DK0955313T3 - Nyt protein og fremgangsmåde til fremstilling af samme - Google Patents

Nyt protein og fremgangsmåde til fremstilling af samme

Info

Publication number
DK0955313T3
DK0955313T3 DK96910198T DK96910198T DK0955313T3 DK 0955313 T3 DK0955313 T3 DK 0955313T3 DK 96910198 T DK96910198 T DK 96910198T DK 96910198 T DK96910198 T DK 96910198T DK 0955313 T3 DK0955313 T3 DK 0955313T3
Authority
DK
Denmark
Prior art keywords
protein
same
seq
purifying
amino acid
Prior art date
Application number
DK96910198T
Other languages
Danish (da)
English (en)
Inventor
Fusao Makishima
Hiroyuki Takamatsu
Hideo Miki
Shinji Kawai
Michio Kimura
Tomoaki Matsumoto
Mieko Katsuura
Koichi Enomoto
Yusuke Satoh
Original Assignee
Bioph Biotech Entw Pharm Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bioph Biotech Entw Pharm Gmbh filed Critical Bioph Biotech Entw Pharm Gmbh
Application granted granted Critical
Publication of DK0955313T3 publication Critical patent/DK0955313T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/51—Bone morphogenetic factor; Osteogenins; Osteogenic factor; Bone-inducing factor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Zoology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Rheumatology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Toxicology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
DK96910198T 1995-04-19 1996-04-19 Nyt protein og fremgangsmåde til fremstilling af samme DK0955313T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP9366495 1995-04-19
JP32240395 1995-11-17

Publications (1)

Publication Number Publication Date
DK0955313T3 true DK0955313T3 (da) 2006-08-21

Family

ID=26434967

Family Applications (1)

Application Number Title Priority Date Filing Date
DK96910198T DK0955313T3 (da) 1995-04-19 1996-04-19 Nyt protein og fremgangsmåde til fremstilling af samme

Country Status (18)

