DK0902785T3 - Fremgangsmåder og mellemprodukter til fremstilling af 4'-trifluormethylbiphenyl-2-carboxylsyre-[2-(2H-[1,2,4]triazol-3-ylmethyl)-1,2,3,4-tetrahydroisoquinolin-2-yl]amid - Google Patents

Fremgangsmåder og mellemprodukter til fremstilling af 4'-trifluormethylbiphenyl-2-carboxylsyre-[2-(2H-[1,2,4]triazol-3-ylmethyl)-1,2,3,4-tetrahydroisoquinolin-2-yl]amid

Info

Publication number
DK0902785T3
DK0902785T3 DK97905354T DK97905354T DK0902785T3 DK 0902785 T3 DK0902785 T3 DK 0902785T3 DK 97905354 T DK97905354 T DK 97905354T DK 97905354 T DK97905354 T DK 97905354T DK 0902785 T3 DK0902785 T3 DK 0902785T3
Authority
DK
Denmark
Prior art keywords
trifluoromethylbiphenyl
tetrahydroisoquinolin
triazol
ylmethyl
intermediates
Prior art date
Application number
DK97905354T
Other languages
Danish (da)
English (en)
Inventor
Frank John Urban
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Application granted granted Critical
Publication of DK0902785T3 publication Critical patent/DK0902785T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
DK97905354T 1996-04-30 1997-03-13 Fremgangsmåder og mellemprodukter til fremstilling af 4'-trifluormethylbiphenyl-2-carboxylsyre-[2-(2H-[1,2,4]triazol-3-ylmethyl)-1,2,3,4-tetrahydroisoquinolin-2-yl]amid DK0902785T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US1649596P 1996-04-30 1996-04-30
PCT/IB1997/000254 WO1997041111A1 (fr) 1996-04-30 1997-03-13 Procedes et intermediaires pour la preparation de [2-(2h-[1,2,4]triazol-3-ylmethyl)-1,2,3,4-tetrahydro-isoquinolein-6-yl]-amide d'acide 4'-trifluoromethylbiphenyl-2-carboxylique

Publications (1)

Publication Number Publication Date
DK0902785T3 true DK0902785T3 (da) 2002-10-07

Family

ID=21777423

Family Applications (1)

Application Number Title Priority Date Filing Date
DK97905354T DK0902785T3 (da) 1996-04-30 1997-03-13 Fremgangsmåder og mellemprodukter til fremstilling af 4'-trifluormethylbiphenyl-2-carboxylsyre-[2-(2H-[1,2,4]triazol-3-ylmethyl)-1,2,3,4-tetrahydroisoquinolin-2-yl]amid

Country Status (23)

Country Link
US (1) US5998623A (fr)
EP (1) EP0902785B1 (fr)
JP (1) JPH11507959A (fr)
KR (1) KR20000065152A (fr)
CN (1) CN1216988A (fr)
AR (1) AR006876A1 (fr)
AT (1) ATE223400T1 (fr)
AU (1) AU711279B2 (fr)
BR (1) BR9709137A (fr)
CA (1) CA2252621C (fr)
CZ (1) CZ346498A3 (fr)
DE (1) DE69715188T2 (fr)
DK (1) DK0902785T3 (fr)
ES (1) ES2180935T3 (fr)
HU (1) HUP9902157A3 (fr)
ID (1) ID17294A (fr)
IL (1) IL126202A0 (fr)
PL (1) PL329739A1 (fr)
PT (1) PT902785E (fr)
TR (1) TR199802163T2 (fr)
WO (1) WO1997041111A1 (fr)
YU (1) YU16297A (fr)
ZA (1) ZA973696B (fr)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6197798B1 (en) 1998-07-21 2001-03-06 Novartis Ag Amino-benzocycloalkane derivatives
CA2324801A1 (fr) * 1999-11-10 2001-05-10 Andrew Gordon Swick Utilisation d'inhibiteurs de secretion d'apo b et/ou de mtp et d'agents contre l'obesite
IL139450A0 (en) * 1999-11-10 2001-11-25 Pfizer Prod Inc Methods of administering apo b-secretion/mtp inhibitors
IL139449A0 (en) * 1999-11-10 2001-11-25 Pfizer Prod Inc Use of apo b secretion/mtp inhibitors
CA2324800A1 (fr) * 1999-11-10 2001-05-10 Mary Anne Hickman Utilisation d'inhibiteurs de secretion d'apo b et/ou de mtp
ES2240420T3 (es) * 2000-01-18 2005-10-16 Novartis Ag Carboxamidas utiles como inhibidores de la proteina de transferencia de trigliceridos microsomicos y de la secrecion de apolipoproteina b.
WO2002014277A1 (fr) * 2000-08-10 2002-02-21 Tanabe Seiyaku Co., Ltd. Composes de biphenylcarboxamidoisoindoline, procedes de preparation de ceux-ci et produits intermediaires destines a la synthese de ceux-ci
WO2002014276A1 (fr) * 2000-08-10 2002-02-21 Tanabe Seiyaku Co., Ltd. Composes a base de benzoylaminoisoindoline, leurs procedes de preparation et produits intermediaires utilises dans leur synthese
JP5697296B2 (ja) 2004-03-05 2015-04-08 ザ トラスティーズ オブ ザ ユニバーシティ オブ ペンシルバニア 高脂血症および高コレステロール血症に関連する障害または疾患を、副作用を最小限にしつつ処置するための方法
WO2008075949A1 (fr) * 2006-12-20 2008-06-26 Friesland Brands B.V. Modulation de l'expression génique d'une protéine microsomale de transfert des triglycérides (mtp ou mttp) au moyen de microorganismes alimentaires ingérés/de qualité alimentaire

