DK0809652T3 - Kombineret fremgangsmåde til rensning af vancomycinhydrochlorid - Google Patents
Kombineret fremgangsmåde til rensning af vancomycinhydrochloridInfo
- Publication number
- DK0809652T3 DK0809652T3 DK96901183T DK96901183T DK0809652T3 DK 0809652 T3 DK0809652 T3 DK 0809652T3 DK 96901183 T DK96901183 T DK 96901183T DK 96901183 T DK96901183 T DK 96901183T DK 0809652 T3 DK0809652 T3 DK 0809652T3
- Authority
- DK
- Denmark
- Prior art keywords
- pct
- vancomycin hydrochloride
- purification
- sec
- silica gel
- Prior art date
Links
- 108010059993 Vancomycin Proteins 0.000 title abstract 4
- 229960001572 vancomycin hydrochloride Drugs 0.000 title abstract 4
- LCTORFDMHNKUSG-XTTLPDOESA-N vancomycin monohydrochloride Chemical compound Cl.O([C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1=C2C=C3C=C1OC1=CC=C(C=C1Cl)[C@@H](O)[C@H](C(N[C@@H](CC(N)=O)C(=O)N[C@H]3C(=O)N[C@H]1C(=O)N[C@H](C(N[C@@H](C3=CC(O)=CC(O)=C3C=3C(O)=CC=C1C=3)C(O)=O)=O)[C@H](O)C1=CC=C(C(=C1)Cl)O2)=O)NC(=O)[C@@H](CC(C)C)NC)[C@H]1C[C@](C)(N)[C@H](O)[C@H](C)O1 LCTORFDMHNKUSG-XTTLPDOESA-N 0.000 title abstract 4
- 238000000034 method Methods 0.000 title abstract 3
- 238000000746 purification Methods 0.000 title abstract 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 2
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 abstract 2
- 239000000741 silica gel Substances 0.000 abstract 2
- 229910002027 silica gel Inorganic materials 0.000 abstract 2
- 230000005526 G1 to G0 transition Effects 0.000 abstract 1
- 238000004587 chromatography analysis Methods 0.000 abstract 1
- 238000001914 filtration Methods 0.000 abstract 1
- 239000012535 impurity Substances 0.000 abstract 1
- 238000007911 parenteral administration Methods 0.000 abstract 1
- 238000001556 precipitation Methods 0.000 abstract 1
- 238000004237 preparative chromatography Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K9/00—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof
- C07K9/006—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence being part of a ring structure
- C07K9/008—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence being part of a ring structure directly attached to a hetero atom of the saccharide radical, e.g. actaplanin, avoparcin, ristomycin, vancomycin
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Saccharide Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Cephalosporin Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SI9500039A SI9500039B (sl) | 1995-02-07 | 1995-02-07 | Nov kombiniran postopek čiščenja Vankomicin hidroklorida |
| PCT/SI1996/000003 WO1996024615A1 (en) | 1995-02-07 | 1996-02-06 | New combined process for the purification of vancomycin hydrochloride |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK0809652T3 true DK0809652T3 (da) | 2003-12-08 |
Family
ID=20431542
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK96901183T DK0809652T3 (da) | 1995-02-07 | 1996-02-06 | Kombineret fremgangsmåde til rensning af vancomycinhydrochlorid |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US5853720A (de) |
| EP (1) | EP0809652B1 (de) |
| JP (1) | JPH10513196A (de) |
