DK0947197T3 - Fremgangsmåde til fremstilling af vanddispergerbare sterolformuleringer - Google Patents

Fremgangsmåde til fremstilling af vanddispergerbare sterolformuleringer

Info

Publication number
DK0947197T3
DK0947197T3 DK99301209T DK99301209T DK0947197T3 DK 0947197 T3 DK0947197 T3 DK 0947197T3 DK 99301209 T DK99301209 T DK 99301209T DK 99301209 T DK99301209 T DK 99301209T DK 0947197 T3 DK0947197 T3 DK 0947197T3
Authority
DK
Denmark
Prior art keywords
preparation
water
sitosterol
sterol formulations
dispersible sterol
Prior art date
Application number
DK99301209T
Other languages
Danish (da)
English (en)
Inventor
Brid Burruano
Michael R Hoy
Richard D Bruce
John D Higgins
Original Assignee
Mcneil Ppc Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US09/025,952 external-priority patent/US6110502A/en
Application filed by Mcneil Ppc Inc filed Critical Mcneil Ppc Inc
Application granted granted Critical
Publication of DK0947197T3 publication Critical patent/DK0947197T3/da

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/575—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/145—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
    • A61P5/42—Drugs for disorders of the endocrine system of the suprarenal hormones for decreasing, blocking or antagonising the activity of mineralocorticosteroids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
    • A61P5/46—Drugs for disorders of the endocrine system of the suprarenal hormones for decreasing, blocking or antagonising the activity of glucocorticosteroids

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Steroid Compounds (AREA)
  • Seeds, Soups, And Other Foods (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DK99301209T 1998-02-19 1999-02-18 Fremgangsmåde til fremstilling af vanddispergerbare sterolformuleringer DK0947197T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/025,952 US6110502A (en) 1998-02-19 1998-02-19 Method for producing water dispersible sterol formulations
US09/185,788 US6054144A (en) 1998-02-19 1998-11-04 Method for producing water dispersible sterol formulations

Publications (1)

Publication Number Publication Date
DK0947197T3 true DK0947197T3 (da) 2004-07-26

Family

ID=26700515

Family Applications (1)

Application Number Title Priority Date Filing Date
DK99301209T DK0947197T3 (da) 1998-02-19 1999-02-18 Fremgangsmåde til fremstilling af vanddispergerbare sterolformuleringer

Country Status (16)

