DK0902085T3 - Rekombinant human erythropoietin med fordelagtig glycosyleringsprofil - Google Patents
Rekombinant human erythropoietin med fordelagtig glycosyleringsprofilInfo
- Publication number
- DK0902085T3 DK0902085T3 DK97115081T DK97115081T DK0902085T3 DK 0902085 T3 DK0902085 T3 DK 0902085T3 DK 97115081 T DK97115081 T DK 97115081T DK 97115081 T DK97115081 T DK 97115081T DK 0902085 T3 DK0902085 T3 DK 0902085T3
- Authority
- DK
- Denmark
- Prior art keywords
- dna sequences
- vectors
- polypeptides
- glycosylation profile
- erythropoietin
- Prior art date
Links
- 230000013595 glycosylation Effects 0.000 title abstract 2
- 238000006206 glycosylation reaction Methods 0.000 title abstract 2
- 101000987586 Homo sapiens Eosinophil peroxidase Proteins 0.000 title 1
- 101000920686 Homo sapiens Erythropoietin Proteins 0.000 title 1
- 230000002349 favourable effect Effects 0.000 title 1
- 102000044890 human EPO Human genes 0.000 title 1
- 108091028043 Nucleic acid sequence Proteins 0.000 abstract 6
- 229920001184 polypeptide Polymers 0.000 abstract 5
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 5
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 5
- 239000013598 vector Substances 0.000 abstract 4
- 102000003951 Erythropoietin Human genes 0.000 abstract 2
- 108090000394 Erythropoietin Proteins 0.000 abstract 2
- 230000004071 biological effect Effects 0.000 abstract 2
- 229940105423 erythropoietin Drugs 0.000 abstract 2
- OXCMYAYHXIHQOA-UHFFFAOYSA-N potassium;[2-butyl-5-chloro-3-[[4-[2-(1,2,4-triaza-3-azanidacyclopenta-1,4-dien-5-yl)phenyl]phenyl]methyl]imidazol-4-yl]methanol Chemical compound [K+].CCCCC1=NC(Cl)=C(CO)N1CC1=CC=C(C=2C(=CC=CC=2)C2=N[N-]N=N2)C=C1 OXCMYAYHXIHQOA-UHFFFAOYSA-N 0.000 abstract 2
- 125000003275 alpha amino acid group Chemical group 0.000 abstract 1
- 208000007502 anemia Diseases 0.000 abstract 1
- 238000001727 in vivo Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 230000001105 regulatory effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/505—Erythropoietin [EPO]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Toxicology (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP97115081A EP0902085B1 (en) | 1997-09-01 | 1997-09-01 | Recombinant human erythropoietin with advantageous glycosylation profile |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK0902085T3 true DK0902085T3 (da) | 2004-04-05 |
Family
ID=8227297
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK97115081T DK0902085T3 (da) | 1997-09-01 | 1997-09-01 | Rekombinant human erythropoietin med fordelagtig glycosyleringsprofil |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US6673609B1 (pt) |
| EP (2) | EP0902085B1 (pt) |
| JP (1) | JP4345077B2 (pt) |
| KR (1) | KR100563017B1 (pt) |
| AT (1) | ATE255634T1 (pt) |
| AU (1) | AU743833B2 (pt) |
| CA (1) | CA2303476A1 (pt) |
| DE (1) | DE69726571T2 (pt) |
| DK (1) | DK0902085T3 (pt) |
| ES (1) | ES2208798T3 (pt) |
| PT (1) | PT902085E (pt) |
| WO (1) | WO1999011781A1 (pt) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7304150B1 (en) | 1998-10-23 | 2007-12-04 | Amgen Inc. | Methods and compositions for the prevention and treatment of anemia |
| CN1346369B (zh) * | 1998-10-23 | 2011-09-28 | 安姆根有限公司 | 用于预防和治疗贫血的方法以及组合物 |
| WO2000067769A1 (en) * | 1999-05-11 | 2000-11-16 | Ortho-Mcneil Pharmaceutical, Inc. | Enhanced survival of cancer patients treated with erythropoietin and antitumor agents |
| CZ299516B6 (cs) | 1999-07-02 | 2008-08-20 | F. Hoffmann-La Roche Ag | Konjugát erythropoetinového glykoproteinu, zpusobjeho výroby a použití a farmaceutická kompozice sjeho obsahem |
| PT1471871E (pt) | 2001-02-02 | 2007-06-05 | Ortho Mcneil Pharm Inc | Tratamento de disfunção neurológica compreendendo sulfamatos de frutopiranose e eritropoietina |
