DK0779810T3 - Anvendelse af ketoconazol og beslægtede stoffer i medikamenter til behandling af type II-diabetes - Google Patents
Anvendelse af ketoconazol og beslægtede stoffer i medikamenter til behandling af type II-diabetesInfo
- Publication number
- DK0779810T3 DK0779810T3 DK94927881T DK94927881T DK0779810T3 DK 0779810 T3 DK0779810 T3 DK 0779810T3 DK 94927881 T DK94927881 T DK 94927881T DK 94927881 T DK94927881 T DK 94927881T DK 0779810 T3 DK0779810 T3 DK 0779810T3
- Authority
- DK
- Denmark
- Prior art keywords
- ketoconazole
- diabetes
- drugs
- type
- treatment
- Prior art date
Links
- XMAYWYJOQHXEEK-OZXSUGGESA-N (2R,4S)-ketoconazole Chemical compound C1CN(C(=O)C)CCN1C(C=C1)=CC=C1OC[C@@H]1O[C@@](CN2C=NC=C2)(C=2C(=CC(Cl)=CC=2)Cl)OC1 XMAYWYJOQHXEEK-OZXSUGGESA-N 0.000 title abstract 2
- 229960004125 ketoconazole Drugs 0.000 title abstract 2
- 208000001072 type 2 diabetes mellitus Diseases 0.000 title abstract 2
- 229940079593 drug Drugs 0.000 title 1
- 239000003814 drug Substances 0.000 title 1
- 239000000126 substance Substances 0.000 title 1
- MUMGGOZAMZWBJJ-DYKIIFRCSA-N Testostosterone Chemical compound O=C1CC[C@]2(C)[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CCC2=C1 MUMGGOZAMZWBJJ-DYKIIFRCSA-N 0.000 abstract 2
- JYGXADMDTFJGBT-VWUMJDOOSA-N hydrocortisone Chemical compound O=C1CC[C@]2(C)[C@H]3[C@@H](O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 JYGXADMDTFJGBT-VWUMJDOOSA-N 0.000 abstract 2
- 208000031773 Insulin resistance syndrome Diseases 0.000 abstract 1
- 208000001145 Metabolic Syndrome Diseases 0.000 abstract 1
- 201000000690 abdominal obesity-metabolic syndrome Diseases 0.000 abstract 1
- 230000001857 anti-mycotic effect Effects 0.000 abstract 1
- 239000002543 antimycotic Substances 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 230000002498 deadly effect Effects 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 229940088597 hormone Drugs 0.000 abstract 1
- 239000005556 hormone Substances 0.000 abstract 1
- 229960000890 hydrocortisone Drugs 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 208000011580 syndromic disease Diseases 0.000 abstract 1
- 238000003786 synthesis reaction Methods 0.000 abstract 1
- 229960003604 testosterone Drugs 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65B—MACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
- B65B1/00—Packaging fluent solid material, e.g. powders, granular or loose fibrous material, loose masses of small articles, in individual containers or receptacles, e.g. bags, sacks, boxes, cartons, cans, or jars
- B65B1/04—Methods of, or means for, filling the material into the containers or receptacles
- B65B1/08—Methods of, or means for, filling the material into the containers or receptacles by vibratory feeders
Landscapes
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Diabetes (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Mechanical Engineering (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Steroid Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/SE1994/000729 WO1996004912A1 (en) | 1994-08-09 | 1994-08-09 | Use of ketoconazole and related substances in medicaments for treatment of type ii diabetes |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK0779810T3 true DK0779810T3 (da) | 2003-10-20 |
Family
ID=20393155
