DK0832101T3 - Urethan-formidlede, GST-specifikke molekylfrigörelsessystemer - Google Patents
Urethan-formidlede, GST-specifikke molekylfrigörelsessystemerInfo
- Publication number
- DK0832101T3 DK0832101T3 DK96918420T DK96918420T DK0832101T3 DK 0832101 T3 DK0832101 T3 DK 0832101T3 DK 96918420 T DK96918420 T DK 96918420T DK 96918420 T DK96918420 T DK 96918420T DK 0832101 T3 DK0832101 T3 DK 0832101T3
- Authority
- DK
- Denmark
- Prior art keywords
- glu
- gly
- asp
- formula
- gst
- Prior art date
Links
- JOYRKODLDBILNP-UHFFFAOYSA-N Ethyl urethane Chemical compound CCOC(N)=O JOYRKODLDBILNP-UHFFFAOYSA-N 0.000 title 1
- 230000001404 mediated effect Effects 0.000 title 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 5
- CKLJMWTZIZZHCS-REOHCLBHSA-N L-aspartic acid Chemical compound OC(=O)[C@@H](N)CC(O)=O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 abstract 2
- ZTEDWFWBGPKUOD-UHFFFAOYSA-N L-beta-aspartyl-L-glycine Chemical compound OC(=O)C(N)CC(=O)NCC(O)=O ZTEDWFWBGPKUOD-UHFFFAOYSA-N 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 229910052711 selenium Inorganic materials 0.000 abstract 2
- 229910052717 sulfur Inorganic materials 0.000 abstract 2
- JHFNSBBHKSZXKB-VKHMYHEASA-N Asp-Gly Chemical compound OC(=O)C[C@H](N)C(=O)NCC(O)=O JHFNSBBHKSZXKB-VKHMYHEASA-N 0.000 abstract 1
- LSPKYLAFTPBWIL-BYPYZUCNSA-N Glu-Gly Chemical compound OC(=O)CC[C@H](N)C(=O)NCC(O)=O LSPKYLAFTPBWIL-BYPYZUCNSA-N 0.000 abstract 1
- 102000005720 Glutathione transferase Human genes 0.000 abstract 1
- 108010070675 Glutathione transferase Proteins 0.000 abstract 1
- WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 abstract 1
- ACIJGUBIMXQCMF-UHFFFAOYSA-N N-L-gamma-glutamyl-glycine Natural products OC(=O)C(N)CCC(=O)NCC(O)=O ACIJGUBIMXQCMF-UHFFFAOYSA-N 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 150000001408 amides Chemical class 0.000 abstract 1
- 150000001413 amino acids Chemical class 0.000 abstract 1
- 108010047857 aspartylglycine Proteins 0.000 abstract 1
- KXAWLANLJYMEGB-UHFFFAOYSA-N beta-Asp-Asp Natural products OC(=O)C(N)CC(=O)NC(C(O)=O)CC(O)=O KXAWLANLJYMEGB-UHFFFAOYSA-N 0.000 abstract 1
- 108010056625 beta-aspartylglycine Proteins 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- ACIJGUBIMXQCMF-BYPYZUCNSA-N gamma-Glu-Gly Chemical compound OC(=O)[C@@H](N)CCC(=O)NCC(O)=O ACIJGUBIMXQCMF-BYPYZUCNSA-N 0.000 abstract 1
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 abstract 1
- 229940002612 prodrug Drugs 0.000 abstract 1
- 239000000651 prodrug Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
- PIZNQHDTOZMVBH-UHFFFAOYSA-N thionylimide Chemical compound N=S=O PIZNQHDTOZMVBH-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/0215—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing natural amino acids, forming a peptide bond via their side chain functional group, e.g. epsilon-Lys, gamma-Glu
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Materials For Medical Uses (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/476,119 US5908919A (en) | 1993-10-01 | 1995-06-07 | Urethane mediated, GST specific molecular release systems |
| PCT/US1996/009831 WO1996040739A2 (en) | 1995-06-07 | 1996-06-07 | Urethane mediated, gst specific molecular release systems |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK0832101T3 true DK0832101T3 (da) | 2004-11-29 |
Family
ID=23890586
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK96918420T DK0832101T3 (da) | 1995-06-07 | 1996-06-07 | Urethan-formidlede, GST-specifikke molekylfrigörelsessystemer |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US5908919A (da) |
