DK0922045T3 - Bicykliske pyrimidinderivater og deres anvendelse som antikoagulanter - Google Patents

Bicykliske pyrimidinderivater og deres anvendelse som antikoagulanter

Info

Publication number
DK0922045T3
DK0922045T3 DK97937584T DK97937584T DK0922045T3 DK 0922045 T3 DK0922045 T3 DK 0922045T3 DK 97937584 T DK97937584 T DK 97937584T DK 97937584 T DK97937584 T DK 97937584T DK 0922045 T3 DK0922045 T3 DK 0922045T3
Authority
DK
Denmark
Prior art keywords
pyrimidine derivatives
anticoagulants
bicyclic pyrimidine
compounds
directed
Prior art date
Application number
DK97937584T
Other languages
Danish (da)
English (en)
Inventor
Michael M Morrissey
Brad Buckman
Raju Mohan
Original Assignee
Schering Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Ag filed Critical Schering Ag
Application granted granted Critical
Publication of DK0922045T3 publication Critical patent/DK0922045T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D475/00—Heterocyclic compounds containing pteridine ring systems
    • C07D475/02—Heterocyclic compounds containing pteridine ring systems with an oxygen atom directly attached in position 4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
DK97937584T 1996-08-16 1997-08-14 Bicykliske pyrimidinderivater og deres anvendelse som antikoagulanter DK0922045T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/699,372 US5693641A (en) 1996-08-16 1996-08-16 Bicyclic pyrimidine derivatives and their use as anti-coagulants
PCT/EP1997/004444 WO1998007723A1 (en) 1996-08-16 1997-08-14 Bicyclic pyrimidine derivatives and their use as anti-coagulants

Publications (1)

Publication Number Publication Date
DK0922045T3 true DK0922045T3 (da) 2003-06-30

Family

ID=24809035

Family Applications (1)

Application Number Title Priority Date Filing Date
DK97937584T DK0922045T3 (da) 1996-08-16 1997-08-14 Bicykliske pyrimidinderivater og deres anvendelse som antikoagulanter

Country Status (21)

Country Link
US (3) US5693641A (cs)
EP (1) EP0922045B1 (cs)
JP (1) JP2000516241A (cs)
KR (1) KR20000068173A (cs)
CN (1) CN1112363C (cs)
AT (1) ATE237617T1 (cs)
AU (1) AU724413B2 (cs)
CA (1) CA2261908A1 (cs)
CZ (1) CZ297323B6 (cs)
DE (1) DE69721008T2 (cs)
DK (1) DK0922045T3 (cs)
ES (1) ES2195163T3 (cs)
IL (1) IL128062A0 (cs)
NO (1) NO990708L (cs)
NZ (1) NZ333774A (cs)
PL (1) PL331634A1 (cs)
PT (1) PT922045E (cs)
RU (1) RU2198884C2 (cs)
SK (1) SK19199A3 (cs)
UA (1) UA59370C2 (cs)
WO (1) WO1998007723A1 (cs)

