DK0865435T3 - Fremgangsmåde til fremstilling af 3-amino-1,2,4-benzotriazin-dioxid - Google Patents

Fremgangsmåde til fremstilling af 3-amino-1,2,4-benzotriazin-dioxid

Info

Publication number
DK0865435T3
DK0865435T3 DK96941445T DK96941445T DK0865435T3 DK 0865435 T3 DK0865435 T3 DK 0865435T3 DK 96941445 T DK96941445 T DK 96941445T DK 96941445 T DK96941445 T DK 96941445T DK 0865435 T3 DK0865435 T3 DK 0865435T3
Authority
DK
Denmark
Prior art keywords
amino
preparation
benzofurazan
oxide
benzotriazine
Prior art date
Application number
DK96941445T
Other languages
Danish (da)
English (en)
Inventor
Richard E Philion
Original Assignee
Sanofi Synthelabo
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Synthelabo filed Critical Sanofi Synthelabo
Application granted granted Critical
Publication of DK0865435T3 publication Critical patent/DK0865435T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D253/00—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00
    • C07D253/02—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00 not condensed with other rings
    • C07D253/06—1,2,4-Triazines
    • C07D253/065—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D253/00—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00
    • C07D253/08—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00 condensed with carbocyclic rings or ring systems
    • C07D253/10—Condensed 1,2,4-triazines; Hydrogenated condensed 1,2,4-triazines

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
DK96941445T 1995-12-04 1996-11-21 Fremgangsmåde til fremstilling af 3-amino-1,2,4-benzotriazin-dioxid DK0865435T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/566,979 US5672702A (en) 1995-12-04 1995-12-04 Process for preparing 3 amino 1, 2, 4-benzotriazine dioxide
PCT/US1996/018761 WO1997020828A1 (en) 1995-12-04 1996-11-21 Process for preparing 3-amino-1,2,4-benzotriazine dioxide

Publications (1)

Publication Number Publication Date
DK0865435T3 true DK0865435T3 (da) 2002-05-27

Family

ID=24265255

Family Applications (1)

Application Number Title Priority Date Filing Date
DK96941445T DK0865435T3 (da) 1995-12-04 1996-11-21 Fremgangsmåde til fremstilling af 3-amino-1,2,4-benzotriazin-dioxid

Country Status (18)

Country Link
US (1) US5672702A (cs)
EP (1) EP0865435B1 (cs)
JP (1) JP2000501705A (cs)
KR (1) KR100502041B1 (cs)
CN (1) CN1068595C (cs)
AT (1) ATE213234T1 (cs)
AU (1) AU721627B2 (cs)
BR (1) BR9611864A (cs)
CZ (1) CZ292732B6 (cs)
DE (1) DE69619267T2 (cs)
DK (1) DK0865435T3 (cs)
ES (1) ES2172696T3 (cs)
MX (1) MX9804421A (cs)
NO (1) NO311216B1 (cs)
NZ (1) NZ323602A (cs)
PT (1) PT865435E (cs)
RU (1) RU2178413C2 (cs)
WO (1) WO1997020828A1 (cs)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2005509033A (ja) * 2001-11-13 2005-04-07 サノフィ−シンテラボ ３−アミノ−１，２，４−ベンゾトリアジンジオキドを調製する方法
US20090136521A1 (en) * 2005-10-03 2009-05-28 Genetix Pharmaceuticals , Inc. Method for Selectively Depleting Hypoxic Cells
CN101683319B (zh) * 2008-09-24 2012-09-05 杭州民生药业有限公司 一种替拉扎明非肠道给药含水制剂及其制备方法
CN104105692B (zh) * 2011-12-07 2016-06-29 思研（Sri）国际顾问与咨询公司 作为结核分枝杆菌靶向药物的苯并三嗪氧化物
US9278124B2 (en) 2012-10-16 2016-03-08 Halozyme, Inc. Hypoxia and hyaluronan and markers thereof for diagnosis and monitoring of diseases and conditions and related methods

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE794742A (fr) * 1972-02-01 1973-07-30 Bayer Ag Nouveaux di-n-oxydes (1,4) de benzo-1,2,4-triazine, leur procede de preparation et leur application comme medicaments et additifs de nutrition
US3980779A (en) * 1972-02-01 1976-09-14 Bayer Aktiengesellschaft 3-Amino-1,2,4-benzotriazine-1,4-di-N-oxide compositions and method of using same
DE2255947A1 (de) * 1972-11-15 1974-05-22 Bayer Ag Substituierte 3-amino-benzo-1,2,4triazin-di-n-oxide (1,4), verfahren zu ihrer herstellung sowie ihre verwendung als antimikrobielle mittel
US3991189A (en) * 1972-11-15 1976-11-09 Bayer Aktiengesellschaft Microbiocidal methods and compositions using substituted 1,2,4-triazine-1,4-di-N-oxide derivatives
DE2255946A1 (de) * 1972-11-15 1974-05-22 Bayer Ag Verfahren zur herstellung von neuen eckige klammer auf 3-benzo-1,2,4-triazinyldioxid (1,4) eckige klammer zu -harnstoffen, sowie ihre verwendung als arzneimittel und futterzusatzmittel
US3957779A (en) * 1972-11-15 1976-05-18 Bayer Aktiengesellschaft Benzo-1,2,4-triazines
CH576231A5 (en) * 1973-02-02 1976-06-15 Ciba Geigy Ag 1,2,4,-benztriazine-1,4-di-N-oxide derivs. - used in veterinary medicine against pathogenic micro-organisms or to promote growth
US5175287A (en) * 1986-09-25 1992-12-29 S R I International Process for preparing 1,2,4-benzotriazine oxides
GB2203151B (en) * 1986-09-25 1991-05-29 Stanford Res Inst Int 1,2,4-benzotriazine oxides as radiosensitisers and selective cytotoxic agents
DE68929050T2 (de) * 1989-09-18 2000-02-03 Sri International, Menlo Park 1,2,4-benzotriazinoxide als funkempfindliche und selektive zytotoxische mittel
US5484612A (en) * 1993-09-22 1996-01-16 The Board Of Trustees Of The Leland Stanford Junior University Method of treating a mammal having a solid tumor susceptible to treatment with cisplatin

Also Published As

Publication number Publication date
PT865435E (pt) 2002-07-31
JP2000501705A (ja) 2000-02-15
CN1207736A (zh) 1999-02-10
NO982315D0 (no) 1998-05-20
NO311216B1 (no) 2001-10-29
EP0865435B1 (en) 2002-02-13
CN1068595C (zh) 2001-07-18
MX9804421A (es) 1998-09-30
WO1997020828A1 (en) 1997-06-12
HK1017358A1 (en) 1999-11-19
RU2178413C2 (ru) 2002-01-20
NZ323602A (en) 1999-10-28
AU1058897A (en) 1997-06-27
CZ172398A3 (cs) 1998-09-16
EP0865435A4 (en) 1998-12-23
KR100502041B1 (ko) 2005-09-26
ES2172696T3 (es) 2002-10-01
DE69619267T2 (de) 2003-12-24
BR9611864A (pt) 1999-05-18
ATE213234T1 (de) 2002-02-15
AU721627B2 (en) 2000-07-13
EP0865435A1 (en) 1998-09-23
KR19990071913A (ko) 1999-09-27
NO982315L (no) 1998-05-20
CZ292732B6 (cs) 2003-12-17
US5672702A (en) 1997-09-30
DE69619267D1 (de) 2002-03-21

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