| AT (1) | ATE247665T1 (de) |
| AU (1) | AU4500396A (de) |
| CA (1) | CA2210990C (de) |
| DE (1) | DE69629551T2 (de) |
| DK (1) | DK0809652T3 (de) |
| ES (1) | ES2205012T3 (de) |
| SI (1) | SI9500039B (de) |
| WO (1) | WO1996024615A1 (de) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI233932B (en) * | 2001-08-24 | 2005-06-11 | Theravance Inc | Process for purifying glycopeptide phosphonate derivatives |
| AU2003294262B2 (en) * | 2002-11-18 | 2007-08-23 | Vicuron Pharmaceuticals Inc. | Methods of administering dalbavancin for treatment of bacterial infections |
| KR100554481B1 (ko) * | 2004-06-30 | 2006-03-03 | 씨제이 주식회사 | 반코마이신 염산염의 정제방법 |
| CN100408596C (zh) * | 2005-11-30 | 2008-08-06 | 上海医药工业研究院 | 供hplc分析的万古霉素发酵液前处理方法 |
| EP1798237A1 (de) | 2005-12-16 | 2007-06-20 | Pharmatex Italia Srl | Prozess zur Reinigung von Makrolid-Antibiotika |
| KR101101663B1 (ko) | 2009-01-13 | 2011-12-30 | (주) 제노텍 | 반코마이신 습체의 정제방법 |
| JP2011153119A (ja) * | 2010-01-27 | 2011-08-11 | Mylan Seiyaku Ltd | バンコマイシンまたはその塩を含有する錠剤 |
| US8709310B2 (en) * | 2011-01-05 | 2014-04-29 | Hospira, Inc. | Spray drying vancomycin |
| CN104043104B (zh) | 2013-03-15 | 2018-07-10 | 浙江创新生物有限公司 | 含盐酸万古霉素的喷雾干粉及其工业化制备方法 |
| CN104610434B (zh) * | 2013-11-01 | 2019-06-07 | 浙江医药股份有限公司新昌制药厂 | 一种盐酸万古霉素的分离纯化方法 |
| CN104991028B (zh) * | 2015-07-31 | 2017-10-31 | 北京市药品检验所 | Lc‑ms测试物中不挥发性缓冲盐含量的降低方法 |
| CN105461786B (zh) * | 2016-01-23 | 2018-11-16 | 雅赛利(台州)制药有限公司 | 一种盐酸万古霉素的分离纯化工艺 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2577133B2 (ja) * | 1989-11-27 | 1997-01-29 | スティフティング フォール ド テフニスヘ ウェッテンスハッペン | 船舶のプロペラ |
| US5235037A (en) * | 1991-08-15 | 1993-08-10 | American Cyanamid Company | Vancomycin precipitation process |
-
1995
- 1995-02-07 SI SI9500039A patent/SI9500039B/sl not_active IP Right Cessation
-
1996
- 1996-02-06 JP JP8524215A patent/JPH10513196A/ja not_active Withdrawn
- 1996-02-06 DE DE69629551T patent/DE69629551T2/de not_active Expired - Fee Related
- 1996-02-06 DK DK96901183T patent/DK0809652T3/da active
- 1996-02-06 EP EP96901183A patent/EP0809652B1/de not_active Expired - Lifetime
- 1996-02-06 AU AU45003/96A patent/AU4500396A/en not_active Abandoned
- 1996-02-06 US US08/875,443 patent/US5853720A/en not_active Expired - Fee Related
- 1996-02-06 AT AT96901183T patent/ATE247665T1/de not_active IP Right Cessation
- 1996-02-06 ES ES96901183T patent/ES2205012T3/es not_active Expired - Lifetime
- 1996-02-06 CA CA002210990A patent/CA2210990C/en not_active Expired - Fee Related
- 1996-02-06 WO PCT/SI1996/000003 patent/WO1996024615A1/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| AU4500396A (en) | 1996-08-27 |
| EP0809652B1 (de) | 2003-08-20 |
| SI9500039B (sl) | 2002-02-28 |
| ATE247665T1 (de) | 2003-09-15 |
| WO1996024615A1 (en) | 1996-08-15 |
| CA2210990C (en) | 2001-07-03 |
| JPH10513196A (ja) | 1998-12-15 |
| DE69629551T2 (de) | 2004-06-17 |
| SI9500039A (en) | 1996-08-31 |
| ES2205012T3 (es) | 2004-05-01 |
| EP0809652A1 (de) | 1997-12-03 |
| DE69629551D1 (de) | 2003-09-25 |
| CA2210990A1 (en) | 1996-08-15 |
| US5853720A (en) | 1998-12-29 |
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