DK0783473T3 - Fremgangsmåde til oprensning af 2,6-diisopropylphenol - Google Patents
Fremgangsmåde til oprensning af 2,6-diisopropylphenolInfo
- Publication number
- DK0783473T3 DK0783473T3 DK95934071T DK95934071T DK0783473T3 DK 0783473 T3 DK0783473 T3 DK 0783473T3 DK 95934071 T DK95934071 T DK 95934071T DK 95934071 T DK95934071 T DK 95934071T DK 0783473 T3 DK0783473 T3 DK 0783473T3
- Authority
- DK
- Denmark
- Prior art keywords
- diisopropylphenol
- purification
- propofol
- crystallization
- hydrolysis
- Prior art date
Links
- OLBCVFGFOZPWHH-UHFFFAOYSA-N propofol Chemical compound CC(C)C1=CC=CC(C(C)C)=C1O OLBCVFGFOZPWHH-UHFFFAOYSA-N 0.000 title abstract 4
- 238000000034 method Methods 0.000 title abstract 2
- 238000000746 purification Methods 0.000 title abstract 2
- 229960004134 propofol Drugs 0.000 abstract 2
- 150000001732 carboxylic acid derivatives Chemical class 0.000 abstract 1
- 238000002425 crystallisation Methods 0.000 abstract 1
- 230000008025 crystallization Effects 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 230000007062 hydrolysis Effects 0.000 abstract 1
- 238000006460 hydrolysis reaction Methods 0.000 abstract 1
- BDHFUVZGWQCTTF-UHFFFAOYSA-N sulfonic acid Chemical compound OS(=O)=O BDHFUVZGWQCTTF-UHFFFAOYSA-N 0.000 abstract 1
- 230000009466 transformation Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C303/00—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides
- C07C303/24—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of esters of sulfuric acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C37/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring
- C07C37/01—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring by replacing functional groups bound to a six-membered aromatic ring by hydroxy groups, e.g. by hydrolysis
- C07C37/055—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring by replacing functional groups bound to a six-membered aromatic ring by hydroxy groups, e.g. by hydrolysis the substituted group being bound to oxygen, e.g. ether group
- C07C37/0555—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring by replacing functional groups bound to a six-membered aromatic ring by hydroxy groups, e.g. by hydrolysis the substituted group being bound to oxygen, e.g. ether group being esterified hydroxy groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C37/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring
- C07C37/68—Purification; separation; Use of additives, e.g. for stabilisation
- C07C37/86—Purification; separation; Use of additives, e.g. for stabilisation by treatment giving rise to a chemical modification
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C67/00—Preparation of carboxylic acid esters
- C07C67/14—Preparation of carboxylic acid esters from carboxylic acid halides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Solid-Sorbent Or Filter-Aiding Compositions (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ITMI941969A IT1270093B (it) | 1994-09-28 | 1994-09-28 | Processo per la purificazione di 2,6-diisopropilfenolo |
| PCT/EP1995/003676 WO1996010004A1 (en) | 1994-09-28 | 1995-09-18 | Process for the purification of 2,6-diisopropylphenol |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK0783473T3 true DK0783473T3 (da) | 1999-10-18 |
Family
ID=11369606
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK95934071T DK0783473T3 (da) | 1994-09-28 | 1995-09-18 | Fremgangsmåde til oprensning af 2,6-diisopropylphenol |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US5589598A (cs) |
| EP (1) | EP0783473B1 (cs) |
| JP (1) | JP3701974B2 (cs) |
| AT (1) | ATE178041T1 (cs) |
| AU (1) | AU687643B2 (cs) |
| CA (1) | CA2200317C (cs) |
| CZ (1) | CZ290597B6 (cs) |
| DE (1) | DE69508599T2 (cs) |
| DK (1) | DK0783473T3 (cs) |
| ES (1) | ES2130656T3 (cs) |
| FI (1) | FI118923B (cs) |
| GR (1) | GR3030327T3 (cs) |
| HU (1) | HU215409B (cs) |
| IT (1) | IT1270093B (cs) |
| NO (1) | NO306506B1 (cs) |
| WO (1) | WO1996010004A1 (cs) |
| ZA (1) | ZA957899B (cs) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5705039A (en) * | 1995-10-13 | 1998-01-06 | Albemarle Corporation | Process for purifying a 2,6-dialkylphenol |
