DK0762897T3 - Fremgangsmåde til forebyggelse af aggregering af proteiner/peptider ved rehydratisering eller optøning - Google Patents
Fremgangsmåde til forebyggelse af aggregering af proteiner/peptider ved rehydratisering eller optøningInfo
- Publication number
- DK0762897T3 DK0762897T3 DK95921031T DK95921031T DK0762897T3 DK 0762897 T3 DK0762897 T3 DK 0762897T3 DK 95921031 T DK95921031 T DK 95921031T DK 95921031 T DK95921031 T DK 95921031T DK 0762897 T3 DK0762897 T3 DK 0762897T3
- Authority
- DK
- Denmark
- Prior art keywords
- thawing
- rehydration
- preventing protein
- peptide aggregation
- substances
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 2
- 238000010257 thawing Methods 0.000 title abstract 2
- 230000006919 peptide aggregation Effects 0.000 title 1
- 230000004845 protein aggregation Effects 0.000 title 1
- 108090000623 proteins and genes Proteins 0.000 title 1
- 102000004169 proteins and genes Human genes 0.000 title 1
- 239000000126 substance Substances 0.000 abstract 3
- 238000004220 aggregation Methods 0.000 abstract 1
- 230000002776 aggregation Effects 0.000 abstract 1
- 230000008014 freezing Effects 0.000 abstract 1
- 238000007710 freezing Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/61—Growth hormone [GH], i.e. somatotropin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/14—Blood; Artificial blood
- A61K35/18—Erythrocytes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Veterinary Medicine (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Zoology (AREA)
- Biophysics (AREA)
- Endocrinology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Toxicology (AREA)
- Analytical Chemistry (AREA)
- Biotechnology (AREA)
- Cell Biology (AREA)
- Developmental Biology & Embryology (AREA)
- Hematology (AREA)
- Virology (AREA)
- General Chemical & Material Sciences (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Immunology (AREA)
- Biomedical Technology (AREA)
- Gastroenterology & Hepatology (AREA)
- Dermatology (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Freezing, Cooling And Drying Of Foods (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US25296794A | 1994-06-02 | 1994-06-02 | |
PCT/GB1995/001277 WO1995033488A1 (fr) | 1994-06-02 | 1995-06-02 | Procede prevenant l'aggregation de differentes substances lors de rehydratations et de decongelations, et compositions obtenues |
Publications (1)
Publication Number | Publication Date |
---|---|
DK0762897T3 true DK0762897T3 (da) | 2003-07-21 |
Family
ID=22958303
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK95921031T DK0762897T3 (da) | 1994-06-02 | 1995-06-02 | Fremgangsmåde til forebyggelse af aggregering af proteiner/peptider ved rehydratisering eller optøning |
Country Status (10)
Country | Link |
---|---|
US (2) | US6890512B2 (fr) |
EP (1) | EP0762897B1 (fr) |
JP (2) | JP4142095B2 (fr) |
CN (1) | CN1188171C (fr) |
AT (1) | ATE235919T1 (fr) |
DE (1) | DE69530196T2 (fr) |
DK (1) | DK0762897T3 (fr) |
ES (1) | ES2194911T3 (fr) |
PT (1) | PT762897E (fr) |
WO (1) | WO1995033488A1 (fr) |
Families Citing this family (66)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5621094A (en) * | 1990-05-14 | 1997-04-15 | Quadrant Holdings Cambridge Limited | Method of preserving agarose gel structure during dehydration by adding a non-reducing glycoside of a straight-chain sugar alcohol |
US5955448A (en) * | 1994-08-19 | 1999-09-21 | Quadrant Holdings Cambridge Limited | Method for stabilization of biological substances during drying and subsequent storage and compositions thereof |
