DK0869809T3 - Oxideret glutathion som et middel, der øger endogen produktion af cytokin og hæmatopoietisk faktor - Google Patents

Oxideret glutathion som et middel, der øger endogen produktion af cytokin og hæmatopoietisk faktor

Info

Publication number
DK0869809T3
DK0869809T3 DK96941915T DK96941915T DK0869809T3 DK 0869809 T3 DK0869809 T3 DK 0869809T3 DK 96941915 T DK96941915 T DK 96941915T DK 96941915 T DK96941915 T DK 96941915T DK 0869809 T3 DK0869809 T3 DK 0869809T3
Authority
DK
Denmark
Prior art keywords
agent
cytokine production
oxidized glutathione
hematopoietic factor
increases endogenous
Prior art date
Application number
DK96941915T
Other languages
Danish (da)
English (en)
Inventor
Leonid Andreevich Kozhemyakin
Mark Borisovich Balazovsky
Original Assignee
Novelos Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novelos Therapeutics Inc filed Critical Novelos Therapeutics Inc
Priority claimed from PCT/RU1996/000340 external-priority patent/WO1997021444A1/en
Application granted granted Critical
Publication of DK0869809T3 publication Critical patent/DK0869809T3/da

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/06—Tripeptides
    • A61K38/063—Glutathione
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/20—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Dermatology (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DK96941915T 1995-12-14 1996-12-10 Oxideret glutathion som et middel, der øger endogen produktion af cytokin og hæmatopoietisk faktor DK0869809T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
RU95120403/14A RU2089179C1 (ru) 1995-12-14 1995-12-14 Стимулятор эндогенной продукции цитокинов и гепопоэтических факторов и способ его использования
PCT/RU1996/000226 WO1997021443A1 (en) 1995-12-14 1996-08-08 Cytokine and hemopoietic factor endogenous production enhancer and methods of use thereof
PCT/RU1996/000340 WO1997021444A1 (en) 1995-12-14 1996-12-10 Cytokine and hemopoietic factor endogenous production enhancer and methods of use thereof

Publications (1)

Publication Number Publication Date
DK0869809T3 true DK0869809T3 (da) 2002-07-29

Family

ID=20174317

Family Applications (1)

Application Number Title Priority Date Filing Date
DK96941915T DK0869809T3 (da) 1995-12-14 1996-12-10 Oxideret glutathion som et middel, der øger endogen produktion af cytokin og hæmatopoietisk faktor

Country Status (8)

Country Link
US (1) US6165979A (ru)
CN (1) CN1161149C (ru)
AU (1) AU6839196A (ru)
DK (1) DK0869809T3 (ru)
OA (1) OA10698A (ru)
PT (1) PT869809E (ru)
RU (1) RU2089179C1 (ru)
WO (1) WO1997021443A1 (ru)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6251857B1 (en) 1995-12-14 2001-06-26 Novelos Therapeutics, Inc. Cytokine and hemopoietic factor endogenous production enhancer and methods of use thereof
AU1890399A (en) 1998-01-19 1999-08-02 Takara Shuzo Co., Ltd. Substances capable of inducing apoptosis
JP2002509715A (ja) * 1998-03-30 2002-04-02 イ・デ・エム・イミュノ−デジネ・モレキュル 刺激された単球に由来する細胞、その調製及び用途
US6251868B1 (en) 1998-04-30 2001-06-26 Teijin Limited Method for treating a human immunodeficiency virus infection
US20070142267A1 (en) 1998-11-23 2007-06-21 Novelos Therapeutics, Inc. Methods for production of the oxidized glutathione composite with CIS-diamminedichloroplatinum and pharmaceutical compositions based thereof regulating metabolism, proliferation, differentiation and apoptotic mechanisms for normal and transformed cells
US6312734B1 (en) * 1998-11-23 2001-11-06 Novelos Therapeutics, Inc. Methods for production of the oxidized glutathione composite with cis-diamminedichloroplatinum and pharmaceutical compositions based thereof regulating metabolism, proliferation, differentiation and apoptotic mechanisms for normal and transformed cells
RU2144374C1 (ru) * 1998-11-23 2000-01-20 Закрытое акционерное общество "ВАМ" Способ получения композита окисленного глутатиона с cis-диаминодихлорплатиной и фармацевтических композиций на его основе, регулирующих метаболизм, пролиферацию, дифференцировку и механизмы апоптоза нормальных и трансформированных клеток
CA2453140C (en) * 2000-10-20 2016-01-05 Hamburger Stiftung Zur Forderung Von Wissenschaft Und Kultur Oxidized proteins, their biological activity, and therapeutic and diagnostic measures, which are derived from the active mechanism, from the use of these proteins and from the inhibition thereof
DE10051983A1 (de) * 2000-10-20 2002-06-13 Beate Kehrel Inhibierung der pathogenen Wirkung oxidierter Proteine
US20030073618A1 (en) * 2001-02-08 2003-04-17 Kozhemyakin Leonid A. Compounds comprising disulfide-containing peptides and nitrogenous bases, and medical uses thereof
US7790762B2 (en) * 2002-10-31 2010-09-07 National Jewish Health Compounds and methods for thiol-containing compound efflux and cancer treatment
US20080221029A1 (en) * 2002-10-31 2008-09-11 Regents Of The University Of Colorado Methods for treatment of thiol-containing compound deficient conditions
US20040087527A1 (en) * 2002-10-31 2004-05-06 Day Brian J. Methods for treatment of thiol-containing compound deficient conditions
EA010926B1 (ru) * 2006-01-20 2008-12-30 Леонид Андреевич Кожемякин Средство для лечения туберкулеза глаз, способ его получения и применения
US20110064828A1 (en) * 2009-09-11 2011-03-17 Novelos Therapeutics, Incorporated Treatment of metastatic tumors and other conditions
RU2451010C1 (ru) * 2011-01-11 2012-05-20 Закрытое Акционерное Общество "Ива Фарм" Палладиево-медные катализаторы гомогенного селективного окисления тиольных групп, комбинация и композиция на их основе и способ терапевтического воздействия
JP6055408B2 (ja) * 2011-06-30 2016-12-27 株式会社カネカ 固体状酸化型グルタチオン塩及びその製造方法
RU2659161C1 (ru) 2017-11-17 2018-06-28 Общество С Ограниченной Ответственностью "Ива Фарм" Фармацевтическая композиция, включающая дисульфид глутатиона и глутатион дисульфид s-оксид
CN114425051A (zh) * 2022-03-07 2022-05-03 茂名市人民医院 硫辛酸在制备治疗脓毒症和/或脓毒性休克的药物中的应用
CN114617899B (zh) * 2022-04-14 2023-10-20 苏州大学附属儿童医院 S-腺苷甲硫氨酸在制备治疗脓毒血症相关性脑病药物中的应用

