DK0828758T3 - Kimæriske fedtlegeme-pro-GRF-analoger med forøget biologisk potensering - Google Patents
Kimæriske fedtlegeme-pro-GRF-analoger med forøget biologisk potenseringInfo
- Publication number
- DK0828758T3 DK0828758T3 DK96914826T DK96914826T DK0828758T3 DK 0828758 T3 DK0828758 T3 DK 0828758T3 DK 96914826 T DK96914826 T DK 96914826T DK 96914826 T DK96914826 T DK 96914826T DK 0828758 T3 DK0828758 T3 DK 0828758T3
- Authority
- DK
- Denmark
- Prior art keywords
- grf
- pro
- chimeric
- grf analogs
- adipose
- Prior art date
Links
- 230000002209 hydrophobic effect Effects 0.000 abstract 2
- 206010056438 Growth hormone deficiency Diseases 0.000 abstract 1
- 150000001413 amino acids Chemical class 0.000 abstract 1
- 229940124325 anabolic agent Drugs 0.000 abstract 1
- 239000003263 anabolic agent Substances 0.000 abstract 1
- 230000001195 anabolic effect Effects 0.000 abstract 1
- 238000004873 anchoring Methods 0.000 abstract 1
- 238000003745 diagnosis Methods 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 230000002163 immunogen Effects 0.000 abstract 1
- 230000002035 prolonged effect Effects 0.000 abstract 1
- 238000003786 synthesis reaction Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/60—Growth hormone-releasing factor [GH-RF], i.e. somatoliberin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/25—Growth hormone-releasing factor [GH-RF], i.e. somatoliberin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/02—Nutrients, e.g. vitamins, minerals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/02—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S930/00—Peptide or protein sequence
- Y10S930/01—Peptide or protein sequence
- Y10S930/12—Growth hormone, growth factor other than t-cell or b-cell growth factor, and growth hormone releasing factor; related peptides
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Endocrinology (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Biochemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Zoology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Gastroenterology & Hepatology (AREA)
- Genetics & Genomics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biophysics (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Hematology (AREA)
- Toxicology (AREA)
- Immunology (AREA)
- Biomedical Technology (AREA)
- Diabetes (AREA)
- Urology & Nephrology (AREA)
- Biotechnology (AREA)
- Physics & Mathematics (AREA)
- Obesity (AREA)
- Cell Biology (AREA)
- Microbiology (AREA)
- Nutrition Science (AREA)
- Food Science & Technology (AREA)
- Epidemiology (AREA)
- Analytical Chemistry (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US45306795A | 1995-05-26 | 1995-05-26 | |
US65164596A | 1996-05-22 | 1996-05-22 | |
PCT/CA1996/000327 WO1996037514A1 (en) | 1995-05-26 | 1996-05-22 | Chimeric fatty body-pro-grf analogs with increased biological potency |
Publications (1)
Publication Number | Publication Date |
---|---|
DK0828758T3 true DK0828758T3 (da) | 2002-01-07 |
Family
ID=27036979
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK96914826T DK0828758T3 (da) | 1995-05-26 | 1996-05-22 | Kimæriske fedtlegeme-pro-GRF-analoger med forøget biologisk potensering |
Country Status (13)
Country | Link |
---|---|
US (2) | US5861379A (ko) |
EP (1) | EP0828758B1 (ko) |
JP (1) | JP3576170B2 (ko) |
KR (1) | KR100543190B1 (ko) |
AT (1) | ATE204881T1 (ko) |
AU (1) | AU697119B2 (ko) |
BR (2) | BRPI9608799B8 (ko) |
CA (1) | CA2222068C (ko) |
DE (1) | DE69614849T2 (ko) |
DK (1) | DK0828758T3 (ko) |
ES (1) | ES2163020T3 (ko) |
PT (1) | PT828758E (ko) |
WO (1) | WO1996037514A1 (ko) |
Families Citing this family (33)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6020311A (en) * | 1995-05-26 | 2000-02-01 | Theratechnologies, Inc. | GRF analogs with increased biological potency |