| US6204257B1 (en) | 1998-08-07 | 2001-03-20 | Universtiy Of Kansas | Water soluble prodrugs of hindered alcohols |
| KR100777647B1 (ko) | 1998-08-19 | 2007-11-19 | 스키에파마 캐나다 인코포레이티드 | 프로포폴의 수용성 주사용 분산액 |
| EP1115657B1 (en) * | 1998-09-22 | 2003-05-14 | ExxonMobil Chemical Patents Inc. | Preparation of high silica zeolites bound by zeolite and use thereof |
| KR20000047871A (ko) * | 1998-12-04 | 2000-07-25 | 강재헌 | 고순도 2,6-디이소프로필페놀의 정제방법 |
| IL162692A0 (en) * | 2001-12-28 | 2005-11-20 | Guilford Pharm Inc | Aqueous based pharmaceutical formulations of water-soluble prodrugs of propofol |
| RU2297216C2 (ru) * | 2002-04-08 | 2007-04-20 | Эм-Джи-Ай Джи-Пи,Инк. | Фармацевтические композиции, содержащие растворимые в воде пролекарства пропофола, и способы их применения |
| WO2011161687A1 (en) | 2010-06-23 | 2011-12-29 | Harman Finochem Limited | Process for preparing extra pure 2, 6-diisopropyl phenol |
| EP2522651B1 (en) * | 2011-05-12 | 2013-11-20 | Siegfried AG | Process for the purification of 2,6-diisopropyl phenol |
| CN103360219B (zh) * | 2012-04-06 | 2015-08-19 | 辽宁诺康生物制药有限责任公司 | 一种高纯度丙泊酚的合成方法 |
| KR20160048123A (ko) * | 2013-08-30 | 2016-05-03 | 퓨라닉스 테크놀러지스 비.브이. | 2-포밀-퓨란-5카복실산과 2, 5-퓨란디카복실산을 포함하는 산성 조성물을 정제하는 방법 |
| CN104649867B (zh) * | 2013-11-21 | 2017-02-15 | 辽宁药联制药有限公司 | 一种丙泊酚的制备方法 |
| CN108530269A (zh) * | 2018-04-11 | 2018-09-14 | 南安市创培电子科技有限公司 | 一种高纯度丙泊酚的生产方法 |
| JP7288665B2 (ja) * | 2019-08-02 | 2023-06-08 | 株式会社デ・ウエスタン・セラピテクス研究所 | エチルアニリノトルエンスルホン酸誘導体の製造方法 |
| EP4100384A1 (en) | 2020-02-06 | 2022-12-14 | Nandkumar Chodankar | Simple manufacturing and purification technology for high purity propofol |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3271314A (en) * | 1958-12-04 | 1966-09-06 | Ethyl Corp | 2, 6-diisopropylphenol |
| GB1472793A (en) * | 1974-03-28 | 1977-05-04 | Ici Ltd | Pharmaceutical compositions |
| FI912102A7 (fi) * | 1991-04-30 | 1992-10-31 | Leiras Oy | Menetelmä 2,6-di-isopropyylifenolin puhdistamiseksi |
-
1994
- 1994-09-28 IT ITMI941969A patent/IT1270093B/it active IP Right Grant
-
1995
- 1995-06-01 US US08/457,592 patent/US5589598A/en not_active Expired - Lifetime
- 1995-09-18 DK DK95934071T patent/DK0783473T3/da active
- 1995-09-18 CA CA002200317A patent/CA2200317C/en not_active Expired - Fee Related
- 1995-09-18 ES ES95934071T patent/ES2130656T3/es not_active Expired - Lifetime
- 1995-09-18 DE DE69508599T patent/DE69508599T2/de not_active Expired - Lifetime
- 1995-09-18 WO PCT/EP1995/003676 patent/WO1996010004A1/en active IP Right Grant
- 1995-09-18 JP JP51132896A patent/JP3701974B2/ja not_active Expired - Fee Related
- 1995-09-18 AU AU36504/95A patent/AU687643B2/en not_active Ceased
- 1995-09-18 HU HU9701798A patent/HU215409B/hu not_active IP Right Cessation
- 1995-09-18 CZ CZ1997935A patent/CZ290597B6/cs not_active IP Right Cessation
- 1995-09-18 AT AT95934071T patent/ATE178041T1/de active
- 1995-09-18 EP EP95934071A patent/EP0783473B1/en not_active Expired - Lifetime
- 1995-09-19 ZA ZA957899A patent/ZA957899B/xx unknown
-
1997
- 1997-03-25 NO NO971425A patent/NO306506B1/no not_active IP Right Cessation
- 1997-03-26 FI FI971264A patent/FI118923B/fi not_active IP Right Cessation
-
1999
- 1999-05-27 GR GR990401414T patent/GR3030327T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP0783473A1 (en) | 1997-07-16 |
| FI118923B (fi) | 2008-05-15 |
| CZ290597B6 (cs) | 2002-08-14 |
| ITMI941969A1 (it) | 1996-03-28 |
| FI971264L (fi) | 1997-03-26 |
| EP0783473B1 (en) | 1999-03-24 |
| ATE178041T1 (de) | 1999-04-15 |
| IT1270093B (it) | 1997-04-28 |
| HUT77183A (hu) | 1998-03-02 |
| AU687643B2 (en) | 1998-02-26 |
| DE69508599D1 (de) | 1999-04-29 |
| WO1996010004A1 (en) | 1996-04-04 |
| ITMI941969A0 (it) | 1994-09-28 |
| GR3030327T3 (en) | 1999-09-30 |
| JP3701974B2 (ja) | 2005-10-05 |
| US5589598A (en) | 1996-12-31 |
| DE69508599T2 (de) | 1999-11-18 |
| CZ93597A3 (en) | 1997-09-17 |
| CA2200317C (en) | 2007-04-17 |
| NO306506B1 (no) | 1999-11-15 |
| ES2130656T3 (es) | 1999-07-01 |
| HU215409B (hu) | 1998-12-28 |
| AU3650495A (en) | 1996-04-19 |
| JPH10506626A (ja) | 1998-06-30 |
| NO971425L (no) | 1997-03-25 |
| ZA957899B (en) | 1996-05-09 |
| CA2200317A1 (en) | 1996-04-04 |
| NO971425D0 (no) | 1997-03-25 |
| FI971264A0 (fi) | 1997-03-26 |
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