DK0847388T3 - Heterocyklisk substituerede biphenylamidderivater, fremstilling heraf og anvendelse heraf som fungicider - Google Patents

Heterocyklisk substituerede biphenylamidderivater, fremstilling heraf og anvendelse heraf som fungicider

Info

Publication number
DK0847388T3
DK0847388T3 DK96930102T DK96930102T DK0847388T3 DK 0847388 T3 DK0847388 T3 DK 0847388T3 DK 96930102 T DK96930102 T DK 96930102T DK 96930102 T DK96930102 T DK 96930102T DK 0847388 T3 DK0847388 T3 DK 0847388T3
Authority
DK
Denmark
Prior art keywords
fungicides
preparation
heterocyclic substituted
biphenylamide
derivatives
Prior art date
Application number
DK96930102T
Other languages
Danish (da)
English (en)
Inventor
Eberhard Ammermann
Harald Rang
Norbert Goetz
Gisela Lorenz
Karl Eicken
Albrecht Harreus
Siegfried Strathmann
Original Assignee
Basf Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Basf Ag filed Critical Basf Ag
Application granted granted Critical
Publication of DK0847388T3 publication Critical patent/DK0847388T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/81—Amides; Imides
    • C07D213/82—Amides; Imides in position 3
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/34—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom
    • A01N43/40—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom six-membered rings
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/48—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with two nitrogen atoms as the only ring hetero atoms
    • A01N43/56—1,2-Diazoles; Hydrogenated 1,2-diazoles
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/72—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms
    • A01N43/74—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms five-membered rings with one nitrogen atom and either one oxygen atom or one sulfur atom in positions 1,3
    • A01N43/78—1,3-Thiazoles; Hydrogenated 1,3-thiazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Dentistry (AREA)
  • Pest Control & Pesticides (AREA)
  • Plant Pathology (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Agronomy & Crop Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Environmental Sciences (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
DK96930102T 1995-08-30 1996-08-26 Heterocyklisk substituerede biphenylamidderivater, fremstilling heraf og anvendelse heraf som fungicider DK0847388T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19531813A DE19531813A1 (de) 1995-08-30 1995-08-30 Bisphenylamide
PCT/EP1996/003753 WO1997008148A1 (fr) 1995-08-30 1996-08-26 Derives de biphenylamide a substitution heterocyclique, leur preparation et leur utilisation comme fongicides

Publications (1)

Publication Number Publication Date
DK0847388T3 true DK0847388T3 (da) 2003-08-18

Family

ID=7770702

Family Applications (1)

Application Number Title Priority Date Filing Date
DK96930102T DK0847388T3 (da) 1995-08-30 1996-08-26 Heterocyklisk substituerede biphenylamidderivater, fremstilling heraf og anvendelse heraf som fungicider

Country Status (14)

Country Link
US (1) US5998450A (fr)
EP (1) EP0847388B1 (fr)
JP (1) JP3930049B2 (fr)
AR (1) AR003397A1 (fr)
AT (1) ATE243682T1 (fr)
AU (1) AU6928596A (fr)
CO (1) CO4750588A1 (fr)
DE (2) DE19531813A1 (fr)
DK (1) DK0847388T3 (fr)
ES (1) ES2202463T3 (fr)
PT (1) PT847388E (fr)
TW (1) TW328086B (fr)
WO (1) WO1997008148A1 (fr)
ZA (1) ZA967315B (fr)