Country Link
US (3) US7235527B2 (de)
EP (1) EP0955313B1 (de)
AT (1) ATE325131T1 (de)
AU (1) AU704515C (de)
BR (1) BR9608019A (de)
CA (1) CA2216741C (de)
DE (2) DE69636728D1 (de)
DK (1) DK0955313T3 (de)
EA (1) EA000582B1 (de)
ES (1) ES2258774T3 (de)
HU (1) HU225424B1 (de)
NO (1) NO321153B1 (de)
NZ (1) NZ305472A (de)
OA (1) OA10528A (de)
PL (1) PL186518B1 (de)
PT (1) PT955313E (de)
UA (1) UA46767C2 (de)
WO (1) WO1996033215A1 (de)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6586388B2 (en) 1988-04-08 2003-07-01 Stryker Corporation Method of using recombinant osteogenic protein to repair bone or cartilage defects
US20070166353A1 (en) * 1988-04-08 2007-07-19 Stryker Corporation Osteogenic proteins
US20080233170A1 (en) * 1992-02-21 2008-09-25 Stryker Corporation Osteogenic Proteins
ZA9711580B (en) * 1996-12-25 1999-09-23 Hoechst Marion Roussel Ltd Process for the production of purified dimeric bone morphogenetic factors.
SI0972520T1 (sl) * 1997-01-30 2006-02-28 Bioph Biotech Entw Pharm Gmbh Liofiliziran sestavek humanega kostnega morfogenetskega proteina MP52
ATE239514T1 (de) † 1997-02-07 2003-05-15 Stryker Corp Matrixlose osteogene vorrichtungen und implantate und verfahren zu deren verwendung
US6727224B1 (en) 1999-02-01 2004-04-27 Genetics Institute, Llc. Methods and compositions for healing and repair of articular cartilage
EP1863850B1 (de) * 2005-03-30 2009-09-23 Jung Moon Kim Nichtaktivierte polypeptide mit einer geweberegenerationsfunktion und verfahren zu ihrer herstellung
KR100775958B1 (ko) 2005-03-30 2007-11-13 김정문 조직재생 기능을 가지는 비활성 폴리펩티드 및 그 제조방법
US20060286144A1 (en) * 2005-06-17 2006-12-21 Chunlin Yang Reinforced collagen scaffold
PT1948689E (pt) 2005-11-18 2012-05-09 Bioph Biotech Entw Pharm Gmbh Mutantes do fator de crescimento com atividade elevada
EP1880731A1 (de) * 2006-07-18 2008-01-23 BIOPHARM GESELLSCHAFT ZUR BIOTECHNOLOGISCHEN ENTWICKLUNG VON PHARMAKA mbH Menschlicher Wachstums und Differenzierungsfaktor GDF-5
AU2007234612B2 (en) 2006-12-14 2013-06-27 Johnson & Johnson Regenerative Therapeutics, Llc Protein stabilization formulations
EP2121142B1 (de) * 2007-01-25 2013-04-03 Biopharm Gesellschaft Zur Biotechnologischen Entwicklung Von Pharmaka mbH Verwendung von gdf-5 zur verbesserung oder aufrechterhaltung des aussehens der haut
US7678764B2 (en) 2007-06-29 2010-03-16 Johnson & Johnson Regenerative Therapeutics, Llc Protein formulations for use at elevated temperatures
EP2019117A1 (de) * 2007-07-27 2009-01-28 BIOPHARM GESELLSCHAFT ZUR BIOTECHNOLOGISCHEN ENTWICKLUNG VON PHARMAKA mbH Optimiertes Reinigungsverfahren für rekombinantes Wachstumsfaktorprotein
JP5323832B2 (ja) 2007-08-07 2013-10-23 アドバンスト・テクノロジーズ・アンド・リジェネレイティブ・メディスン・エルエルシー 酸性水溶液中にｇｄｆ−５を含むタンパク質製剤
JP2009106163A (ja) * 2007-10-26 2009-05-21 Kyushu Univ 核酸配列、ベクター、形質転換体、製造方法、及び、核酸配列プライマー
CA2720845A1 (en) 2008-04-14 2009-10-22 Advanced Technologies And Regenerative Medicine, Llc Liquid buffered gdf-5 formulations
US11260110B2 (en) 2009-11-18 2022-03-01 Ptlnv, Llc, Series Four (4) Nanoparticles for the therapeutic treatment of radiation-induced skin ulcers
US9226898B1 (en) * 2009-11-18 2016-01-05 Richard C. K. Yen Submicron particles for the treatment of radiation damage in patients
WO2012013790A1 (en) 2010-07-30 2012-02-02 Biopharm Gesellschaft Zur Biotechnologischen Entwicklung Von Pharmaka Mbh Drug delivery devices and growth factor formulations for accelerated wound healing
US8551525B2 (en) 2010-12-23 2013-10-08 Biostructures, Llc Bone graft materials and methods
US8455436B2 (en) 2010-12-28 2013-06-04 Depuy Mitek, Llc Compositions and methods for treating joints
US8398611B2 (en) 2010-12-28 2013-03-19 Depuy Mitek, Inc. Compositions and methods for treating joints
US8524662B2 (en) 2010-12-28 2013-09-03 Depuy Mitek, Llc Compositions and methods for treating joints
EP2537538A1 (de) 2011-06-22 2012-12-26 Biopharm Gesellschaft Zur Biotechnologischen Entwicklung Von Pharmaka mbH Bioresorbierbarer Wundverband
US8623839B2 (en) 2011-06-30 2014-01-07 Depuy Mitek, Llc Compositions and methods for stabilized polysaccharide formulations
EP2602264A1 (de) 2011-12-05 2013-06-12 Biopharm Gesellschaft Zur Biotechnologischen Entwicklung Von Pharmaka mbH GDF-5-Mutant zur Induzierung der Knorpelbildung
US9682099B2 (en) 2015-01-20 2017-06-20 DePuy Synthes Products, Inc. Compositions and methods for treating joints
WO2021122545A1 (en) 2019-12-18 2021-06-24 Merck Patent Gmbh Use of the gdf-5 mutant for the treatment of pain and cartilage destruction
KR20240064367A (ko) * 2022-11-04 2024-05-13 주식회사 대웅제약 TGF-β3 단백질의 정제방법

