DK0971930T3 - Fremgangsmåde til fremstilling af enkelt enantiomert narwedin - Google Patents

Fremgangsmåde til fremstilling af enkelt enantiomert narwedin

Info

Publication number
DK0971930T3
DK0971930T3 DK98915005T DK98915005T DK0971930T3 DK 0971930 T3 DK0971930 T3 DK 0971930T3 DK 98915005 T DK98915005 T DK 98915005T DK 98915005 T DK98915005 T DK 98915005T DK 0971930 T3 DK0971930 T3 DK 0971930T3
Authority
DK
Denmark
Prior art keywords
narwedine
preparation
single enantiomeric
solvent
single enantiomer
Prior art date
Application number
DK98915005T
Other languages
Danish (da)
English (en)
Inventor
Gerard Andrew De Montfo Potter
Peter David Chirotech T Tiffen
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Application granted granted Critical
Publication of DK0971930T3 publication Critical patent/DK0971930T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/06—Peri-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Hospice & Palliative Care (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Psychiatry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Glass Compositions (AREA)
  • Iron Core Of Rotating Electric Machines (AREA)
DK98915005T 1997-04-11 1998-04-08 Fremgangsmåde til fremstilling af enkelt enantiomert narwedin DK0971930T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9707413.2A GB9707413D0 (en) 1997-04-11 1997-04-11 Process
PCT/GB1998/001029 WO1998046610A1 (fr) 1997-04-11 1998-04-08 Procede de preparation de narwedine possedant un seul enantiomere

Publications (1)

Publication Number Publication Date
DK0971930T3 true DK0971930T3 (da) 2004-01-26

Family

ID=10810680

Family Applications (1)

Application Number Title Priority Date Filing Date
DK98915005T DK0971930T3 (da) 1997-04-11 1998-04-08 Fremgangsmåde til fremstilling af enkelt enantiomert narwedin

Country Status (15)

Country Link
US (1) US6392038B1 (fr)
EP (1) EP0971930B1 (fr)
JP (1) JP4322317B2 (fr)
KR (1) KR100523125B1 (fr)
AT (1) ATE253579T1 (fr)
AU (1) AU726812B2 (fr)
CA (1) CA2284976C (fr)
DE (1) DE69819479T2 (fr)
DK (1) DK0971930T3 (fr)
ES (1) ES2209125T3 (fr)
GB (1) GB9707413D0 (fr)
NO (1) NO325949B1 (fr)
NZ (1) NZ337962A (fr)
PT (1) PT971930E (fr)
WO (1) WO1998046610A1 (fr)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005030713A2 (fr) * 2003-09-26 2005-04-07 George Schloemer Resolution d'un derive d'amine narwedine
WO2005065662A1 (fr) * 2003-12-31 2005-07-21 Actavis Group Hf Formulations solides d'administration de galantamine
US20050191349A1 (en) * 2003-12-31 2005-09-01 Garth Boehm Galantamine formulations
WO2006046096A2 (fr) * 2004-08-16 2006-05-04 Ranbaxy Laboratories Limited Forme polymorphe de la narwedine et son utilisation dans la synthese de la galantamine

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5428159A (en) * 1994-04-08 1995-06-27 Ciba-Geigy Corporation Method of manufacture of (-)-galanthamine in high yield and purity substantially free of epigalanthamine
NZ294191A (en) * 1994-10-21 1998-10-28 Waldheim Pharmazeutika Gmbh Process for preparing 4a,5,9,10,11,12-hexahydro-6h-benzofuro[3a,3,2-ef][2]benzazepine derivatives and intermediates thereof

Also Published As

Publication number Publication date
AU6929698A (en) 1998-11-11
NO325949B1 (no) 2008-08-25
PT971930E (pt) 2004-02-27
JP2001518911A (ja) 2001-10-16
EP0971930A1 (fr) 2000-01-19
ES2209125T3 (es) 2004-06-16
US6392038B1 (en) 2002-05-21
AU726812B2 (en) 2000-11-23
NO994928D0 (no) 1999-10-08
KR100523125B1 (ko) 2005-10-19
CA2284976A1 (fr) 1998-10-22
JP4322317B2 (ja) 2009-08-26
NO994928L (no) 1999-10-08
ATE253579T1 (de) 2003-11-15
WO1998046610A1 (fr) 1998-10-22
DE69819479D1 (de) 2003-12-11
NZ337962A (en) 2001-05-25
GB9707413D0 (en) 1997-05-28
KR20010006117A (ko) 2001-01-26
EP0971930B1 (fr) 2003-11-05
DE69819479T2 (de) 2004-08-26
CA2284976C (fr) 2006-10-17

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