DK0730581T3 - 3-acylaminobezazepiner - Google Patents

3-acylaminobezazepiner

Info

Publication number
DK0730581T3
DK0730581T3 DK95901954T DK95901954T DK0730581T3 DK 0730581 T3 DK0730581 T3 DK 0730581T3 DK 95901954 T DK95901954 T DK 95901954T DK 95901954 T DK95901954 T DK 95901954T DK 0730581 T3 DK0730581 T3 DK 0730581T3
Authority
DK
Denmark
Prior art keywords
pct
date
sec
image
pub
Prior art date
Application number
DK95901954T
Other languages
Danish (da)
English (en)
Inventor
John J Baldwin
David A Claremon
Nigel Liverton
Harold G Selnick
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Application granted granted Critical
Publication of DK0730581T3 publication Critical patent/DK0730581T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/16—Benzazepines; Hydrogenated benzazepines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Hydrogenated Pyridines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DK95901954T 1993-11-22 1994-11-21 3-acylaminobezazepiner DK0730581T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US15634893A 1993-11-22 1993-11-22
PCT/US1994/013413 WO1995014671A1 (fr) 1993-11-22 1994-11-21 3-acylaminobenzazepines

Publications (1)

Publication Number Publication Date
DK0730581T3 true DK0730581T3 (da) 2001-11-26

Family

ID=22559195

Family Applications (1)

Application Number Title Priority Date Filing Date
DK95901954T DK0730581T3 (da) 1993-11-22 1994-11-21 3-acylaminobezazepiner

Country Status (12)

Country Link
US (1) US5696111A (fr)
EP (1) EP0730581B1 (fr)
JP (1) JPH09505597A (fr)
AT (1) ATE206402T1 (fr)
AU (1) AU681924B2 (fr)
CA (1) CA2176019A1 (fr)
DE (1) DE69428546T2 (fr)
DK (1) DK0730581T3 (fr)
ES (1) ES2162907T3 (fr)
GR (1) GR3036814T3 (fr)
PT (1) PT730581E (fr)
WO (1) WO1995014671A1 (fr)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2162715A1 (fr) * 1993-05-13 1994-11-24 Hideo Tomozane Compose a base de 3-aminoazepine et son utilisation en pharmacie
WO1996010564A1 (fr) * 1994-10-04 1996-04-11 Pfizer Inc. Procedes et intermediaires permettant de preparer des 3-amino-benzo(b)azepinones
US6683075B1 (en) 1996-12-23 2004-01-27 Athena Neurosciences, Inc. Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use
US6635632B1 (en) 1996-12-23 2003-10-21 Athena Neurosciences, Inc. Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds
US5965734A (en) * 1997-01-31 1999-10-12 Celgene Corporation Processes and intermediates for preparing 2-substituted piperidine stereoisomers
US6528505B1 (en) 1998-06-22 2003-03-04 Elan Pharmaceuticals, Inc. Cyclic amino acid compounds pharmaceutical compositions comprising same and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds
US6569851B1 (en) 1998-06-22 2003-05-27 Elan Pharmaceutials, Inc. Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds
US6509331B1 (en) 1998-06-22 2003-01-21 Elan Pharmaceuticals, Inc. Deoxyamino acid compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds
US6958330B1 (en) 1998-06-22 2005-10-25 Elan Pharmaceuticals, Inc. Polycyclic α-amino-ε-caprolactams and related compounds
US6552013B1 (en) 1998-06-22 2003-04-22 Elan Pharmaceuticals, Inc. Deoxyamino acid compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds
US6774125B2 (en) 1998-06-22 2004-08-10 Elan Pharmaceuticals, Inc. Deoxyamino acid compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds
US6784192B2 (en) 2000-01-20 2004-08-31 Eisai Co., Ltd. Piperidine compound and pharmaceutical composition thereof
DE60234057D1 (de) 2001-07-25 2009-11-26 Raptor Pharmaceutical Inc Zusammensetzungen und verfahren zur modulation des transports durch die blut-hirn-schranke
CN103259027A (zh) 2005-04-28 2013-08-21 普罗透斯数字保健公司 药物信息系统
KR20090071598A (ko) 2006-09-18 2009-07-01 랩터 파마슈티컬 인코포레이티드 수용체 결합 단백질(ｒａｐ)-접합체 투여에 의한 간 질환의 치료
PT2398500T (pt) 2009-02-20 2019-06-14 2 Bbb Medicines B V Sistema de entrega de medicamentos à base de glutationas
TWI556839B (zh) 2009-05-06 2016-11-11 研究室護膚股份有限公司 包含活性劑－磷酸鈣粒子複合物之皮膚遞送組成物及其使用方法
AR079170A1 (es) * 2009-12-10 2011-12-28 Lilly Co Eli Compuesto de ciclopropil-benzamida-imidazo-benzazepina inhibidor de diacil-glicerol aciltransferasa, sal del mismo, composicion farmaceutica que lo comprende, su uso para preparar un medicamento util para el tratamiento de obesidad o para mejorar la sensibilidad a insulina y compuesto intermedio par
US20120077778A1 (en) 2010-09-29 2012-03-29 Andrea Bourdelais Ladder-Frame Polyether Conjugates
WO2020239074A1 (fr) * 2019-05-31 2020-12-03 南京明德新药研发有限公司 Composé bicyclique en tant qu'inhibiteur de la kinase rip-1 et son application

