DE69708136D1 - Selektive alkylierung einer durch einen alkohol substituierten phenolverbindung - Google Patents
Selektive alkylierung einer durch einen alkohol substituierten phenolverbindungInfo
- Publication number
- DE69708136D1 DE69708136D1 DE69708136T DE69708136T DE69708136D1 DE 69708136 D1 DE69708136 D1 DE 69708136D1 DE 69708136 T DE69708136 T DE 69708136T DE 69708136 T DE69708136 T DE 69708136T DE 69708136 D1 DE69708136 D1 DE 69708136D1
- Authority
- DE
- Germany
- Prior art keywords
- alcohol
- phenol compound
- compound substituted
- selective alkylation
- alkylation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 230000029936 alkylation Effects 0.000 title abstract 2
- 238000005804 alkylation reaction Methods 0.000 title abstract 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 title 1
- -1 PHENOL COMPOUND Chemical group 0.000 title 1
- NWIUTZDMDHAVTP-UHFFFAOYSA-N betaxolol Chemical compound C1=CC(OCC(O)CNC(C)C)=CC=C1CCOCC1CC1 NWIUTZDMDHAVTP-UHFFFAOYSA-N 0.000 abstract 1
- 229960004324 betaxolol Drugs 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C41/00—Preparation of ethers; Preparation of compounds having groups, groups or groups
- C07C41/01—Preparation of ethers
- C07C41/16—Preparation of ethers by reaction of esters of mineral or organic acids with hydroxy or O-metal groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
- C07C213/06—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton from hydroxy amines by reactions involving the etherification or esterification of hydroxy groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
- C07D303/02—Compounds containing oxirane rings
- C07D303/12—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms
- C07D303/18—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms by etherified hydroxyl radicals
- C07D303/20—Ethers with hydroxy compounds containing no oxirane rings
- C07D303/22—Ethers with hydroxy compounds containing no oxirane rings with monohydroxy compounds
- C07D303/23—Oxiranylmethyl ethers of compounds having one hydroxy group bound to a six-membered aromatic ring, the oxiranylmethyl radical not being further substituted, i.e.
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/02—Systems containing only non-condensed rings with a three-membered ring
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/717,381 US5731463A (en) | 1996-09-23 | 1996-09-23 | Selective alkylation of an alcohol substituted phenol compound |
| PCT/US1997/016769 WO1998012172A1 (en) | 1996-09-23 | 1997-09-22 | Selective alkylation of an alcohol substituted phenol compound |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE69708136D1 true DE69708136D1 (de) | 2001-12-13 |
| DE69708136T2 DE69708136T2 (de) | 2002-08-14 |
Family
ID=24881803
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69708136T Expired - Fee Related DE69708136T2 (de) | 1996-09-23 | 1997-09-22 | Selektive alkylierung einer durch einen alkohol substituierten phenolverbindung |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US5731463A (de) |
| EP (1) | EP0931055B1 (de) |
| JP (1) | JP2001500881A (de) |
| AT (1) | ATE208370T1 (de) |
| CA (1) | CA2266488C (de) |
| DE (1) | DE69708136T2 (de) |
| DK (1) | DK0931055T3 (de) |
| ES (1) | ES2167794T3 (de) |
| PT (1) | PT931055E (de) |
| WO (1) | WO1998012172A1 (de) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7019172B2 (en) * | 2004-06-30 | 2006-03-28 | Council Of Scientific And Industrial Research | Process for preparation of S-(-)-betaxolol and salts thereof |
| US7227039B2 (en) * | 2004-11-01 | 2007-06-05 | Council Of Scientific And Industrial Research | RS 1-{4-[2-(allyloxy)-ethyl]phenoxy}-3-isopropylamino propan-2-ol, process for preparation thereof and process for preparation of RS betaxolol |
| CN1300079C (zh) * | 2004-12-03 | 2007-02-14 | 南京大学 | 合成4－[2－(环丙基甲氧基)乙基]苯酚的新工艺 |
| WO2010029566A2 (en) * | 2008-07-18 | 2010-03-18 | Indoco Remedies Limited | Process for preparation of phenoxypropanol amines |
| ES2664801T3 (es) * | 2010-09-17 | 2018-04-23 | Mallinckrodt Llc | Proceso mejorado para la preparación de un precursor de sufentanilo base |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3625970A (en) * | 1968-04-17 | 1971-12-07 | Cutter Lab | 1-(disubstituted phenyl or benzyl)-1h-indazol-3-yloxyacetic acid |
| FR2330383A1 (fr) * | 1975-11-06 | 1977-06-03 | Synthelabo | Nouveaux ethers de phenols substitues, leurs sels, leur preparation et les medicaments qui les renferment |
| CA1265523A (en) * | 1984-08-21 | 1990-02-06 | Stephen Vigmond | Preparation of phenol ethers using cyclic intermediates |
| ES8609190A1 (es) * | 1985-02-07 | 1986-07-16 | Pharma Investi S A | Un procedimiento para preparar eteres fenolicos |
| SE8801518D0 (sv) * | 1988-04-22 | 1988-04-22 | Astra Pharma Prod | A novel process |
| BE1007421A3 (nl) * | 1993-08-20 | 1995-06-13 | Tessenderlo Chem Nv | Werkwijze voor het selectief alkyleren van een alifatische alcohol tegenover een fenolverbinding. |
-
1996
- 1996-09-23 US US08/717,381 patent/US5731463A/en not_active Expired - Lifetime
-
1997
- 1997-09-22 EP EP97943421A patent/EP0931055B1/de not_active Expired - Lifetime
- 1997-09-22 JP JP10514948A patent/JP2001500881A/ja not_active Ceased
- 1997-09-22 DK DK97943421T patent/DK0931055T3/da active
- 1997-09-22 PT PT97943421T patent/PT931055E/pt unknown
- 1997-09-22 ES ES97943421T patent/ES2167794T3/es not_active Expired - Lifetime
- 1997-09-22 AT AT97943421T patent/ATE208370T1/de not_active IP Right Cessation
- 1997-09-22 DE DE69708136T patent/DE69708136T2/de not_active Expired - Fee Related
- 1997-09-22 WO PCT/US1997/016769 patent/WO1998012172A1/en active IP Right Grant
- 1997-09-22 CA CA002266488A patent/CA2266488C/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| JP2001500881A (ja) | 2001-01-23 |
| EP0931055A1 (de) | 1999-07-28 |
| PT931055E (pt) | 2002-04-29 |
| EP0931055B1 (de) | 2001-11-07 |
| CA2266488A1 (en) | 1998-03-26 |
| WO1998012172A1 (en) | 1998-03-26 |
| DK0931055T3 (da) | 2002-02-18 |
| CA2266488C (en) | 2006-08-15 |
| US5731463A (en) | 1998-03-24 |
| ATE208370T1 (de) | 2001-11-15 |
| ES2167794T3 (es) | 2002-05-16 |
| DE69708136T2 (de) | 2002-08-14 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition | ||
| 8339 | Ceased/non-payment of the annual fee |