US6458764B1 (en) * | 1995-05-26 | 2002-10-01 | Theratechnologies Inc. | GRF analogs with increased biological potency |
US6420518B1 (en) | 1997-04-04 | 2002-07-16 | Genetech, Inc. | Insulin-like growth factor agonist molecules |
US6121416A (en) | 1997-04-04 | 2000-09-19 | Genentech, Inc. | Insulin-like growth factor agonist molecules |
US6696063B1 (en) * | 1998-12-30 | 2004-02-24 | Applied Research Systems Ars Holding N.V. | Treatment of HIV-associated dysmorphia/dysmetabolic syndrome (HADDS) with or without lipodystrophy |
JP3971108B2 (ja) | 1999-01-06 | 2007-09-05 | ジェネンテック・インコーポレーテッド | インシュリン様成長因子(igf)i突然変異体 |
JP2000350590A (ja) * | 1999-04-12 | 2000-12-19 | Pfizer Prod Inc | 成長ホルモン及び成長ホルモン放出ホルモン組成物 |
US6759393B1 (en) | 1999-04-12 | 2004-07-06 | Pfizer Inc. | Growth hormone and growth hormone releasing hormone compositions |
AU2001263215A1 (en) | 2000-05-16 | 2001-11-26 | Genentech Inc. | Method for treating cartilage disorders |
BR0113178A (pt) * | 2000-08-02 | 2004-04-06 | Theratechnologies Inc | Peptìdeos biológicos modificados com potência aumentada |
EP1205551A1 (en) * | 2000-11-09 | 2002-05-15 | Pfizer Products Inc. | Growth hormone and growth hormone releasing hormone compositions |
FR2851461B1 (fr) * | 2003-02-21 | 2007-04-20 | Seppic Sa | Utilisation de n-octanoyl aminoacides comme actif cosmetique et pharmaceutique amincissant |
AU2003229222B2 (en) | 2003-05-29 | 2009-11-12 | Theratechnologies Inc. | GRF analog compositions and their use |
DK2274978T3 (en) | 2003-09-12 | 2015-06-15 | Ipsen Biopharmaceuticals Inc | Methods of treating an insulin-like growth factor-I (IGF-I) deficiency |
CA2542433A1 (en) * | 2003-10-20 | 2005-04-28 | Theratechnologies Inc. | Use of growth hormone releasing factor analogs in treating patients suffering from wasting |
PT2118123E (pt) | 2007-01-31 | 2016-02-10 | Harvard College | Péptidos de p53 estabilizados e suas utilizações |
ES2430067T3 (es) | 2007-03-28 | 2013-11-18 | President And Fellows Of Harvard College | Polipéptidos cosidos |
US20100267635A1 (en) * | 2009-04-20 | 2010-10-21 | Theratechonolgies Inc. | Use of protease inhibitors and grf molecules in combination therapy |
US20100267636A1 (en) * | 2009-04-20 | 2010-10-21 | Theratechnologies Inc. | Use of cytochrome p450-metabolized drugs and grf molecules in combination therapy |
WO2012021874A1 (en) | 2010-08-13 | 2012-02-16 | Aileron Therapeutics, Inc. | Peptidomimetic macrocycles with thioether linkers |
EP2616095A4 (en) * | 2010-09-16 | 2014-03-19 | Univ Miami | ACCELERATING WOUND HEALING WITH HORMONE FOR RELEASE OF GROWTH HORMONE AND AGONISTS |
MX2013012259A (es) | 2011-04-21 | 2013-11-22 | Theratechnologies Inc | Analogos del factor de liberacion de la hormona de crecimiento (grf) y usos de estos. |
BR112014009418A2 (pt) | 2011-10-18 | 2017-04-18 | Aileron Therapeutics Inc | macrociclos peptidomiméticos |
EP2819688A4 (en) | 2012-02-15 | 2015-10-28 | Aileron Therapeutics Inc | TRIAZOL AND THIOETHER-COUPLED PEPTIDOMIMETIC MACROCYCLES |
AU2013221432B2 (en) | 2012-02-15 | 2018-01-18 | Aileron Therapeutics, Inc. | Peptidomimetic macrocycles |
CN102702343A (zh) * | 2012-06-14 | 2012-10-03 | 吉尔生化(上海)有限公司 | 一种固相合成替莫瑞林的方法 |
WO2013190520A2 (en) | 2012-06-22 | 2013-12-27 | The General Hospital Corporation | Gh-releasing agents in the treatment of vascular stenosis and associated conditions |
JP6526563B2 (ja) | 2012-11-01 | 2019-06-05 | エイルロン セラピューティクス,インコーポレイテッド | 二置換アミノ酸ならびにその調製および使用の方法 |
US8871713B2 (en) * | 2013-03-01 | 2014-10-28 | Theratechnologies Inc. | Formulations of growth hormone releasing factor (GRF) molecules with improved stability |
CA2961258A1 (en) | 2014-09-24 | 2016-03-31 | Aileron Therapeutics, Inc. | Peptidomimetic macrocycles and uses thereof |