Families Citing this family (58)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9817548D0 (en) * 1998-08-12 1998-10-07 Novartis Ag Organic compounds
DE19840322A1 (de) 1998-09-04 2000-03-09 Bayer Ag Pyrazol-carboxanilide
HUP0203624A3 (en) * 1999-12-09 2003-10-28 Syngenta Participations Ag Pyrazolecarboxamide and pyrazolethioamide as fungicide, intermediates, preparation and use thereof
GB9930750D0 (en) * 1999-12-29 2000-02-16 Novartis Ag Organic compounds
GB0001447D0 (en) * 2000-01-21 2000-03-08 Novartis Ag Organic compounds
BR0115200B1 (pt) * 2000-11-08 2012-08-07 composto, processo para a preparaÇço do mesmo, composiÇço para o controle de microorganismos e para a prevenÇço contra o ataque e infestaÇço de plantas, uso do composto, e, mÉtodo de controle ou de prevenÇço contra a infestaÇço de plantas cultivadas por microorganismos fitopatogÊnicos.
GB0101996D0 (en) * 2001-01-25 2001-03-14 Syngenta Participations Ag Organtic compounds
GB0103258D0 (en) * 2001-02-09 2001-03-28 Syngenta Participations Ag Organic compounds
CN1259911C (zh) * 2001-07-16 2006-06-21 奥索-麦克尼尔药品公司 用于预防或治疗神经性疼痛和丛集性头痛及偏头痛性疼痛的氨基甲酸酯化合物
DE10204390A1 (de) * 2002-02-04 2003-08-14 Bayer Cropscience Ag Disubstituierte Thiazolylcarboxanilide
DE10204391A1 (de) * 2002-02-04 2003-08-14 Bayer Cropscience Ag Difluormethylthiazolylcarboxanilide
DE10215292A1 (de) * 2002-02-19 2003-08-28 Bayer Cropscience Ag Disubstitutierte Pyrazolylcarbocanilide
DE10246959A1 (de) * 2002-10-09 2004-04-22 Bayer Cropscience Ag Thiazolylbiphenylamide
DE10250110A1 (de) * 2002-10-28 2004-05-13 Bayer Cropscience Ag Thiazol-(bi)cycloalkyl-carboxanilide
US7273866B2 (en) * 2002-12-20 2007-09-25 Bristol-Myers Squibb Company 2-aryl thiazole derivatives as KCNQ modulators
DE10347090A1 (de) 2003-10-10 2005-05-04 Bayer Cropscience Ag Synergistische fungizide Wirkstoffkombinationen
DE10349501A1 (de) 2003-10-23 2005-05-25 Bayer Cropscience Ag Synergistische fungizide Wirkstoffkombinationen
DE502005009089D1 (de) * 2004-06-18 2010-04-08 Basf Se 1-methyl-3-trifluormethyl-pyrazol-4-carbonsäure-(ortho-phenyl)-anilide und ihre verwendung als fungizid
DE102004041532A1 (de) * 2004-08-27 2006-03-02 Bayer Cropscience Ag Biphenylthiazolcarboxamide
DE102004041530A1 (de) 2004-08-27 2006-03-02 Bayer Cropscience Ag Biphenylthiazolcarboxamide
GB0422399D0 (en) * 2004-10-08 2004-11-10 Syngenta Participations Ag Fungicidal compositions
GB0422400D0 (en) * 2004-10-08 2004-11-10 Syngenta Participations Ag Fungicidal compositions
DE102004049761A1 (de) 2004-10-12 2006-04-13 Bayer Cropscience Ag Fungizide Wirkstoffkombinationen
DE102005009458A1 (de) * 2005-03-02 2006-09-07 Bayer Cropscience Ag Pyrazolylcarboxanilide
BRPI0612022B1 (pt) 2005-06-09 2016-12-06 Bayer Cropscience Ag combinações de substâncias ativas, seus usos, processos para combater fungos fitopatogênicos indesejáveis, processo para preparar composições fungicidas, revestimento de semente, e processos para revestir semente e semente transgênica
DE102005026482A1 (de) 2005-06-09 2006-12-14 Bayer Cropscience Ag Wirkstoffkombinationen
DE102005035300A1 (de) * 2005-07-28 2007-02-01 Bayer Cropscience Ag Synergistische fungizide Wirkstoffkombinationen
DE102005060464A1 (de) * 2005-12-17 2007-06-28 Bayer Cropscience Ag Pyrazolylcarboxamide
DE102005060462A1 (de) * 2005-12-17 2007-06-28 Bayer Cropscience Ag Biphenylcarboxamide
WO2007071656A1 (fr) * 2005-12-20 2007-06-28 Basf Aktiengesellschaft Procede pour lutter contre les attaques de rouille chez les legumineuses
EP2020854A1 (fr) * 2006-05-03 2009-02-11 Basf Se Utilisation de biphenylamides d'acide arylcarboxylique pour le traitement de semences
DE102006023263A1 (de) 2006-05-18 2007-11-22 Bayer Cropscience Ag Synergistische Wirkstoffkombinationen
DE102006036222A1 (de) * 2006-08-03 2008-02-07 Bayer Cropscience Ag 3-Difluormethyl-pyrazolylcarboxanilide
WO2008053044A2 (fr) * 2006-11-03 2008-05-08 Basf Se Composés de n-(biphène-2-yl)amide d'acide hétarylcarboxylique
WO2008095890A2 (fr) * 2007-02-05 2008-08-14 Basf Se Mélanges fongicides comprenant des 1-méthylpyrazol-4-ylcarboxanilides substitués
DE102007045920B4 (de) 2007-09-26 2018-07-05 Bayer Intellectual Property Gmbh Synergistische Wirkstoffkombinationen
EP2285779B1 (fr) * 2008-05-08 2013-03-27 Basf Se Procédé de production de carboxamides d aryle
WO2010000856A1 (fr) * 2008-07-03 2010-01-07 Basf Se Procédé de production d’aminobiphényles
US8749032B2 (en) * 2008-12-05 2014-06-10 Sige Semiconductor, Inc. Integrated circuit with improved transmission line structure and electromagnetic shielding between radio frequency circuit paths
BRPI1007937B1 (pt) 2009-01-30 2017-11-21 Bayer Intellectual Property Gmbh Use of fluopiram to control primary eye inflammations
CN102316736B (zh) 2009-02-13 2016-06-01 拜耳知识产权有限责任公司 琥珀酸脱氢酶抑制剂延长果实和蔬菜贮存期限的用途
EP2398764B1 (fr) 2009-02-19 2014-11-26 Basf Se Procédé de fabrication de 2-aminobiphenylènes
US9012360B2 (en) 2009-03-25 2015-04-21 Bayer Intellectual Property Gmbh Synergistic combinations of active ingredients
EP2255626A1 (fr) 2009-05-27 2010-12-01 Bayer CropScience AG Utilisation d'inhibiteurs de succinate déhydrogénase destinés à l'augmentation de la résistance de plantes ou de parties de plantes contre le stress abiotique
AU2010272872B2 (en) 2009-07-16 2014-08-28 Bayer Intellectual Property Gmbh Synergistic active substance combinations containing phenyl triazoles
EP2301350A1 (fr) * 2009-09-16 2011-03-30 Bayer CropScience AG Utilisation d'inhibiteurs de succinate déshydrogénase pour augmenter la teneur d'ingrédients spécifiques dans les cultures
WO2011054733A1 (fr) 2009-11-05 2011-05-12 Basf Se Procédé de préparation d'aminal et utilisation afférente pour la préparation de composés 1,3-pyrazole disubstitués
CN102596912B (zh) 2009-11-05 2015-08-12 巴斯夫欧洲公司 制备1,3-二取代吡唑化合物的方法
EP2353387A1 (fr) 2010-02-05 2011-08-10 Bayer CropScience AG Utilisation d'inhibiteurs de succinate déshydrogénase (SDH) dans le traitement de types de plantes de la famille des graminées
EP2377397A1 (fr) 2010-04-14 2011-10-19 Bayer CropScience AG Utilisation de matières actives fongicides destinées au contrôle des mycoses sur des palmiers
CA2806419C (fr) 2010-07-26 2018-08-21 Lorianne Fought Utilisation d'inhibiteurs de la succinate deshydrogenase et/ou d'inhibiteurs du complexe iii de la chaine respiratoire pour l'amelioration du rapport des microorganismes dangereux a benefiques
CN103476256B (zh) 2011-02-17 2016-01-20 拜耳知识产权有限责任公司 Sdhi杀真菌剂用于常规育种的asr耐受性的茎溃疡抗性和／或蛙眼叶斑病抗性大豆品种的用途
WO2013132006A1 (fr) 2012-03-07 2013-09-12 Friedrich-Alexander-Universität Erlangen-Nürnberg Procédé de synthèse d'aminobiphényles en utilisant des arylhydrazines
EP2919586B1 (fr) 2012-11-19 2019-03-20 Arch Wood Protection, Inc. Compositions contenant d'inhibiteur de succinate déshydrogénase
WO2014083088A2 (fr) 2012-11-30 2014-06-05 Bayer Cropscience Ag Mélanges fongicides binaires
EP2910126A1 (fr) 2015-05-05 2015-08-26 Bayer CropScience AG Combinaisons de composés actifs à propriétés insecticides
CN106316977B (zh) * 2015-06-24 2018-03-20 华中师范大学 一种噻唑双酰胺类化合物及其制备方法和应用
CN110128346A (zh) * 2019-05-17 2019-08-16 南开大学 一类联芳酰胺吡唑衍生物及其制备方法和用途