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT75373B (en) * 1981-08-12 1986-06-18 Agripat Sa Process for the preparation of tinted contact lenses
DE3134672A1 (de) * 1981-09-02 1983-03-17 Boehringer Ingelheim KG, 6507 Ingelheim Heterocyclische verbindungen, ihre herstellung und verwendung
US4473575A (en) * 1982-07-19 1984-09-25 Ciba-Geigy Corporation 3-Amino-(1)-benzazepin-2-one-1-alkanoic acids
DE3373469D1 (en) * 1982-09-30 1987-10-15 Merck & Co Inc 1-n-alkylcarboxy-benzofused lactams useful as antihypertensive agents
DK151808C (da) * 1982-11-16 1988-06-20 Ferrosan As Analogifremgangsmaade til fremstilling af oxadiazolylimidazo-oe1,4aa-benzodiazepinderivater
US4470988A (en) * 1983-02-10 1984-09-11 Ciba-Geigy Corporation Benzazocinone and benzazoninone derivatives, and their pharmaceutical use
US4537885A (en) * 1983-02-10 1985-08-27 Ciba Geigy Corporation Certain benzazocinone and benzazoninone derivatives
CA1252462A (fr) * 1984-01-19 1989-04-11 Walter Hunkeler Derives d'imidazodiazepine
US4600534A (en) * 1984-02-06 1986-07-15 Ciba-Geigy Corporation Process and intermediates for manufacture of 3-(5-amino-1-carboxypentylamino)-tetrahydro-1-benzazepin-2-one-1-acetic acid
US4820834A (en) * 1984-06-26 1989-04-11 Merck & Co., Inc. Benzodiazepine analogs
US4692522A (en) * 1985-04-01 1987-09-08 Merck & Co., Inc. Benzofused lactams useful as cholecystokinin antagonists
ES2142309T3 (es) * 1986-10-13 2000-04-16 Sumitomo Dow Ltd Composicion de resina termoplastica que contiene un colorante organometalico.
US4847248A (en) * 1986-12-23 1989-07-11 Merck & Co., Inc. 1,4-Benzodiazepines with 5- and 6-membered heterocyclic rings and their use as cholecystokinins and gastrin antagonists
EP0322779A3 (fr) * 1987-12-29 1991-05-08 Yoshitomi Pharmaceutical Industries, Ltd. Composés de benzolactame et leur utilisation pharmaceutique
IT215722Z2 (it) * 1989-02-21 1990-10-26 Giancarlo De Giacomi Occhiali con specchietti retrovisori orientabili in tutte le direzioni.
US5206234A (en) * 1990-10-22 1993-04-27 Merck & Co., Inc. Benzolactam analogs as antagonists of cck
DE4125457A1 (de) * 1991-08-01 1993-02-04 Bayer Ag Verfahren zur herstellung von n-substituierten lactamen
WO1993008175A1 (fr) * 1991-10-24 1993-04-29 Glaxo Group Limited Derives de benzodiazepine utilises comme antagonistes de la gastrine et/ou de la cholecystokinine
TW213901B (fr) * 1992-01-27 1993-10-01 Pfizer
IT1254558B (it) * 1992-03-26 1995-09-25 Mini Ricerca Scient Tecnolog Composti a base di 3,4-diaril-(5h)-furan-2-one ad attivita' fungicida 3
CA2162715A1 (fr) * 1993-05-13 1994-11-24 Hideo Tomozane Compose a base de 3-aminoazepine et son utilisation en pharmacie
JPH09314058A (ja) * 1996-05-31 1997-12-09 Toshiba Eng Co Ltd 異物捕捉装置

Also Published As

Publication number Publication date
EP0730581A4 (fr) 1997-02-05
AU1100495A (en) 1995-06-13
EP0730581A1 (fr) 1996-09-11
PT730581E (pt) 2002-02-28
ATE206402T1 (de) 2001-10-15
DE69428546D1 (en) 2001-11-08
US5696111A (en) 1997-12-09
AU681924B2 (en) 1997-09-11
CA2176019A1 (fr) 1995-06-01
GR3036814T3 (en) 2002-01-31
EP0730581B1 (fr) 2001-10-04
WO1995014671A1 (fr) 1995-06-01
DE69428546T2 (de) 2002-04-11
JPH09505597A (ja) 1997-06-03
ES2162907T3 (es) 2002-01-16

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