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK94927881T DK0779810T3 (da) | 1994-08-09 | 1994-08-09 | Anvendelse af ketoconazol og beslægtede stoffer i medikamenter til behandling af type II-diabetes |
Country Status (14)
| Country | Link |
|---|---|
| US (2) | US5849740A (de) |
| EP (2) | EP0779810B8 (de) |
| JP (1) | JP3825469B2 (de) |
| KR (1) | KR100422162B1 (de) |
| AT (1) | ATE244009T1 (de) |
| CA (1) | CA2196174C (de) |
| CZ (1) | CZ285290B6 (de) |
| DE (1) | DE69432905T2 (de) |
| DK (1) | DK0779810T3 (de) |
| ES (1) | ES2202326T3 (de) |
| NO (1) | NO314616B1 (de) |
| PT (1) | PT779810E (de) |
| SI (1) | SI0779810T1 (de) |
| WO (1) | WO1996004912A1 (de) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1996004912A1 (en) * | 1994-08-09 | 1996-02-22 | Metabolic Syndrome I Gbg Ab | Use of ketoconazole and related substances in medicaments for treatment of type ii diabetes |
| US6642236B1 (en) * | 1998-12-14 | 2003-11-04 | Cortendo Ab | Methods for prophylactic treatment of cardiovascular disease with inhibitor of cortisol synthesis |
| SE9700642D0 (sv) | 1997-02-24 | 1997-02-24 | Kronvall Stefan Med Ab | Medel och sätt för förebyggande och behandling av det metabola syndromet |
| GB0001449D0 (en) * | 2000-01-21 | 2000-03-08 | Cortendo Ab | Compositions |
| SE0001899D0 (sv) | 2000-05-22 | 2000-05-22 | Pharmacia & Upjohn Ab | New compounds |
| GB0118300D0 (en) * | 2001-07-26 | 2001-09-19 | Cortendo Ab | Formulations |
| AU2002365122A1 (en) * | 2001-08-23 | 2003-07-15 | New England Biolabs, Inc. | A method for engineering strand-specific, sequence-specific, dna-nicking enzymes |
| US7094792B2 (en) | 2001-11-22 | 2006-08-22 | Biovitrum Ab | Inhibitors of 11-beta-hydroxy steroid dehydrogenase type 1 |
| US9655865B2 (en) | 2002-07-29 | 2017-05-23 | Veroscience, Llc | Therapeutic treatment for metabolic syndrome, type 2 diabetes, obesity, or prediabetes |
| US20080200453A1 (en) | 2002-07-29 | 2008-08-21 | Cincotta Anthony H | Methods of treating metabolic syndrome using dopamine receptor agonists |
| US20040220190A1 (en) * | 2002-07-29 | 2004-11-04 | Cincotta Anthony H. | Methods of treating metabolic syndrome using dopamine receptor agonists |
| US20040081678A1 (en) * | 2002-08-09 | 2004-04-29 | Anthony Cincotta | Therapeutic process for the treatment of obesity and associated metabolic disorders |
| US8821915B2 (en) | 2002-08-09 | 2014-09-02 | Veroscience, Llc | Therapeutic process for the treatment of the metabolic syndrome and associated metabolic disorders |
| EP2053409A1 (de) | 2003-11-20 | 2009-04-29 | F. Hoffmann-La Roche Ag | Spezifische Marker für Stoffwechselsyndrome |
| US20050215558A1 (en) * | 2004-03-25 | 2005-09-29 | Cincotta Anthony H | Methods of identifying responders to dopamine agonist therapy |
| US8137994B2 (en) * | 2004-03-25 | 2012-03-20 | Veroscience Llc | Methods of identifying responders to dopamine agonist therapy and treating metabolic conditions thereof |
| US8137993B2 (en) * | 2004-03-25 | 2012-03-20 | Veroscience Llc | Methods of identifying responders to dopamine agonist therapy and treating metabolic conditions thereof |
| MX2007008331A (es) * | 2005-01-10 | 2008-01-14 | Cortendo Invest Ab Publ | Metodos y composiciones para el tratamiento de diabetes, sindrome metabolico y otras condiciones. |
| EP1976526A2 (de) * | 2006-01-10 | 2008-10-08 | Diobex, Inc. | Verfahren und zusammensetzungen zur behandlung von prostatakrebs |
| JP2006206605A (ja) * | 2006-03-29 | 2006-08-10 | Metabolic Syndrome I Goeteborg Ab | 代謝性症候群の治療薬 |
