DK0722492T3 - Stabilisering af proteiner i oplösning - Google Patents
Stabilisering af proteiner i oplösningInfo
- Publication number
- DK0722492T3 DK0722492T3 DK94928946T DK94928946T DK0722492T3 DK 0722492 T3 DK0722492 T3 DK 0722492T3 DK 94928946 T DK94928946 T DK 94928946T DK 94928946 T DK94928946 T DK 94928946T DK 0722492 T3 DK0722492 T3 DK 0722492T3
- Authority
- DK
- Denmark
- Prior art keywords
- alkyl
- pct
- sec
- hydroxyalkyl
- sulphonate
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/96—Stabilising an enzyme by forming an adduct or a composition; Forming enzyme conjugates
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Analytical Chemistry (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Enzymes And Modification Thereof (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB939320782A GB9320782D0 (en) | 1993-10-08 | 1993-10-08 | Stabilising of proteins on solution |
PCT/GB1994/002180 WO1995010605A1 (en) | 1993-10-08 | 1994-10-06 | Stabilisation of proteins in solution |
Publications (1)
Publication Number | Publication Date |
---|---|
DK0722492T3 true DK0722492T3 (da) | 2005-07-11 |
Family
ID=10743227
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK94928946T DK0722492T3 (da) | 1993-10-08 | 1994-10-06 | Stabilisering af proteiner i oplösning |
Country Status (8)
Country | Link |
---|---|
US (1) | US6133229A (de) |
EP (1) | EP0722492B1 (de) |
AT (1) | ATE290590T1 (de) |
AU (1) | AU7817094A (de) |
DE (1) | DE69434290T2 (de) |
DK (1) | DK0722492T3 (de) |
GB (1) | GB9320782D0 (de) |
WO (1) | WO1995010605A1 (de) |
Families Citing this family (56)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6689265B2 (en) | 1995-10-11 | 2004-02-10 | Therasense, Inc. | Electrochemical analyte sensors using thermostable soybean peroxidase |
GB9708641D0 (en) | 1997-04-29 | 1997-06-18 | Knoll Ag | Enzyme concentrate |
JP4841726B2 (ja) | 1999-02-05 | 2011-12-21 | メルク・シャープ・エンド・ドーム・コーポレイション | ヒトパピローマウイルスワクチン製剤 |
AU2001220765A1 (en) | 2000-01-24 | 2001-07-31 | Medtronic Minimed, Inc. | Mixed buffer system for stabilizing polypeptide formulations |
CA2430127C (en) | 2000-11-29 | 2010-04-20 | Novartis Ag | Aqueous disinfecting system comprising a microbicide and 1,3-bis(tris[hydroxymethyl]methylamino)propane |
JP2004525369A (ja) * | 2001-03-07 | 2004-08-19 | インスツルメンテーション ラボラトリー カンパニー | 参照電極 |
EP1252879A1 (de) * | 2001-04-27 | 2002-10-30 | Cosmoferm B.V. | Stabilisierte Enzym Zusammensetzungen |
US6652720B1 (en) | 2001-05-31 | 2003-11-25 | Instrumentation Laboratory Company | Analytical instruments, biosensors and methods thereof |
US6872297B2 (en) * | 2001-05-31 | 2005-03-29 | Instrumentation Laboratory Company | Analytical instruments, biosensors and methods thereof |
US6960466B2 (en) * | 2001-05-31 | 2005-11-01 | Instrumentation Laboratory Company | Composite membrane containing a cross-linked enzyme matrix for a biosensor |
ES2298378T3 (es) | 2001-06-28 | 2008-05-16 | Novo Nordisk A/S | Formulacion estable de glp-1 modificado. |
US6737401B2 (en) * | 2001-06-28 | 2004-05-18 | Metronic Minimed, Inc. | Methods of evaluating protein formulation stability and surfactant-stabilized insulin formulations derived therefrom |
US7422903B2 (en) * | 2002-12-11 | 2008-09-09 | Instrumentation Laboratory Company | Multi-analyte reference solutions |
US20040256227A1 (en) * | 2003-02-11 | 2004-12-23 | Jungwon Shin | Electrochemical urea sensors and methods of making the same |
US20040154933A1 (en) * | 2003-02-11 | 2004-08-12 | Instrumentation Laboratory Company | Polymeric membranes for use in electrochemical sensors |
CN102940879B (zh) * | 2003-06-03 | 2017-06-06 | 诺沃挪第克公司 | 稳定化的药物肽组合物 |
WO2004105790A1 (en) | 2003-06-03 | 2004-12-09 | Novo Nordisk A/S | Stabilized pharmaceutical peptide compositions |