| EP (1) | EP0832101B1 (da) |
| JP (1) | JPH11507370A (da) |
| AT (1) | ATE273318T1 (da) |
| AU (1) | AU722595B2 (da) |
| CA (1) | CA2224191A1 (da) |
| DE (1) | DE69633126T2 (da) |
| DK (1) | DK0832101T3 (da) |
| ES (1) | ES2227592T3 (da) |
| WO (1) | WO1996040739A2 (da) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5880097A (en) * | 1996-01-04 | 1999-03-09 | Terrapin Techologies, Inc. | Tethered prodrugs |
| US6339151B1 (en) | 1998-01-23 | 2002-01-15 | Newbiotics, Inc. | Enzyme catalyzed therapeutic agents |
| US7462605B2 (en) | 1998-01-23 | 2008-12-09 | Celmed Oncology (Usa), Inc. | Phosphoramidate compounds and methods of use |
| US6683061B1 (en) | 1999-07-22 | 2004-01-27 | Newbiotics, Inc. | Enzyme catalyzed therapeutic activation |
| AU774492B2 (en) | 1999-07-22 | 2004-07-01 | Celmed Oncology (Usa) Inc. | Methods for treating therapy-resistant tumors |
| US7172905B2 (en) * | 2001-08-07 | 2007-02-06 | The University Of Chicago | Polypeptide immobilization |
| AU2003247907A1 (en) * | 2002-07-05 | 2004-01-23 | University Of Chicago | Characterization of biochips containing self-assembled monolayers with maldi-tof-ms |
| ES2314890T3 (es) * | 2005-01-06 | 2009-03-16 | Telik, Inc. | Tioeteres tripeptidicos y tetrapeptidicos. |
| JP5977229B2 (ja) * | 2010-05-05 | 2016-08-24 | プロリンクス リミテッド ライアビリティ カンパニー | 巨大分子共役体からの徐放 |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS60255789A (ja) * | 1984-06-01 | 1985-12-17 | Kyowa Hakko Kogyo Co Ltd | マイトマイシン誘導体，その製造法および抗腫瘍剤 |
| JPH07119760B2 (ja) * | 1984-07-24 | 1995-12-20 | コモンウエルス・セ−ラム・ラボラトリ−ズ・コミッション | ミモトープを検出または決定する方法 |
| WO1986006487A1 (en) * | 1985-04-22 | 1986-11-06 | Commonwealth Serum Laboratories Commission | Method for determining mimotopes |
| US4851388A (en) * | 1986-01-23 | 1989-07-25 | Pfizer Inc. | Heptanoyl-glu-asp-ala-amino acid immunostimulants |
| US5133866A (en) * | 1988-03-24 | 1992-07-28 | Terrapin Technologies, Inc. | Method to identify analyte-bending ligands |
| US4963263A (en) * | 1988-03-24 | 1990-10-16 | Terrapin Technologies, Inc. | Method of identity analyte-binding peptides |
| WO1990012088A1 (en) * | 1989-04-13 | 1990-10-18 | The United States Of America, As Represented By The Secretary, U.S. Department Of Commerce | MONOCLONAL ANTIBODIES TO HUMAN GLUTATHIONE S TRANSFERASE Pi |
| JP2919867B2 (ja) * | 1989-09-27 | 1999-07-19 | 千寿製薬株式会社 | 抗腫瘍剤 |
| WO1991017240A1 (en) * | 1990-05-07 | 1991-11-14 | Baxter Diagnostics Inc. | Method and apparatus for conducting the cytotoxicity assays on tumor cells |
| US5204241A (en) * | 1990-10-22 | 1993-04-20 | Oxi-Gene Inc. | Glutathione-S-transferase mu as a measure of drug resistance |
| EP0630412B1 (en) * | 1991-04-29 | 1998-11-11 | Terrapin Technologies, Inc. | Methods to profile and treat abnormal cells |
| US5786336A (en) * | 1991-04-29 | 1998-07-28 | Terrapin Technologies, Inc. | Target-selective protocols based on mimics |
| US5545621A (en) * | 1991-04-29 | 1996-08-13 | Terrapin Technologies, Inc. | Glutathione S-transferase-activated compounds |
| US5556942A (en) * | 1991-04-29 | 1996-09-17 | Terrapin Technologies, Inc. | Glutathione S-transferase-activated compounds |
| US5430045A (en) * | 1992-04-23 | 1995-07-04 | Free Radical Sciences, Inc. | Method of reducing or preventing bone marrow hypoplasia |
| WO1993024476A1 (en) * | 1992-06-04 | 1993-12-09 | Clover Consolidated, Limited | Water-soluble polymeric carriers for drug delivery |