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4725234A (en) * 1985-08-15 1988-02-16 Ethridge Edwin C Alveolar bone grafting process with controlled surface active ceramics
US5079352A (en) * 1986-08-22 1992-01-07 Cetus Corporation Purified thermostable enzyme
US5354557A (en) * 1988-04-08 1994-10-11 Stryker Corporation Osteogenic devices
GB8927546D0 (en) * 1989-12-06 1990-02-07 Ciba Geigy Process for the production of biologically active tgf-beta
US5143829A (en) * 1990-03-29 1992-09-01 California Biotechnology Inc. High level expression of basic fibroblast growth factor having a homogeneous n-terminus
US5118667A (en) * 1991-05-03 1992-06-02 Celtrix Pharmaceuticals, Inc. Bone growth factors and inhibitors of bone resorption for promoting bone formation
US5171579A (en) * 1991-10-11 1992-12-15 Genetics Institute, Inc. Formulations of blood clot-polymer matrix for delivery of osteogenic proteins
WO1993009229A1 (en) 1991-11-04 1993-05-13 Genetics Institute, Inc. Recombinant bone morphogenetic protein heterodimers, compositions and methods of use
NZ249113A (en) 1992-02-12 1996-07-26 Bioph Biotech Entw Pharm Gmbh Recombinant dna encoding tgf-b, its production and pharmaceutical compositions thereof
CA2153654A1 (en) 1993-01-12 1994-07-21 Se-Jin Lee Growth differentiation factor-5
IL110589A0 (en) * 1993-08-10 1994-11-11 Bioph Biotech Entw Pharm Gmbh Growth/differentiation factor of the TGF- beta family
US6248554B1 (en) 1993-11-24 2001-06-19 The Procter & Gamble Company DNA sequence coding for a BMP receptor
EP0733109B9 (de) * 1993-12-07 2006-07-05 Genetics Institute, LLC Bmp-12, bmp-13 und diese enthaltende sehne-induzierende zusammensetzungen
US5399677A (en) 1993-12-07 1995-03-21 Genetics Institute, Inc. Mutants of bone morphogenetic proteins
US5707962A (en) * 1994-09-28 1998-01-13 Gensci Regeneration Sciences Inc. Compositions with enhanced osteogenic potential, method for making the same and therapeutic uses thereof

Also Published As

Publication number Publication date
EA000582B1 (ru) 1999-12-29
MX9708011A (es) 1998-03-31
US20090325864A1 (en) 2009-12-31
ES2258774T3 (es) 2006-09-01
AU5347096A (en) 1996-11-07
AU704515C (en) 2002-03-28
WO1996033215A1 (fr) 1996-10-24
CA2216741A1 (en) 1996-10-24
UA46767C2 (uk) 2002-06-17
OA10528A (en) 2002-04-26
DE69636728T4 (de) 2007-06-28
HU225424B1 (en) 2006-11-28
US7235527B2 (en) 2007-06-26
AU704515B2 (en) 1999-04-22
DE69636728T2 (de) 2007-02-22
EP0955313A1 (de) 1999-11-10
NO974812L (no) 1997-12-19
PL322945A1 (en) 1998-03-02
NZ305472A (en) 1999-09-29
NO321153B1 (no) 2006-03-27
DE69636728D1 (de) 2007-01-04
EA199700329A1 (ru) 1998-04-30
EP0955313B1 (de) 2006-05-03
PL186518B1 (pl) 2004-01-30
ATE325131T1 (de) 2006-06-15
US20020102633A1 (en) 2002-08-01
US7816103B2 (en) 2010-10-19
EP0955313A4 (de) 2001-11-07
HUP9801697A3 (en) 2000-06-28
NO974812D0 (no) 1997-10-17
BR9608019A (pt) 1999-11-30
HUP9801697A2 (hu) 1998-10-28
US7268114B2 (en) 2007-09-11
PT955313E (pt) 2006-07-31
US20030181378A1 (en) 2003-09-25
CA2216741C (en) 2008-01-15

Similar Documents

Publication Publication Date Title
DK0955313T3 (da) Nyt protein og fremgangsmåde til fremstilling af samme
AU595262B2 (en) Eukaryotic fusion proteins, the preparation and use thereof and means for carrying out the process
WO1995021919A3 (en) Protein having tpo activity
IS4884A (is) Ret bindill til örvunar vaxtar tauga og thvagfæra
US6051399A (en) Production of C-terminal amidated peptides from recombinant protein constructs
CN100469790C (zh) 重组体bmp-2的生产
US5210028A (en) Process for the production of unfused igf-ii protein in e. coli
DE69120626D1 (de) Polypeptid
ATE253639T1 (de) Verfahren zur herstellung von peptiden
ATE163651T1 (de) Neues menschliches, rekombinantes interferon gamma
EP0453456B1 (de) Pdgf-a, pdgf-aa, pdgf-ab, herstellungsverfahren und sie enthaltende arzneimittel
Purchio et al. Synthesis of an active hybrid growth factor (GF) in bacteria: transforming GF-α/vaccinia GF fusion protein
DK595187D0 (da) Minactivin og fremgangsmaade til fremstilling deraf
DE69219242D1 (de) Muteine des menschlichen Parathormons und ihre Herstellung
MX9504057A (es) Proteina que tiene actividad tpo.