DK0722492T3 - Stabilisering af proteiner i oplösning - Google Patents
Stabilisering af proteiner i oplösningInfo
- Publication number
- DK0722492T3 DK0722492T3 DK94928946T DK94928946T DK0722492T3 DK 0722492 T3 DK0722492 T3 DK 0722492T3 DK 94928946 T DK94928946 T DK 94928946T DK 94928946 T DK94928946 T DK 94928946T DK 0722492 T3 DK0722492 T3 DK 0722492T3
- Authority
- DK
- Denmark
- Prior art keywords
- alkyl
- pct
- sec
- hydroxyalkyl
- sulphonate
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/96—Stabilising an enzyme by forming an adduct or a composition; Forming enzyme conjugates
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Biophysics (AREA)
- Analytical Chemistry (AREA)
- General Engineering & Computer Science (AREA)
- Enzymes And Modification Thereof (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB939320782A GB9320782D0 (en) | 1993-10-08 | 1993-10-08 | Stabilising of proteins on solution |
PCT/GB1994/002180 WO1995010605A1 (en) | 1993-10-08 | 1994-10-06 | Stabilisation of proteins in solution |
Publications (1)
Publication Number | Publication Date |
---|---|
DK0722492T3 true DK0722492T3 (da) | 2005-07-11 |
Family
ID=10743227
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK94928946T DK0722492T3 (da) | 1993-10-08 | 1994-10-06 | Stabilisering af proteiner i oplösning |
Country Status (8)
Country | Link |
---|---|
US (1) | US6133229A (de) |
EP (1) | EP0722492B1 (de) |
AT (1) | ATE290590T1 (de) |
AU (1) | AU7817094A (de) |
DE (1) | DE69434290T2 (de) |
DK (1) | DK0722492T3 (de) |
GB (1) | GB9320782D0 (de) |
WO (1) | WO1995010605A1 (de) |
Families Citing this family (56)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6689265B2 (en) | 1995-10-11 | 2004-02-10 | Therasense, Inc. | Electrochemical analyte sensors using thermostable soybean peroxidase |
GB9708641D0 (en) | 1997-04-29 | 1997-06-18 | Knoll Ag | Enzyme concentrate |
SI1150712T1 (sl) * | 1999-02-05 | 2009-02-28 | Merck & Co Inc | Pripravek cepiva proti humanem papiloma virusu |
WO2001052937A1 (en) | 2000-01-24 | 2001-07-26 | Medtronic Minimed, Inc. | Mixed buffer system for stabilizing polypeptide formulations |
CA2430127C (en) | 2000-11-29 | 2010-04-20 | Novartis Ag | Aqueous disinfecting system comprising a microbicide and 1,3-bis(tris[hydroxymethyl]methylamino)propane |
JP2004525369A (ja) * | 2001-03-07 | 2004-08-19 | インスツルメンテーション ラボラトリー カンパニー | 参照電極 |
EP1252879A1 (de) * | 2001-04-27 | 2002-10-30 | Cosmoferm B.V. | Stabilisierte Enzym Zusammensetzungen |
US6652720B1 (en) | 2001-05-31 | 2003-11-25 | Instrumentation Laboratory Company | Analytical instruments, biosensors and methods thereof |
US6872297B2 (en) * | 2001-05-31 | 2005-03-29 | Instrumentation Laboratory Company | Analytical instruments, biosensors and methods thereof |
US6960466B2 (en) * | 2001-05-31 | 2005-11-01 | Instrumentation Laboratory Company | Composite membrane containing a cross-linked enzyme matrix for a biosensor |
DK1412384T3 (da) | 2001-06-28 | 2008-04-28 | Novo Nordisk As | Stabil formulering af modificeret GLP-1 |
US6737401B2 (en) | 2001-06-28 | 2004-05-18 | Metronic Minimed, Inc. | Methods of evaluating protein formulation stability and surfactant-stabilized insulin formulations derived therefrom |
WO2004053483A2 (en) * | 2002-12-11 | 2004-06-24 | Instrumentation Laboratory Company | Multi-analyte reference solutions |
US20040256227A1 (en) * | 2003-02-11 | 2004-12-23 | Jungwon Shin | Electrochemical urea sensors and methods of making the same |
US20040154933A1 (en) * | 2003-02-11 | 2004-08-12 | Instrumentation Laboratory Company | Polymeric membranes for use in electrochemical sensors |