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1176983B (it) * 1984-10-16 1987-08-26 Zambon Spa Dipeptidi ad attivita' farmacologica
DE3784905T2 (de) * 1986-07-07 1993-08-05 Teijin Ltd Gamma-l-glutamyl-l-cysteinethylester und arzneimittel, die dieses als aktives mittel enthalten.
DE3768419D1 (de) * 1986-10-07 1991-04-11 Boehringer Biochemia Srl Pharmazeutische zusammensetzungen mit antineoplastischer wirkung.
US4968671A (en) * 1987-11-26 1990-11-06 Yamanouchi Pharmaceutical Co., Ltd. Therapeutic agents for ischemic heart diseases
JPH049336A (ja) * 1990-04-26 1992-01-14 Yasuo Komoda 催眠剤
US5248697A (en) * 1990-09-20 1993-09-28 Brigham And Women's Hospital Enhancement of glutathione levels with glutamine
ES2106096T3 (es) * 1991-02-04 1997-11-01 Nestle Sa Procedimiento para asegurar glutation intracelular adecuado en el tejido.
US5977073A (en) * 1991-06-06 1999-11-02 Life Sciences' Technologies, Inc. Nutrient composition for treatment of immune disorders
US5618823A (en) * 1992-06-24 1997-04-08 Boehringer Mannheim Italia S.P.A. Glutathione as chemoprotective agent
GB9303854D0 (en) * 1993-02-25 1993-04-14 Holt John A G Method for enhancing t-cell count
JPH11507056A (ja) * 1995-06-07 1999-06-22 テラピン テクノロジーズ、インク． グルタチオンアナログの代謝的効果
US5916878A (en) * 1995-11-28 1999-06-29 Edward T. Wei γ-glutamyl and β-aspartyl containing immunomodulator compounds and methods therewith

Also Published As

Publication number Publication date
AU6839196A (en) 1997-07-03
RU2089179C1 (ru) 1997-09-10
OA10698A (en) 2002-11-26
CN1207683A (zh) 1999-02-10
CN1161149C (zh) 2004-08-11
PT869809E (pt) 2002-09-30
US6165979A (en) 2000-12-26
WO1997021443A1 (en) 1997-06-19

Similar Documents

Publication Publication Date Title
DK0869809T3 (da) Oxideret glutathion som et middel, der øger endogen produktion af cytokin og hæmatopoietisk faktor
DE60002696D1 (de) Redundanzbeseitigung in der persistenz von objektgraphen
AU5903098A (en) Sagnac raman amplifiers and cascade lasers
DK1002084T3 (da) Mammalt cytokin: interleukin-B30 og beslægtede reagenser
AU6316698A (en) Excimer laser with greater spectral bandwidth and beam stability
AU8169598A (en) Excimer laser with magnetic bearings supporting fan
DE69104243D1 (de) Höhere Pentafluorthio-substituierte fluoraliphatische Carbonyl- und Sulfonylfluoride sowie deren Derivate.
DE69300010D1 (de) Hochfeste Aluminiumlegierung.
BR9710884A (pt) Produ-Æo e uso de composi-{es compreendendo altas concentra-{es de atividade de vitamina b12
NO993467D0 (no) Granuler som innbefatter klavulanat og en eller flere eksipienter
IT8819807A0 (it) Metodo per la costruzione di gallerie di grande luce mediante arco cellulare.
ITMI951367A0 (it) Derivati della colchicina loro uso e formulazioni che li contengono
NO20001196D0 (no) Nootropisk middel
NO308090B1 (no) Dobbelt pulset, blitslampepumpet lasersystem
NO20003142D0 (no) Substituerte isokinolin-derivater og anvendelse derav som antikrampemidler
DE69810873T2 (de) Stabile und wasserlösliche Bis-AU(I)-Komplexe und deren Herstellung
DE69738194D1 (de) Mittels gasentladung gepumpter laser
NO984233D0 (no) Cytokin kalt lerk-8
ITRM990508A0 (it) Nitrilossi derivati della (r) e (s)-carnitina.
DE69100898D1 (de) Stanzstempelhalteblock und montageverfahren der stempel im genannten block.
TR200000862T2 (tr) Çok-komponentli taş macun.
ES1030938Y (es) Compresor con bloque de amortiguacion perfeccionado.
IT9047525A1 (it) Profilato per la realizzazione di telai fissi e mobili per serramenti metallici.
ITBO930016A1 (it) Procedimento per la lavorazione elettrochimica di pezzi metallici lastriformi.
IT234419Y1 (it) Portachiavi per automezzi ed altro, con registratore di messaggi parlati