 2001-04-12 Immunogen, Inc. Compositions and methods for treating cancer using immunoconjugates and chemotherapeutic agents
US6518421B1 (en) 2000-03-20 2003-02-11 Bristol-Myers Squibb Company Process for the preparation of epothilone analogs
US6593115B2 (en) 2000-03-24 2003-07-15 Bristol-Myers Squibb Co. Preparation of epothilone intermediates
US6589968B2 (en) * 2001-02-13 2003-07-08 Kosan Biosciences, Inc. Epothilone compounds and methods for making and using the same
UA75365C2 (en) 2000-08-16 2006-04-17 Bristol Myers Squibb Co Epothilone analog polymorph modifications, a method for obtaining thereof (variants), a pharmaceutical composition based thereon
RU2003126171A (ru) 2001-01-25 2005-02-27 Бристол-Маерс Сквибб Компани (Us) Парентеральный состав, содержащий аналоги эпотилона
WO2002058699A1 (en) * 2001-01-25 2002-08-01 Bristol-Myers Squibb Company Pharmaceutical forms of epothilones for oral administration
ATE389401T1 (de) 2001-01-25 2008-04-15 Bristol Myers Squibb Co Verfahren zur herstellung von pharmazeutischen zusammensetzungen enthaltend epothilon-analoga zur krebsbehandlung
US6893859B2 (en) * 2001-02-13 2005-05-17 Kosan Biosciences, Inc. Epothilone derivatives and methods for making and using the same
BR0207487A (pt) 2001-02-20 2004-08-10 Brystol Myers Squibb Company Método de tratamento de tumores em mamìferos e uso de compostos de epotilona
BR0207316A (pt) 2001-02-20 2004-02-10 Bristol Myers Squibb Co Derivados de epotilona para o tratamento de tumores refratários
ATE335746T1 (de) * 2001-02-27 2006-09-15 Biotechnolog Forschung Gmbh Verfahren zur herstellung von epothilonen
CN1496256A (zh) 2001-03-14 2004-05-12 ����˹�ж�-����˹˹������˾ 用于治疗增生性疾病的埃博霉素(epo thilone)类似物和化疗剂的组合
EP1392664A4 (en) 2001-06-01 2005-01-26 Bristol Myers Squibb Co EPOTHILONE DERIVATIVES
TW200303202A (en) 2002-02-15 2003-09-01 Bristol Myers Squibb Co Method of preparation of 21-amino epothilone derivatives
DE60316775T2 (de) * 2002-03-08 2008-04-30 Novartis Ag Kombinationspräparat aus epothilone derivate und imidazotetrazinone
US7211593B2 (en) 2002-03-12 2007-05-01 Bristol-Myers Squibb Co. C12-cyano epothilone derivatives
SI1483251T1 (sl) 2002-03-12 2010-03-31 Bristol Myers Squibb Co C cian epotilonski derivati
TW200403994A (en) 2002-04-04 2004-03-16 Bristol Myers Squibb Co Oral administration of EPOTHILONES
TW200400191A (en) 2002-05-15 2004-01-01 Bristol Myers Squibb Co Pharmaceutical compositions and methods of using C-21 modified epothilone derivatives
US7405234B2 (en) 2002-05-17 2008-07-29 Bristol-Myers Squibb Company Bicyclic modulators of androgen receptor function
AU2003243561A1 (en) 2002-06-14 2003-12-31 Bristol-Myers Squibb Company Combination of epothilone analogs and chemotherapeutic agents for the treatment of proliferative diseases
ATE450534T1 (de) 2002-08-23 2009-12-15 Sloan Kettering Inst Cancer Synthese von epothilonen, zwischenprodukte davon, analoga und ihre verwendung
US6921769B2 (en) 2002-08-23 2005-07-26 Sloan-Kettering Institute For Cancer Research Synthesis of epothilones, intermediates thereto and analogues thereof
US7649006B2 (en) 2002-08-23 2010-01-19 Sloan-Kettering Institute For Cancer Research Synthesis of epothilones, intermediates thereto and analogues thereof
GB0221312D0 (en) * 2002-09-13 2002-10-23 Novartis Ag Organic compounds
CA2695720C (en) 2002-09-23 2013-04-02 Bristol-Myers Squibb Company Method of producing epothilone b by culturing sorangium cellulosum in a medium comprising propionic acid
AU2003302084A1 (en) 2002-11-15 2004-06-15 Bristol-Myers Squibb Company Open chain prolyl urea-related modulators of androgen receptor function
US7820702B2 (en) 2004-02-04 2010-10-26 Bristol-Myers Squibb Company Sulfonylpyrrolidine modulators of androgen receptor function and method
US7378426B2 (en) 2004-03-01 2008-05-27 Bristol-Myers Squibb Company Fused heterotricyclic compounds as inhibitors of 17β-hydroxysteroid dehydrogenase 3
US7696241B2 (en) 2004-03-04 2010-04-13 Bristol-Myers Squibb Company Bicyclic compounds as modulators of androgen receptor function and method
US7625923B2 (en) 2004-03-04 2009-12-01 Bristol-Myers Squibb Company Bicyclic modulators of androgen receptor function
DE602005007376D1 (de) * 2004-11-18 2008-07-17 Bristol Myers Squibb Co Magensaftresistent beschichtetes pellet mit ixabepilon
US20060134214A1 (en) * 2004-11-18 2006-06-22 Ismat Ullah Enteric coated bead comprising epothilone or epothilone analog, and preparation and administration thereof