WO1995033488A1 (fr) | 1994-06-02 | 1995-12-14 | Quadrant Holdings Cambridge Limited | Procede prevenant l'aggregation de differentes substances lors de rehydratations et de decongelations, et compositions obtenues |
US6290991B1 (en) | 1994-12-02 | 2001-09-18 | Quandrant Holdings Cambridge Limited | Solid dose delivery vehicle and methods of making same |
US6586006B2 (en) | 1994-08-04 | 2003-07-01 | Elan Drug Delivery Limited | Solid delivery systems for controlled release of molecules incorporated therein and methods of making same |
JPH10508744A (ja) | 1994-09-22 | 1998-09-02 | クオドラント ホールディングス ケンブリッジ リミテッド | 運動競技の間の水分補給および栄養摂取の用途のための組成物ならびにその製造法 |
US6964771B1 (en) * | 1995-06-07 | 2005-11-15 | Elan Drug Delivery Limited | Method for stably incorporating substances within dry, foamed glass matrices |
US6267958B1 (en) | 1995-07-27 | 2001-07-31 | Genentech, Inc. | Protein formulation |
AU716785B2 (en) | 1995-07-27 | 2000-03-09 | Genentech Inc. | Stabile isotonic lyophilized protein formulation |
US5958455A (en) * | 1996-02-09 | 1999-09-28 | Quadrant Holdings Cambridge Ltd | Oral solid dosage forms, methods of making same and compositions thereof |
US5762961A (en) * | 1996-02-09 | 1998-06-09 | Quadrant Holdings Cambridge Ltd. | Rapidly soluble oral solid dosage forms, methods of making same, and compositions thereof |
US6632648B1 (en) | 1996-05-14 | 2003-10-14 | Elan Drug Delivery Limited | Methods of terminal sterilization of fibrinogen |
IL124275A (en) | 1997-05-02 | 2002-03-10 | Bio Merieux Vitek Inc | A method to produce sequences of nucleic acids |
US6558901B1 (en) | 1997-05-02 | 2003-05-06 | Biomerieux Vitek | Nucleic acid assays |
US20060165606A1 (en) | 1997-09-29 | 2006-07-27 | Nektar Therapeutics | Pulmonary delivery particles comprising water insoluble or crystalline active agents |
RU2244556C2 (ru) | 1999-02-22 | 2005-01-20 | Юниверсити Оф Коннектикут | Новые не содержащие альбумин составы фактора viii |
FR2791895B1 (fr) * | 1999-03-23 | 2001-06-15 | Pasteur Merieux Serums Vacc | Utilisation de trehalose pour stabiliser un vaccin liquide |
US7871598B1 (en) | 2000-05-10 | 2011-01-18 | Novartis Ag | Stable metal ion-lipid powdered pharmaceutical compositions for drug delivery and methods of use |
US9700866B2 (en) | 2000-12-22 | 2017-07-11 | Baxter International Inc. | Surfactant systems for delivery of organic compounds |
AU2002337692B2 (en) | 2001-09-26 | 2007-09-13 | Baxter International Inc. | Preparation of submicron sized nanoparticles via dispersion and solvent or liquid phase removal |
US7112340B2 (en) * | 2001-10-19 | 2006-09-26 | Baxter International Inc. | Compositions of and method for preparing stable particles in a frozen aqueous matrix |
EP1458360B1 (fr) | 2001-12-19 | 2011-05-11 | Novartis AG | Administration pulmonaire d'aminoglycosides |
US7008644B2 (en) * | 2002-03-20 | 2006-03-07 | Advanced Inhalation Research, Inc. | Method and apparatus for producing dry particles |
US20050163725A1 (en) * | 2002-03-20 | 2005-07-28 | Blizzard Charles D. | Method for administration of growth hormone via pulmonary delivery |
WO2003079993A2 (fr) * | 2002-03-20 | 2003-10-02 | Advanced Inhalation Research, Inc. | Preparations d'hormone de croissance humaine (hch) destinees a etre administrees par voie pulmonaire |
WO2005007282A2 (fr) * | 2003-05-13 | 2005-01-27 | Minerva Biotechnologies Corporation | Stockage et utilisation de particules colloidales |
JP4836797B2 (ja) | 2003-10-23 | 2011-12-14 | 大塚製薬株式会社 | 放出制御性無菌注射アリピプラゾール製剤および方法 |
