DK0931055T3 - Selektiv alkylering af en alkohol-substitueret phenolforbindelse - Google Patents
Selektiv alkylering af en alkohol-substitueret phenolforbindelseInfo
- Publication number
- DK0931055T3 DK0931055T3 DK97943421T DK97943421T DK0931055T3 DK 0931055 T3 DK0931055 T3 DK 0931055T3 DK 97943421 T DK97943421 T DK 97943421T DK 97943421 T DK97943421 T DK 97943421T DK 0931055 T3 DK0931055 T3 DK 0931055T3
- Authority
- DK
- Denmark
- Prior art keywords
- alcohol
- phenol compound
- substituted phenol
- selective alkylation
- alkylation
- Prior art date
Links
- 230000029936 alkylation Effects 0.000 title abstract 2
- 238000005804 alkylation reaction Methods 0.000 title abstract 2
- -1 phenol compound Chemical class 0.000 title 1
- NWIUTZDMDHAVTP-UHFFFAOYSA-N betaxolol Chemical compound C1=CC(OCC(O)CNC(C)C)=CC=C1CCOCC1CC1 NWIUTZDMDHAVTP-UHFFFAOYSA-N 0.000 abstract 1
- 229960004324 betaxolol Drugs 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C41/00—Preparation of ethers; Preparation of compounds having groups, groups or groups
- C07C41/01—Preparation of ethers
- C07C41/16—Preparation of ethers by reaction of esters of mineral or organic acids with hydroxy or O-metal groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
- C07C213/06—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton from hydroxy amines by reactions involving the etherification or esterification of hydroxy groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
- C07D303/02—Compounds containing oxirane rings
- C07D303/12—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms
- C07D303/18—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms by etherified hydroxyl radicals
- C07D303/20—Ethers with hydroxy compounds containing no oxirane rings
- C07D303/22—Ethers with hydroxy compounds containing no oxirane rings with monohydroxy compounds
- C07D303/23—Oxiranylmethyl ethers of compounds having one hydroxy group bound to a six-membered aromatic ring, the oxiranylmethyl radical not being further substituted, i.e.
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/02—Systems containing only non-condensed rings with a three-membered ring
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/717,381 US5731463A (en) | 1996-09-23 | 1996-09-23 | Selective alkylation of an alcohol substituted phenol compound |
| PCT/US1997/016769 WO1998012172A1 (en) | 1996-09-23 | 1997-09-22 | Selective alkylation of an alcohol substituted phenol compound |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK0931055T3 true DK0931055T3 (da) | 2002-02-18 |
Family
ID=24881803
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK97943421T DK0931055T3 (da) | 1996-09-23 | 1997-09-22 | Selektiv alkylering af en alkohol-substitueret phenolforbindelse |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US5731463A (da) |
| EP (1) | EP0931055B1 (da) |
| JP (1) | JP2001500881A (da) |
| AT (1) | ATE208370T1 (da) |
| CA (1) | CA2266488C (da) |
| DE (1) | DE69708136T2 (da) |
| DK (1) | DK0931055T3 (da) |
| ES (1) | ES2167794T3 (da) |
| PT (1) | PT931055E (da) |
| WO (1) | WO1998012172A1 (da) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7019172B2 (en) * | 2004-06-30 | 2006-03-28 | Council Of Scientific And Industrial Research | Process for preparation of S-(-)-betaxolol and salts thereof |
| US7227039B2 (en) * | 2004-11-01 | 2007-06-05 | Council Of Scientific And Industrial Research | RS 1-{4-[2-(allyloxy)-ethyl]phenoxy}-3-isopropylamino propan-2-ol, process for preparation thereof and process for preparation of RS betaxolol |
| CN1300079C (zh) * | 2004-12-03 | 2007-02-14 | 南京大学 | 合成4－[2－(环丙基甲氧基)乙基]苯酚的新工艺 |
| WO2010029566A2 (en) * | 2008-07-18 | 2010-03-18 | Indoco Remedies Limited | Process for preparation of phenoxypropanol amines |
| WO2012037309A2 (en) * | 2010-09-17 | 2012-03-22 | Mallinckrodt Llc | Improved process for the preparation of sufentanil base and related compounds |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3625970A (en) * | 1968-04-17 | 1971-12-07 | Cutter Lab | 1-(disubstituted phenyl or benzyl)-1h-indazol-3-yloxyacetic acid |
| FR2330383A1 (fr) * | 1975-11-06 | 1977-06-03 | Synthelabo | Nouveaux ethers de phenols substitues, leurs sels, leur preparation et les medicaments qui les renferment |
| CA1265523A (en) * | 1984-08-21 | 1990-02-06 | Stephen Vigmond | Preparation of phenol ethers using cyclic intermediates |
| ES8609190A1 (es) * | 1985-02-07 | 1986-07-16 | Pharma Investi S A | Un procedimiento para preparar eteres fenolicos |
| SE8801518D0 (sv) * | 1988-04-22 | 1988-04-22 | Astra Pharma Prod | A novel process |
| BE1007421A3 (nl) * | 1993-08-20 | 1995-06-13 | Tessenderlo Chem Nv | Werkwijze voor het selectief alkyleren van een alifatische alcohol tegenover een fenolverbinding. |
-
1996
- 1996-09-23 US US08/717,381 patent/US5731463A/en not_active Expired - Lifetime
-
1997
- 1997-09-22 DE DE69708136T patent/DE69708136T2/de not_active Expired - Fee Related
- 1997-09-22 JP JP10514948A patent/JP2001500881A/ja not_active Ceased
- 1997-09-22 EP EP97943421A patent/EP0931055B1/en not_active Expired - Lifetime
- 1997-09-22 AT AT97943421T patent/ATE208370T1/de not_active IP Right Cessation
- 1997-09-22 WO PCT/US1997/016769 patent/WO1998012172A1/en active IP Right Grant
- 1997-09-22 PT PT97943421T patent/PT931055E/pt unknown
- 1997-09-22 CA CA002266488A patent/CA2266488C/en not_active Expired - Fee Related
- 1997-09-22 DK DK97943421T patent/DK0931055T3/da active
- 1997-09-22 ES ES97943421T patent/ES2167794T3/es not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| ES2167794T3 (es) | 2002-05-16 |
| CA2266488C (en) | 2006-08-15 |
| EP0931055A1 (en) | 1999-07-28 |
| JP2001500881A (ja) | 2001-01-23 |
| PT931055E (pt) | 2002-04-29 |
| EP0931055B1 (en) | 2001-11-07 |
| WO1998012172A1 (en) | 1998-03-26 |
| CA2266488A1 (en) | 1998-03-26 |
| ATE208370T1 (de) | 2001-11-15 |
| DE69708136T2 (de) | 2002-08-14 |
| US5731463A (en) | 1998-03-24 |
| DE69708136D1 (de) | 2001-12-13 |
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