| EP1886695A1 (de) * | 2006-06-27 | 2008-02-13 | Speedel Experimenta AG | Pharmazeutische Kombinationen mit einem Aldosteron Synthasehemmer und Glucocorticoid Rezeptorantagonisten oder Cortisol Synthasehemmer oder Corticotropin Releasing Faktor Antagonisten |
| BRPI0719835A2 (pt) * | 2006-10-02 | 2014-05-06 | Cortendo Invest Ab | Enantiômero de cetoconazol em humanos |
| US9352025B2 (en) | 2009-06-05 | 2016-05-31 | Veroscience Llc | Combination of dopamine agonists plus first phase insulin secretagogues for the treatment of metabolic disorders |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5432176A (en) * | 1988-11-29 | 1995-07-11 | The John Hopkins University | Method of retarding the progression of chronic renal failure |
| US5175144A (en) * | 1988-11-29 | 1992-12-29 | The Johns Hopkins University | Method of retarding the progression of chronic renal failure |
| WO1996004912A1 (en) * | 1994-08-09 | 1996-02-22 | Metabolic Syndrome I Gbg Ab | Use of ketoconazole and related substances in medicaments for treatment of type ii diabetes |
| US5591736A (en) * | 1995-07-03 | 1997-01-07 | The Johns Hopkins University | Method of retarding the progression of chronic renal failure |
-
1994
- 1994-08-09 WO PCT/SE1994/000729 patent/WO1996004912A1/en active IP Right Grant
- 1994-08-09 EP EP94927881A patent/EP0779810B8/de not_active Expired - Lifetime
- 1994-08-09 AT AT94927881T patent/ATE244009T1/de active
- 1994-08-09 KR KR1019970700852A patent/KR100422162B1/ko not_active IP Right Cessation
- 1994-08-09 EP EP03012414A patent/EP1360960A1/de not_active Ceased
- 1994-08-09 JP JP50722396A patent/JP3825469B2/ja not_active Expired - Fee Related
- 1994-08-09 SI SI9430454T patent/SI0779810T1/xx unknown
- 1994-08-09 DE DE69432905T patent/DE69432905T2/de not_active Expired - Lifetime
- 1994-08-09 CZ CZ97360A patent/CZ285290B6/cs not_active IP Right Cessation
- 1994-08-09 DK DK94927881T patent/DK0779810T3/da active
- 1994-08-09 ES ES94927881T patent/ES2202326T3/es not_active Expired - Lifetime
- 1994-08-09 CA CA002196174A patent/CA2196174C/en not_active Expired - Fee Related
- 1994-08-09 PT PT94927881T patent/PT779810E/pt unknown
- 1994-08-09 US US08/776,983 patent/US5849740A/en not_active Expired - Lifetime
-
1997
- 1997-02-07 NO NO19970567A patent/NO314616B1/no not_active IP Right Cessation
-
1998
- 1998-12-14 US US09/211,282 patent/US6166017A/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| ES2202326T3 (es) | 2004-04-01 |
| DE69432905T2 (de) | 2004-05-27 |
| NO970567L (no) | 1997-02-07 |
| US6166017A (en) | 2000-12-26 |
| EP0779810B8 (de) | 2003-09-17 |
| CZ285290B6 (cs) | 1999-06-16 |
| JPH10510241A (ja) | 1998-10-06 |
| SI0779810T1 (en) | 2003-12-31 |
| AU695011B2 (en) | 1998-08-06 |
| WO1996004912A1 (en) | 1996-02-22 |
| KR100422162B1 (ko) | 2004-07-07 |
| CZ36097A3 (en) | 1997-06-11 |
| EP1360960A1 (de) | 2003-11-12 |
| US5849740A (en) | 1998-12-15 |
| ATE244009T1 (de) | 2003-07-15 |
| EP0779810B1 (de) | 2003-07-02 |
| JP3825469B2 (ja) | 2006-09-27 |
| DE69432905D1 (de) | 2003-08-07 |
| CA2196174A1 (en) | 1996-02-22 |
| AU7711894A (en) | 1996-03-07 |
| NO314616B1 (no) | 2003-04-22 |
| KR970704440A (ko) | 1997-09-06 |
| EP0779810A1 (de) | 1997-06-25 |
| PT779810E (pt) | 2003-11-28 |
| NO970567D0 (no) | 1997-02-07 |
| CA2196174C (en) | 2005-03-01 |
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