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US5994375A (en) 1996-02-12 1999-11-30 Berlex Laboratories, Inc. Benzamidine derivatives substituted by amino acid and hydroxy acid derivatives and their use as anti-coagulants
CA2264521A1 (en) 1996-09-12 1998-03-19 Schering Aktiengesellschaft Benzamidine derivatives substituted by cyclic amino acid or cyclic hydroxy acid derivatives and their use as anti-coagulants
US6004985A (en) * 1996-10-09 1999-12-21 Berlex Laboratories, Inc. Thio acid derived monocylic N-heterocyclics as anticoagulants
US6686364B2 (en) 1997-12-08 2004-02-03 Berlex Laboratories, Inc. Benzamidine derivatives and their use as anti-coagulants
US6140351A (en) * 1997-12-19 2000-10-31 Berlex Laboratories, Inc. Ortho-anthranilamide derivatives as anti-coagulants
SK9432000A3 (en) 1997-12-19 2001-02-12 Schering Ag Ortho-anthranilamide derivatives as anti-coagulants, pharmaceutical composition containing such derivatives and use thereof
US6262088B1 (en) 1998-11-19 2001-07-17 Berlex Laboratories, Inc. Polyhydroxylated monocyclic N-heterocyclic derivatives as anti-coagulants
US6127376A (en) 1998-12-04 2000-10-03 Berlex Laboratories, Inc. Aryl and heterocyclyl substituted pyrimidine derivatives as anti-coagulants
EP1140862A4 (en) 1998-12-23 2004-07-28 Bristol Myers Squibb Pharma Co THROMBIN OR Xa FACTOR INHIBITORS
US6350761B1 (en) 1999-07-30 2002-02-26 Berlex Laboratories, Inc. Benzenamine derivatives as anti-coagulants
AU2002351412B2 (en) 2001-12-21 2010-05-20 Exelixis Patent Company Llc Modulators of LXR
US7482366B2 (en) 2001-12-21 2009-01-27 X-Ceptor Therapeutics, Inc. Modulators of LXR
DE10239821A1 (de) * 2002-08-29 2004-03-11 Roche Diagnostics Gmbh Verbesserung der Spezifität bei der Bestimmung von Antithrombin
CA2507707C (en) 2002-12-03 2011-06-21 Axys Pharmaceuticals, Inc. 2-(2-hydroxybiphenyl-3-yl)-1h-benzoimidazole-5-carboxamidine derivatives as factor viia inhibitors
US7176196B2 (en) * 2004-05-28 2007-02-13 Bristol-Myers Squibb Company Bicyclic heterocycles as HIV integrase inhibitors
NZ576278A (en) 2006-10-19 2011-12-22 Signal Pharm Llc Heteroaryl compounds, compositions thereof, and their use as protein kinase inhibitors
US8383654B2 (en) * 2008-11-17 2013-02-26 Panmira Pharmaceuticals, Llc Heterocyclic antagonists of prostaglandin D2 receptors
SG172060A1 (en) 2008-12-09 2011-07-28 Gilead Sciences Inc Modulators of toll-like receptors
AU2010292102B2 (en) * 2009-09-14 2015-04-09 Gilead Sciences, Inc. Modulators of Toll-like receptors
CN103180318B (zh) 2010-05-14 2017-05-10 达那-法伯癌症研究所 雄性避孕组合物以及使用方法
US9714946B2 (en) 2013-03-14 2017-07-25 Dana-Farber Cancer Institute, Inc. Bromodomain binding reagents and uses thereof
EP3733060B1 (en) 2013-05-07 2021-06-16 St. Jude Medical, Atrial Fibrillation Division, Inc. Utilization of electrode spatial arrangements for characterizing cardiac conduction conditions
US9975896B2 (en) 2013-07-25 2018-05-22 Dana-Farber Cancer Institute, Inc. Inhibitors of transcription factors and uses thereof
US11446309B2 (en) 2013-11-08 2022-09-20 Dana-Farber Cancer Institute, Inc. Combination therapy for cancer using bromodomain and extra-terminal (BET) protein inhibitors
JP2017504653A (ja) 2014-01-31 2017-02-09 ダナ−ファーバー キャンサー インスティテュート， インコーポレイテッド ジアミノピリミジンベンゼンスルホン誘導体およびその使用
WO2015117087A1 (en) 2014-01-31 2015-08-06 Dana-Farber Cancer Institute, Inc. Uses of diazepane derivatives
CA2936256A1 (en) 2014-01-31 2015-08-06 Dana-Farber Cancer Institute, Inc. Diazepane derivatives and uses thereof
MX377534B (es) 2014-02-28 2025-03-10 Tensha Therapeutics Inc Compuestos para usarse en el tratamiento de hiperinsulinemia.
NZ728072A (en) 2014-07-11 2018-06-29 Gilead Sciences Inc Modulators of toll-like receptors for the treatment of hiv
BR112017002190A2 (pt) 2014-08-08 2017-11-21 Dana Farber Cancer Inst Inc derivados de di-hidropteridinona e usos dos mesmos
EP3177626A4 (en) 2014-08-08 2017-12-27 Dana Farber Cancer Institute, Inc. Diazepane derivatives and uses thereof
SG11201701520TA (en) 2014-09-16 2017-04-27 Gilead Sciences Inc Solid forms of a toll-like receptor modulator
CN115043840A (zh) 2014-09-16 2022-09-13 吉利德科学公司 制备toll样受体调节剂的方法
BR112017008714A2 (pt) 2014-10-27 2017-12-19 Tensha Therapeutics Inc inibidores de bromodomínio
EP3307728A4 (en) 2015-06-12 2019-07-17 Dana Farber Cancer Institute, Inc. COMBINATION THERAPY OF TRANSCRIPTION INHIBITORS AND CHINESE INHIBITORS
BR112018004617A2 (pt) 2015-09-11 2018-09-25 Dana Farber Cancer Inst Inc acetamida tienotriazoldiazepinas e usos das mesmas
CR20180200A (es) 2015-09-11 2018-05-31 Dana Farber Cancer Inst Inc Ciano tienotriazolpirazinas y usos de las mismas
WO2017091673A2 (en) 2015-11-25 2017-06-01 Dana-Farber Cancer Institute, Inc. Bivalent bromodomain inhibtors and uses thereof
CN114423785B (zh) 2019-07-01 2025-04-22 通尼克斯制药有限公司 抗-cd154抗体及其用途
WO2022150452A1 (en) 2021-01-06 2022-07-14 Seth Lederman Methods of inducing immune tolerance with modified anti-cd154 antibodies

