DK0950056T3 - N-(pyridinylamino)isoindoliner og beslægtede forbindelser - Google Patents

N-(pyridinylamino)isoindoliner og beslægtede forbindelser

Info

Publication number
DK0950056T3
DK0950056T3 DK97948250T DK97948250T DK0950056T3 DK 0950056 T3 DK0950056 T3 DK 0950056T3 DK 97948250 T DK97948250 T DK 97948250T DK 97948250 T DK97948250 T DK 97948250T DK 0950056 T3 DK0950056 T3 DK 0950056T3
Authority
DK
Denmark
Prior art keywords
isoindolines
pyridinylamino
related compounds
intermediates
compositions
Prior art date
Application number
DK97948250T
Other languages
Danish (da)
English (en)
Inventor
David M Fink
Brian S Freed
Gregory H Merriman
Barbara E Kurys
Original Assignee
Aventis Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/959,789 external-priority patent/US6004977A/en
Application filed by Aventis Pharma Inc filed Critical Aventis Pharma Inc
Application granted granted Critical
Publication of DK0950056T3 publication Critical patent/DK0950056T3/da

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D213/00Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72Nitrogen atoms
    • C07D213/76Nitrogen atoms to which a second hetero atom is attached
    • C07D213/77Hydrazine radicals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/24Antidepressants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D263/00Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/08Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D263/10Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D263/14Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with radicals substituted by oxygen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Psychiatry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Pain & Pain Management (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
DK97948250T 1996-12-27 1997-11-13 N-(pyridinylamino)isoindoliner og beslægtede forbindelser DK0950056T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US77430896A 1996-12-27 1996-12-27
US08/959,789 US6004977A (en) 1996-12-27 1997-10-29 N-(pyridinylamino) isoindolines and related compounds
PCT/US1997/020591 WO1998029407A2 (en) 1996-12-27 1997-11-13 N-(pyridinylamino)isoindolines for treating alzheimer's and depression

Publications (1)

Publication Number Publication Date
DK0950056T3 true DK0950056T3 (da) 2003-01-27

Family

ID=27118867

Family Applications (1)

Application Number Title Priority Date Filing Date
DK97948250T DK0950056T3 (da) 1996-12-27 1997-11-13 N-(pyridinylamino)isoindoliner og beslægtede forbindelser

Country Status (15)

Country Link
EP (1) EP0950056B1 (no)
JP (1) JP4256937B2 (no)
KR (1) KR20000062358A (no)
AT (1) ATE224387T1 (no)
AU (1) AU720466B2 (no)
BR (1) BR9714189A (no)
CA (1) CA2276203C (no)
DE (1) DE69715668T2 (no)
DK (1) DK0950056T3 (no)
ES (1) ES2179377T3 (no)
HU (1) HUP0000783A2 (no)
IL (1) IL130642A0 (no)
NO (1) NO993180L (no)
PT (1) PT950056E (no)
WO (1) WO1998029407A2 (no)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6772195B1 (en) 1999-10-29 2004-08-03 Electronic Arts, Inc. Chat clusters for a virtual world application
US7229986B2 (en) * 2000-05-16 2007-06-12 Takeda Pharmaceutical Company Ltd. Melanin-concentrating hormone antagonist
KR20060009686A (ko) * 2004-07-26 2006-02-01 엘지이노텍 주식회사 반도체 발광소자 및 그 제조방법
KR101763674B1 (ko) 2007-01-22 2017-08-01 지티엑스, 인코포레이티드 핵 수용체에 결합하는 물질
US9623021B2 (en) 2007-01-22 2017-04-18 Gtx, Inc. Nuclear receptor binding agents
US9604931B2 (en) 2007-01-22 2017-03-28 Gtx, Inc. Nuclear receptor binding agents

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0287982B1 (en) * 1987-04-24 1994-12-07 Hoechst-Roussel Pharmaceuticals Incorporated N-(Pyridinyl)-1H-indol-1-amines, a process for their preparation and their use as medicaments
US5006537A (en) * 1989-08-02 1991-04-09 Hoechst-Roussel Pharmaceuticals, Inc. 1,3-dihydro-1-(pyridinylamino)-2H-indol-2-ones
NZ234726A (en) * 1989-08-02 1992-01-29 Hoechst Roussel Pharma 2,3-dihydro-1-(pyridinylamino)-indoles and pharmaceutical compositions
US5102891A (en) * 1990-07-23 1992-04-07 Hoechst-Roussel Pharmaceuticals Inc. 1-(substituted pyridinylamino)-1H-indol-5-yl substituted carbamates
US5177088A (en) * 1991-04-17 1993-01-05 Hoechst-Roussel Pharmaceuticals Incorporated Substituted 3-(pyridinylamino)-indoles
US5328920A (en) * 1991-04-17 1994-07-12 Hoechst-Roussel Pharmaceuticals Incorporated Substituted (pyridinylamino)-indoles

Also Published As

Publication number Publication date
NO993180L (no) 1999-08-26
ES2179377T3 (es) 2003-01-16
IL130642A0 (en) 2000-06-01
PT950056E (pt) 2002-12-31
BR9714189A (pt) 2000-02-29
AU5434998A (en) 1998-07-31
CA2276203C (en) 2003-07-22
EP0950056A2 (en) 1999-10-20
HUP0000783A2 (hu) 2001-04-28
JP4256937B2 (ja) 2009-04-22
DE69715668D1 (de) 2002-10-24
JP2001511119A (ja) 2001-08-07
WO1998029407A3 (en) 1998-10-22
KR20000062358A (ko) 2000-10-25
WO1998029407A2 (en) 1998-07-09
DE69715668T2 (de) 2003-07-31
AU720466B2 (en) 2000-06-01
EP0950056B1 (en) 2002-09-18
NO993180D0 (no) 1999-06-25
CA2276203A1 (en) 1998-07-09
ATE224387T1 (de) 2002-10-15

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