EP1633391B1 (de) | 2003-06-03 | 2011-10-19 | Novo Nordisk A/S | Stabilisierte pharmazeutische peptid zusammensetzungen |
JP4936884B2 (ja) * | 2003-06-03 | 2012-05-23 | ノボ・ノルデイスク・エー/エス | 安定化された薬学的ペプチド組成物 |
CN102784386A (zh) | 2003-11-20 | 2012-11-21 | 诺沃挪第克公司 | 对于生产和用于注射装置中是最佳的含有丙二醇的肽制剂 |
SG151298A1 (en) | 2004-04-08 | 2009-04-30 | Biomatrica Inc | Integration of sample storage and sample management for life science |
US7740861B2 (en) | 2004-06-16 | 2010-06-22 | University Of Massachusetts | Drug delivery product and methods |
PL1789434T3 (pl) | 2004-08-31 | 2014-07-31 | Novo Nordisk As | Zastosowanie tris(hydroksymetylo)aminometanu do stabilizacji peptydów, polipeptydów i białek |
WO2006032039A2 (en) | 2004-09-17 | 2006-03-23 | University Of Massachusetts | Compositions and their uses for lysosomal enzyme deficiencies |
AU2005303777B2 (en) | 2004-11-12 | 2010-12-16 | Novo Nordisk A/S | Stable formulations of insulinotropic peptides |
US7964200B2 (en) | 2005-05-18 | 2011-06-21 | Children's Hospital & Research Center At Oakland | Methods and compositions for immunizing against Chlamydia infection |
US20070031914A1 (en) * | 2005-08-05 | 2007-02-08 | Wei Zhu | Devices for analyte assays and methods of use |
AU2008289225A1 (en) * | 2007-08-17 | 2009-02-26 | Amgen Inc. | Formulations of antibodies and Fc-fusion molecules using polycations |
JP2011517279A (ja) * | 2007-10-29 | 2011-06-02 | ユニバーシティ オブ マサチューセッツ | 核酸(siRNA)送達用の酵母細胞壁粒子(YCWP)多層状ナノ粒子 |
WO2010008582A2 (en) | 2008-07-18 | 2010-01-21 | Rxi Pharmaceuticals Corporation | Phagocytic cell drug delivery system |
EP2949752B1 (de) | 2008-09-22 | 2017-12-20 | RXi Pharmaceuticals Corporation | Selbstfreisetzende rnai-verbindungen von reduzierter grösse |
WO2010078536A1 (en) | 2009-01-05 | 2010-07-08 | Rxi Pharmaceuticals Corporation | Inhibition of pcsk9 through rnai |
US9745574B2 (en) | 2009-02-04 | 2017-08-29 | Rxi Pharmaceuticals Corporation | RNA duplexes with single stranded phosphorothioate nucleotide regions for additional functionality |
AU2011234264B2 (en) | 2010-03-31 | 2016-02-04 | Stabilitech Ltd | Excipients for stabilising viral particles, polypeptides or biological material |
JP5960120B2 (ja) | 2010-03-31 | 2016-08-02 | スタビリテック リミテッド | ウイルス粒子の安定化 |
JP5933544B2 (ja) | 2010-07-26 | 2016-06-08 | バイオマトリカ, インコーポレーテッド | 外界温度で出荷および貯蔵中の血中dna、rnaおよびタンパク質ならびに他の生体試料を安定化させるための組成物 |
WO2012018639A2 (en) | 2010-07-26 | 2012-02-09 | Biomatrica, Inc. | Compositions for stabilizing dna, rna and proteins in saliva and other biological samples during shipping and storage at ambient temperatures |
WO2012024229A1 (en) | 2010-08-14 | 2012-02-23 | University Of Massachusetts | Yeast cell wall particle for receptor-targeted nanoparticle delivery |
US11246915B2 (en) | 2010-09-15 | 2022-02-15 | Applied Molecular Transport Inc. | Cholix toxin-derived fusion molecules for oral delivery of biologically active cargo |
JP6133208B2 (ja) | 2010-09-15 | 2017-05-24 | マースニー, ランドル, ジェイMRSNY, Randall, J | 細菌毒素由来輸送配列を使用する生物活性剤の送達の系および方法 |
GB201117233D0 (en) * | 2011-10-05 | 2011-11-16 | Stabilitech Ltd | Stabilisation of polypeptides |
EP2934572A4 (de) | 2012-12-20 | 2016-11-23 | Biomatrica Inc | Formulierungen und verfahren zur stabilisierung von pcr-reagenzien |
GB201406569D0 (en) | 2014-04-11 | 2014-05-28 | Stabilitech Ltd | Vaccine compositions |
CA2948346C (en) | 2014-05-07 | 2023-06-27 | Applied Molecular Transport Llc | Cholix toxin-derived fusion molecules for oral delivery of biologically active cargo |
EP3656215B1 (de) | 2014-06-10 | 2021-08-04 | Biomatrica, INC. | Stabilisierung von thrombozyten bei umgebungstemperatur |