WO2005049061A2 (en) | 2003-11-20 | 2005-06-02 | Novo Nordisk A/S | Propylene glycol-containing peptide formulations which are optimal for production and for use in injection devices |
SG151298A1 (en) | 2004-04-08 | 2009-04-30 | Biomatrica Inc | Integration of sample storage and sample management for life science |
US7740861B2 (en) * | 2004-06-16 | 2010-06-22 | University Of Massachusetts | Drug delivery product and methods |
ES2442223T3 (es) | 2004-08-31 | 2014-02-10 | Novo Nordisk A/S | Uso de tris(hidroximetil) aminometano para la estabilización de péptidos, polipéptidos y proteínas |
CA2580537C (en) | 2004-09-17 | 2015-04-21 | University Of Massachusetts | Compositions and their uses for lysosomal enzyme deficiencies |
BRPI0517341A (pt) | 2004-11-12 | 2008-10-07 | Novo Nordisk As | composição farmacêutica estável em prateleira, métodos para a preparação de uma composição farmacêutica, para o tratamento de hiperglicemia, para o tratamento de obesidade, deficiência de célula beta, igt ou dislipidemia, para a preparação de uma solução estável de um composto glp-1, para a preparação de um composto glp-1 estável e para a preparação de uma composição farmacêutica estável em prateleira de um composto glp-1, solução estável de um composto glp-1, e, uso de uma solução estável de um composto glp-1 |
AU2006247188A1 (en) | 2005-05-18 | 2006-11-23 | Children's Hospital & Research Center At Oakland | Methods and compositions for immunizing against chlamydia infection |
US20070031914A1 (en) * | 2005-08-05 | 2007-02-08 | Wei Zhu | Devices for analyte assays and methods of use |
WO2009026122A1 (en) * | 2007-08-17 | 2009-02-26 | Amgen Inc. | Formulations of antibodies and fc-fusion molecules using polycations |
CA2704056A1 (en) * | 2007-10-29 | 2009-05-07 | University Of Massachusetts | Encapsulated nanoparticles for nucleic acid delivery |
WO2010008582A2 (en) | 2008-07-18 | 2010-01-21 | Rxi Pharmaceuticals Corporation | Phagocytic cell drug delivery system |
CA2746527A1 (en) | 2008-09-22 | 2010-03-25 | Rxi Pharmaceuticals Corporation | Rna interference in skin indications |
US9493774B2 (en) | 2009-01-05 | 2016-11-15 | Rxi Pharmaceuticals Corporation | Inhibition of PCSK9 through RNAi |
WO2010090762A1 (en) | 2009-02-04 | 2010-08-12 | Rxi Pharmaceuticals Corporation | Rna duplexes with single stranded phosphorothioate nucleotide regions for additional functionality |
EP2552478B1 (de) | 2010-03-31 | 2016-12-21 | Stabilitech Ltd. | Hilfsstoffe zur stabilisierung von viralen partikeln |
US10206960B2 (en) | 2010-03-31 | 2019-02-19 | Stabilitech Biopharma Ltd | Stabilisation of viral particles |
US9376709B2 (en) | 2010-07-26 | 2016-06-28 | Biomatrica, Inc. | Compositions for stabilizing DNA and RNA in blood and other biological samples during shipping and storage at ambient temperatures |
EP2598661B1 (de) | 2010-07-26 | 2017-09-27 | Biomatrica, INC. | Zusammensetzungen zur stabilisierung von dna, rna und proteinen in speichel- und anderen biologischen proben während des transports und der lagerung bei umgebungstemperaturen |
EP2603450B1 (de) | 2010-08-14 | 2016-11-02 | University of Massachusetts | Wandpartikel aus hefezellen für rezeptorengerichtete nanopartikelfreisetzung |
US11246915B2 (en) | 2010-09-15 | 2022-02-15 | Applied Molecular Transport Inc. | Cholix toxin-derived fusion molecules for oral delivery of biologically active cargo |
NO2616045T3 (de) | 2010-09-15 | 2018-03-24 | ||
GB201117233D0 (en) * | 2011-10-05 | 2011-11-16 | Stabilitech Ltd | Stabilisation of polypeptides |
EP3249054A1 (de) | 2012-12-20 | 2017-11-29 | Biomatrica, INC. | Formulierungen und verfahren zur stabilisierung von pcr-reagenzien |
GB201406569D0 (en) | 2014-04-11 | 2014-05-28 | Stabilitech Ltd | Vaccine compositions |