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2417216A1 (de) * 1974-04-09 1975-11-06 Basf Ag Fungizide
US4214090A (en) * 1976-01-14 1980-07-22 Commonwealth Scientific And Industrial Research Organization Fungicidal carboxamidopyrazoles
US4134987A (en) * 1976-01-14 1979-01-16 Huppatz John L Compounds and compositions
CA2081935C (fr) * 1991-11-22 2004-05-25 Karl Eicken Derives d'anilide et leur emploi contre botrytis
DE4231517A1 (de) * 1992-09-21 1994-03-24 Basf Ag Carbonsäureanilide, Verfahren zu ihrer Herstellung und sie enthaltende Mittel zur Bekämpfung von Schadpilzen
JPH07145156A (ja) * 1993-11-24 1995-06-06 Mitsui Toatsu Chem Inc チアゾールカルボン酸アミド誘導体およびこれを有効成分とする農園芸用殺菌剤
GB9405347D0 (en) * 1994-03-18 1994-05-04 Agrevo Uk Ltd Fungicides

Also Published As

Publication number Publication date
JPH11511449A (ja) 1999-10-05
TW328086B (en) 1998-03-11
PT847388E (pt) 2003-10-31
JP3930049B2 (ja) 2007-06-13
DE59610557D1 (de) 2003-07-31
DE19531813A1 (de) 1997-03-06
WO1997008148A1 (fr) 1997-03-06
CO4750588A1 (es) 1999-03-31
US5998450A (en) 1999-12-07
ATE243682T1 (de) 2003-07-15
ZA967315B (en) 1998-03-02
EP0847388B1 (fr) 2003-06-25
ES2202463T3 (es) 2004-04-01
AR003397A1 (es) 1998-07-08
EP0847388A1 (fr) 1998-06-17
AU6928596A (en) 1997-03-19

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