| US6818613B2 (en) | 2001-11-07 | 2004-11-16 | Ortho-Mcneil Pharmaceutical, Inc. | Aqueous sustained-release formulations of proteins |
| NZ532988A (en) | 2001-11-28 | 2008-04-30 | Ortho Mcneil Pharm Inc | Erythropoietin dosing regimen for treating anemia |
| EP1463751B1 (en) | 2001-12-21 | 2013-05-22 | Human Genome Sciences, Inc. | Albumin fusion proteins |
| US7129267B2 (en) | 2002-03-11 | 2006-10-31 | Janssen Pharmaceutica N.V. | Methods for SHP1 mediated neuroprotection |
| US7553930B2 (en) | 2003-01-06 | 2009-06-30 | Xencor, Inc. | BAFF variants and methods thereof |
| EP4155385A1 (en) | 2005-12-08 | 2023-03-29 | Amgen Inc. | Improved production of glycoproteins using manganese |
| CN101062407A (zh) | 2006-04-29 | 2007-10-31 | 中国科学院上海生命科学研究院 | 促红细胞生成素在预防或治疗视网膜损伤中的用途 |
| SG188143A1 (en) | 2008-02-08 | 2013-03-28 | Ambrx Inc | Modified leptin polypeptides and their uses |
| PL2342223T3 (pl) | 2008-09-26 | 2017-09-29 | Ambrx, Inc. | Zmodyfikowane polipeptydy zwierzęcej erytropoetyny i ich zastosowania |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL77081A (en) * | 1984-12-04 | 1999-10-28 | Genetics Inst | AND sequence encoding human erythropoietin, a process for its preparation and a pharmacological preparation of human erythropoietin |
| US5641663A (en) * | 1985-11-06 | 1997-06-24 | Cangene Corporation | Expression system for the secretion of bioactive human granulocyte macrophage colony stimulating factor (GM-CSF) and other heterologous proteins from steptomyces |
| US4954437A (en) * | 1986-09-15 | 1990-09-04 | Integrated Genetics, Inc. | Cell encoding recombinant human erythropoietin |
| DE3923963A1 (de) * | 1989-07-20 | 1991-01-31 | Behringwerke Ag | Muteine des menschlichen erythropoetins, ihre herstellung und ihre verwendung |
| JPH03151399A (ja) * | 1989-11-07 | 1991-06-27 | Snow Brand Milk Prod Co Ltd | 変異ヒトエリスロポエチン |
| CA2069746A1 (en) * | 1990-09-28 | 1992-03-29 | Jonathan I. Rosen | Hybrid growth factors |
| IL110669A (en) * | 1993-08-17 | 2008-11-26 | Kirin Amgen Inc | Erythropoietin analogs |
| US9505465B2 (en) * | 2014-12-15 | 2016-11-29 | Fundamental Consulting Services Inc. | Apparatus and method for attaching watercraft |
-
1997
- 1997-09-01 ES ES97115081T patent/ES2208798T3/es not_active Expired - Lifetime
- 1997-09-01 PT PT97115081T patent/PT902085E/pt unknown
- 1997-09-01 DE DE69726571T patent/DE69726571T2/de not_active Expired - Lifetime
- 1997-09-01 EP EP97115081A patent/EP0902085B1/en not_active Expired - Lifetime
- 1997-09-01 AT AT97115081T patent/ATE255634T1/de active
- 1997-09-01 DK DK97115081T patent/DK0902085T3/da active
-
1998
- 1998-08-26 CA CA002303476A patent/CA2303476A1/en not_active Abandoned
- 1998-08-26 AU AU95337/98A patent/AU743833B2/en not_active Ceased
- 1998-08-26 EP EP98948868A patent/EP1007679A1/en not_active Ceased
- 1998-08-26 JP JP2000508791A patent/JP4345077B2/ja not_active Expired - Fee Related
- 1998-08-26 US US09/486,222 patent/US6673609B1/en not_active Expired - Fee Related
- 1998-08-26 WO PCT/EP1998/005399 patent/WO1999011781A1/en not_active Application Discontinuation
- 1998-08-26 KR KR1020007002146A patent/KR100563017B1/ko not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| PT902085E (pt) | 2004-02-27 |
| DE69726571T2 (de) | 2004-11-04 |
| WO1999011781A1 (en) | 1999-03-11 |
| CA2303476A1 (en) | 1999-03-11 |
| EP1007679A1 (en) | 2000-06-14 |
| KR20010023500A (ko) | 2001-03-26 |
| AU9533798A (en) | 1999-03-22 |
| DE69726571D1 (de) | 2004-01-15 |
| EP0902085A1 (en) | 1999-03-17 |
| ES2208798T3 (es) | 2004-06-16 |
| KR100563017B1 (ko) | 2006-03-22 |
| EP0902085B1 (en) | 2003-12-03 |
| JP2001514851A (ja) | 2001-09-18 |
| AU743833B2 (en) | 2002-02-07 |
| US6673609B1 (en) | 2004-01-06 |
| ATE255634T1 (de) | 2003-12-15 |
| JP4345077B2 (ja) | 2009-10-14 |
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