PT931055E - Alquilacao selectiva de um composto fenolico substituido com um alcool - Google Patents
Alquilacao selectiva de um composto fenolico substituido com um alcoolInfo
- Publication number
- PT931055E PT931055E PT97943421T PT97943421T PT931055E PT 931055 E PT931055 E PT 931055E PT 97943421 T PT97943421 T PT 97943421T PT 97943421 T PT97943421 T PT 97943421T PT 931055 E PT931055 E PT 931055E
- Authority
- PT
- Portugal
- Prior art keywords
- selective
- hiring
- alcohol
- phenolic compound
- compound replaced
- Prior art date
Links
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical group CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 title 1
- 150000002989 phenols Chemical class 0.000 title 1
- 230000029936 alkylation Effects 0.000 abstract 1
- 238000005804 alkylation reaction Methods 0.000 abstract 1
- NWIUTZDMDHAVTP-UHFFFAOYSA-N betaxolol Chemical compound C1=CC(OCC(O)CNC(C)C)=CC=C1CCOCC1CC1 NWIUTZDMDHAVTP-UHFFFAOYSA-N 0.000 abstract 1
- 229960004324 betaxolol Drugs 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C41/00—Preparation of ethers; Preparation of compounds having groups, groups or groups
- C07C41/01—Preparation of ethers
- C07C41/16—Preparation of ethers by reaction of esters of mineral or organic acids with hydroxy or O-metal groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
- C07C213/06—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton from hydroxy amines by reactions involving the etherification or esterification of hydroxy groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
- C07D303/02—Compounds containing oxirane rings
- C07D303/12—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms
- C07D303/18—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms by etherified hydroxyl radicals
- C07D303/20—Ethers with hydroxy compounds containing no oxirane rings
- C07D303/22—Ethers with hydroxy compounds containing no oxirane rings with monohydroxy compounds
- C07D303/23—Oxiranylmethyl ethers of compounds having one hydroxy group bound to a six-membered aromatic ring, the oxiranylmethyl radical not being further substituted, i.e.
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/02—Systems containing only non-condensed rings with a three-membered ring
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/717,381 US5731463A (en) | 1996-09-23 | 1996-09-23 | Selective alkylation of an alcohol substituted phenol compound |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PT931055E true PT931055E (pt) | 2002-04-29 |
Family
ID=24881803
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT97943421T PT931055E (pt) | 1996-09-23 | 1997-09-22 | Alquilacao selectiva de um composto fenolico substituido com um alcool |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US5731463A (pt) |
| EP (1) | EP0931055B1 (pt) |
| JP (1) | JP2001500881A (pt) |
| AT (1) | ATE208370T1 (pt) |
| CA (1) | CA2266488C (pt) |
| DE (1) | DE69708136T2 (pt) |
| DK (1) | DK0931055T3 (pt) |
| ES (1) | ES2167794T3 (pt) |
| PT (1) | PT931055E (pt) |
| WO (1) | WO1998012172A1 (pt) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7019172B2 (en) * | 2004-06-30 | 2006-03-28 | Council Of Scientific And Industrial Research | Process for preparation of S-(-)-betaxolol and salts thereof |
| US7227039B2 (en) * | 2004-11-01 | 2007-06-05 | Council Of Scientific And Industrial Research | RS 1-{4-[2-(allyloxy)-ethyl]phenoxy}-3-isopropylamino propan-2-ol, process for preparation thereof and process for preparation of RS betaxolol |
| CN1300079C (zh) * | 2004-12-03 | 2007-02-14 | 南京大学 | 合成4－[2－(环丙基甲氧基)乙基]苯酚的新工艺 |
| WO2010029566A2 (en) * | 2008-07-18 | 2010-03-18 | Indoco Remedies Limited | Process for preparation of phenoxypropanol amines |
| US8946433B2 (en) * | 2010-09-17 | 2015-02-03 | Mallinckrodt Llc | Process for the preparation of sufentanil base and related compounds |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3625970A (en) * | 1968-04-17 | 1971-12-07 | Cutter Lab | 1-(disubstituted phenyl or benzyl)-1h-indazol-3-yloxyacetic acid |
| FR2330383A1 (fr) * | 1975-11-06 | 1977-06-03 | Synthelabo | Nouveaux ethers de phenols substitues, leurs sels, leur preparation et les medicaments qui les renferment |
| CA1265523A (en) * | 1984-08-21 | 1990-02-06 | Stephen Vigmond | Preparation of phenol ethers using cyclic intermediates |
| ES8609190A1 (es) * | 1985-02-07 | 1986-07-16 | Pharma Investi S A | Un procedimiento para preparar eteres fenolicos |
| SE8801518D0 (sv) * | 1988-04-22 | 1988-04-22 | Astra Pharma Prod | A novel process |
| BE1007421A3 (nl) * | 1993-08-20 | 1995-06-13 | Tessenderlo Chem Nv | Werkwijze voor het selectief alkyleren van een alifatische alcohol tegenover een fenolverbinding. |
-
1996
- 1996-09-23 US US08/717,381 patent/US5731463A/en not_active Expired - Lifetime
-
1997
- 1997-09-22 DE DE69708136T patent/DE69708136T2/de not_active Expired - Fee Related
- 1997-09-22 DK DK97943421T patent/DK0931055T3/da active
- 1997-09-22 JP JP10514948A patent/JP2001500881A/ja not_active Ceased
- 1997-09-22 CA CA002266488A patent/CA2266488C/en not_active Expired - Fee Related
- 1997-09-22 ES ES97943421T patent/ES2167794T3/es not_active Expired - Lifetime
- 1997-09-22 EP EP97943421A patent/EP0931055B1/en not_active Expired - Lifetime
- 1997-09-22 WO PCT/US1997/016769 patent/WO1998012172A1/en active IP Right Grant
- 1997-09-22 PT PT97943421T patent/PT931055E/pt unknown
- 1997-09-22 AT AT97943421T patent/ATE208370T1/de not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| DE69708136D1 (de) | 2001-12-13 |
| EP0931055B1 (en) | 2001-11-07 |
| ATE208370T1 (de) | 2001-11-15 |
| US5731463A (en) | 1998-03-24 |
| JP2001500881A (ja) | 2001-01-23 |
| CA2266488C (en) | 2006-08-15 |
| CA2266488A1 (en) | 1998-03-26 |
| DK0931055T3 (da) | 2002-02-18 |
| ES2167794T3 (es) | 2002-05-16 |
| WO1998012172A1 (en) | 1998-03-26 |
| DE69708136T2 (de) | 2002-08-14 |
| EP0931055A1 (en) | 1999-07-28 |
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