EP1730516A1 (fr) * | 2004-03-30 | 2006-12-13 | Pfizer Products Incorporated | Procede et dispositif pour l'evaluation de compositions pharmaceutiques |
RU2008117396A (ru) | 2005-10-04 | 2009-11-10 | Альк-Абелло А/С (Dk) | Твердая вакцинная композиция |
WO2008065502A1 (fr) * | 2006-11-29 | 2008-06-05 | Pfizer Products Inc. | Compositions pharmaceutiques constituées a) de nanoparticules comprenant des polymères entériques et b) de la caséine |
DK2131857T3 (en) * | 2007-03-22 | 2015-09-14 | Univ Colorado Regents | A method of producing an immunologically active adjuvansbundet dried vaccine composition |
WO2008125940A2 (fr) * | 2007-04-17 | 2008-10-23 | Pfizer Products Inc. | Nanoparticules comprenant un médicament non cristallin |
US8309129B2 (en) | 2007-05-03 | 2012-11-13 | Bend Research, Inc. | Nanoparticles comprising a drug, ethylcellulose, and a bile salt |
WO2008135855A2 (fr) * | 2007-05-03 | 2008-11-13 | Pfizer Products Inc. | Nanoparticules contenant un inhibiteur de la protéine de transfert d'ester de cholestéryle et un polymère non ionisable |
WO2008135852A2 (fr) * | 2007-05-03 | 2008-11-13 | Pfizer Products Inc. | Compositions pharmaceutiques comprenant des nanoparticules et de la caséine |
EP2162120B1 (fr) * | 2007-06-04 | 2016-05-04 | Bend Research, Inc | Nanoparticules comportant un polymère cellulosique non ionisable et un copolymère bloc amphiphile non ionisable |
US9545384B2 (en) | 2007-06-04 | 2017-01-17 | Bend Research, Inc. | Nanoparticles comprising drug, a non-ionizable cellulosic polymer and tocopheryl polyethylene glocol succinate |
BRPI0813698A2 (pt) * | 2007-07-09 | 2014-12-30 | Novartis Ag | Conservação de estrutura secundária de peptídeos |
US20100215747A1 (en) * | 2007-07-13 | 2010-08-26 | Corey Jay Bloom | Nanoparticles comprising ionizable, poorly water soluble cellulosic polymers |
AR067747A1 (es) | 2007-07-31 | 2009-10-21 | Otsuka Pharma Co Ltd | Metodos para producir suspension de aripiprazol y formulacion liofilizada |
US20090081785A1 (en) * | 2007-09-24 | 2009-03-26 | Hememics Biotechnologies, Inc. | Desiccated Biologics And Methods Of Preparing The Same |
US20090090022A1 (en) * | 2007-10-09 | 2009-04-09 | Hememics Biotechnologies, Inc. | Desiccation Chamber and Methods for Drying Biological Materials |
US9724362B2 (en) * | 2007-12-06 | 2017-08-08 | Bend Research, Inc. | Pharmaceutical compositions comprising nanoparticles and a resuspending material |
EP2240162A4 (fr) * | 2007-12-06 | 2013-10-09 | Bend Res Inc | Nanoparticules comprenant un polymère non ionisable et un copolymère de méthacrylate fonctionnalisé par amine |
JP4563476B2 (ja) | 2008-07-09 | 2010-10-13 | パナソニック株式会社 | 符号化器、復号化器及び符号化方法 |
WO2010036226A1 (fr) * | 2008-09-26 | 2010-04-01 | George Nelson | Méthode de traitement de la polyarthrite rhumatoïde, des tremblements/de la maladie de parkinson et de la sclérose en plaques |
JP5779780B2 (ja) | 2008-11-07 | 2015-09-16 | バクスター・インターナショナル・インコーポレイテッドBaxter International Incorp0Rated | 第viii因子製剤 |
US9827205B2 (en) * | 2008-12-12 | 2017-11-28 | Mallinckrodt Pharma Ip Trading D.A.C. | Dry powder fibrin sealant |
US20120241356A1 (en) * | 2009-07-06 | 2012-09-27 | Sanofi-Aventis Deutschland Gmbh | Heat- and vibration-stable insulin preparations |
US9943075B2 (en) | 2010-02-17 | 2018-04-17 | Hememics Biotechnologies, Inc. | Preservation solutions for biologics and methods related thereto |
JP5341059B2 (ja) * | 2010-11-09 | 2013-11-13 | 株式会社大塚製薬工場 | 幹細胞懸濁液 |
ES2870529T3 (es) | 2010-12-09 | 2021-10-27 | Abbott Point Of Care Inc | Aparato que usa un agente anti-adsorción para facilitar la mezcla y el análisis de muestras |