US20170007694A1 (en) * | 2015-07-07 | 2017-01-12 | Nanobio Corporation | Methods and compositions for the stabilization of proteins |
WO2017007835A1 (en) | 2015-07-07 | 2017-01-12 | Nanobio Corporation | Methods and compositions for nanoemulsion vaccine formulations |
AU2016368265B2 (en) | 2015-12-08 | 2021-10-28 | Biomatrica, Inc. | Reduction of erythrocyte sedimentation rate |
GB2562241B (en) | 2017-05-08 | 2022-04-06 | Stabilitech Biopharma Ltd | Vaccine compositions |
KR102665710B1 (ko) | 2017-08-24 | 2024-05-14 | 노보 노르디스크 에이/에스 | Glp-1 조성물 및 그 용도 |
SG11202009925PA (en) | 2018-03-08 | 2020-11-27 | Applied Molecular Transport Inc | Toxin-derived delivery constructs for oral delivery |
PT3762009T (pt) | 2018-03-08 | 2022-08-22 | Applied Molecular Transport Inc | Construções de administração derivadas de toxinas para administração oral |
WO2021034727A1 (en) | 2019-08-16 | 2021-02-25 | Applied Molecular Transport Inc. | Compositions, formulations, and interleukin production and purification |
GB202001501D0 (en) | 2020-02-04 | 2020-03-18 | Fabricnano Ltd | Nucleic acid nanostructures |
US20230082544A1 (en) | 2020-02-18 | 2023-03-16 | Novo Nordisk A/S | Pharmaceutical formulations |
GB202007428D0 (en) | 2020-05-19 | 2020-07-01 | Fabricnano Ltd | Polynucleotide synthesis |
GB202110595D0 (en) | 2021-07-22 | 2021-09-08 | Fabricnano Ltd | Functionalised nucleic acid structure |
CN115494232B (zh) * | 2022-10-31 | 2023-10-27 | 江苏三联生物工程股份有限公司 | 4,4-二甲基噁唑啉在制备含辣根过氧化物酶的试剂中的应用 |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4282316A (en) * | 1979-09-11 | 1981-08-04 | Modrovich Ivan Endre | Stabilized enzymic solutions for determining urea |
US4318818A (en) * | 1979-11-09 | 1982-03-09 | The Procter & Gamble Company | Stabilized aqueous enzyme composition |
GB2064543A (en) * | 1979-12-07 | 1981-06-17 | Slovenska Akademia Vied | An Agent for the Release of Cells From Tissues or From the Surface of a Cultivation Vessel |
JPS61176532A (ja) * | 1985-01-30 | 1986-08-08 | Green Cross Corp:The | プラスミノ−ゲンアクチベ−タ−前駆体の安定化方法 |
GB8826429D0 (en) * | 1988-11-11 | 1988-12-14 | Univ Leeds Ind Service Ltd | Enzyme stabilisation systems |
US5116729A (en) * | 1989-03-10 | 1992-05-26 | Miles Inc. | Stabilization of oxidase enzyme-based test strips |
GB9006642D0 (en) * | 1990-03-24 | 1990-05-23 | Gibson Timothy D | Enzyme stabilisation |
JPH07503700A (ja) * | 1991-01-03 | 1995-04-20 | アルカーメス コントロールド セラピューティックス, インコーポレイテッド | カチオン生体ポリマーによるタンパク質の安定化 |
US5356800A (en) * | 1992-11-30 | 1994-10-18 | Buckman Laboratories International, Inc. | Stabilized liquid enzymatic compositions |
-
1993
- 1993-10-08 GB GB939320782A patent/GB9320782D0/en active Pending
-
1994
- 1994-10-06 DK DK94928946T patent/DK0722492T3/da active
- 1994-10-06 EP EP94928946A patent/EP0722492B1/de not_active Expired - Lifetime
- 1994-10-06 AT AT94928946T patent/ATE290590T1/de active
- 1994-10-06 AU AU78170/94A patent/AU7817094A/en not_active Abandoned
- 1994-10-06 WO PCT/GB1994/002180 patent/WO1995010605A1/en active IP Right Grant
- 1994-10-06 DE DE69434290T patent/DE69434290T2/de not_active Expired - Lifetime
- 1994-10-06 US US08/624,585 patent/US6133229A/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
EP0722492A1 (de) | 1996-07-24 |
EP0722492B1 (de) | 2005-03-09 |
AU7817094A (en) | 1995-05-04 |
DE69434290T2 (de) | 2005-12-29 |
ATE290590T1 (de) | 2005-03-15 |
WO1995010605A1 (en) | 1995-04-20 |
US6133229A (en) | 2000-10-17 |
GB9320782D0 (en) | 1993-12-01 |
DE69434290D1 (de) | 2005-04-14 |
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