CN107614003A (zh) | 2015-03-20 | 2018-01-19 | 艾瑞朗医疗公司 | 拟肽大环化合物及其用途 |
MX2018012716A (es) | 2016-04-19 | 2019-02-11 | Griffon Pharmaceuticals Inc | Peptidos bioactivos pegilados y usos de los mismos. |
WO2024091863A1 (en) * | 2022-10-25 | 2024-05-02 | Starrock Pharma Llc | Combinatorial, and rotational combinatorial therapies for obesity and other diseases |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4622312A (en) * | 1984-09-24 | 1986-11-11 | Hoffmann-La Roche Inc. | Growth hormone releasing factor analogs |
CA1271600A (en) * | 1985-01-07 | 1990-07-10 | David Howard Coy | Growth hormone-releasing peptides and method of treating mammals therewith |
US4870054A (en) * | 1985-09-27 | 1989-09-26 | Recker Robert R | Treatment for osteoporosis using GRF or a biologically active analog thereof |
DE3742633A1 (de) * | 1987-12-16 | 1989-06-29 | Hoechst Ag | Peptide mit beeinflussender wirkung auf die hypophyse von saeugern |
IL86102A (en) * | 1987-05-11 | 1994-04-12 | Univ Tulane | Alkylated peptides that release growth hormone and their use |
FR2622455B1 (fr) * | 1987-11-04 | 1991-07-12 | Agronomique Inst Nat Rech | Application du facteur de stimulation de la secretion de l'hormone de croissance humaine, de ses fragments actifs et des analogues correspondants, pour augmenter la production laitiere et le poids des nouveau-nes chez les mammiferes |
US5065748A (en) * | 1989-11-14 | 1991-11-19 | University Of South Florida | Method of diagnosing growth hormone disorders employing somatostatin and growth hormone releasing hormone |
US5126324A (en) * | 1990-06-07 | 1992-06-30 | Genentech, Inc. | Method of enhancing growth in patients using combination therapy |
ZA922746B (en) * | 1991-04-26 | 1992-12-30 | Lilly Co Eli | Superactive grf analogs |
-
1996
- 1996-05-22 ES ES96914826T patent/ES2163020T3/es not_active Expired - Lifetime
- 1996-05-22 DK DK96914826T patent/DK0828758T3/da active
- 1996-05-22 KR KR1019970708413A patent/KR100543190B1/ko not_active IP Right Cessation
- 1996-05-22 EP EP96914826A patent/EP0828758B1/en not_active Expired - Lifetime
- 1996-05-22 BR BRPI9608799A patent/BRPI9608799B8/pt unknown
- 1996-05-22 AU AU56833/96A patent/AU697119B2/en not_active Expired
- 1996-05-22 JP JP53522596A patent/JP3576170B2/ja not_active Expired - Lifetime
- 1996-05-22 WO PCT/CA1996/000327 patent/WO1996037514A1/en not_active Application Discontinuation
- 1996-05-22 PT PT96914826T patent/PT828758E/pt unknown
- 1996-05-22 AT AT96914826T patent/ATE204881T1/de active
- 1996-05-22 DE DE69614849T patent/DE69614849T2/de not_active Expired - Lifetime
- 1996-05-22 CA CA002222068A patent/CA2222068C/en not_active Expired - Lifetime
- 1996-05-22 BR BRPI9608799-4A patent/BR9608799B1/pt not_active IP Right Cessation
- 1996-08-23 US US08/702,114 patent/US5861379A/en not_active Expired - Lifetime
- 1996-08-23 US US08/702,113 patent/US5939386A/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
KR100543190B1 (ko) | 2006-06-23 |
WO1996037514A1 (en) | 1996-11-28 |
BR9608799A (pt) | 1999-12-07 |
JP3576170B2 (ja) | 2004-10-13 |
AU697119B2 (en) | 1998-09-24 |
EP0828758A1 (en) | 1998-03-18 |
MX9709098A (es) | 1998-06-30 |
US5861379A (en) | 1999-01-19 |
EP0828758B1 (en) | 2001-08-29 |
KR19990021938A (ko) | 1999-03-25 |
BR9608799B1 (pt) | 2009-12-01 |
BRPI9608799B8 (pt) | 2019-11-05 |
AU5683396A (en) | 1996-12-11 |
CA2222068C (en) | 2007-04-10 |
ES2163020T3 (es) | 2002-01-16 |
DE69614849D1 (de) | 2001-10-04 |
CA2222068A1 (en) | 1996-11-28 |
DE69614849T2 (de) | 2002-05-16 |
US5939386A (en) | 1999-08-17 |
JPH11505807A (ja) | 1999-05-25 |
PT828758E (pt) | 2002-02-28 |
ATE204881T1 (de) | 2001-09-15 |
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