KR102374576B1 (ko) * | 2011-05-17 | 2022-03-15 | 솔리제닉스, 인크. | 열안정성 백신 조성물 및 그의 제조방법 |
CN104023743B (zh) | 2011-10-25 | 2017-05-03 | 普罗西纳治疗有限公司 | 抗体制剂和方法 |
US20150044251A1 (en) * | 2011-12-23 | 2015-02-12 | Novartis Ag | Stable compositions for immunising against staphylococcus aureus |
JP5432322B2 (ja) * | 2012-05-08 | 2014-03-05 | 株式会社大塚製薬工場 | トレハロース含有肺塞栓形成予防用哺乳動物細胞懸濁液 |
KR20150034170A (ko) * | 2012-06-25 | 2015-04-02 | 이머전트 프로덕트 디벨롭먼트 게이더스버그 인코포레이티드 | 온도 안정성 백신 제형 |
WO2015100344A1 (fr) | 2013-12-27 | 2015-07-02 | Emergent Product Development Gaithersburg Inc. | Formulations de vaccin thermostables |
WO2016069173A2 (fr) * | 2014-09-29 | 2016-05-06 | Cook General Biotechnology Llc | Utilisations du tréhalose dans des suspensions cellulaires |
WO2017172679A1 (fr) * | 2016-03-28 | 2017-10-05 | Cook General Biotechnology Llc | Compositions de cellules viables et procédés associés |
CN107307422B (zh) * | 2017-07-07 | 2018-09-18 | 许辉良 | 速溶石斛提取物及其制备方法 |
CN107373663B (zh) * | 2017-07-07 | 2020-12-25 | 江西清源汉本生物科技有限公司 | 速溶菊花提取物及其制备方法 |
CN107373662B (zh) * | 2017-07-07 | 2020-12-22 | 江西清源汉本生物科技有限公司 | 速溶金银花提取物及其制备方法 |
CA3078625C (fr) | 2017-10-09 | 2023-01-17 | Terumo Bct Biotechnologies, Llc | Recipient de lyophilisation et son procede d'utilisation |
US20200325020A1 (en) * | 2017-10-25 | 2020-10-15 | Merck Sharp & Dohme Corp. | Adjuvanted vaccines |
WO2020185916A1 (fr) | 2019-03-14 | 2020-09-17 | Terumo Bct Biotechnologies, Llc | Agencement de remplissage de contenant de lyophilisation, système et procédé d'utilisation |
Family Cites Families (35)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3557717A (en) | 1968-05-17 | 1971-01-26 | Gen Mills Inc | Process for making candy floss |
US3619294A (en) | 1968-07-15 | 1971-11-09 | Penick & Ford Ltd | Method of combining crystalline sugar with impregnating agents and products produced thereby |
US3632357A (en) | 1969-07-29 | 1972-01-04 | Standard Brands Inc | Method of producing hard candy |
US3655442A (en) | 1969-08-27 | 1972-04-11 | California & Hawaiian Sugar | Method of making sugar and sugar products |
US4127502A (en) | 1977-06-10 | 1978-11-28 | Eastman Kodak Company | Stabilizers for reconstituted, lyophilized samples |
DE2748132A1 (de) | 1977-10-27 | 1979-05-03 | Behringwerke Ag | Stabilisator fuer polysaccharid |
US4158544A (en) | 1978-07-17 | 1979-06-19 | Beckman Instruments, Inc. | Process for preparing a biological composition for use as a reference control in diagnostic analysis |
US4588744A (en) | 1978-09-19 | 1986-05-13 | Mchugh John E | Method of forming an aqueous solution of 3-3-Bis(p-hydroxyphenyl)-phthalide |
US4327076A (en) | 1980-11-17 | 1982-04-27 | Life Savers, Inc. | Compressed chewable antacid tablet and method for forming same |
US4327077A (en) | 1981-05-29 | 1982-04-27 | Life Savers, Inc. | Compressed chewable antacid tablet and method for forming same |
US4457916A (en) | 1982-08-31 | 1984-07-03 | Asahi Kasei Kogyo Kabushiki Kaisha | Method for stabilizing Tumor Necrosis Factor and a stable aqueous solution or powder containing the same |
US4883762A (en) | 1983-06-06 | 1989-11-28 | Ciba Corning Diagnostics Corp. | Stabilized isoenzyme control products |
US4865871A (en) | 1983-08-23 | 1989-09-12 | Board Of Regents The University Of Texas System | Method for cryopreparing biological tissue |
DE3445010A1 (de) | 1984-12-10 | 1986-06-19 | Boehringer Mannheim Gmbh | Kontroll- bzw. eichserum fuer die lipid-diagnostik |
DE229810T1 (de) | 1985-07-09 | 1987-11-05 | Quadrant Bioresources Ltd., Soulbury, Leighton Buzzard, Bedfordshire | Beschuetzung von proteinen und aehnlichem. |