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU218419B (hu) * 1992-03-06 2000-08-28 E.R. Squibb And Sons, Inc. Mikroszomális triglicerid transzfer protein (MTP) nagy molekulatömegű alegységének rekombináns úton történő előállítására és a protein és inhibitorainak kimutatására szolgáló eljárások
US5595872A (en) * 1992-03-06 1997-01-21 Bristol-Myers Squibb Company Nucleic acids encoding microsomal trigyceride transfer protein
IL110172A (en) * 1993-07-22 2001-10-31 Lilly Co Eli Bicycle compounds and pharmaceuticals containing them
US5919795A (en) * 1995-06-07 1999-07-06 Pfizer Inc. Biphenyl-2-carboxylic acid-tetrahydro-isoquinolin-6-yl amide derivatives, their preparation and their use as inhibitors of microsomal triglyceride transfer protein and/or apolipoprotein B (Apo B) secretion
WO1996040640A1 (fr) * 1995-06-07 1996-12-19 Pfizer Inc. DERIVES DE BIPHENYL-2-ACIDE CARBOXYLIQUE-TETRAHYDRO-ISOQUINOLEINE-6-YL AMIDES, PREPARATION DE CES AMIDES ET UTILISATION EN TANT QU'INHIBITEURS DE LA PROTEINE DE TRANSFERT DE TRIGLYCERIDE MICROSOMAL ET/OU DE LA SECRETION D'APOLIPOPROTEINES B (Apo B)

Also Published As

Publication number Publication date
AU2226697A (en) 1997-11-19
BR9709137A (pt) 1999-08-03
IL126202A0 (en) 1999-05-09
DE69715188D1 (de) 2002-10-10
ATE223400T1 (de) 2002-09-15
DE69715188T2 (de) 2003-01-02
ID17294A (id) 1997-12-18
TR199802163T2 (xx) 1999-02-22
KR20000065152A (ko) 2000-11-06
WO1997041111A1 (fr) 1997-11-06
CA2252621C (fr) 2002-09-03
YU16297A (sh) 1999-09-27
CN1216988A (zh) 1999-05-19
CZ346498A3 (cs) 1999-09-15
HUP9902157A2 (hu) 2000-04-28
HUP9902157A3 (en) 2000-07-28
EP0902785A1 (fr) 1999-03-24
PT902785E (pt) 2002-12-31
JPH11507959A (ja) 1999-07-13
ZA973696B (en) 1998-10-29
CA2252621A1 (fr) 1997-11-06
AU711279B2 (en) 1999-10-07
AR006876A1 (es) 1999-09-29
US5998623A (en) 1999-12-07
ES2180935T3 (es) 2003-02-16
EP0902785B1 (fr) 2002-09-04
PL329739A1 (en) 1999-04-12

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