IL285716B (en) | 2014-05-07 | 2022-09-01 | Applied Molecular Transp Llc | Compacted molecules derived from colic toxin for oral delivery of biologically active cargo |
JP6661554B2 (ja) | 2014-06-10 | 2020-03-11 | バイオマトリカ,インク. | 周囲温度における血小板の安定化 |
JP2018521129A (ja) * | 2015-07-07 | 2018-08-02 | ナノビオ コーポレイションNanobio Corporation | タンパク質の安定化のための方法および組成物 |
US11173197B2 (en) | 2015-07-07 | 2021-11-16 | Bluewillow Biologics, Inc. | Methods and compositions for nanoemulsion vaccine formulations |
WO2017100212A1 (en) | 2015-12-08 | 2017-06-15 | Biomatrica, Inc. | Reduction of erythrocyte sedimentation rate |
GB2562241B (en) | 2017-05-08 | 2022-04-06 | Stabilitech Biopharma Ltd | Vaccine compositions |
MX2020001525A (es) | 2017-08-24 | 2020-03-20 | Novo Nordisk As | Composiciones de peptido similar al glucagon tipo 1 (glp-1) y sus usos. |
CA3093386A1 (en) | 2018-03-08 | 2019-09-12 | Applied Molecular Transport Inc. | Toxin-derived delivery constructs for oral delivery |
HUE059330T2 (hu) | 2018-03-08 | 2022-11-28 | Applied Molecular Transport Inc | Toxinból származó bejuttatási konstrukciók orális beadásra |
AU2020331939A1 (en) | 2019-08-16 | 2022-03-24 | Applied Molecular Transport Inc. | Compositions, formulations, and interleukin production and purification |
GB202001501D0 (en) | 2020-02-04 | 2020-03-18 | Fabricnano Ltd | Nucleic acid nanostructures |
US20230093542A1 (en) | 2020-02-18 | 2023-03-23 | Novo Nordisk A/S | Glp-1 compositions and uses thereof |
GB202007428D0 (en) | 2020-05-19 | 2020-07-01 | Fabricnano Ltd | Polynucleotide synthesis |
GB202110595D0 (en) | 2021-07-22 | 2021-09-08 | Fabricnano Ltd | Functionalised nucleic acid structure |
CN115494232B (zh) * | 2022-10-31 | 2023-10-27 | 江苏三联生物工程股份有限公司 | 4,4-二甲基噁唑啉在制备含辣根过氧化物酶的试剂中的应用 |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4282316A (en) * | 1979-09-11 | 1981-08-04 | Modrovich Ivan Endre | Stabilized enzymic solutions for determining urea |
US4318818A (en) * | 1979-11-09 | 1982-03-09 | The Procter & Gamble Company | Stabilized aqueous enzyme composition |
GB2064543A (en) * | 1979-12-07 | 1981-06-17 | Slovenska Akademia Vied | An Agent for the Release of Cells From Tissues or From the Surface of a Cultivation Vessel |
JPS61176532A (ja) * | 1985-01-30 | 1986-08-08 | Green Cross Corp:The | プラスミノ−ゲンアクチベ−タ−前駆体の安定化方法 |
GB8826429D0 (en) * | 1988-11-11 | 1988-12-14 | Univ Leeds Ind Service Ltd | Enzyme stabilisation systems |
US5116729A (en) * | 1989-03-10 | 1992-05-26 | Miles Inc. | Stabilization of oxidase enzyme-based test strips |
GB9006642D0 (en) * | 1990-03-24 | 1990-05-23 | Gibson Timothy D | Enzyme stabilisation |
WO1992011844A1 (en) * | 1991-01-03 | 1992-07-23 | Alkermes Controlled Therapeutics, Inc. | Stabilization of proteins by cationic biopolymers |
US5356800A (en) * | 1992-11-30 | 1994-10-18 | Buckman Laboratories International, Inc. | Stabilized liquid enzymatic compositions |
-
1993
- 1993-10-08 GB GB939320782A patent/GB9320782D0/en active Pending
-
1994
- 1994-10-06 DK DK94928946T patent/DK0722492T3/da active
- 1994-10-06 WO PCT/GB1994/002180 patent/WO1995010605A1/en active IP Right Grant
- 1994-10-06 AT AT94928946T patent/ATE290590T1/de active
- 1994-10-06 US US08/624,585 patent/US6133229A/en not_active Expired - Lifetime
- 1994-10-06 AU AU78170/94A patent/AU7817094A/en not_active Abandoned
- 1994-10-06 DE DE69434290T patent/DE69434290T2/de not_active Expired - Lifetime
- 1994-10-06 EP EP94928946A patent/EP0722492B1/de not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
ATE290590T1 (de) | 2005-03-15 |
EP0722492B1 (de) | 2005-03-09 |
WO1995010605A1 (en) | 1995-04-20 |
US6133229A (en) | 2000-10-17 |
DE69434290D1 (de) | 2005-04-14 |
GB9320782D0 (en) | 1993-12-01 |
AU7817094A (en) | 1995-05-04 |
DE69434290T2 (de) | 2005-12-29 |
EP0722492A1 (de) | 1996-07-24 |
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