US4806343A (en) * | 1986-03-13 | 1989-02-21 | University Of Southwestern Louisiana | Cryogenic protectant for proteins |
US4762857A (en) | 1986-05-30 | 1988-08-09 | E. I. Du Pont De Nemours And Company | Trehalose as stabilizer and tableting excipient |
US5037644A (en) * | 1986-10-27 | 1991-08-06 | Cetus Corporation | Pharmaceutical compositions of recombinant interleukin-2 and formulation processes |
GB8715238D0 (en) * | 1987-06-29 | 1987-08-05 | Quadrant Bioresources Ltd | Food process |
GB8801338D0 (en) | 1988-01-21 | 1988-02-17 | Quadrant Bioresources Ltd | Preservation of viruses |
CA1331133C (fr) | 1988-03-01 | 1994-08-02 | Michael Jon Pikal | Formulations pharmaceutiques d'hormone de croissance humaine |
US5262296A (en) * | 1988-03-30 | 1993-11-16 | Toray Industries, Inc. | Freeze-dried composition containing enzyme-labeled anti-human interferon-β antibody and enzyme immunoassay kit containing the composition |
US5059518A (en) * | 1988-10-20 | 1991-10-22 | Coulter Corporation | Stabilized lyophilized mammalian cells and method of making same |
US5102788A (en) * | 1988-11-21 | 1992-04-07 | Hygeia Sciences, Inc. | Immunoassay including lyophilized reactant mixture |
GB8903593D0 (en) | 1989-02-16 | 1989-04-05 | Pafra Ltd | Storage of materials |
GB8917470D0 (en) | 1989-07-31 | 1989-09-13 | Quadrant Bioresources Ltd | Composition and method |
AU650678B2 (en) | 1990-08-10 | 1994-06-30 | Analytical Control Systems, Inc. | Stabilization (using gelatin from a cold water fish) of enzymes in diagnostic controls |
US5200399A (en) | 1990-09-14 | 1993-04-06 | Boyce Thompson Institute For Plant Research, Inc. | Method of protecting biological materials from destructive reactions in the dry state |
US5242792A (en) * | 1991-02-25 | 1993-09-07 | The United States Of America As Represented By The Secretary Of The Navy | Method for the preservation of red blood cells by lyophilization using glycerol or inositol with disaccharides |
US5422384A (en) | 1992-11-25 | 1995-06-06 | Battelle Memorial Institute | Glass/polymer composites and methods of making |
EP0717988B1 (fr) | 1993-08-20 | 2001-10-17 | Nippon Shinyaku Company, Limited | Preparation restant dans l'estomac, forme moulee gonflee, et procede de preparation |
US5902565A (en) * | 1993-12-24 | 1999-05-11 | Csl Limited | Spray dried vaccine preparation comprising aluminium adsorbed immunogens |
WO1995033488A1 (fr) * | 1994-06-02 | 1995-12-14 | Quadrant Holdings Cambridge Limited | Procede prevenant l'aggregation de differentes substances lors de rehydratations et de decongelations, et compositions obtenues |
US5512547A (en) | 1994-10-13 | 1996-04-30 | Wisconsin Alumni Research Foundation | Pharmaceutical composition of botulinum neurotoxin and method of preparation |
AU713599B2 (en) | 1995-06-07 | 1999-12-09 | Quadrant Drug Delivery Limited | Methods for stably incorporating substances within dry, foamed glass matrices and compositions obtained thereby |
-
1995
- 1995-06-02 WO PCT/GB1995/001277 patent/WO1995033488A1/fr active IP Right Grant
- 1995-06-02 DE DE69530196T patent/DE69530196T2/de not_active Revoked
- 1995-06-02 ES ES95921031T patent/ES2194911T3/es not_active Expired - Lifetime
- 1995-06-02 AT AT95921031T patent/ATE235919T1/de not_active IP Right Cessation
- 1995-06-02 JP JP50054296A patent/JP4142095B2/ja not_active Expired - Fee Related
- 1995-06-02 CN CNB951944339A patent/CN1188171C/zh not_active Expired - Fee Related
- 1995-06-02 DK DK95921031T patent/DK0762897T3/da active