Country Link
EP (1) EP0947197B1 (enExample)
JP (1) JPH11313644A (enExample)
CN (1) CN1161123C (enExample)
AT (1) ATE264683T1 (enExample)
AU (1) AU760314B2 (enExample)
BR (1) BR9902325A (enExample)
CZ (1) CZ298506B6 (enExample)
DE (1) DE69916522T2 (enExample)
DK (1) DK0947197T3 (enExample)
ES (1) ES2216439T3 (enExample)
HU (1) HUP9900434A2 (enExample)
IN (1) IN185730B (enExample)
NO (1) NO990747L (enExample)
NZ (1) NZ334189A (enExample)
PL (1) PL192906B1 (enExample)
PT (1) PT947197E (enExample)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE512958C2 (sv) * 1998-04-30 2000-06-12 Triple Crown Ab Kolesterolsänkande komposition innehållande beta-sitosterol och/eller beta-sitostanol samt förfarande för dess framställning
US6123978A (en) 1998-08-31 2000-09-26 Mcneil-Ppc, Inc. Stable salad dressings
US6376481B2 (en) * 1998-09-02 2002-04-23 Mcneil-Ppc, Inc. Sterol esters in tableted solid dosage forms
US6677327B1 (en) * 1999-11-24 2004-01-13 Archer-Daniels-Midland Company Phytosterol and phytostanol compositions
GB0021498D0 (en) 2000-09-01 2000-10-18 Novartis Nutrition Ag New formulation
AU2005234649B2 (en) * 2000-09-01 2008-01-17 Forbes Medi-Tech, Inc. Water-dispersible encapsulated sterols
KR20020026053A (ko) 2000-09-30 2002-04-06 노승권 음료용 식물성 스테롤의 분산방법 및 이를 함유하는 음료
GB0104074D0 (en) * 2001-02-19 2001-04-04 Novartis Ag New composition
US20030003131A1 (en) * 2001-06-22 2003-01-02 Matthew Dyer Method for manufacture of free-flowing powder containing water-dispersible sterols
ATE541569T1 (de) 2001-07-24 2012-02-15 Cargill Inc Verfahren zur isolation von phenolischen verbindungen
JP2005520508A (ja) * 2002-03-20 2005-07-14 ユージーン サイエンス インコーポレイテッド 植物ステロールと乳化剤の混合粉末及びその製造方法
US6623780B1 (en) 2002-03-26 2003-09-23 Cargill, Inc. Aqueous dispersible sterol product
WO2003086108A1 (en) * 2002-04-10 2003-10-23 Archer-Daniels-Midland Company Hydrothermically processed compositions containing phytosterols
DK1549159T3 (da) 2002-06-12 2009-03-02 Coca Cola Co Drikkevarer indeholdende plantesteroler
US7306819B2 (en) 2002-06-12 2007-12-11 The Coca-Cola Company Beverages containing plant sterols
US7732000B2 (en) 2002-06-20 2010-06-08 General Mills, Inc. Food intermediate having sequestered phytosteryl esters in a polysaccharide matrix
US20060035009A1 (en) * 2004-08-10 2006-02-16 Kraft Foods Holdings, Inc. Compositions and processes for water-dispersible phytosterols and phytostanols
US20080206407A1 (en) * 2005-01-14 2008-08-28 Veldhuizen Yvonne Susanna J Sachets Comprising Plant Sterol
DE102005008445A1 (de) * 2005-02-24 2006-08-31 Cognis Ip Management Gmbh Zuckerhaltige Sterolfeststoffdispersionen
DE102005039835A1 (de) * 2005-08-23 2007-03-01 Cognis Ip Management Gmbh Pulverförmige Sterolformulierungen mit Kolloidbildnern
CN111529500B (zh) * 2020-06-28 2021-09-24 江西谷物源食品有限公司 一种提高谷维素溶解度的药物组合物及其制备方法
CN112618665B (zh) * 2020-12-19 2022-06-14 杭州益品新五丰药业有限公司 一种提高免疫反应的糠甾醇-谷维素联合用药制剂
CN118252251A (zh) * 2022-12-28 2024-06-28 丰益(上海)生物技术研发中心有限公司 含植物甾醇酯的组合物及其制备方法及食品
CN120754308A (zh) * 2025-07-21 2025-10-10 暨南大学 一种多功能油凝胶伤口敷料及其制备方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3881005A (en) * 1973-08-13 1975-04-29 Lilly Co Eli Pharmaceutical dispersible powder of sitosterols and a method for the preparation thereof
US4195084A (en) * 1977-01-07 1980-03-25 Eli Lilly And Company Taste-stable aqueous pharmaceutical suspension of tall oil sitosterols and a method for the preparation thereof
DE3829643A1 (de) * 1988-09-01 1990-03-15 Roecar Holdings Nv Phyto- und zoosterole und deren derivate mit verbesserter wasserloeslichkeit
DE59004337D1 (de) * 1989-07-21 1994-03-03 Marigen Sa Sterole, deren fettsäureester und glucoside; verfahren zu ihrer herstellung; spontan dispergierbare mittel mit diesen verbindungen, sowie ihre verwendung zur behandlung von tumoren.
CH681153A5 (de) * 1991-01-28 1993-01-29 Marigen S.A. Neue sterolester- und sterolphosphorverbindungen.
EP0594612B2 (en) * 1991-05-03 2010-02-24 Raisio Nutrition Ltd. Process for the preparation of a substance comprising a beta-sitostanol fatty acid ester or a mixture thereof

Also Published As

Publication number Publication date
EP0947197A1 (en) 1999-10-06
HU9900434D0 (en) 1999-04-28
ATE264683T1 (de) 2004-05-15
CZ54799A3 (cs) 1999-09-15
AU760314B2 (en) 2003-05-15
ES2216439T3 (es) 2004-10-16
CZ298506B6 (cs) 2007-10-24
PL192906B1 (pl) 2006-12-29
PL331546A1 (en) 1999-08-30
NZ334189A (en) 1999-07-29
JPH11313644A (ja) 1999-11-16
IN185730B (enExample) 2001-04-14
PT947197E (pt) 2004-08-31
EP0947197B1 (en) 2004-04-21
DE69916522D1 (de) 2004-05-27
CN1232668A (zh) 1999-10-27
HUP9900434A2 (hu) 2001-06-28
CN1161123C (zh) 2004-08-11
BR9902325A (pt) 2000-04-11
NO990747D0 (no) 1999-02-18
AU1735899A (en) 2000-06-08
DE69916522T2 (de) 2005-07-21
NO990747L (no) 1999-08-20

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