-
1995
- 1995-06-07 US US08/476,119 patent/US5908919A/en not_active Expired - Fee Related
-
1996
- 1996-06-07 JP JP9502035A patent/JPH11507370A/ja active Pending
- 1996-06-07 CA CA002224191A patent/CA2224191A1/en not_active Withdrawn
- 1996-06-07 WO PCT/US1996/009831 patent/WO1996040739A2/en not_active Ceased
- 1996-06-07 AU AU61088/96A patent/AU722595B2/en not_active Ceased
- 1996-06-07 EP EP96918420A patent/EP0832101B1/en not_active Expired - Lifetime
- 1996-06-07 DK DK96918420T patent/DK0832101T3/da active
- 1996-06-07 DE DE69633126T patent/DE69633126T2/de not_active Expired - Fee Related
- 1996-06-07 AT AT96918420T patent/ATE273318T1/de not_active IP Right Cessation
- 1996-06-07 ES ES96918420T patent/ES2227592T3/es not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| EP0832101B1 (en) | 2004-08-11 |
| WO1996040739A2 (en) | 1996-12-19 |
| WO1996040739A3 (en) | 1997-01-30 |
| AU722595B2 (en) | 2000-08-10 |
| EP0832101A2 (en) | 1998-04-01 |
| DE69633126T2 (de) | 2005-08-11 |
| DE69633126D1 (de) | 2004-09-16 |
| US5908919A (en) | 1999-06-01 |
| ES2227592T3 (es) | 2005-04-01 |
| ATE273318T1 (de) | 2004-08-15 |
| JPH11507370A (ja) | 1999-06-29 |
| AU6108896A (en) | 1996-12-30 |
| CA2224191A1 (en) | 1996-12-19 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DE69424298D1 (de) | Durch glutathion-s-transferase aktivierte verbindungen | |
| TR199700844T1 (xx) | Pirazolil-Benzoil T�revleri. | |
| ES8707552A1 (es) | Procedimiento de preparacion de nuevos derivados tetrapep- tidos de estructura policiclica nitrogenada,asi como sus sales de adicion a un acido o una base farmaceuticamente aceptables | |
| MX9606331A (es) | Nuevos compuestos, procesos para la preparacion de los mismos y agentes antitumor. | |
| ATE132150T1 (de) | 3-alkenyl-1-azabicyclo(3.2.0)hept-2-en-2- carbonsäure-verbindungen | |
| EP0938317A4 (en) | COMPOSITIONS AND METHODS FOR REDUCING RESPIRATORY DEPRESSION | |
| ATE109149T1 (de) | 3-pyrrolidinylthio-1-azabicyclo(3.2.0>-hept-2-e - 2-carbonsäureverbindungen. | |
| DK0832101T3 (da) | Urethan-formidlede, GST-specifikke molekylfrigörelsessystemer | |
| KR870700067A (ko) | 피리도(2,3-d)-피리미딘 유도체 | |
| ES8802421A1 (es) | Un procedimiento para la preparacion de un derivado de acido 5-imidazolcarboxilico | |
| TW256832B (da) | ||
| AU3367693A (en) | Methotrexate derivative | |
| DE69203724D1 (de) | Amidderivate vom Antibiotikum A 40926. | |
| HUP9801156A2 (hu) | Karbapenem-3-karbonsav-észter-származékok | |
| GR1002573B (el) | Μικροβιακη μεθοδος παρασκευης μεβινολινης. | |
| EP1020447A4 (en) | PYRAZOLE-BASED COMPOUNDS AND PLANT DISEASE CONTROL AGENT | |
| AU4765796A (en) | Imidazolidinone derivatives as corrosion inhibitors | |
| ES2103161A1 (es) | Derivados de cicloheptimidazol, metodo de fabricacion de los mismos y agentes terapeuticos que contienen estos compuestos. | |
| RU94046387A (ru) | Производные пиримидина, способ их получения, фармацевтическая композиция, ее применение и промежуточные продукты | |
| AU8226891A (en) | Benzopyran derivative, production thereof, and pharmaceutical composition containing the same | |
| AU6117698A (en) | Antiviral agents | |
| AU5715894A (en) | Methotrexate derivative | |
| CA2211681A1 (en) | Novel pyridonecarboxylic acid derivatives or salts thereof and antibacterial agents comprising the same as active ingredient | |
| AU740079C (en) | Antirheumatic agents | |
| AU1076802A (en) | Selective glucocorticoid receptor agonists |