- 1995-06-02 PT PT95921031T patent/PT762897E/pt unknown
- 1995-06-02 EP EP95921031A patent/EP0762897B1/fr not_active Revoked
-
2001
- 2001-04-16 US US09/836,625 patent/US6890512B2/en not_active Expired - Fee Related
-
2005
- 2005-03-18 US US11/084,223 patent/US20050163750A1/en not_active Abandoned
-
2008
- 2008-01-21 JP JP2008010077A patent/JP2008179636A/ja not_active Withdrawn
Also Published As
Publication number | Publication date |
---|---|
DE69530196D1 (de) | 2003-05-08 |
JP4142095B2 (ja) | 2008-08-27 |
CN1156967A (zh) | 1997-08-13 |
JPH10500990A (ja) | 1998-01-27 |
WO1995033488A1 (fr) | 1995-12-14 |
US20010055583A1 (en) | 2001-12-27 |
DE69530196T2 (de) | 2003-11-20 |
ES2194911T3 (es) | 2003-12-01 |
US20050163750A1 (en) | 2005-07-28 |
PT762897E (pt) | 2003-07-31 |
EP0762897B1 (fr) | 2003-04-02 |
US6890512B2 (en) | 2005-05-10 |
JP2008179636A (ja) | 2008-08-07 |
EP0762897A1 (fr) | 1997-03-19 |
CN1188171C (zh) | 2005-02-09 |
ATE235919T1 (de) | 2003-04-15 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
DK0762897T3 (da) | Fremgangsmåde til forebyggelse af aggregering af proteiner/peptider ved rehydratisering eller optøning | |
DK0804163T3 (da) | Forbedret fremgangsmåde til stabilisering af biologiske stoffer under tørring og efterfølgende opbevaring samt præparater deraf | |
ATE500323T1 (de) | Subtilisin-variante | |
ATE430801T1 (de) | Von wd-40 abstammende peptide und ihre verwendung | |
EA199900381A1 (ru) | Арил(тио)эфиры галогенпиримидина в качестве пестицидов | |
PT101297A (pt) | Factores mitogenicos gliais, sua preparacao e utilizacao | |
DK1142485T3 (da) | Fremgangsmåde til forbedring af oplöseligheden af planteproteiner | |
DE59410380D1 (de) | Endosomolytisch wirksame partikel | |
NO20000265L (no) | Kontrollerte cytolyser av mõlceller, midler og sammensetninger som forõrsaker cytolyse og forbindelser som kan anvendes for õ fremstille midlene | |
IT8323814A0 (it) | Metodo per l'eliminazione di incrinature da basso ciclo di fatica per dischi con palette integrali di rotori di turbina. | |
NO166303C (no) | Fremgangsmaate ved kvantitativ bestemmelse av protein c ogaktivatorpreparat til gjennomfoering av fremgangsmaaten. | |
WO1994012637A3 (fr) | Nouvel homologue de precurseur de proteine amyloide humaine et nouveaux inhibiteurs de type kunitz | |
NO885013D0 (no) | Fremgangsmte for fremstilling av bionedbrytbare mikrokapsler av vannopplelige peptider og proteiner, samt mikroka psler oppndd ved fremgangsmten. | |
EP0335654A3 (fr) | Protéine liant des odeurs à partir du rat | |
ATE270305T1 (de) | Peptide des antisekretorischen faktors, welches krankhafte permeabilitätsanderungen reguliert | |
FI822224L (fi) | Stabiliseringsfoerfarande | |
WO1999047558A3 (fr) | Nouvelles formes de protèines de co-stimulation des lymphocytes t, molècules d'acide nuclèique et leur utilisation | |
ATE356831T1 (de) | Neuer galaninrezeptor | |
DK0939769T3 (da) | Vertebrat-Smoothened-proteiner | |
DE69526972D1 (de) | Verwendung von Gabapentin in der Behandlung vonAngst - und Panikstörungen | |
DK199683D0 (da) | Fremgangsmade til fremstilling af 3-vinylsubstituerede 2,2-dimethylcyclopropan-1-carboxylsyrer eller deres estere, ved fremgangsmaden anvendelige mellemprodukter samt disses fremstilling | |
DK78490D0 (da) | Fremgangsmaade til udvinding af komponenter, grundstoffer eller forbindelser af materialeblandinger | |
ATE265221T1 (de) | Modifizierte, verkürzte regulatoren des komplementsystems | |
SE9604439D0 (sv) | New receptor | |
DE69812597D1 (de) | Peptide zur Inhibition von HPV E7 Proteinen |