CA2607940C (en) 2005-05-18 2009-12-15 Aegera Therapeutics Inc. Bir domain binding compounds
CN101535300B (zh) 2006-05-16 2014-05-28 埃格拉医疗公司 Iap bir域结合化合物
CA2671492A1 (en) 2006-12-04 2008-06-12 The Board Of Trustees Of The University Of Illinois Compositions and methods to treat cancer with cupredoxins and cpg rich dna
RU2567544C2 (ru) 2010-02-12 2015-11-10 Фармасайенс Инк. Bir домен iap связывающие соединения
EA035193B1 (ru) 2010-05-18 2020-05-14 Серулин Фарма Инк. Композиции и способы лечения аутоиммунных и других заболеваний
AU2012207142B2 (en) 2011-01-20 2017-04-27 Board Of Regents, The University Of Texas System MRI markers, delivery and extraction systems, and methods of manufacture and use thereof
EP3228325A1 (en) 2011-06-10 2017-10-11 Mersana Therapeutics, Inc. Protein-polymer-drug conjugates
CN102863474A (zh) 2011-07-09 2013-01-09 陈小平 一类治疗细胞增殖性疾病的铂化合物、其制备方法和应用
CN102993239A (zh) 2011-09-19 2013-03-27 陈小平 离去基团含氨基或烷胺基的丁二酸衍生物的铂类化合物
US9725477B2 (en) 2012-11-17 2017-08-08 Beijing Fswelcome Technology Development Co., Ltd Platinum compounds of malonic acid derivative having leaving group containing amino or alkylamino
WO2014093394A1 (en) 2012-12-10 2014-06-19 Mersana Therapeutics, Inc. Protein-polymer-drug conjugates
WO2014093640A1 (en) 2012-12-12 2014-06-19 Mersana Therapeutics,Inc. Hydroxy-polmer-drug-protein conjugates
SG11201509350RA (en) 2013-06-11 2015-12-30 Bayer Pharma AG Combinations for the treatment of cancer comprising a mps-1 kinase inhibitor and a mitotic inhibitor
WO2015054669A1 (en) 2013-10-11 2015-04-16 Asana Biosciences, Llc Protein-polymer-drug conjugates
US9849191B2 (en) 2013-10-11 2017-12-26 Mersana Therapeutics, Inc. Protein-polymer-drug conjugates
WO2018004338A1 (en) 2016-06-27 2018-01-04 Tagworks Pharmaceuticals B.V. Cleavable tetrazine used in bio-orthogonal drug activation
US11135307B2 (en) 2016-11-23 2021-10-05 Mersana Therapeutics, Inc. Peptide-containing linkers for antibody-drug conjugates
AU2018290330A1 (en) 2017-06-22 2020-01-02 Mersana Therapeutics, Inc. Methods of producing drug-carrying polymer scaffolds and protein-polymer-drug conjugates
EP3788032B1 (en) 2018-05-04 2024-01-24 Tagworks Pharmaceuticals B.V. Compounds comprising a linker for increasing transcyclooctene stability
US20210299286A1 (en) 2018-05-04 2021-09-30 Tagworks Pharmaceuticals B.V. Tetrazines for high click conjugation yield in vivo and high click release yield
EP3873534A1 (en) 2018-10-29 2021-09-08 Mersana Therapeutics, Inc. Cysteine engineered antibody-drug conjugates with peptide-containing linkers
DK3983363T3 (da) 2019-06-17 2024-06-24 Tagworks Pharmaceuticals B V Forbindelser til hurtig og effektiv klikfrigivelse
IL289094A (en) 2019-06-17 2022-02-01 Tagworks Pharmaceuticals B V Tetrazines for increasing the speed and yield of the "click release" reaction
WO2023031445A2 (en) 2021-09-06 2023-03-09 Veraxa Biotech Gmbh Novel aminoacyl-trna synthetase variants for genetic code expansion in eukaryotes
DK4186529T3 (da) 2021-11-25 2025-08-25 Veraxa Biotech Gmbh Forbedrede antistof-payload-konjugater (apc) fremstillet ved stedspecifik konjugering ved hjælp af genetisk kodeudvidelse
WO2023094525A1 (en) 2021-11-25 2023-06-01 Veraxa Biotech Gmbh Improved antibody-payload conjugates (apcs) prepared by site-specific conjugation utilizing genetic code expansion
WO2023104941A1 (en) 2021-12-08 2023-06-15 European Molecular Biology Laboratory Hydrophilic tetrazine-functionalized payloads for preparation of targeting conjugates
EP4314031B1 (en) 2022-02-15 2024-03-13 Tagworks Pharmaceuticals B.V. Masked il12 protein
EP4554624A1 (en) 2022-07-15 2025-05-21 Pheon Therapeutics Ltd Antibody-drug conjugates
IL320221A (en) 2022-10-12 2025-06-01 Tagworks Pharmaceuticals B V Strained bicyclo-nonanes
CN120569216A (zh) 2023-01-20 2025-08-29 巴斯夫欧洲公司 稳定型生物聚合物组合物、其制造和用途
WO2024191293A1 (en) 2023-03-10 2024-09-19 Tagworks Pharmaceuticals B.V. Trans-cyclooctene with improved t-linker
WO2025021929A1 (en) 2023-07-27 2025-01-30 Veraxa Biotech Gmbh Hydrophilic trans-cyclooctene (hytco) compounds, constructs and conjugates containing the same
WO2025056807A1 (en) 2023-09-15 2025-03-20 Basf Se Stabilized biopolymer composition, their manufacture and use
WO2025149667A1 (en) 2024-01-12 2025-07-17 Pheon Therapeutics Ltd Antibody drug conjugates and uses thereof
WO2025174248A1 (en) 2024-02-16 2025-08-21 Tagworks Pharmaceuticals B.V. Trans-cyclooctenes with "or gate" release