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CA1297100C (en) * 1986-08-28 1992-03-10 Ryuji Niwa Medicament for curing arteriosclerosis, comprising pyrimido [2,1-b]-benxothiazole derivative
ZA924760B (en) * 1991-06-28 1993-03-31 Smithkline Beecham Corp Bicyclic fibrinogen antagonists
ZA928276B (en) * 1991-10-31 1993-05-06 Daiichi Seiyaku Co Aromatic amidine derivates and salts thereof.
CA2129339C (en) * 1992-02-14 2002-09-10 George P. Vlasuk Inhibitors of thrombosis
DE4213919A1 (de) * 1992-04-28 1993-11-04 Thomae Gmbh Dr K Cyclische iminoderivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
AU675981B2 (en) * 1992-12-02 1997-02-27 Bristol-Myers Squibb Company Guanidinyl-substituted heterocyclic thrombin inhibitors
US5883077A (en) * 1992-12-15 1999-03-16 Corvas International, Inc. Inhibitors of factor Xa
US5332822A (en) * 1992-12-24 1994-07-26 Bristol-Myers Squibb Company Heteroaromatic and thioheteroaromatic substituted sulfonamide thrombin inhibitors
DE69419141D1 (de) * 1993-02-12 1999-07-22 Corvas Int Inc Inhibitoren gegen thrombose
IL115420A0 (en) * 1994-09-26 1995-12-31 Zeneca Ltd Aminoheterocyclic derivatives

Also Published As

Publication number Publication date
NO990708L (no) 1999-04-15
UA59370C2 (uk) 2003-09-15
JP2000516241A (ja) 2000-12-05
CZ50199A3 (cs) 1999-06-16
KR20000068173A (ko) 2000-11-25
ES2195163T3 (es) 2003-12-01
DE69721008D1 (de) 2003-05-22
NO990708D0 (no) 1999-02-15
CA2261908A1 (en) 1998-02-26
PT922045E (pt) 2003-07-31
AU724413B2 (en) 2000-09-21
US5846972A (en) 1998-12-08
ATE237617T1 (de) 2003-05-15
US5846970A (en) 1998-12-08
CN1112363C (zh) 2003-06-25
RU2198884C2 (ru) 2003-02-20
SK19199A3 (en) 1999-07-12
NZ333774A (en) 2000-08-25
US5693641A (en) 1997-12-02
IL128062A0 (en) 1999-11-30
PL331634A1 (en) 1999-08-02
CN1227553A (zh) 1999-09-01
HK1020058A1 (en) 2000-03-10
EP0922045A1 (en) 1999-06-16
EP0922045B1 (en) 2003-04-16
DE69721008T2 (de) 2003-12-24
CZ297323B6 (cs) 2006-11-15
AU4015697A (en) 1998-03-06
WO1998007723A1 (en) 1998-02-26

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