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4138042C2 (de) * 1991-11-19 1993-10-14 Biotechnolog Forschung Gmbh Epothilone, deren Herstellungsverfahren sowie diese Verbindungen enthaltende Mittel
DE59609305D1 (de) * 1995-11-17 2002-07-11 Biotechnolog Forschung Gmbh Epothilon-Derivate und deren Herstellung
US6441186B1 (en) * 1996-12-13 2002-08-27 The Scripps Research Institute Epothilone analogs
KR100494179B1 (ko) * 1997-02-25 2005-06-10 게젤샤프트 퓌어 비오테크놀로기쉐 포르슝 엠베하(게베에프) 변환된 측쇄를 가진 에포틸론

Also Published As

Publication number Publication date
PL190422B1 (pl) 2005-12-30
EP0975638B1 (de) 2002-08-07
US6359140B1 (en) 2002-03-19
BR9807742A (pt) 2000-02-22
DE59805110D1 (de) 2002-09-12
AU736062B2 (en) 2001-07-26
IL131343A (en) 2004-03-28
CN1128803C (zh) 2003-11-26
IL131343A0 (en) 2001-01-28
CZ286599A3 (cs) 2000-03-15
NO994071L (no) 1999-10-21
HUP0002189A3 (en) 2001-12-28
NO327211B1 (no) 2009-05-11
PL335329A1 (en) 2000-04-25
EP0975638A1 (de) 2000-02-02
HUP0002189A2 (hu) 2001-10-28
HK1023774A1 (en) 2000-09-22
PT975638E (pt) 2002-12-31
ES2183338T3 (es) 2003-03-16
BR9807742B1 (pt) 2010-12-14
CN1248974A (zh) 2000-03-29
DE19880193D2 (de) 2000-08-24
NO994071D0 (no) 1999-08-24
RU2201932C2 (ru) 2003-04-10
EP1201666A2 (de) 2002-05-02
CN1544436A (zh) 2004-11-10
EP1201666A3 (de) 2003-03-05
AU6724998A (en) 1998-09-18
NZ337195A (en) 2001-05-25
CZ298027B6 (cs) 2007-05-30
KR20000075705A (ko) 2000-12-26
JP2001513098A (ja) 2001-08-28
WO1998038192A1 (de) 1998-09-03
ATE221888T1 (de) 2002-08-15
TW480263B (en) 2002-03-21
KR100494179B1 (ko) 2005-06-10
AR011878A1 (es) 2000-09-13
CA2281105A1 (en) 1998-09-03
ZA981575B (en) 1998-09-08
HU228851B1 (en) 2013-06-28

Similar Documents

Publication Publication Date Title
DK0975638T3 (da) Sidekædemodificerede epothiloner
DE69832294D1 (de) Epothilonderivate
DE19810476B4 (de) Laryngomaske
DE59809278D1 (de) Hysteresebremse
ID23803A (id) Turunan-turunan 2-(4-aril atau heteroaril-piperazin-1-ilmetil)-1h-indola
DE59803185D1 (de) Baulaser
ATA111897A (de) Kimme
DE59804631D1 (de) Diketopyrrolopyrrolzusammensetzungen
DE59802506D1 (de) Weichspülmittelzusammemsetzung
NO20002555D0 (no) Skjøt
DE59804377D1 (de) Kryoventil
DE59801498D1 (de) Dioxacycloalkan-8-one
DE59710388D1 (de) Mikropolarimeter
ATE236897T1 (de) 3-benzylpiperidine
ATA112597A (de) Snowboard - bindung
DE19881798D2 (de) Waschtisch
DE59805053D1 (de) Bogenflexodruckmaschine
ATA86797A (de) Verschleissschuh
DE59800820D1 (de) Stiellose kniegelenkendoprothese
ATA46498A (de) Kunststoffgleitbahn
BR9701194A (pt) Hidrociclo
ATA161897A (de) Zielfernrohr
ATA118697A (de) Zielfernrohr
KR970018153U (ko) 세면대
DE59804542D1 (de) Arylaminomethylencampherderivate